Enteral nutrition support composition for tumor patients and / or postoperative people and preparation method of enteral nutrition support composition

Abstract

The invention relates to an enteral nutrition support composition for tumor patients and / or postoperative people and a preparation method thereof, and the nutrition support composition comprises the following raw material components: protein powder (isolated protein, whey protein, collagen, vegetable protein, animal peptide and vegetable peptide, the feed is prepared by adding or partially adding rice flour, corn flour, prebiotics, whole egg powder, milk powder, beta-1, 3 / alpha-1, 3-glucan and edible salt into one or more of the components (such as one or more of the components), maltodextrin, powdered oil, dietary fibers, flaxseed powder and compound trace elements. The feed is prepared by adding or partially adding rice flour, corn flour, prebiotics, whole egg powder, milk powder, beta-1, 3 / alpha-1, 3-glucan and edible salt. The composition disclosed by the invention is scientific in nutrition proportion and reasonable in energy supply ratio of various nutrients, can balance nutritional requirements of a human body, effectively improves nutritional conditions of tumor patients and other postoperative patients, enhances immune functions, improves body functions and life quality and prolongs survival time, and has the characteristics of easiness in taking, fine and smooth taste and no unpleasant odor.

Description

Technical Field

[0001] The present invention belongs to the technical field of functional foods, and in particular relates to an enteral nutritional support composition for tumor patients and / or postoperative people and a preparation method thereof. Background Art

[0002] Malnutrition is a common complication in patients with malignant tumors. About 40-80% of tumor patients suffer from malnutrition, which causes decreased tolerance and effectiveness of anti-tumor surgery, chemotherapy, and radiotherapy, increased toxic side effects, decreased physical state, organ damage, poor quality of life, and shortened survival time. Studies have reported that the direct cause of death of about 20% of malignant tumor patients is due to malnutrition. Therefore, improving the nutritional status of tumor patients through nutritional support plays a vital role.

[0003] Enteral nutrition is a nutritional support method that provides nutrients required for metabolism and various other nutrients through the gastrointestinal tract. There are two ways of enteral nutrition: oral and catheter-based. Enteral nutrition is a nutritional support for cancer patients and other postoperative people. It has very important clinical significance for ensuring treatment effects and improving prognosis. On the one hand, special people in such special periods often need high-calorie, high-vitamin and high-protein diets to meet the body consumption and tissue repair required for treatment, and such dietary structure requirements are difficult to obtain through natural or traditional diets. On the other hand, special people in such special periods generally have symptoms such as oral ulcers, esophageal mucosal edema, dysphagia, anorexia, mild abdominal pain and diarrhea, which also causes the problem of difficulty in taking. Summary of the invention

[0004] The purpose of the present invention is to provide an enteral nutritional support composition and a preparation method. The enteral nutritional support composition is specially developed for the nutritional needs of tumor patients and / or postoperative people, has a scientific nutritional ratio, a reasonable energy supply ratio of major nutrients, is easy to take, has a delicate taste, and has no bad smell. It can improve the nutritional status of people in such special periods to improve their immune status and organ function, reduce the toxic and side effects caused by anti-tumor and / or postoperative treatment, and thus play a role in improving the prognosis of patients.

[0005] In order to achieve the above-mentioned purpose of the present invention, the present invention adopts the following technical solutions:

[0006] An enteral nutrition support composition for tumor patients and / or postoperative people comprises the following raw material components in parts by weight: 10-50 parts of whey protein powder, 10-50 parts of maltodextrin, 10-50 parts of powdered oil, 1-50 parts of rice flour, 1-10 parts of dietary fiber, 1-15 parts of corn flour, 0.1-1 parts of complex trace elements, 0.002-0.02 parts of prebiotics, 0.001-0.01 parts of whole egg powder, 0.001-0.01 parts of milk powder, 0.001-0.01 parts of flaxseed powder and 0.05-0.5 parts of edible salt.

