Nicotine buccal cotton sliver and preparation method thereof

Abstract

The invention discloses a nicotine buccal cotton sliver and a preparation method thereof. According to the nicotine buccal cotton sliver, a cotton material serves as a carrier, water-soluble colloid containing nicotine organic acid salt is evenly distributed in the cotton material through an infiltration method, and the cotton sliver capable of evenly releasing nicotine in the oral cavity is prepared. The prepared buccal cotton sliver is a novel nicotine delivery system, nicotine is absorbed through oral mucosa, the buccal cotton sliver has the advantages of being convenient to use, good in concealment, stable in release and the like, and the buccal cotton sliver is good in appearance state and good in experience feeling.

Description

Technical Field

[0001] The invention belongs to the technical field of nicotine products, and particularly relates to a nicotine oral tampon and a preparation method thereof. Background Art

[0002] Nicotine is an alkaloid found in tobacco and is addictive. Traditional cigarettes release nicotine by burning tobacco, but they also produce a large amount of harmful substances that endanger human health. In recent years, with the improvement of people's health awareness, new nicotine products have gradually emerged, such as electronic cigarettes, nicotine patches, nicotine gum, etc. These products are designed to provide nicotine while reducing the intake of harmful substances. At present, there are many smoking cessation aids on the market, such as nicotine patches, nicotine gum and electronic cigarettes, which help users gradually reduce their dependence on nicotine by providing controllable doses of nicotine.

[0003] However, these products have some inconveniences during use, such as patches and chewing gum may cause oral discomfort, while e-cigarettes have health risks and usage restrictions. In the prior art, nicotine patches absorb nicotine through the skin, which may cause skin allergies, nicotine chewing gum releases nicotine through chewing, which may cause oral discomfort, and e-cigarettes heat nicotine liquid to generate steam for users to inhale, which may have health risks and usage restrictions. Summary of the invention

[0004] In view of the shortcomings of the prior art such as poor user experience and potential health risks, and in order to provide a safer and more convenient way of nicotine intake and reduce user discomfort and health risks during use, the present invention provides a nicotine oral tampon and a preparation method thereof. The oral tampon of the present invention is a new type of nicotine delivery system, which absorbs nicotine through the oral mucosa and has the characteristics of easy use, good concealment, and stable release.

[0005] The nicotine oral tampon of the present invention uses cotton material as a carrier, and evenly distributes a water-soluble colloid containing a nicotine organic acid salt in the cotton material by an infiltration method to prepare a tampon that can evenly release nicotine in the oral cavity. The nicotine oral tampon of the present invention has a simple process, is easy to operate, and can be mass-produced.

[0006] A method for preparing a nicotine oral tampon of the present invention comprises the following steps:

[0007] S1. 88-95 parts by weight of glycerol are heated to 110°C-125°C, 3-5 parts by weight of higher fatty acid salts are added, stirred and dissolved into a mixed solution, cooled to 60°C-80°C and kept warm, 1.25-5 parts by weight of nicotine organic acid salt aqueous solution and 1-3 parts by weight of flavors and fragrances are added, kept warm at 60°C-80°C, and stirred to mix to form a water-soluble colloid of nicotine organic acid salt;

[0008] S2. Soak the cotton material in the water-soluble colloid of nicotine organic acid salt for full absorption and uniform distribution, cool and solidify at room temperature, and obtain a nicotine oral cotton strip.

[0009] Preferably, the higher fatty acid salt is sodium stearate, sodium palmitate, sodium myristic acid or sodium laurate.

[0010] Preferably, the nicotine organic acid salt aqueous solution is an aqueous solution prepared by mixing nicotine and an organic acid in a molar ratio of 1:1 and dissolving in water, and the organic acid is lactic acid, citric acid, benzoic acid, tartaric acid, gluconic acid, malic acid, acetic acid, levulinic acid, salicylic acid or sorbic acid.

[0011] Preferably, the nicotine content in the nicotine organic acid salt aqueous solution is 30%-80% by mass, wherein the nicotine concentration can be adjusted according to user needs.

[0012] More preferably, the nicotine content in the aqueous solution of nicotine organic acid salt is 40% by mass.

[0013] Preferably, the flavor is mint flavor, strawberry flavor, lemon flavor, citronella flavor, grape flavor, rose flavor, tobacco flavor or sweet orange flavor. The types of flavors can be adjusted according to different taste requirements.

[0014] Preferably, the cotton material is medical grade cotton, cotton fiber, wood pulp fiber, viscose fiber or lyocell fiber.

