Awake monkey head and coil fixation device and magnetic resonance imaging system

Abstract

The present application relates to the technical field of magnetic resonance imaging system, especially to a conscious monkey head and coil fixing device and a magnetic resonance imaging system, the conscious monkey head and coil fixing device, including a monkey box for accommodating the monkey body, one end face of the monkey box is an upward inclined plane, a head hole for exposing the monkey head is formed in the middle part of the inclined plane, and a neck positioning module, left and right positioning modules, an upper end positioning module and a lower end positioning module are respectively arranged on the outer surface of the monkey box, through the above arrangement, the problem that the fixing device in the existing magnetic resonance imaging system is difficult to fix the head of a conscious macaque and the conscious macaque is prone to restlessness is solved.

Description

Technical Field

[0001] This invention relates to the field of magnetic resonance imaging system technology, and in particular to a conscious monkey head and coil fixation device and a magnetic resonance imaging system. Background Technology

[0002] Currently, with the increasing number of patients with brain diseases worldwide, research into the mechanisms and treatments of brain diseases is urgently needed. Ideal animal models are crucial for studying the mechanisms of brain diseases and developing drugs. Non-human primates, such as macaques, share high similarities with humans in brain structure, physiological activities, and behavior, and can perform cognitive and social tasks similar to humans, making them the most ideal models for studying brain diseases.

[0003] Magnetic resonance imaging (MRI) is a crucial scientific tool for studying brain function and diseases. While MRI experiments on anesthetized monkeys are relatively mature, anesthetics can affect the nervous system activity of these monkeys, meaning that data obtained under anesthesia may not fully reflect the brain's activity and function. Therefore, MRI studies on awake monkeys are essential. However, existing MRI systems often struggle to hold the head still in a conscious macaque monkey, as these monkeys are prone to agitation, leading to unclear images and increasing the difficulty of the research. Summary of the Invention

[0004] To address the problem that existing fixation devices in magnetic resonance imaging systems are difficult to use to secure the head of awake macaques, and that awake macaques are prone to restlessness, this invention proposes a head and coil fixation device for awake macaques and a magnetic resonance imaging system.

[0005] The technical solution adopted in this invention is a conscious monkey head and coil fixing device, including a monkey box for accommodating the monkey's body, one end face of the monkey box being an upward-facing slope, the middle of which has a head hole for the monkey's head to protrude, and further including the following respectively disposed on the outer surface of the monkey box: a neck positioning module, which includes a pair of neck plates that can move closer or further away from each other, the pair of neck plates together forming a neck collar that restricts the monkey's neck, the neck collar being located inside the head hole; a left and right positioning module, which includes a pair of fixing components disposed on the left and right sides of the head hole, the pair of fixing components that can move closer or further away from each other toward the head hole and can drive the coil to move closer or further away from the head hole; an upper positioning module, which is disposed at the upper end of the head hole, the upper positioning module can move closer or further away from the head hole and can drive the coil to move closer or further away from the head hole; and a lower positioning module, which is disposed at the lower end of the head hole, the lower positioning module can move closer or further away from the head hole.

[0006] Preferably, the fixing component includes a first slider disposed on the monkey box, an ear rod inserted into the first slider, and an ear rod fixing member. The ear rod can slide within the first slider and move closer to or further away from the head hole. The ear rod fixing member is used to fix the ear rod to the first slider.

[0007] Preferably, an ear cover is detachably fixed to one end of the ear rod near the head hole, and an ear plug is provided at one end of the ear cover near the head hole.

[0008] Preferably, the ear rod is provided with a coil fixing member, the coil can be slidably inserted into the ear rod, and can be fixed to the ear rod by the coil fixing member.

[0009] Preferably, the upper positioning module includes a second slider disposed on the monkey box, a head rod inserted into the second slider, and a head rod fixing member. The head rod can slide within the second slider and move closer to or away from the head hole. The head rod fixing member is used to fix the head rod on the second slider.

[0010] Preferably, the end of the head rod near the head hole is detachably fixed with a suction cup for adsorbing the coil.

