Oral care composition and method for improving structural stability of oral care composition

Abstract

The invention discloses an oral care composition and a method for improving the structural stability of the composition. The oral care composition comprises: 1) peroxide; 2) a fluoride ion source; 3) an antioxidant; 4) a thickening agent; 5) an orally acceptable carrier; wherein the antioxidant is prepared from one or two of butylated hydroxytoluene and butylated hydroxyanisole; and the thickening agent comprises poloxamer. Also disclosed are methods of improving the structural stability of an oral care composition comprising a peroxide and a fluoride ion source. When a fluoride ion source is added into the oral care composition containing peroxide, the composition is unstable in structure, and the paste is liquefied, while an antioxidant is further added into the formula of the oral care composition, and the antioxidant contains butylated hydroxytoluene or butylated hydroxyanisole, so that the oral care composition containing peroxide can be used for preparing the oral care composition containing peroxide. And when the thickening agent contains poloxamer, the condition that the paste structure of the composition is unstable can be improved.

Description

Technical Field

[0001] The invention relates to the technical field of oral care, in particular to an oral care composition comprising peroxide, a fluoride ion source, poloxamer and an antioxidant, and a method for improving the structural stability of the composition. Background Art

[0002] Peroxides (such as hydrogen peroxide, sodium percarbonate or phthalimidoperoxycaproic acid) are common teeth whitening ingredients in oral care products, which achieve the effect of teeth whitening by decomposing stains on the surface of teeth. However, peroxides are usually unstable and easy to decompose, which not only affects the whitening effect, but also easily causes flatulence in the packaging of oral care products.

[0003] In the prior art, stabilizers are usually added to the formula of oral care products containing peroxides to stabilize the peroxides. For example, Chinese invention patent application CN115645307A discloses a post-foaming tooth whitening gel aerosol, the aerosol contains a stabilizer, and the stabilizer includes ethylenediaminetetraacetic acid and 2,6-di-tert-butyl-p-cresol (BHT); the post-foaming tooth whitening gel aerosol of the patent can act on the teeth softly and evenly through the action of the foaming agent, and cooperate with the action of the film-forming agent to make the product fit the teeth perfectly and the whitening effect uniform. Under the action of the moisturizer and the stabilizer, it can be gradually released to maintain the stability of the whitening composition to obtain a lasting whitening effect. For another example, U.S. Patent US6824704B discloses a stable tooth whitening gel, the gel contains a stabilizer, and the stabilizer is selected from aminocarboxylic acids and salts thereof; suitable aminocarboxylic acids include ethylenediaminetetraacetic acid. That is to say, the oral care composition containing peroxide can be kept stable by adding a stabilizer.

[0004] Although a stabilizer can be added to an oral care composition containing peroxide to stabilize the peroxide in the composition, the stabilizer cannot improve the paste structure of the composition. Therefore, a formula that can stabilize the peroxide and improve the paste structure is still needed. Summary of the invention

[0005] The first technical problem to be solved by the present invention is to provide an oral care composition comprising hydrogen peroxide and a fluoride ion source, wherein the structural stability of the oral care composition is significantly improved.

[0006] The second technical problem to be solved by the present invention is to provide a method for improving the structural stability of an oral care composition comprising hydrogen peroxide and a fluoride ion source.

[0007] In order to solve the above-mentioned first technical problem, the invention adopts the following technical solution :

[0008] An oral care composition comprising hydrogen peroxide and a fluoride ion source, comprising:

[0009] 1) Peroxide;

[0010] 2) fluoride ion source;

[0011] 3) Antioxidants;

[0012] 4) thickener;

[0013] 5) an orally acceptable carrier;

[0014] Wherein, the antioxidant comprises one or both of butylated hydroxytoluene or butylated hydroxyanisole;

[0015] The thickening agent comprises poloxamer.

[0016] As an embodiment, the peroxide is one or more of hydrogen peroxide, sodium percarbonate, phthalimidoperoxycaproic acid (PAP), and urea peroxide.

[0017] As an embodiment, the mass proportion of the peroxide in the oral care composition is 0.05-12%.

[0018] As an embodiment, the fluoride ion source is one or more of stannous fluoride, sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, olafluor, and zinc fluoride.

[0019] As an embodiment, the antioxidant accounts for 0.005-0.1% by weight in the oral care composition.

[0020] As an embodiment, the oral care composition further comprises ethylenediaminetetraacetic acid or an alkali metal salt thereof.

