Device for pathological AI auxiliary diagnosis

Abstract

The invention relates to a device for pathological AI auxiliary diagnosis, belongs to the technical field of medical equipment, and solves the problem that spatial information of a pathological section scanning image provided by an auxiliary diagnosis device in the prior art is lost. The device comprises a workbench, a section fixing assembly, a microscope assembly, a lifting assembly, an overturning assembly and a control assembly. The slice fixing assembly is supported on the workbench and can be driven by the workbench to move horizontally. The microscope assembly is fixedly arranged on one side of the workbench; the lifting assembly is fixedly arranged on the other side of the workbench, the overturning assembly is arranged on the lifting assembly, and the lifting assembly and the overturning assembly are linked to drive the slice fixing assembly to move up and down and overturn by 180 degrees at the same time. According to the method, front and back scanning is realized by turning over the pathological section, and the spatial information of the scanned image of the pathological section can be obtained through data processing, so that the image quality and the diagnosis accuracy are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular, to a device for pathological AI-assisted diagnosis. Background Art

[0002] Using the method of scanning pathological sections with a microscope for pathological assisted diagnosis is an important technology in the field of modern pathology. This method combines the high-resolution imaging ability of an optical microscope and the advantages of digital image processing technology, realizing the rapid and accurate scanning and analysis of pathological sections, and providing strong support for pathological diagnosis.

[0003] In the prior art, first, the prepared pathological section is placed on the stage of a pathological scanner, and the scanner is started. The computer control system will control the electric stage to move the slide along a preset path and step length. At each position, the microscope optical system images the tissue section, and a camera or imaging sensor converts the image into a digital signal. Finally, the collected images are transmitted to a computer for stitching and processing to generate a high-resolution whole-slide image. Pathologists can view the scanned high-definition pathological images on a computer screen. Combining information such as the clinical manifestations and medical history of the patient, the pathologists analyze and interpret the images to make an accurate pathological diagnosis. Image analysis software can also be used to perform quantitative analysis on pathological images, such as cell counting, cell morphology measurement, nucleus-to-cytoplasm ratio analysis, immunohistochemical staining intensity quantitative analysis, etc.

[0004] However, the planar images generated by the existing scanning methods have obvious disadvantages in pathological diagnosis, such as lack of spatial information and insufficient depth information, which in turn lead to difficulties in identifying lesion features, inability to support complex analysis, and being unfavorable for remote consultation and collaboration. In contrast, three-dimensional images have significant advantages in pathological diagnosis, being able to provide more complete and accurate information support, which helps to improve the accuracy and consistency of diagnosis. However, the existing assisted diagnosis devices cannot provide three-dimensional scanned images of pathological sections, and dedicated three-dimensional scanning devices are too costly and not suitable for scanning pathological sections. Summary of the Invention

[0005] In view of the above analysis, embodiments of the present invention aim to provide a device for pathological AI-assisted diagnosis to solve the problem of lack of spatial information in the scanned images of pathological sections provided by the existing assisted diagnosis devices.

[0006] On the one hand, the present invention provides a device for pathological AI-assisted diagnosis, comprising a workbench, a section fixing assembly, a microscope assembly, a lifting assembly, a flipping assembly and a control assembly; wherein, the section fixing assembly is used for fixing and supporting pathological sections, and the section fixing assembly is supported on the workbench and can move longitudinally and / or transversely; the microscope assembly is fixedly arranged on one side of the workbench for scanning the pathological sections; the lifting assembly is fixedly arranged on the side surface of the workbench, the flipping assembly is arranged on the lifting assembly and can be driven by the lifting assembly to rise or fall; the flipping assembly can clamp the section fixing assembly and drive the section fixing assembly to move up and down, and can drive the section fixing assembly to flip 180°.

[0007] Further, the workbench comprises a bottom plate and a sliding table, the sliding table is arranged on the bottom plate, and the sliding table can move longitudinally and / or transversely relative to the bottom plate.