[0007] The nutritional support composition provided by the present invention comprises concentrated whey protein powder which provides a protein source for the body. The concentrated whey protein powder is a soluble powder obtained by concentrating protein in whey by ultrafiltration technology and then drying. The main components of the concentrated whey protein powder include beta-lactoglobulin, alpha-lactalbumin, immunoglobulin and lactoferrin. The concentrated whey protein powder is easy to digest and has high biological value, high efficiency, high protein efficacy ratio and high utilization rate.

[0008] The present invention also adds powdered oil and flaxseed powder. The powdered oil is made of refined hydrogenated vegetable oil and various food auxiliary materials, and is prepared by blending, emulsification, sterilization and spray drying. It can improve the nutritional value and calorific value, improve the solubility and reconstitution, and improve the taste, making the product more delicious. Flaxseed powder is rich in various nutritional elements such as selenium, vegetable protein, unsaturated fatty acids and dietary fiber, and has a nutritional effect on the human body. In addition, it also has the effect of improving constipation, can increase the weight of feces, and promote intestinal peristalsis.

[0009] In addition, the present invention also specially adds dietary fiber and complex trace elements, which are beneficial to promoting gastrointestinal motility, improving intestinal microecology, participating in immune regulation, and promoting lipid, protein and mineral metabolism.

[0010] Based on this, the various components of the present invention together constitute a nutrient that is rich in nutrition and balanced, meets the needs of special periods and special groups of people, can effectively prevent cell metabolic disorders, support the structure and function of organs and tissues, and is easy to digest and easy to take. It is particularly suitable for postoperative consumption by tumor patients and / or postoperative people and patients with other gastrointestinal diseases, and can enhance their own immunity through scientific nutritional intake, thereby obtaining better therapeutic effects.

[0011] According to the nutritional support composition of the specific embodiment of the present invention, the energy supply ratio of carbohydrates, proteins and fats is 50-60%: 12-20%: 20-35%.

[0012] According to the nutritional support composition of a specific embodiment of the present invention, the dietary fiber includes any one or more of polydextrose, resistant dextrin and fruit and vegetable powder;

[0013] According to the nutritional support composition of a specific embodiment of the present invention, the complex trace elements include vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacinamide, folic acid, pantothenic acid, biotin, calcium hydrogen phosphate, magnesium chloride, ferric pyrophosphate, zinc gluconate, copper sulfate, magnesium sulfate, potassium iodide, chromium chloride, potassium chloride, sodium molybdate, and sodium selenite.

[0014] According to the nutritional support composition of a specific embodiment of the present invention, the protein content in the whey protein powder is ≥80%, the protein content in the plant protein powder is ≥40%, and the fat content in the milk powder is ≥20%.

[0015] The present invention also provides a method for preparing the nutritional support composition, which specifically comprises the following steps: weighing each raw material by weight, and mixing them thoroughly and evenly to obtain the nutritional support composition.

[0016] The beneficial effects of the present invention are:

[0017] 1. The nutritional support composition of the present invention, each component together provides the human body with essential nutrients including protein, fat, carbohydrate, dietary fiber, vitamins and minerals, wherein the protein comes from high-quality plant and animal protein, and the dietary fiber comes from a scientific ratio of water-soluble dietary fiber and water-insoluble dietary fiber. The nutritional ratio of the composition of the present invention is scientific, and the energy supply ratio of each major nutrient is reasonable, which can balance the nutritional needs of the human body, effectively improve the nutritional status of tumor patients and other postoperative patients, enhance immune function, improve physical function and quality of life, and prolong survival time.

[0018] 2. The nutritional support composition of the present invention has suitable osmotic pressure, pH value, viscosity, and is lactose-free, has a good taste, does not cause abdominal distension, diarrhea, and other intestinal reactions, is easy to swallow, has a delicate taste, and has no bad smell. It is suitable for cancer patients and other postoperative patients who commonly suffer from oral ulcers, esophageal mucosal edema, dysphagia, anorexia, mild abdominal pain, diarrhea, and other complex conditions. DETAILED DESCRIPTION

[0019] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0020] In the following examples, 1 part represents 1 g. The complex trace elements include vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacinamide, folic acid, pantothenic acid, biotin, calcium hydrogen phosphate, magnesium chloride, ferric pyrophosphate, zinc gluconate, copper sulfate, magnesium sulfate, potassium iodide, chromium chloride, potassium chloride, sodium molybdate, and sodium selenite.