[0021] As an embodiment, the mass proportion of the ethylenediaminetetraacetic acid or its alkali metal salt in the oral care composition is 0.01-0.5%.

[0022] As an embodiment, the pH value of the oral care composition is 3.5-5.5; preferably, the pH value is 4-5.

[0023] As an embodiment, the oral care composition further comprises an acidic pH adjuster.

[0024] As an embodiment, the acidic pH adjuster is phosphoric acid.

[0025] To solve the above second technical problem, the present invention adopts the following technical solution :

[0026] A method for improving the structural stability of an oral care composition comprising a peroxide and a fluoride ion source comprises the following steps:

[0027] Poloxamer as a thickener and butylated hydroxytoluene or butylated hydroxyanisole as an antioxidant are added to an oral care composition comprising hydrogen peroxide and a fluoride ion source.

[0028] Any range described in the present invention includes the end value and any numerical value between the end values ​​and any sub-range formed by the end value or any numerical value between the end values.

[0029] Unless otherwise specified, all raw materials in the present invention can be purchased from the market, and the equipment used in the present invention can adopt conventional equipment in the relevant field or refer to the existing technology in the relevant field.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] When a fluoride ion source is added to an oral care composition containing peroxide, the composition structure may become unstable and the paste may liquefy. However, when a peroxide stabilizer such as butylated hydroxytoluene or butylated hydroxyanisole is further added to the oral care composition formula and a thickener such as poloxamer is included, the unstable paste structure of the composition can be improved. DETAILED DESCRIPTION

[0032] In order to explain the present invention more clearly, the present invention is further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the following specific description is illustrative rather than restrictive, and should not be used to limit the scope of protection of the present invention.

[0033] Unless otherwise specified, all percentages and ratios used herein are based on the weight of the total composition. Unless otherwise specified, the percentages, ratios and amounts of all ingredients mentioned herein are based on the actual amount of the ingredient and do not include solvents, fillers or other materials that can be combined with these ingredients in commercial products.

[0034] The term "comprising" herein means that other steps and ingredients which do not affect the end result can be added.

[0035] The term "preferably" and its variants herein refer to embodiments of the present invention that can provide specific beneficial effects under specific circumstances. However, other embodiments may also be preferred under the same or other environments. In addition, the detailed description of one or more preferred embodiments does not mean that other embodiments are useless, and is not intended to exclude other embodiments in the scope of the present invention.

[0036] If no specific conditions are specified in the examples of the present invention, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer; if no manufacturer is specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0037] As one aspect of the present invention, an oral care composition comprising hydrogen peroxide and a fluoride ion source comprises:

[0038] 1) Peroxide;

[0039] 2) fluoride ion source;

[0040] 3) Antioxidants;

[0041] 4) thickener;

[0042] 5) an orally acceptable carrier;

[0043] Wherein, the antioxidant comprises one or both of butylated hydroxytoluene or butylated hydroxyanisole;

[0044] The thickening agent comprises poloxamer;

[0045] The present invention unexpectedly discovered that when a fluoride ion source is added to an oral care composition containing peroxide, the composition structure may be unstable, resulting in liquefaction of the paste; however, when an antioxidant butylated hydroxytoluene or butylated hydroxyanisole is added to the oral care composition containing peroxide and a fluoride ion source, and the thickener contains poloxamer, the unstable composition structure can be improved.

[0046] peroxide

[0047] Peroxides are commonly used as tooth whitening agents in oral care compositions.

[0048] In certain embodiments of the present invention, the peroxide is one or a combination of two or more of hydrogen peroxide, sodium percarbonate, phthalimidoperoxycaproic acid (PAP), and urea peroxide.

[0049] In certain preferred embodiments of the present invention, the peroxide is hydrogen peroxide;

[0050] In certain embodiments of the present invention, the mass proportion of the peroxide in the oral care composition is 0.5-12%, for example, but not limited to, preferably 0.5-10%, 0.5-7%, 0.5-5%, 0.5-3%, 0.5-1.5%, 0.5-1%, 1-12%, 1-10%, 1-7%, 1-5%, 1-3%, 1-2.5%, 1-1.5%, 2-12%, 2-10%, 2-8%, 2-7%, 2-5%, 3-12%, 3-10%, 3-7%, 3-5%, 3-4%, 4-12%, 4-10%, 4-7%, 4-5%, 5-8%, 5-7%, 5-6%, 6-8%, 6-7%, 7-8%.