[0011] Preferably, the lower positioning module includes a third slider slidably connected to the monkey box, at least a portion of which is disposed at the lower end of the head hole and can slide up and down along the inclined surface.

[0012] Preferably, the portion of the third slider located at the lower end of the head hole is concave at the end near the head hole.

[0013] Preferably, the fixing component further includes a first fixing member, the first slider being slidably connected to the monkey box and capable of sliding up and down on the monkey box, the first fixing member being used to fix the first slider to the monkey box.

[0014] Preferably, the upper positioning module further includes a second fixing member, the second slider is slidably connected to the monkey box and can be close to or away from the inclined surface, and the second fixing member is used to fix the second slider on the monkey box.

[0015] Preferably, the lower positioning module further includes a third fixing member, which is used to fix the third slider on the monkey box.

[0016] The present invention also proposes a magnetic resonance imaging system, including a coil and the aforementioned conscious monkey head and coil fixation device.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The conscious monkey head and coil fixation device of this invention uses a monkey box to house the monkey's body, restricts neck movement through a head opening and a pair of neck plates, and limits head displacement in four directions (left, right, up, and down) through left-right, upper, and lower positioning modules. This makes it difficult for the conscious monkey's head to move significantly, ensuring image clarity and reducing research difficulty. Furthermore, the pair of fixation components and the upper positioning module can fix the coil to both sides and the head, allowing the coil to cover a large area of ​​the head. The large coverage area results in better imaging when applied to magnetic resonance imaging. Moreover, when used in other procedures such as two-photon surgery (head-column mounting), this device is adaptable to different coils and can fix the matching coil to the monkey's head, making it widely applicable. Attached Figure Description

[0019] The present invention will now be described in detail with reference to the embodiments and accompanying drawings, wherein:

[0020] Figure 1 This is a schematic diagram of the monkey box structure;

[0021] Figure 2 This is a schematic diagram of a pair of neck plates;

[0022] Figure 3 This is a partial structural diagram of the fixed component;

[0023] Figure 4 This is a schematic diagram of the shaft structure;

[0024] Figure 5 This is a schematic diagram of the second slider;

[0025] Figure 6 This is a schematic diagram of the headstock structure;

[0026] Figure 7 This is a schematic diagram of the third slider.

[0027] 10. Monkey box; 11. Sloping surface; 12. Head hole; 13. Handle; 14. Operating window; 15. Door panel; 16. First slide bar; 161. First screw hole; 17. Second slide bar; 18. Third slide bar; 19. Neck plate groove;

[0028] 20. Neck plate;

[0029] 30. Fixing component; 31. First slider; 32. Ear rod; 33. Ear cover; 34. Ear plug; 35. Ear rod fixing component; 36. Coil fixing component; 37. First fixing component; 38. Ear rod placement hole; 39. First sliding groove;

[0030] 40. Second slider; 41. Head rod; 42. Suction cup; 43. Head rod fixing component; 44. Second fixing component; 45. Head rod placement hole; 46. Second slide groove;

[0031] 50. Third slider; 51. Third fixing component; 52. Third slide groove. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of the present invention clearer, the embodiments of the present invention will be further described in detail below with reference to the accompanying drawings. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar components or components having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0033] In one embodiment, such as Figure 1 As shown, a device for securing a conscious monkey's head and coil includes a monkey box 10 for accommodating the monkey's body. One end face of the monkey box 10 is an upward-facing inclined surface 11, with a head hole 12 in the middle of the inclined surface 11. The monkey box 10 is used to accommodate the monkey's body, and the head hole 12 allows the monkey's head to protrude. Specifically, an openable door 15 can be provided at the end of the monkey box 10 away from the inclined surface 11, allowing the experimental monkey to enter the monkey box 10 through the door 15, thereby accommodating the monkey's body inside the monkey box 10.