[0021] The protein content in whey protein powder is 80%, the protein content in plant protein powder is 40%, and the fat content in milk powder is 20%.

[0022] Example 1

[0023] This embodiment provides an enteral nutrition support composition for tumor patients and / or postoperative patients, comprising the following raw material components in parts by weight:

[0024] 30 parts of soy protein isolate powder, 30 parts of maltodextrin, 20 parts of powdered oil, 25 parts of rice flour, 1 part of polydextrose, 0.01 parts of resistant dextrin, 0.001 parts of apple powder, 0.01 parts of banana powder, 0.001 parts of orange powder, 0.01 parts of orange powder, 0.001 parts of pear powder, 0.01 parts of pineapple powder, 0.001 parts of tomato powder, 0.01 parts of carrot powder, 0.001 parts of kiwi powder, 0.01 parts of pumpkin powder, 0.001 parts of strawberry powder, 0.01 parts of grapefruit powder, 0.001 parts of grape powder, 0.01 parts of broccoli powder, 0.001 parts of loquat powder, 0.01 parts of mango powder, 0.01 parts of citrus fruit powder Melon powder 0.001 part, raspberry powder 0.01 part, cherry powder 0.001 part, passion fruit powder 0.01 part, peach powder 0.001 part, blueberry powder 0.01 part, spinach powder 0.001 part, cucumber powder 0.01 part, cantaloupe powder 0.001 part, mushroom powder 0.01 part, red beet powder 0.001 part, lemon powder 0.01 part, complex trace elements 0.5 part, oligofructose 0.01 part, oligomalto-oligosaccharide 0.01 part, corn flour 5 parts, concentrated whey protein powder 0.005 part, whole egg powder 0.005 part, milk powder 0.005 part, flaxseed powder 0.005 part, edible salt 0.2 part;

[0025] Fruit and vegetable powders including apple powder, banana powder, tangerine powder, orange powder, pear powder, pineapple powder, tomato powder, carrot powder, kiwi powder, pumpkin powder, strawberry powder, grapefruit powder, grape powder, broccoli powder, loquat powder, mango powder, watermelon powder, raspberry powder, cherry powder, passion fruit powder, peach powder, blueberry powder, spinach powder, cucumber powder, cantaloupe powder, mushroom powder, red beet powder and lemon powder are prepared according to the following method: fresh fruits or vegetables are taken to extract juice; water (juice: water = 1: 3) is added to the juice to dilute it to obtain a dilution, the dilution is first homogenized (2500r / min homogenization for 5min), and then 2% of a composite enzyme preparation (cellulase: pectinase: amylase = 1.8: 1.5: 0.5) is added, and enzymolysis is performed at 50°C for 1.5h. After completion, the obtained enzymolysis solution is centrifuged, concentrated in a low-temperature vacuum, and freeze-dried to obtain the obtained product.

[0026] The preparation method of the nutritional support composition described in this embodiment is: weigh each raw material by weight, mix them thoroughly and evenly, and then obtain the nutritional support composition. After testing, the osmotic pressure is 258mOsmol / Kg, the pH value is 7.02, and the viscosity is 140mPa.S.