[0051] Fluoride ion source

[0052] The oral care composition of the present invention further comprises a fluoride ion source.

[0053] The fluoride ion source is derived from one or more of stannous fluoride, sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, olafluor, and zinc fluoride.

[0054] In certain embodiments of the present invention, the mass proportion of the fluoride ion source in the composition is the conventional amount of fluoride in oral care products, such as but not limited to 0.05-1.2%, 0.08-1.2%, 0.1-1.2%, 0.15-1.2%, 0.2-1.2%, 0.3-1.2%, 0.4-1.2%, 0.5-1.2%, 0.6-1.2%, 0.8-1.2%, 1.0-1.2%, 0.05-1.0%, 0.08-1.0%, 0.1-1.0%, 0.15-1.0%, 0.2-1.0%, 0.3-1.0%, 0.4-1.0%, 0.5-1.0%, 0.6-1.0%, 0.8-1.0%, 0.05-0.8%, 0.08-0.8%, 0.1-0.8%, 0.15-0.8%, 0.2-0.8%, 0.3-0.8%, 0.4- 0.8%, 0.5-0.8%, 0.6-0.8%, 0.05-0.6%, 0.08-0.6%, 0.1-0.6%, 0.15-0.6%, 0.2-0.6%, 0.3-0.6%, 0.4-0.6%, 0.5-0.6%, 0.05-0.5%, 0.08-0.5%, 0.1-0.5%, 0.15-0.5%, 0.2-0.5%, 0.3-0.5% , 0.4-0.5%, 0.05-0.4%, 0.08-0.4%, 0.1-0.4%, 0.15-0.4%, 0.2-0.4%, 0.3-0.4%, 0.05-0.3%, 0.08-0.3%, 0.1-0.3%, 0.15-0.3%, 0.2-0.3%, 0.05-0.2%, 0.08-0.2%, 0.1-0.2%, 0.15-0.2%,

[0055] Poloxamer

[0056] Poloxamer is a block copolymer formed by polymerization of ethylene oxide and propylene oxide, and is commonly used as a nonionic surfactant in oral care compositions. In the present invention, poloxamer is added to the composition paste containing peroxide as a thickener.

[0057] In certain embodiments of the present invention, the poloxamer includes but is not limited to poloxamer 188, poloxamer 237, poloxamer 401 and poloxamer 407; in a preferred embodiment, the poloxamer is poloxamer 407.

[0058] In certain embodiments of the present invention, the mass proportion of the poloxamer in the oral care composition is 15-25%, for example but not limited to: 15-23%, 15-21%, 15-19%, 15-17%, 18-25%, 18-23%, 18-21%, 18-19%, 20-25%, 20-23%, 20-21%, 22-25%, 24-25%.

[0059] Antioxidants

[0060] Butylated Hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) can be used as antioxidants in cosmetics to prevent lipid oxidation, thereby extending the shelf life of cosmetics.

[0061] The present invention unexpectedly discovered that adding butylated hydroxytoluene or butylated hydroxyanisole to the oral care composition containing peroxide of the present invention can not only improve the stability of the peroxide, but also improve the problem of liquefaction of the composition formula caused by adding a fluoride ion source to the peroxide formula, thereby improving the structural stability of the composition formula.

[0062] In certain embodiments of the present invention, the antioxidant accounts for 0.005-0.1% by mass in the composition, for example but not limited to 0.005-0.08%, 0.005-0.05%, 0.005-0.03%, 0.005-0.01%, 0.01-0.1%, 0.01-0.1%, 0.01-0.1%, 0.01-0.08%, 0.01-0.05%, 0.01-0.03%, 0.05-0.1%.

[0063] EDTA

[0064] Ethylenediamine tetraacetic acid (EDTA) has a history of extensive use in toiletries. The six coordinated atoms in its structure give it good chelating properties, which can effectively chelate trace amounts of metal ions such as iron, copper, nickel, and lead that may be present in the raw materials, thereby enhancing the stability of the product. Adding EDTA to the formula of oral care products containing hydrogen peroxide can effectively improve the stability of the peroxide.

[0065] Although adding EDTA to the oral care composition containing peroxide of the present invention can improve the stability of the peroxide, it cannot improve the problem of liquefaction of the composition formula caused by adding a fluoride ion source to the peroxide formula. The present invention unexpectedly found that by adding BHT and EDTA simultaneously to the formula containing peroxide, EDTA can improve the application of BHT in improving the liquefaction problem of the composition formula.