[0034] The conscious monkey head and coil fixing device also includes a neck positioning module, a left and right positioning module, an upper positioning module, and a lower positioning module respectively disposed on the outer surface of the monkey box 10. The neck positioning module includes a pair of neck plates 20 that can move closer to or further away from each other, forming a neck collar that restricts the monkey's neck. The neck collar is located inside the head hole 12. The left and right positioning modules include a pair of fixing components 30 disposed on the left and right sides of the head hole 12. The pair of fixing components 30 can move closer to or further away from each other towards the head hole 12, and can also drive the coil to move closer to or further away from the head hole 12. The upper positioning module is disposed at the upper end of the head hole 12, and can move closer to or further away from the head hole 12. The lower positioning module is disposed at the lower end of the head hole 12, and can move closer to or further away from the head hole 12.

[0035] During operation, the door panel 15 is opened, and after the experimental monkey enters, the door panel 15 is closed, allowing the experimental monkey to squat inside the device. After the experimental monkey's head protrudes from the head hole 12, a pair of neck plates 20 are first used to fix its neck. Then, a pair of fixing components 30 are used to fix the left and right ends of the monkey's head, and the upper and lower positioning modules are used to fix the upper and lower ends of the monkey's head. At the same time, a pair of fixing components 30 and the upper fixing module are used to fix and cover the coil on the monkey's head, so that the coil wraps around the top and sides of the experimental monkey's head.

[0036] Among them, such as Figure 1-2 As shown, a neck plate slot 19 can be provided on the inclined surface 11, and a neck plate 20 is provided with a neck plate 20 retaining strip that matches the neck plate slot 19. In use, the lower neck plate 20 is first installed onto the inclined surface 11 through the neck plate slot 19. After the monkey's head extends, the upper neck plate 20 is then inserted, completing the fixation of the monkey's neck by a pair of neck plates 20. The positions of the neck plate slot 19 and the neck plate 20 retaining strip can be interchanged. A limiting member can be provided at the lower end of the inclined surface 11. When the lower neck plate 20 slides along the neck plate slot 19 to the limiting member, it is limited by the limiting member. The upper neck plate 20 can be fixed at the position that precisely fixes the monkey's neck using a fixing knob or similar means.

[0037] In this embodiment, the conscious monkey head and coil fixation device accommodates the monkey's body in a monkey box 10. The movement of the monkey's neck is restricted by a head opening 12 and a pair of neck plates 20. The displacement of the monkey's head in four directions (left, right, up, and down) is restricted by left-right, upper, and lower positioning modules. This makes it difficult for the conscious monkey's head to undergo significant displacement, ensuring the clarity of the final image and reducing the difficulty of the research. Furthermore, the pair of fixation components 30 and the upper positioning module can fix the coil to the monkey's head, covering the top and sides of the head. This allows the coil to cover a large area of ​​the monkey's head, providing a large coverage area and conforming well to the scalp. When this fixation device is applied to magnetic resonance imaging, the final imaging effect is better. Moreover, when this fixation device is applied to other surgeries such as two-photon surgery (head-column mounting), it can be adapted to different coils and fix the matching coil to the monkey's head, making it widely applicable.

[0038] In one embodiment, the monkey box 10 is provided with handles 13 on both sides, which can be used to easily move the monkey box 10 and the experimental monkeys inside the monkey box 10 at the same time.

[0039] In one embodiment, the monkey box 10 is also provided with operation windows 14 on both sides. The operation windows 14 are made of transparent materials such as glass, so that the experimental monkeys can be observed at any time through the operation windows 14, and other experimental operations can also be performed through the operation windows.