[0008] Further, the sliding table comprises a lower fixing plate, a middle sliding plate and an upper sliding plate; the lower fixing plate is fixedly arranged on the bottom plate; the middle sliding plate is arranged on the lower fixing plate and can move longitudinally relative to the lower fixing plate; the upper sliding plate is arranged on the middle sliding plate and can move transversely relative to the middle sliding plate.

[0009] Further, the upper sliding plate is of a U-shaped structure, and the middle opening faces the lifting assembly.

[0010] Further, support plate bearing surfaces are arranged on the inner walls of the two opposite sides or the inner walls of the three sides of the middle opening.

[0011] Further, the depth of the middle opening is 2 / 3 - 3 / 4 of the length of the section fixing assembly.

[0012] Further, the support plate bearing surface is made of an electromagnetic material, or an electromagnetic chuck or a vacuum chuck is embedded inside the support plate bearing surface.

[0013] Further, the section fixing assembly comprises a section support plate and a fixing strip.

[0014] Further, a plurality of section mounting grooves are arranged on the section support plate; the fixing strip is fixedly arranged on the upper surface of the section support plate and is close to the top or bottom of the section mounting groove.

[0015] On the other hand, the present invention provides a method for automatically double-sided scanning of pathological sections, which realizes double-sided scanning by using the device for pathological AI-assisted diagnosis described above.

[0016] Compared with the prior art, the present invention can achieve at least one of the following beneficial effects:

[0017] (1) The present invention drives the slicing fixing component to move up and down and flip 180° through the lifting component and the flipping component, so as to realize the scanning of both the front and back sides of the pathological section. Through data processing, the spatial information of the scanned image of the pathological section can be obtained, improving the image quality and diagnosis accuracy.

[0018] (2) The present invention controls the automatic operation of the workbench, the microscope component, the lifting component and the flipping component through the control component, effectively improving the work efficiency and saving time.

[0019] (3) A movable sliding table is arranged on the workbench of the present invention. The slicing fixing component can be driven to translate through the sliding table, so as to realize the automatic scanning of all sections, and at the same time, the slicing fixing component can be engaged with or disengaged from the flipping component.

[0020] (4) In the method for pathological AI-assisted diagnosis of the present invention, the double-sided scanning of the same section is realized by using the device for assisted diagnosis, and the scanned pictures of the upper and lower sides are obtained and then transmitted to the diagnostic software system for comparison processing. Through the AI pathological diagnosis based on big data, a more accurate diagnosis result can be obtained than that of a single-sided picture.

[0021] In the present invention, the above technical solutions can also be combined with each other to realize more preferred combination schemes. Other features and advantages of the present invention will be described in the subsequent specification, and some advantages can be made obvious from the specification or understood by implementing the present invention. The objectives and other advantages of the present invention can be realized and obtained from the content specifically pointed out in the specification and the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The drawings are only for the purpose of showing specific embodiments and are not considered as a limitation to the present invention. Throughout the drawings, the same reference signs denote the same components.

[0023] Figure 1 is a schematic structural diagram of the device for pathological AI-assisted diagnosis of the present invention;

[0024] Figure 2 is a schematic structural diagram of the bottom plate of the device for pathological AI-assisted diagnosis of the present invention;

[0025] Figure 3 is a schematic structural diagram of the sliding table of the device for pathological AI-assisted diagnosis of the present invention;

[0026] Figure 4 is a schematic structural diagram of another state of the sliding table of the device for pathological AI-assisted diagnosis of the present invention;

[0027] Figure 5 Schematic structural diagram of the section fixing component of the device for pathological AI-assisted diagnosis of the present invention;

[0028] Figure 6 Schematic structural diagram of the fixing bar of the device for pathological AI-assisted diagnosis of the present invention;

[0029] Figure 7 Schematic structural diagram of the microscope component of the device for pathological AI-assisted diagnosis of the present invention;

[0030] Figure 8 Schematic structural diagram of the lifting component of the device for pathological AI-assisted diagnosis of the present invention;

[0031] Figure 9 Schematic structural diagram of the flipping component of the device for pathological AI-assisted diagnosis of the present invention.