[0027] Example 2

[0028] This embodiment provides an enteral nutrition support composition for tumor patients and / or postoperative patients, comprising the following raw material components in parts by weight:

[0029] 50 parts of isolated soy protein powder, 10 parts of maltodextrin, 50 parts of powdered oil, 10 parts of rice flour, 10 parts of polydextrose, 0.001 parts of resistant dextrin, 0.01 parts of apple powder, 0.001 parts of banana powder, 0.01 parts of orange powder, 0.001 parts of orange powder, 0.01 parts of pear powder, 0.001 parts of pineapple powder, 0.01 parts of tomato powder, 0.001 parts of carrot powder, 0.01 parts of kiwi powder, 0.001 parts of pumpkin powder, 0.01 parts of strawberry powder, 0.001 parts of grapefruit powder, 0.01 parts of grape powder, 0.001 parts of broccoli powder, 0.01 parts of loquat powder, 0.001 parts of mango powder , 0.01 parts of watermelon powder, 0.001 parts of raspberry powder, 0.01 parts of cherry powder, 0.001 parts of passion fruit powder, 0.01 parts of peach powder, 0.001 parts of blueberry powder, 0.01 parts of spinach powder, 0.001 parts of cucumber powder, 0.001 parts of cantaloupe powder, 0.001 parts of mushroom powder, 0.01 parts of red beet powder, 0.001 parts of lemon powder, 1 part of complex trace elements, 0.001 parts of oligofructose, 0.001 parts of isomaltooligosaccharide, 1 part of corn flour, 0.01 parts of concentrated whey protein powder, 0.001 parts of whole egg powder, 0.01 parts of milk powder, 0.001 parts of flaxseed powder, 0.5 parts of edible salt;

[0030] Fruit and vegetable powders including apple powder, banana powder, tangerine powder, orange powder, pear powder, pineapple powder, tomato powder, carrot powder, kiwi powder, pumpkin powder, strawberry powder, grapefruit powder, grape powder, broccoli powder, loquat powder, mango powder, watermelon powder, raspberry powder, cherry powder, passion fruit powder, peach powder, blueberry powder, spinach powder, cucumber powder, cantaloupe powder, mushroom powder, red beet powder and lemon powder are prepared according to the following method: fresh fruits or vegetables are taken to extract juice; water (juice: water = 1: 6) is added to the juice to dilute it to obtain a dilution, the dilution is first homogenized (3000r / min homogenization for 3min), and then 3% of a composite enzyme preparation (cellulase: pectinase: amylase = 2: 1.5: 0.5) is added, and enzymolysis is performed at 55°C for 1h. After completion, the obtained enzymolysis solution is centrifuged, and low-temperature vacuum concentration and freeze-drying are performed to obtain the obtained product.

[0031] The preparation method of the nutritional support composition described in this embodiment is: weigh each raw material by weight, mix them thoroughly and evenly, and then obtain the nutritional support composition. After testing, the osmotic pressure is 256mOsmol / Kg, the pH value is 7.11, and the viscosity is 141mPa.S.

[0032] Example 3

[0033] This embodiment provides an enteral nutrition support composition for tumor patients and / or postoperative patients, comprising the following raw material components in parts by weight:

[0034] 25 parts of concentrated whey protein powder, 35 parts of maltodextrin, 35 parts of powdered oil, 1 part of rice protein peptide powder, 0.03 parts of thymus protein peptide powder, 5 parts of resistant dextrin, 1.5 parts of flaxseed powder, and 0.1 parts of complex vitamins and trace elements.

[0035] The preparation method of the nutritional support composition described in this embodiment is: weigh each raw material by weight, mix them thoroughly and evenly, and then obtain the nutritional support composition. After testing, the osmotic pressure is 258mOsmol / Kg, the pH value is 7.06, and the viscosity is 144mPa.S.

[0036] Example 4

[0037] The difference between this embodiment and embodiment 3 is that the preparation method of the fruit and vegetable powder is different. The fruit and vegetable powder of this embodiment is prepared by the following method: fresh fruits or vegetables are taken to extract juice; water (juice: water = 1:2) is added to the juice to dilute it to obtain a dilution, the dilution is first homogenized (2000r / min homogenization for 5min), and then 1.5% pectinase is added, and enzymolysis is performed at 45°C for 1.5h. After completion, the obtained enzymolysis solution is centrifuged, and low-temperature vacuum concentration and freeze-drying are performed to obtain the obtained product.

[0038] Comparative Example

[0039] The only difference between this comparative example and Example 3 is that the complex trace elements, fructooligosaccharides and isomaltooligosaccharides are removed.