[0040] In one embodiment, such as Figure 3-4As shown, the fixing assembly 30 includes a first slider 31, an ear rod 32, and an ear rod fixing member 35. The first slider 31 is mounted on the monkey box 10, and the ear rod 32 is inserted into the first slider 31. The ear rod 32 can slide within the first slider 31, moving closer to or away from the head hole 12. The ear rod fixing member 35 can fix the ear rod 32 onto the first slider 31. Specifically, a through ear rod placement hole 38 is opened in the first slider 31 facing the head hole 12. The ear rod 32 is inserted into the ear rod placement hole 38 of the first slider 31. By manually pushing or pulling the end of the head rod 41 away from the head hole 12, the ear rod 32 can be easily moved closer to or away from the head hole 12. Thus, when the monkey head extends out of the head hole 12, the pair of ear rods 32 on the fixing assembly 30 can approach and fix the monkey head at both ends, thereby restricting the monkey head's lateral movement. The ear rod fixing component 35 can be a bolt. The first slider 31 has a screw hole perpendicular to the length direction of the ear rod placement hole 38. The screw hole is connected to the ear rod placement hole 38. So when the ear rod 32 is adjusted to the appropriate position of the monkey head, the bolt is screwed into the screw hole, so that the ear rod 32 is pressed against the side wall of the ear rod placement hole 38, thereby fixing the ear rod 32 and limiting the displacement of the monkey head to the left and right sides.

[0041] In other embodiments, the ear rod fixing member 35 can also be a pair of locking nuts, etc. The ear rod 32 has matching threads, so that when the ear rod 32 reaches the appropriate position, the left and right ends of the ear rod 32 can be locked by the locking nuts, so that the ear rod 32 cannot slide in the ear rod placement hole 38, thereby limiting the displacement of the ear rod 32 on the left and right sides of the monkey head. The ear rod placement hole 38 does not need to be completely through, as long as the end of the ear rod 32 near the head hole 12 can extend out of the ear rod placement hole 38, and the ear rod 32 can slide in the ear rod placement hole 38 and move closer to or away from the head hole 12.

[0042] In one embodiment, the first slider 31 has three spaced-apart ear rod placement holes 38, which are sequentially positioned close to the inclined surface 11. The screw holes on the first slider 31 are perpendicular to the length direction (i.e., the depth direction) of the three ear rod placement holes 38, and are connected to all three holes. In use, the ear rod placement hole 38 facing the monkey head can be selected according to its size and position. The ear rod 32 inserted into this hole 38 is then fixed to both sides of the monkey head using bolts. The three spaced-apart ear rod placement holes 38 provide some adjustment space for the ear rod 32 in the direction perpendicular to the inclined surface 11, improving the applicability of the awakened monkey head and coil fixing device. In other embodiments, different numbers of ear rod placement holes 38 can be provided according to actual needs.

[0043] In one embodiment, an earmuff 33 is detachably fixed to one end of the ear rod 32 near the head hole 12, and an ear plug 34 is provided at the other end of the earmuff 33 near the head hole 12. The earmuff 33 can cover both ears of the experimental monkey, and the ear plug 34 can block the ear canal of the experimental monkey, thereby reducing the sound heard by the experimental monkey to a certain extent, especially the noise from experiments such as magnetic resonance imaging, thus reducing the anxiety of the experimental monkey and making the experimental results more reliable. The earmuff 33 is detachable, which also facilitates cleaning and replacement, and facilitates the installation of the ear rod 32 and the coil. In use, the earmuff 33 can be removed first, then the ear rod 32 can be passed through the ear rod placement hole 38, and then the earmuff 33 can be installed at the end of the ear rod 32, which is convenient. In other embodiments, both the earmuff 33 and the ear plug 34 are made of sound-insulating material, which further improves the sound insulation effect of the earmuff 33 and the ear plug 34 and reduces the adaptation time of the experimental monkey to noise. In one embodiment, both the earmuffs 33 and earplugs 34 are made of flexible material. The flexible material of the earmuffs 33 and earplugs 34 can improve the comfort of the experimental monkeys, further reduce their anxiety, and is more humane, making the experimental results more reliable.