[0032] Reference numerals:

[0033] 10 - Workbench; 11 - Base plate; 111 - Slide table installation area; 112 - Microscope installation area; 12 - Slide table; 121 - Lower fixing plate; 1211 - Longitudinal motor; 1212 - Longitudinal motor fixing bracket; 1213 - Longitudinal guide rail; 122 - Middle slide plate; 1221 - Transverse motor; 1222 - Transverse motor fixing bracket; 1223 - Transverse guide rail; 123 - Upper slide plate; 1231 - Support plate receiving surface; 20 - Section fixing component; 21 - Section support plate; 22 - Clamping end; 23 - Section installation groove; 231 - Section supporting surface; 232 - Pick-up and placement groove; 24 - Installation hole; 25 - Fixing bar; 251 - Installation part; 252 - Through hole; 30 - Microscope component; 31 - Electron microscope; 32 - Microscope bracket; 321 - Microscope base; 322 - Vertical guide rod; 323 - Support rod; 40 - Lifting component; 41 - Lifting motor; 42 - Vertical slide rail; 43 - Vertical slider; 50 - Flipping component; 51 - Flipping plate; 511 - Input shaft end; 512 - Clamping mechanism; 5121 - Support plate receiving groove; 5122 - Electromagnetic chuck; 52 - Flipping motor; 53 - Flipping motor mounting seat. Detailed implementation manners

[0034] The following will specifically describe the preferred embodiments of the present invention in conjunction with the accompanying drawings, where the accompanying drawings form a part of the present invention and are used together with the embodiments of the present invention to explain the principle of the present invention, and are not used to limit the scope of the present invention.

[0035] Embodiment 1

[0036] A specific embodiment of the present invention, as Figure 1As shown, a device for pathological AI-assisted diagnosis is disclosed. This device can automatically perform double-sided scanning on pathological sections and transmit the scanning results to a control system, facilitating subsequent analysis and calculation of the scanning results using AI to obtain three-dimensional scanning results, thereby more accurately assisting in diagnosis.

[0037] Referring to Figure 1 , the device for pathological AI-assisted diagnosis of the present invention includes a workbench 10, a section fixing assembly 20, a microscope assembly 30, a flipping assembly 50, a lifting assembly 40, and a control assembly. Among them, the section fixing assembly 20 is used to fix and support pathological sections and can place all pathological sections within the field of view of the microscope assembly 30. The microscope assembly 30 is fixedly arranged on the front side of the workbench 10, and its objective lens is aligned above the workbench 10, capable of automatically scanning the pathological sections on the section fixing assembly 20 placed on the workbench 10 and transmitting data to the control assembly. During the working process, the section fixing assembly 20 can be movably placed on the workbench 10, and the section fixing assembly 20 can be driven by the workbench 10 to move longitudinally and / or transversely. The lifting assembly 40 is fixedly arranged on the left side of the workbench 10, the flipping assembly 50 is arranged on the lifting assembly 40, and can be driven by the lifting assembly 40 to rise or fall. The flipping assembly 50 can clamp the section fixing assembly 20 and drive the section fixing assembly 20 to move up and down and flip 180°. The control assembly can control the movement of the workbench 10, the lifting assembly 40, and the flipping assembly 50, and can control the operation of the microscope assembly 30, receive and process the scanning data fed back by the microscope assembly 30.

[0038] The workbench 10 includes a bottom plate 11 and a sliding table 12. Among them, the structure of the bottom plate 11 is as Figure 2 shown. A sliding table installation area 111 and a microscope installation area 112 are arranged on the bottom plate 11.