[0015] Preferably, the method comprises the following steps:

[0016] S1. 93 parts by mass of glycerol are heated to 110° C., 3 parts by mass of sodium stearate are added, and the mixture is stirred and dissolved into a mixed solution, and the mixture is cooled to 65° C. and kept warm, and 2.5 parts by mass of nicotine-lactate aqueous solution and 1.5 parts by mass of mint essence are added, and the mixture is kept warm at 65° C., and stirred and mixed to form a water-soluble colloid of nicotine organic acid salt; the nicotine-lactate aqueous solution is an aqueous solution prepared by mixing nicotine and lactic acid in a molar ratio of 1:1 and dissolving them in water, and the nicotine content in the nicotine-lactate aqueous solution is 40% by mass;

[0017] S2. Soak the medical-grade cotton in the water-soluble colloid of nicotine organic acid salt for 15 minutes, cool and solidify at room temperature to obtain a nicotine oral cotton strip.

[0018] Preferably, the method comprises the following steps:

[0019] S1. 93 parts by mass of glycerol are heated to 110° C., 3 parts by mass of sodium stearate are added, and the mixture is dissolved by stirring to form a mixed solution, and the mixture is cooled to 65° C. and kept warm, and 2 parts by mass of nicotine-malate aqueous solution and 2 parts by mass of grape essence are added, and the mixture is kept warm at 65° C., and the mixture is stirred and mixed to form a water-soluble colloid of nicotine organic acid salt; the nicotine-malate aqueous solution is an aqueous solution prepared by mixing nicotine and malic acid in a molar ratio of 1:1 and dissolving them in water, and the nicotine content in the nicotine-malate aqueous solution is 40% by mass;

[0020] S2. Soak the lyocell fiber in the water-soluble colloid of nicotine organic acid salt for 15 minutes, cool and solidify at room temperature, and obtain a nicotine oral tampon.

[0021] The present invention also provides a nicotine oral tampon prepared according to the method.

[0022] The present invention uses nicotine salt as a source of nicotine, so that consumers can achieve the purpose of addiction relief. Glycerol as a solvent can be absorbed by higher fatty acid salts to form a solid. Higher fatty acid salts are used as hardeners, which absorb glycerol after heating and dissolving, and can solidify to form a solid after cooling. Flavors and spices play a role in adjusting the taste. The method of the present invention can fully dissolve higher fatty acid salts, better absorb glycerol, maintain a good solid gel state, and the prepared nicotine oral cotton strip has a good appearance, and allows nicotine salts to be evenly distributed in the cotton strip, avoiding uneven distribution of nicotine salts and causing a bad experience. Cooling to 60°C-80°C to add nicotine salts and flavors and spices can ensure that nicotine salts and flavors and spices are not destroyed by high temperature, ensure their stability, and ensure that the mixed solution remains in a liquid state. By adopting the above method, the prepared nicotine oral cotton strip can maintain a solid form at room temperature, melt in the oral environment, slowly release nicotine, and the process is simple to operate, convenient to produce, and safe.

[0023] The present invention has the following beneficial effects:

[0024] The present invention provides a safer and more convenient way to ingest nicotine, reducing the discomfort and health risks of users during use. The oral tampon prepared by the present invention is a new type of nicotine delivery system, which absorbs nicotine through the oral mucosa and has the characteristics of easy use, good concealment, stable release, etc., and the product appearance is good and has a good experience. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is the appearance of the nicotine oral tampon prepared in Example 1. DETAILED DESCRIPTION

[0026] The following examples are provided to further illustrate the present invention, rather than to limit the present invention.

[0027] Example 1

[0028] The raw materials and auxiliary materials used in the nicotine oral tampon of this embodiment are as follows: the material of the tampon is medical grade cotton. The nicotine organic acid salt aqueous solution is a nicotine-lactate aqueous solution (that is, the organic acid therein is lactic acid), which is an aqueous solution prepared by mixing nicotine and lactic acid in a molar ratio of 1:1 and dissolving in water, wherein the mass fraction of nicotine is 40%; that is, taking the preparation of 10g of nicotine-lactate aqueous solution as an example, the composition is 4g nicotine (24.5mmol) + 2.78g lactic acid (24.5mmol, the purity of commercial lactic acid is 80%, 20% is water) + the remainder is water (3.22g). The flavor is mint flavor. Based on the mass of the prepared water-soluble colloid of nicotine organic acid salt of 100g, it contains 2.5g nicotine-lactate aqueous solution, 3g sodium stearate, 93g glycerin, and 1.5g mint flavor. The nicotine concentration in the water-soluble colloid of nicotine organic acid salt is 1% by mass.