[0044] In one embodiment, a coil fixing member 36 is provided on the ear rod 32. The coil can be slidably inserted into the ear rod 32 and fixed to the ear rod 32 by the coil fixing member 36. Specifically, the coil generally has an ear rod 32 insertion hole. During installation, the ear cover 33 is first removed, then the ear rod 32 is inserted into the ear rod 32 insertion hole on the coil, and then the ear cover 33 is installed on the ear rod 32. The coil is then fixed to the ear rod 32 using the coil fixing member 36. Thus, when the ear cover 33 is pressed against both ends of the monkey's head through the ear rod 32, the coil fixed to the ear rod 32 can also be close to the scalp of the experimental monkey. With the help of the upper positioning module, the coil can be placed on the top of the experimental monkey's head. The coil fixing member 36 can be a pair of screw rings. The diameter of the screw rings is larger than the ear rod 32 insertion hole. The ear rod 32 is threaded around its circumference. The thread is located near the coil, so that the pair of screw rings can fix the coil on the ear rod 32 near the ear cover 33.

[0045] In one embodiment, such as Figure 5-6As shown, the upper positioning module includes a second slider 40, a head rod 41, and a head rod fixing member 43. The second slider 40 is disposed on the monkey box 10, and the head rod 41 is inserted into the second slider 40. The head rod 41 can slide within the second slider 40 and move closer to or away from the head hole 12. The head rod fixing member 43 is used to fix the head rod 41 on the second slider 40. Specifically, a through head rod placement hole 45 is opened in the second slider 40 facing the head hole 12. The head rod 41 is inserted into the head rod placement hole 45 of the second slider 40. By manually pushing and pulling the end of the head rod 41 away from the head hole 12, the head rod 41 can be easily driven closer to or away from the head hole 12. Thus, when the monkey head extends out of the head hole 12, the head rod 41 of the upper positioning module can approach and fix the monkey head at the top of the monkey head, thereby restricting the upward movement of the monkey head. The head rod fixing component 43 can be a bolt. The second slider 40 has a screw hole perpendicular to the length direction of the head rod placement hole 45. The screw hole is connected to the head rod placement hole 45. So when the head rod 41 is adjusted to the appropriate position of the monkey head, the bolt is screwed into the screw hole, so that the head rod 41 is pressed against the side wall of the head rod placement hole 45, thereby fixing the head rod 41 and thus restricting the upper end of the monkey head.

[0046] In other embodiments, the head rod fixing member 43 can also be a pair of locking nuts, etc. The head rod 41 has matching threads, so that when the head rod 41 reaches the appropriate position, the left and right ends of the head rod 41 can be locked by the locking nuts, so that the head rod 41 cannot slide in the head rod placement hole 45, thereby achieving the restriction of the head rod 41 on the upper end of the monkey head. The head rod placement hole 45 does not need to be completely through, as long as the end of the head rod 41 near the head hole 12 can extend out of the head rod placement hole 45, and the head rod 41 can slide in the head rod placement hole 45 and move closer to or away from the head hole 12. The second slider 40 can also have multiple head rod placement holes 45 spaced apart from each other, so that the appropriate head rod placement hole 45 can be selected according to the different extension positions of the monkey head, so that the head rod 41 is directly facing the monkey head and pressing against the top of the monkey head.

[0047] In one embodiment, a suction cup 42 for adsorbing a coil is detachably fixed to one end of the head rod 41 near the head hole 12. The suction cup 42 can be made of silicone, rubber, or other materials. The suction cup 42 can firmly adsorb the top of the coil, thereby pressing and fixing the coil against the head of the experimental monkey. Using the suction cup 42 of the head rod 41 and the coil fixing part 36 of the ear rod 32, the coil can be covered on the head of the experimental monkey. The coil is a surface coil on the head. The ear rod 32 and the head rod 41 can be adapted to different coils, such as top-wrapped coils and top-part hollowed-out coils. By replacing different customized surface coils, it can be adapted to experimental monkeys of different body sizes and experimental conditions for magnetic resonance imaging, and can also be adapted to different brain experiments.

[0048] In one embodiment, such as Figure 7As shown, the lower positioning module includes a third slider 50, which is slidably connected to the monkey box 10. At least a portion of the third slider 50 is located at the lower end of the head hole 12, and this portion can slide up and down along the inclined surface 11. The third slider 50 can abut against the chin of the experimental monkey, thereby allowing the monkey's head to move downwards. Furthermore, the portion of the third slider 50 located at the lower end of the head hole 12 is concave at the end closest to the head hole 12. The concave shape of the third slider 50 can better fit the chin of the experimental monkey, increasing the monkey's comfort and reducing anxiety. Furthermore, a soft pad can be placed in the recessed area, or the third slider 50 can be made of a soft material to further improve comfort.