[0039] See Figure 1 , the sliding table 12 is fixedly arranged in the sliding table installation area 111 on the bottom plate 11. The sliding table 12 can drive the section fixing assembly 20 to move in two directions, namely longitudinally and transversely. In the present invention, the longitudinal direction refers to the direction close to or away from the microscope assembly 30, and the transverse direction refers to the direction close to or away from the flipping assembly 50. The connection between the bottom plate 11 and the sliding table 12 and the connection between the bottom plate 11 and the microscope assembly 30 are rigid connections, which can be bolt connections, snap connections, magnetic attraction connections, etc.

[0040] The structure of the sliding table 12 is as Figure 3 , Figure 4 shown. The sliding table 12 includes a lower layer fixing plate 121, a middle layer sliding plate 122, and an upper layer sliding plate 123.

[0041] The lower fixing plate 121 is fixedly installed on the bottom plate 11, and a longitudinal driving module is arranged on the lower fixing plate 121, which can drive the middle sliding plate 122 to move longitudinally.

[0042] In a preferred embodiment, referring to Figure 3 , the longitudinal driving module includes a longitudinal motor 1211, a longitudinal motor fixing bracket 1212, a longitudinal guide rail 1213 and a longitudinal slider.

[0043] Referring to Figure 3 , the longitudinal motor fixing bracket 1212 is fixedly arranged on the side of the middle sliding plate 122, the longitudinal motor 1211 is sleeved on the longitudinal motor fixing bracket 1212, and at the same time, the bottom of the longitudinal motor 1211 is fixedly connected to the lower fixing plate 121. The longitudinal motor 1211 is a linear motor and can reciprocate relative to the longitudinal motor fixing bracket 1212, that is, the longitudinal motor 1211 can drive the longitudinal motor fixing bracket 1212 to drive the middle sliding plate 122 to move longitudinally. The longitudinal guide rail 1213 is fixedly arranged on the lower fixing plate 121, and a longitudinal slider is arranged at the bottom of the middle sliding plate 122, and this longitudinal slider can move along the longitudinal guide rail 1213.

[0044] In another embodiment, the longitudinal driving module includes a longitudinal motor 1211, a longitudinal motor fixing bracket 1212, a longitudinal guide rail 1213 and a longitudinal transmission mechanism (not shown in the figure). The longitudinal motor fixing bracket 1212 is arranged on one side of the lower fixing plate 121, and the longitudinal motor 1211 is fixedly arranged on this longitudinal motor fixing bracket 1212. The longitudinal guide rail 1213 is fixedly arranged on the lower fixing plate 121, and a slider is arranged at the bottom of the middle sliding plate 122, and this slider can move along the longitudinal guide rail 1213. The output end of the longitudinal motor 1211 is connected to the longitudinal transmission mechanism, and the longitudinal transmission mechanism is connected to the middle sliding plate 122 and can drive the middle sliding plate 122 to move along the longitudinal guide rail 1213. The longitudinal transmission mechanism can be a conventional lead screw nut mechanism, a chain transmission mechanism or a belt transmission mechanism, etc.

[0045] A transverse driving module is arranged on the upper surface of the middle sliding plate 122, which can drive the upper sliding plate 123 to move transversely. The structural composition and connection method of the transverse driving module are the same as those of the longitudinal driving module, and will not be elaborated here. The difference is that the transverse driving module and the longitudinal driving module are arranged on different sides of the workbench 10.

[0046] Specifically, referring to Figure 3, The horizontal motor fixing bracket 1222 is fixedly arranged on the other side of the upper slide plate 123. The horizontal motor 1221 is sleeved on the horizontal motor fixing bracket 1222. At the same time, the bottom of the horizontal motor 1221 is fixedly connected to the middle slide plate 122. The horizontal motor 1221 can move relative to the horizontal motor fixing bracket 1222. That is, the horizontal motor 1221 can drive the horizontal motor fixing bracket 1222 to drive the middle slide plate 122 to move horizontally. The horizontal guide rail 1223 is fixedly arranged on the middle slide plate 122. A horizontal slider is arranged at the bottom of the upper slide plate 123, and this horizontal slider can move along the longitudinal guide rail 1213.