[0029] The specific preparation process is as follows:

[0030] S1. Preparation of a water-soluble colloid of nicotine organic acid salt: Heat 93 g of glycerol to 110 ° C, add 3 g of sodium stearate, stir to dissolve, form a mixed solution, cool to 65 ° C and keep warm, add 2.5 g of nicotine-lactate aqueous solution and 1.5 g of mint flavor, keep warm at 65 ° C, stir and mix to form a water-soluble colloid of nicotine organic acid salt, which is now in liquid state, and keep warm at 65 ° C for later use;

[0031] S2. Soaking cotton strips: Soak an appropriate amount of medical-grade cotton in the water-soluble colloid of nicotine organic acid salt prepared in step S1 for 15 minutes, so that the medical-grade cotton absorbs 1g of the water-soluble colloid of nicotine organic acid salt, and cools and solidifies at room temperature (25°C-30°C) to obtain a nicotine oral cotton strip (such as Figure 1 shown).

[0032] S3. Packaging: Pack the nicotine oral tampons to obtain the finished product.

[0033] Embodiment 2-10

[0034] The nicotine oral tampons of Examples 2-10 are different from those of Example 1 in that the types and amounts of raw materials and auxiliary materials are different, and the specific types and masses (based on 100 g of the water-soluble colloid mass of the prepared nicotine organic acid salt) are shown in Table 1. The nicotine organic acid salt aqueous solution is an aqueous solution prepared by mixing nicotine and a corresponding organic acid at a molar ratio of 1:1 and dissolving them in water, and contains 40% by mass of nicotine.

[0035] Table 1 Components of Nicotine Oral Tampons in Examples 1-10

[0036]

[0037] Comparative Examples 1-5

[0038] The nicotine oral tampons of Comparative Examples 1-5 are different from those of Example 1 in that the types and amounts of raw materials and auxiliary materials are different, and the specific types and masses (based on 100 g of the water-soluble colloid mass of the prepared nicotine organic acid salt) are shown in Table 2. The nicotine organic acid salt aqueous solution is an aqueous solution prepared by mixing nicotine and a corresponding organic acid at a molar ratio of 1:1 and dissolving in water, and contains 40% by mass of nicotine.

[0039] Table 2 Comparative Examples 1-5 Nicotine oral tampon components

[0040]

[0041] Comparative Example 6

[0042] The types and amounts of raw materials and auxiliary materials used to prepare the nicotine oral tampon of this comparative example are the same as those of Example 1, and the difference lies in the preparation process. The preparation process of the nicotine oral tampon of this comparative example is as follows:

[0043] S1. Preparation of a water-soluble colloid of nicotine organic acid salt: 93 g of glycerol was heated to 90 ° C, 3 g of sodium stearate was added, and the mixture was stirred to dissolve, and the mixture was cooled to 65 ° C and kept warm, 2.5 g of nicotine-lactate aqueous solution and 1.5 g of mint flavor were added, and the mixture was kept warm at 65 ° C, and the mixture was stirred to form a water-soluble colloid of nicotine organic acid salt, which was in liquid state at this time, and the mixture was kept warm at 65 ° C for later use;

[0044] S2. Soaking cotton strips: soak an appropriate amount of medical-grade cotton in the water-soluble colloid of nicotine organic acid salt prepared in step S1 for 15 minutes, so that the medical-grade cotton absorbs 1g of the water-soluble colloid of nicotine organic acid salt, and cool and solidify at room temperature (25°C-30°C) to obtain a nicotine oral cotton strip.

[0045] S3. Packaging: Pack the nicotine oral tampons to obtain the finished product.

[0046] Comparative Example 7

[0047] The types and amounts of raw materials and auxiliary materials used to prepare the nicotine oral tampon of this comparative example are the same as those of Example 1, and the difference lies in the preparation process. The preparation process of the nicotine oral tampon of this comparative example is as follows:

[0048] S1. Preparation of a water-soluble colloid of nicotine organic acid salt: 93 g of glycerol was heated to 150 ° C, 3 g of sodium stearate was added, and the mixture was stirred to dissolve, and the mixture was cooled to 65 ° C and kept warm, 2.5 g of nicotine-lactate aqueous solution and 1.5 g of mint flavor were added, and the mixture was kept warm at 65 ° C, and the mixture was stirred to form a water-soluble colloid of nicotine organic acid salt, which was in liquid state at this time, and the mixture was kept warm at 65 ° C for later use;

[0049] S2. Soaking cotton strips: soak an appropriate amount of medical-grade cotton in the water-soluble colloid of nicotine organic acid salt prepared in step S1 for 15 minutes, so that the medical-grade cotton absorbs 1g of the water-soluble colloid of nicotine organic acid salt, and cool and solidify at room temperature (25°C-30°C) to obtain a nicotine oral cotton strip.