[0049] In one embodiment, the fixing component 30 further includes a first fixing member 37, a first slider 31 slidably connected to the monkey box 10 and capable of sliding up and down on the monkey box 10, the first fixing member 37 being used to fix the first slider 31 to the monkey box 10; the upper positioning module further includes a second fixing member 44, a second slider 40 slidably connected to the monkey box 10 and capable of moving closer to or further away from the inclined surface 11, the second fixing member 44 being used to fix the second slider 40 to the monkey box 10; the lower positioning module further includes a third fixing member 51, the third fixing member 51 being used to fix the third slider 50 to the monkey box 10.

[0050] Specifically, the monkey box 10 is provided with a first slide bar 16, and the first slider 31 is provided with a first slide groove 39 that matches the first slide bar 16. The first slider 31 slides up and down on the monkey box 10 via the first slide bar 16. The monkey box 10 is provided with a second slide bar 17, and the second slider 40 is provided with a second slide groove 46 that matches the second slide bar 17. The second slider 40 slides left and right on the monkey box 10 via the second slide bar 17. The monkey box 10 is provided with a third slide bar 18, and the third slider 50 is provided with a third slide groove 52 that matches the third slide bar 18. The third slider 50 slides up and down on the monkey box 10 via the third slide bar 18. The first fixing member 37, the second fixing member 44, and the third fixing member 51 can be respectively a first fixing knob, a second fixing knob, and a third fixing knob. The first slider 31, the second slider 40, and the third slider 50 have first fixing holes, second fixing holes, and third fixing holes respectively corresponding to the first fixing knob, second fixing knob, and third fixing knob. These holes are perpendicular to and connect to the first slide groove 39, the second slide groove 46, and the third slide groove 52. Thus, when the first slider 31, the second slider 40, and the third slider 50 slide to the appropriate position facing the monkey head, the first fixing holes, second fixing holes, and third fixing holes can respectively abut against the first slide bar 16, the second slide bar 17, and the third slide bar 18, fixing the first slider 31, the second slider 40, and the third slider 50 onto the monkey box 10. In other embodiments, the positions of the slide bars and slide grooves can be interchanged.

[0051] In other embodiments, the first slider 31, the second slider 40, and the third slider 50 are respectively provided with first through holes, second through holes, and third through holes corresponding to the first fixing knob, second fixing knob, and third fixing knob. One end opening of each of the first, second, and third through holes is located on the surface of the monkey box 10. The monkey box 10 is provided with first screw holes 161, second screw holes, and third screw holes corresponding to these openings, allowing the first, second, and third fixing knobs to pass through the first, second, and third through holes and screw into the first screw holes 161, second screw holes, and third screw holes, respectively, thus locking the first slider 31, second slider 40, and third slider 50 onto the monkey box 10. In other embodiments, multiple first fixing knobs, second fixing knobs, and third fixing knobs, as well as multiple first through holes, second through holes, and third through holes, and multiple first screw holes 161, second screw holes, and third screw holes are provided, resulting in a more secure connection.

[0052] In one embodiment, a magnetic resonance imaging system includes a coil and the aforementioned conscious monkey head and coil fixation device. The coil is a surface coil for the head, which covers the top of the experimental monkey's head and is attached to the monkey's scalp. Different customized surface coils can be replaced to adapt to experimental monkeys of different body sizes and experimental conditions for magnetic resonance imaging.

[0053] In the description of this specification, the use of terms such as "Embodiment 1," "this embodiment," or "in one embodiment" indicates that the specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example; moreover, the specific features, structures, materials, or characteristics described may be combined in any appropriate manner in one or more embodiments or examples.