[0047] The upper slide plate 123 is preferably of a U-shaped structure, and the middle opening thereof faces the flipping assembly 50. Support plate receiving surfaces 1231 are arranged on three side walls or two opposite side walls of the middle opening of the U-shaped structure for supporting the slice fixing assembly 20. Refer to Figure 1 , During operation, the slice fixing assembly 20 is placed on the upper surface of the upper slide plate 123, and three side edges of the slice support plate 21 are respectively located on the three support plate receiving surfaces 1231. The U-shaped upper slide plate 123 can save materials and reduce the weight of the equipment.

[0048] The longitudinal guide rail 1213 and the horizontal guide rail 1223 are preferably cross roller guide rails, and their limit stroke is 2 / 3 of the guide rail length.

[0049] In a preferred solution, the depth of the middle opening is less than the length of the slice fixing assembly 20. That is, when the slice fixing assembly 20 is placed above the middle opening, it cannot be completely located within the middle opening, and one end of the side facing the flipping assembly 50 will protrude a certain distance from the side wall of the workbench 10. Further, the protruding distance is between 1 / 4 and 1 / 3 of the length of the slice fixing assembly 20, that is, the depth of the middle opening is between 2 / 3 and 3 / 4 of the length of the slice fixing assembly 20. By this setting method, the slice fixing assembly 20 can be stably supported and can be inserted into the flipping assembly 50 and be driven by the flipping assembly 50 to achieve flipping.

[0050] In some other embodiments, the upper slide plate 123 can also be of a flat plate structure, and a middle groove with an opening facing the flipping assembly 50 is arranged on its upper surface. Support plate receiving surfaces 1231 as described above are arranged on opposite side walls or all three side walls of the middle groove. The upper slide plate 123 of the flat plate structure has better rigidity and can avoid deformation during operation.

[0051] In some preferred embodiments, the receiving surface 1231 of the support plate is made of an electromagnetic material, or an electromagnetic chuck 5122 or a vacuum chuck is embedded therein. In this way, stable support for the section support plate 21 can be achieved, and it can also ensure that the pathological section does not move during scanning to cause errors. At the same time, it can ensure that when it is necessary to move the section fixing assembly 20 away from the flipping assembly 50 with the section support plate 21, the section fixing assembly 20 can overcome the frictional force with the flipping assembly 50. Meanwhile, the power supply or negative pressure source can also be turned off when needed, facilitating the movement of the section support plate 21 with the flipping assembly 50.

[0052] The structure of the section fixing assembly 20 is as Figure 5 shown, including a section support plate 21 and a fixing strip 25.

[0053] The section support plate 21 is of a flat plate structure, on which a plurality of section mounting grooves 23 are provided, and in this embodiment, there are 4 section mounting grooves 23. These section mounting grooves 23 are arranged in parallel and evenly arranged along the length direction of the section support plate 21. On both side walls of each section mounting groove 23, there are protruding section supporting surfaces 231, and the pathological section is placed in the section mounting groove 23 and supported by the section supporting surfaces 231 on both sides. On both side walls of each section mounting groove 23, there is also a pick-up and placement groove 232 recessed inward into the side wall, facilitating the pick-up and placement of the pathological section.

[0054] One end of the section support plate 21 is provided with a protruding clamping end 22. This clamping end 22 is used to be adapted to the clamping mechanism 512 of the flipping assembly 50, facilitating the stable clamping of the section support plate 21 by the flipping assembly 50.

[0055] On the two side borders of the section support plate 21, there are also mounting holes 24 respectively, and these mounting holes 24 are used to mount the fixing strip 25.

