A sesquiterpene compound in ilex hainanensis and an extraction and separation method and application thereof

Lactones F, G, and H, which were not previously reported in the literature, were separated from *Tea japonica* by water decoction and column chromatography. This method fills the gap in the application of these compounds in antifungal infections, anti-inflammatory analgesia, antitumor drugs, and skin damage repair cosmetics, and enables the separation and efficacy verification of new compounds.

CN119912471BActive Publication Date: 2026-06-09GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARM CO LTD
Filing Date
2025-01-22
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

There are no reports in the prior art regarding the use of quinquefoliolide FH and its application in the preparation of antifungal drugs, anti-inflammatory and analgesic drugs, antitumor drugs, and skin damage repair cosmetics.

Method used

Nine-section tea was extracted by water decoction, and purified by normal-phase silica gel column chromatography and C18 reversed-phase chromatography to separate nine-section tea lactone F, nine-section tea lactone G and nine-section tea lactone H. The lactones were then purified by gradient elution and purification using solvent systems with different ratios.

Benefits of technology

Three novel compounds previously unreported in the literature were successfully isolated and identified, exhibiting antibacterial and anti-inflammatory activities. They have potential development value for diseases such as fungal infections, pharyngitis, and pneumonia, and also possess skin damage repair and anti-aging effects, making them suitable for use in the cosmetics field.

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Abstract

The application discloses a sesquiterpene compound in llex spicata and an extraction and separation method and application thereof, relates to the technical field of plant chemical extraction and separation, and provides a sesquiterpene compound in llex spicata, which is characterized by comprising at least one of llex spicata lactone F, llex spicata lactone G and llex spicata lactone H. The application provides an extraction method of the sesquiterpene compound in llex spicata, and the three sesquiterpenes obtained by the extraction and separation method are all new compounds which have not been reported. The llex spicata sesquiterpene compound has antibacterial and anti-inflammatory activities, and has potential development value for diseases such as fungal infection, pharyngitis and pneumonia. The llex spicata sesquiterpene compound also has the effects of skin damage repair and anti-aging, and can be applied to the field of cosmetics.
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