[0050] S3. Packaging: Pack the nicotine oral tampons to obtain the finished product.

[0051] Comparative Example 8

[0052] The types and amounts of raw materials and auxiliary materials used to prepare the nicotine oral tampon of this comparative example are the same as those of Example 1, and the difference lies in the preparation process. The preparation process of the nicotine oral tampon of this comparative example is as follows:

[0053] S1. Preparation of a water-soluble colloid of nicotine organic acid salt: 93 g of glycerol was heated to 110 ° C, 3 g of sodium stearate was added, and the mixture was stirred to dissolve, and the mixture was cooled to 90 ° C and kept warm, 2.5 g of nicotine-lactate aqueous solution and 1.5 g of mint flavor were added, and the mixture was kept warm at 90 ° C, and the mixture was stirred to form a water-soluble colloid of nicotine organic acid salt, which was in liquid state at this time, and the mixture was kept warm at 90 ° C for later use;

[0054] S2. Soaking cotton strips: soak an appropriate amount of medical-grade cotton in the water-soluble colloid of nicotine organic acid salt prepared in step S1 for 15 minutes, so that the medical-grade cotton absorbs 1g of the water-soluble colloid of nicotine organic acid salt, and cool and solidify at room temperature (25°C-30°C) to obtain a nicotine oral cotton strip.

[0055] S3. Packaging: Pack the nicotine oral tampons to obtain the finished product.

[0056] Comparative Example 9

[0057] The types and amounts of raw materials and auxiliary materials used to prepare the nicotine oral tampon of this comparative example are the same as those of Example 1, and the difference lies in the preparation process. The preparation process of the nicotine oral tampon of this comparative example is as follows:

[0058] S1. Preparation of a water-soluble colloid of nicotine organic acid salt: 93 g of glycerol was heated to 110 ° C, 3 g of sodium stearate was added, and the mixture was stirred to dissolve, and the mixture was cooled to 50 ° C and kept warm, 2.5 g of nicotine-lactate aqueous solution and 1.5 g of mint flavor were added, and the mixture was kept warm at 50 ° C, and stirred to form a water-soluble colloid of nicotine organic acid salt, which was in liquid state at this time, and kept warm at 50 ° C for later use;

[0059] S2. Soaking cotton strips: soak an appropriate amount of medical-grade cotton in the water-soluble colloid of nicotine organic acid salt prepared in step S1 for 15 minutes, so that the medical-grade cotton absorbs 1g of the water-soluble colloid of nicotine-lactate, and cools and solidifies at room temperature (25°C-30°C) to obtain a nicotine oral cotton strip.

[0060] S3. Packaging: Pack the nicotine oral tampons to obtain the finished product.

[0061] Performance testing:

[0062] 20 professional sensory evaluators were selected to evaluate the nicotine oral tampons samples prepared in the above embodiments or comparative examples. The evaluation items and standards are shown in Table 3, and the evaluation results (average value, n=20) are shown in Table 4.

[0063] Combined with the sensory evaluation of the samples of Examples 1 and 2-10, and combined with Tables 3 and 4, it can be seen that within the preparation process range of Examples 1-10, the solidification effect of the cotton strip after absorbing the water-soluble colloid of nicotine organic acid salt is good, and after oral administration, it melts slowly, and nicotine is released slowly and evenly, with a better experience.

[0064] Combined with the sensory evaluation of the samples of Example 1 and Comparative Examples 1-5, and combined with Table 4, it can be seen that in Comparative Examples 1-5, when the amount of glycerol or sodium stearate used is lower than the amount used in Example 1, it is not easy to solidify and the product appearance is poor. When the amount used is higher than the amount used in Example 1, the solidification effect is better, but the hardness is too large, the melting effect in the mouth is poor, and the taste is greatly affected.