[0056] The structure of the fixing strip 25 is as Figure 6 shown, being a slender strip-like structure, and at both ends of this slender strip, there is an installation part 251 each, and a through hole 252 is provided in the installation part 251. The length of the fixing strip 25 is suitable for aligning the through holes 252 at both ends of the fixing strip 25 with the mounting holes 24 on both sides of the section support plate 21 respectively, and the fixing strip 25 is fixed on the section support plate 21 by screws. This fixing strip 25 can fix the pathological section on the section support plate 21 and ensure that the pathological section does not fall or move during the flipping of the section support plate 21.

[0057] In a preferred solution, two fixing strips 25 are provided on the upper surface of the section support plate 21, as Figure 1 shown. The setting positions of the fixing strips 25 are as close as possible to the top or bottom of the section mounting groove 23 to avoid blocking the specimen in the pathological section.

[0058] The structure of the microscope assembly 30 is as follows Figure 7 shown. The microscope assembly 30 includes an electron microscope 31 and a microscope support 32. The electron microscope 31 can be a conventional electron microscope, which can automatically scan the section and feed the data back to the control component. The electron microscope 31 includes a scanning unit, which can adopt a high-resolution CCD or CMOS image sensor. The distance between the scanning unit and the workbench 10 is adjustable to adapt to sections of different thicknesses.

[0059] The microscope support 32 includes a microscope base 321, a vertical guide rod 322, and a support rod 323. The microscope base 321 is a disc-shaped structure for fixing the microscope assembly 30 in the microscope mounting area 112 on the workbench 10. The vertical guide rod 322 is fixedly arranged in the middle of the microscope base 321. One end of the support rod 323 is sleeved on the vertical guide rod 322 and can move up and down along the vertical guide rod 322. The other end of the support rod 323 is fixedly provided with the electron microscope 31. Through this setting method, the distance between the electron microscope 31 and the section can be freely adjusted, so that scanning can be conveniently carried out.

[0060] See Figure 1 and Figure 8 , the lifting assembly 40 is arranged on one side of the workbench 10 and has a certain distance from the workbench 10. The lifting assembly 40 includes a lifting motor 41, a vertical slide rail 42, and a vertical slider 43. The lifting motor 41 is arranged at the top of the vertical slide rail 42 and can drive the vertical slider 43 to move up and down along the vertical slide rail 42, thereby driving the flipping assembly 50 to move up and down synchronously.

[0061] See Figure 1 , Figure 9 , the flipping assembly 50 includes a flipping plate 51, a flipping motor 52, and a flipping motor mounting seat 53. Among them, the flipping motor mounting seat 53 is fixedly arranged on the side of the vertical slider 43, and the flipping motor 52 is fixedly arranged on the flipping motor mounting seat 53. The output end of the flipping motor 52 is connected to the flipping plate 51 and can drive the flipping plate 51 to rotate around the horizontal axis.

[0062] The structure of the flipping plate 51 is as follows Figure 9As shown in the figure. The flipping plate 51 includes an input shaft end 511 and a clamping mechanism 512. Among them, the input shaft end 511 is in transmission connection with the output end of the flipping motor 52. The clamping mechanism 512 is of a U-shaped structure, and each of its two inner side walls is provided with a support plate receiving groove 5121. The size and spacing of the support plate receiving groove 5121 are adapted to the size of the slicing support plate 21. The clamping mechanism 512 of the flipping plate 51 extends towards the slicing support plate 21. When the sliding table 12 drives the slicing support plate 21 to move horizontally to the limit position, the end of the slicing support plate 21 is inserted into the support plate receiving groove 5121 and clamped by the clamping mechanism 512 of the flipping plate 51, so that it can be driven by the flipping plate 51 to move up and down and be flipped 180° at the same time.

[0063] The flipping plate 51 is made of a lightweight and high-strength material to reduce the influence of inertia and improve the stability and accuracy of the flipping process.