[0054] In the description of this specification, the terms "connection," "installation," "fixing," "setting," and "having" are interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0055] In the description of this specification, relational terms such as “first” and “second” are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase “comprising one…” does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0056] The above description of the embodiments is intended to enable those skilled in the art to understand and apply the technology of this invention. Those skilled in the art can easily make various modifications to these examples and apply the general principles described herein to other embodiments without creative effort. Therefore, this invention is not limited to the above embodiments. Modifications in the following situations should be within the scope of protection of this invention: ① New technical solutions implemented based on the technical solution of this invention and combined with existing common knowledge, where the technical effects of the new technical solution do not exceed the technical effects of this invention; ② Equivalent substitutions of some features of the technical solution of this invention using known technology, resulting in the same technical effects as those of this invention; ③ Extendable technical solutions based on the technical solution of this invention, where the substantive content of the extended technical solution does not exceed the technical solution of this invention; ④ Equivalent transformations made using the content of this specification and drawings, directly or indirectly applied to other related technical fields.

Claims

1. A device for securing a conscious monkey head and coil, comprising a monkey box for accommodating the monkey's body, wherein one end face of the monkey box is an upward-facing slope, and a head hole for the monkey's head to protrude is formed in the middle of the slope, characterized in that, It also includes those respectively disposed on the outer surface of the monkey box: A neck positioning module includes a pair of neck plates that can move closer to or further away from each other, the pair of neck plates together forming a neck collar that restricts the monkey's neck, the neck collar being located within the head hole; The left and right positioning module includes a pair of fixing components disposed on the left and right sides of the head hole. The pair of fixing components can move closer to or further away from each other toward the head hole and can drive the coil to move closer to or further away from the head hole. The fixing components include a first slider disposed on the monkey box, an ear rod inserted into the first slider, and an ear rod fixing member. The ear rod can slide within the first slider and move closer to or further away from the head hole. The ear rod fixing member is used to fix the ear rod to the first slider. A coil fixing member is disposed on the ear rod. The coil can be slidably inserted into the ear rod and can be fixed to the ear rod by the coil fixing member. An upper positioning module is disposed at the upper end of the head hole. The upper positioning module can move closer to or away from the head hole and can drive the coil closer to or away from the head hole. The upper positioning module includes a second slider disposed on the monkey box, a head rod inserted into the second slider, and a head rod fixing member. The head rod can slide within the second slider and move closer to or away from the head hole. The head rod fixing member is used to fix the head rod on the second slider. A suction cup for adsorbing the coil is detachably fixed at one end of the head rod near the head hole. A lower positioning module is disposed at the lower end of the head hole, and the lower positioning module can be close to or far away from the head hole.

2. The conscious monkey head and coil fixing device according to claim 1, characterized in that, An ear cover is detachably fixed to one end of the ear rod near the head hole, and an ear plug is provided at one end of the ear cover near the head hole.

3. The conscious monkey head and coil fixing device according to claim 1, characterized in that, The lower positioning module includes a third slider slidably connected to the monkey box. At least a portion of the third slider is disposed at the lower end of the head hole and can slide up and down along the inclined surface.

4. The conscious monkey head and coil fixing device according to claim 3, characterized in that, The portion of the third slider located at the lower end of the head hole is configured as concave at the end near the head hole.

5. The conscious monkey head and coil fixing device according to claim 1 or 2, characterized in that, The fixing component further includes a first fixing member, the first slider being slidably connected to the monkey box and capable of sliding up and down on the monkey box, the first fixing member being used to fix the first slider on the monkey box.

6. The conscious monkey head and coil fixing device according to claim 1, characterized in that, The upper positioning module also includes a second fixing member. The second slider is slidably connected to the monkey box and can move closer to or away from the inclined surface. The second fixing member is used to fix the second slider to the monkey box.

7. The conscious monkey head and coil fixing device according to claim 3, characterized in that, The lower positioning module also includes a third fixing member, which is used to fix the third slider on the monkey box.

8. A magnetic resonance imaging system, characterized in that, Includes a coil and a conscious monkey head and coil fixing device according to any one of claims 1-7.

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