[0065] Combined with the sensory evaluation of Example 1 and Comparative Examples 6-9 samples, and combined with Table 4, it can be seen that when the dissolution temperature is too low, sodium stearate is not easy to dissolve and solidify, and when the dissolution temperature is too high, glycerol will polymerize, affecting the taste; when the insulation temperature is too low, the fluidity is poor, the nicotine salt and the flavor are unevenly distributed, and when the cotton strip is soaked, they cannot be evenly distributed on the cotton strip; when the insulation temperature is too high, the nicotine salt and the flavor are easily destroyed, affecting the taste.

[0066] Table 3 Evaluation indicators

[0067]

[0068] Note: [2,5)min means greater than or equal to 2 and less than 5min, [5,7)min means greater than or equal to 5 and less than 7min, and [7,10)min means greater than or equal to 7 and less than 10min.

[0069] Table 4 Evaluation results

[0070]

[0071]

Claims

1. A method for preparing a nicotine oral tampon, characterized in that: The steps include: S1. 88-95 parts by weight of glycerol are heated to 110°C-125°C, 3-5 parts by weight of higher fatty acid salts are added, stirred and dissolved into a mixed solution, cooled to 60°C-80°C and kept warm, 1.25-5 parts by weight of nicotine organic acid salt aqueous solution and 1-3 parts by weight of flavors and fragrances are added, kept warm at 60°C-80°C, and stirred to mix to form a water-soluble colloid of nicotine organic acid salt; S2. Soak the cotton material in the water-soluble colloid of nicotine organic acid salt for full absorption and uniform distribution, cool and solidify at room temperature, and obtain a nicotine oral cotton strip.

2. The method according to claim 1, characterized in that The higher fatty acid salt is sodium stearate, sodium palmitate, sodium myristic acid or sodium laurate.

3. The method according to claim 1, characterized in that The nicotine organic acid salt aqueous solution is an aqueous solution prepared by mixing nicotine and an organic acid in a molar ratio of 1:1 and dissolving in water, and the organic acid is lactic acid, citric acid, benzoic acid, tartaric acid, gluconic acid, malic acid, acetic acid, levulinic acid, salicylic acid or sorbic acid.

4. The method according to claim 1, characterized in that: The nicotine content in the nicotine organic acid salt aqueous solution is 30%-80% by mass.

5. The method according to claim 1, characterized in that The nicotine content in the nicotine organic acid salt aqueous solution is 40% by mass.

6. The method according to claim 1, characterized in that The flavor and fragrance are mint flavor, strawberry flavor, lemon flavor, citronella flavor, grape flavor, rose flavor, tobacco flavor or sweet orange flavor.

7. The method according to claim 1, characterized in that The cotton material is medical grade cotton, cotton fiber, wood pulp fiber, viscose fiber or lyocell fiber.

8. The method according to claim 1, characterized in that The steps include: S1. 93 parts by mass of glycerol are heated to 110° C., 3 parts by mass of sodium stearate are added, and the mixture is stirred and dissolved into a mixed solution, and the mixture is cooled to 65° C. and kept warm, and 2.5 parts by mass of nicotine-lactate aqueous solution and 1.5 parts by mass of mint essence are added, and the mixture is kept warm at 65° C., and stirred and mixed to form a water-soluble colloid of nicotine organic acid salt; the nicotine-lactate aqueous solution is an aqueous solution prepared by mixing nicotine and lactic acid in a molar ratio of 1:1 and dissolving them in water, and the nicotine content in the nicotine-lactate aqueous solution is 40% by mass; S2. Soak the medical-grade cotton in the water-soluble colloid of nicotine organic acid salt for 15 minutes, cool and solidify at room temperature to obtain a nicotine oral cotton strip.

9. The method according to claim 1, characterized in that: The steps include: S1. 93 parts by mass of glycerol are heated to 110° C., 3 parts by mass of sodium stearate are added, and the mixture is dissolved by stirring to form a mixed solution, and the mixture is cooled to 65° C. and kept warm, and 2 parts by mass of nicotine-malate aqueous solution and 2 parts by mass of grape essence are added, and the mixture is kept warm at 65° C., and the mixture is stirred and mixed to form a water-soluble colloid of nicotine organic acid salt; the nicotine-malate aqueous solution is an aqueous solution prepared by mixing nicotine and malic acid in a molar ratio of 1:1 and dissolving them in water, and the nicotine content in the nicotine-malate aqueous solution is 40% by mass; S2. Soak the lyocell fiber in the water-soluble colloid of nicotine organic acid salt for 15 minutes, cool and solidify at room temperature, and obtain a nicotine oral tampon.

10. The nicotine oral tampon prepared according to the method according to any one of claims 1 to 9.

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