[0064] In some preferred solutions, the clamping mechanism 512 further includes an electromagnetic chuck 5122, as Figure 1 , Figure 9 shown. The electromagnetic chuck 5122 is arranged at the bottom of the U-shaped opening of the clamping mechanism 512. When the slicing support plate 21 is inserted into the support plate receiving groove 5121 to the limit position, the clamping end 22 of the slicing support plate 21 is adsorbed onto the electromagnetic chuck 5122, so as to ensure that the slicing support plate 21 will not fall or move during the process of the flipping plate 51 driving the slicing support plate 21 to flip. After the flipping action is completed, the electromagnetic chuck 5122 can be powered off, and the slicing support plate 21 can be separated from the flipping plate 51, which is convenient for the next scanning.

[0065] In another solution, the clamping mechanism 512 may include pneumatic clamping strips or pneumatic clamping blocks, and the pneumatic clamping strips or pneumatic clamping blocks are arranged on the upper surface and / or the lower surface of the support plate receiving groove 5121. When inflated, the volume of the pneumatic clamping strips or pneumatic clamping blocks expands and tightly clamps the slicing support plate 21; when deflated, the pneumatic clamping strips or pneumatic clamping blocks are close to the surface of the support plate receiving groove 5121, which is convenient for the slicing support plate 21 to be inserted into or separated from the support plate receiving groove 5121.

[0066] Preferably, the device for pathological AI-assisted diagnosis in Embodiment 1 further includes a dust-proof protection structure to protect the scanning component and the slice from external environmental pollution and ensure the scanning clarity and the service life of the device.

[0067] The device for pathological AI-assisted diagnosis in Embodiment 1 realizes the flipping of pathological sections through the linkage of the lifting component 40 and the flipping component 50, and then realizes the full-automatic scanning of the front and back sides of pathological sections, providing a basis for subsequent AI-assisted diagnosis, greatly improving the scanning efficiency, and at the same time reducing the technical requirements for operators. The device has a simple structure and low cost, and is suitable for large-scale production and popularization; the scanned images have high clarity, which can significantly improve the accuracy and efficiency of pathological diagnosis. In addition, the automated design of this device avoids multiple manual operations of the sections, reduces the risks of contamination and damage, and meets the working requirements of high efficiency and safety in the laboratory.

[0068] Embodiment 2

[0069] Embodiment 2 relates to a method for automatically double-sided scanning of pathological sections, and this method uses the device for pathological AI-assisted diagnosis in Embodiment 1 to achieve double-sided scanning.

[0070] The method in Embodiment 2 specifically includes the following steps:

[0071] First step, install the pathological section on the section support plate 21, then install the fixing strip 25 on the section support plate 21, and then place the assembled section fixing component 20 on the support plate receiving surface 1231 on the workbench 10;

[0072] Second step, respectively control the operation of the transverse motor 1221 and the longitudinal motor 1211 of the control slide 12 to achieve full scanning of the specimen on the pathological section, and transmit the data to the control component;

[0073] Third step, the longitudinal motor 1211 of the control slide 12 drives the middle slide plate 122 to move to the starting position, and then the transverse motor 1221 of the control slide 12 drives the upper slide plate 123 to move towards the direction of the flipping component 50, so that the section support plate 21 of the section fixing component 20 is inserted into the support plate receiving groove 5121;

[0074] Fourth step, the lifting component 40 and the flipping component 50 are linked to drive the section fixing component 20 to flip 180°;

[0075] Fifth step, repeat the operation of the second step, and the scanning ends.

[0076] Further, in the third step, it also includes turning on the electromagnetic chuck 5122.

[0077] The specific steps of the fourth step are as follows: First, control the lifting motor 41 of the lifting assembly 40 to drive the turning plate 51 to drive the slicing fixing assembly 20 to move upward, and the upward movement distance should be greater than half of the width of the slicing fixing assembly 20; Second, control the turning motor 52 of the turning assembly 50 to drive the turning plate 51 to drive the slicing fixing assembly 20 to turn 180°; Finally, control the lifting motor 41 of the lifting assembly 40 to drive the turning plate 51 to drive the slicing fixing assembly 20 to move downward until the slicing fixing assembly 20 is placed on the support receiving surface 1231 of the workbench 10. Through this step, the slicing fixing assembly 20 can be turned 180° without interference, avoiding damaging the slices.