[0040] The nutritional components of the nutritional support composition of the present invention (Example 3) are analyzed and the results are shown in Table 1:

[0041] Table 1 Nutritional composition analysis

[0042]

[0043] Effects of the present invention on growth and immune function of mice

[0044] 50 male SPF BALB / C mice weighing 18-22g were selected, and all mice were randomly divided into 5 groups, including negative control group, positive control group, test group 1, test group 2 and test group 3, with 10 mice in each group. Among them, the negative control group was gavaged with normal saline, the positive control group was gavaged with Pepi-2000, and the test groups 1, 2 and 3 were gavaged with the nutritional support composition of Example 3, Example 4 and the comparative example of the present invention, respectively, and each group was gavaged with a dose of 0.05g / g·bw for 10 consecutive days. The weight gain of each group after 10 days was measured, and the mouse spleen lymphocyte transformation experiment and the mouse carbon particle clearance experiment were carried out according to the method of the 2003 edition of the "Health Food Inspection and Evaluation Standards" of the Ministry of Health to investigate the effects on the immune function of mice. The results are shown in the table below:

[0045] Table 2 Effect of the nutritional support composition of the present invention on weight gain in mice

[0046]

[0047] Table 3 Effect of the nutritional support composition of the present invention on the proliferation capacity of mouse spleen lymphocytes

[0048]

[0049] Table 4 Effect of the nutritional support composition of the present invention on the function of mouse monocytes and macrophages

[0050]

[0051] * p<0.05, compared with the negative control group; # p<0.05, compared with the positive control group.

[0052] The results show that the nutritional support composition prepared by each embodiment of the present invention can significantly increase the weight of mice, improve the proliferation capacity of mouse spleen lymphocytes and monocyte-macrophage function (p <0.05), and Example 3 is the best. It shows that the nutritional ratio of the present invention is scientific, the energy supply ratio of each nutrient is reasonable, and it can meet the nutritional needs of the human body, while having the effect of enhancing immunity. The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of changes or replacements within the technical scope disclosed by the present invention, which should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. An enteral nutritional support composition for tumor patients and / or postoperative patients, characterized in that: The raw material components include the following parts by weight: 10-50 parts of concentrated whey protein powder, 10-50 parts of maltodextrin, 10-50 parts of powdered oil, 1-10 parts of dietary fiber, 0.1-1 parts of complex trace elements, 0.001-0.01 parts of flaxseed powder, 0.001-0.01 parts of β-1,3 / α-1,3-glucan, 0.01-0.01 parts of protein peptides, and 0.05-0.5 parts of edible salt.

2. The nutritional support composition according to claim 1, characterized in that In the nutritional support composition, the energy supply ratio of carbohydrates, proteins and fats is 10-50%: 12-20%: 15-35%.

3. The nutritional support composition according to claim 1, characterized in that The dietary fiber includes any one or more of polydextrose, resistant dextrin, inulin, soybean dietary fiber, pea dietary fiber, wheat dietary fiber, oat dietary fiber, konjac and thickener.

4. The nutritional support composition according to claim 3, characterized in that The dietary fiber comprises the following raw material components in parts by weight: 1-10 parts of polydextrose and 0.001-0.01 parts of resistant dextrin.

5. The nutritional support composition according to claim 1, characterized in that The complex trace elements include vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacinamide, folic acid, pantothenic acid, biotin, calcium hydrogen phosphate, magnesium chloride, ferric pyrophosphate, zinc gluconate, copper sulfate, magnesium sulfate, potassium iodide, chromium chloride, potassium chloride, sodium molybdate, and sodium selenite.

6. The nutritional support composition according to claim 1, characterized in that The protein content of the whey protein powder is ≥80%, the protein content of the plant protein powder is ≥40%, and the fat content of the milk powder is ≥20%.

7. The method for preparing the nutritional support composition according to any one of claims 1 to 6, characterized in that: The specific steps are: weigh each raw material according to weight, mix them thoroughly and evenly, and then obtain the product.

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