[0078] To further improve work efficiency, in the fourth step, the up and down movement and the turning movement can also be carried out simultaneously, that is, turning while moving upward, turning to 90° when reaching the apex during the upward movement, continuing to turn during the downward movement, and turning to 180° when reaching the apex during the downward movement. It is necessary to control the turning speed to ensure that the slicing fixing assembly 20 does not hit the workbench 10 during the turning process.

[0079] Further, after the fourth step is completed, turn off the electromagnetic chuck 5122.

[0080] According to the method for automatically double-sided scanning of pathological slices in this embodiment, scanning pictures of the upper and lower sides of the pathological slices can be obtained, and then transmitted to the diagnostic software system through the control component for comparison processing. Through AI pathological diagnosis based on big data, a more accurate diagnosis result can be obtained than that of a single-sided picture. The double-sided scanning pictures can also be connected to AI-assisted diagnosis, remote consultation, online cloud platform sharing, etc., improving efficiency and reducing the misdiagnosis rate.

[0081] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present invention should be covered by the protection scope of the present invention.

Claims

1. A device for AI-assisted diagnosis of pathology, characterized in that: It comprises a workbench, a slice fixing component, a microscope component, a lifting component, a flipping component and a control component; wherein the slice fixing component is used to fix and support pathological slices, and the slice fixing component is supported on the workbench and can move longitudinally and / or transversely; the microscope component is fixedly arranged on one side of the workbench and is used to scan the pathological slices; the lifting component is fixedly arranged on the other side of the workbench, and the flipping component is arranged on the lifting component and can be driven by the lifting component to rise or fall; the flipping component can clamp the slice fixing component and drive the slice fixing component to move up and down, and can drive the slice fixing component to flip 180°.

2. The device for AI-assisted diagnosis of pathology according to claim 1, characterized in that: The workbench comprises a bottom plate and a slide, wherein the slide is arranged on the bottom plate and can move longitudinally and / or transversely relative to the bottom plate.

3. The device for AI-assisted diagnosis of pathology according to claim 2, characterized in that: The slide includes a lower fixed plate, a middle slide plate and an upper slide plate; the lower fixed plate is fixedly arranged on the bottom plate; the middle slide plate is arranged on the lower fixed plate and can move longitudinally relative to the lower fixed plate; the upper slide plate is arranged on the middle slide plate and can move laterally relative to the middle slide plate.

4. The device for AI-assisted diagnosis of pathology according to claim 3, characterized in that: The upper slide plate is a U-shaped structure, and the middle opening faces the lifting assembly.

5. The device for AI-assisted diagnosis of pathology according to claim 4, characterized in that: Support plate receiving surfaces are arranged on the inner walls of the two opposite sides of the middle opening of the upper slide plate or on the inner walls of the three side surfaces.

6. The device for AI-assisted diagnosis of pathology according to claim 4 or 5, characterized in that: The depth of the middle opening is 2 / 3-3 / 4 of the length of the slice fixing assembly.

7. The device for AI-assisted diagnosis of pathology according to any one of claims 2 to 5, characterized in that: The supporting plate receiving surface is made of electromagnetic material, or an electromagnetic suction cup or a vacuum suction cup is embedded inside the supporting plate receiving surface.

8. The device for AI-assisted diagnosis of pathology according to claim 1, characterized in that: The slice fixing assembly comprises a slice supporting plate and a fixing bar.

9. The device for AI-assisted diagnosis of pathology according to claim 8, characterized in that: A plurality of slice installation grooves are arranged on the slice support plate; and the fixing bar is fixedly arranged on the upper surface of the slice support plate and is close to the top or bottom of the slice installation groove.

10. A method for automatically scanning two sides of a pathological section, characterized in that: The double-sided scanning is achieved by using the device for AI-assisted diagnosis of pathology according to any one of claims 1 to 9.

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