[0066] In certain embodiments of the present invention, the EDTA is an alkali metal salt of EDTA.

[0067] In certain embodiments of the present invention, the alkali metal salt of EDTA is disodium salt of EDTA (hereinafter referred to as EDTA.2Na).

[0068] In certain embodiments of the present invention, the mass percentage of EDTA in the oral care composition is 0.01-0.5%, such as but not limited to 0.01-0.3%, 0.01-0.2%, 0.01-0.1%, 0.01-0.05%, 0.05-0.5%, 0.05-0.3%, 0.05-0.2%, 0.05-0.1%, 0.1-0.5%, 0.1-0.3%, 0.1-0.2%. 0.2-0.5%, 0.2-0.3%.

[0069] Orally acceptable carrier

[0070] In the present invention, the "orally acceptable carrier" refers to any vehicle suitable for formulating the oral care composition disclosed in the present invention; when the orally acceptable carrier is retained in the mouth in the amount disclosed in the present invention without being swallowed for a period of time sufficient to allow effective contact with the tooth surface as required by the present invention, it is harmless to mammals; in general, the orally acceptable carrier will not be harmful even if it is swallowed unintentionally; suitable orally acceptable carriers include, for example, one or more of the following substances: water, abrasives, surfactants, moisturizers, flavoring agents, visual aids (for example, pigments, dyes or mixtures thereof), anti-caries agents, antibacterial agents, desensitizing agents, preservatives, and mixtures thereof, etc. Specific embodiments

[0072] Comparative Examples 1-3, Examples 1-2

[0073] According to the formula in Table 1 below, oral care compositions of Comparative Examples 1-3 and Examples 1-2 were prepared. The data in the table are all parts by weight, and the total is 100 parts. In the present invention, the oral care composition prepared according to the formula can be mixed uniformly in a conventional manner.

[0074] Table 1

[0075]

[0076]

[0077] From Table 1 we can see that:

[0078] Comparative Example 1 added 3% hydrogen peroxide, but no fluoride ion source;

[0079] Comparative Example 2: 0.221% sodium fluoride was added to Comparative Example 1;

[0080] Comparative Example 3 adds 0.05% EDTA.2Na to Comparative Example 2;

[0081] Example 1 adds 0.005% BHT on the basis of Comparative Example 2;

[0082] Example 2: Based on Comparative Example 2, 0.05% EDTA.2Na and 0.005% BHT were added;

[0083] After the preparation of the comparative examples 1-3 and the examples 1-2, the compositions were aged at 50° C. for 1 month, and the recovery rates of hydrogen peroxide in the compositions of the comparative examples and the examples were tested. The results are shown in Table 2.

[0084] Table 2:

[0085] Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Hydrogen peroxide recovery rate (%) 95 10 90 95 98

[0086] From Table 2 we can see that:

[0087] The hydrogen peroxide in the composition of Comparative Example 1 without adding sodium fluoride is relatively stable, and the recovery rate is as high as 95%.

[0088] In Comparative Example 2, in which sodium fluoride was added, hydrogen peroxide was rapidly degraded, and the recovery rate dropped from 95% in Comparative Example 1 to 10%.

[0089] Comparative Example 3: After EDTA.2NA was added to the comparative example 2, although the composition also contained sodium fluoride, the hydrogen peroxide was also relatively stable, and the recovery rate was 90%.

[0090] Example 1 adds BHT on the basis of Comparative Example 2. Although the composition also contains sodium fluoride, the hydrogen peroxide is also stable and the recovery rate is 95%.

[0091] Example 2 adds EDTA.2NA and BHT at the same time on the basis of Comparative Example 2, and the hydrogen peroxide is more stable, and the recovery rate reaches 98%.

[0092] This shows that both EDTA.2Na and BHT have the function of stabilizing hydrogen peroxide, and the combination of the two can synergistically improve the stability of peroxide.

[0093] After the preparation of the comparative examples 2-3 and the examples 1-2, the compositions were aged at 50°C for 1 month and the paste structures were observed. The results are shown in Table 3:

[0094] Table 3

[0095] Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Is the paste liquefied? no yes yes no no

[0096] From Table 3 we can see that:

[0097] After aging for 1 month at 50° C., the paste of Comparative Example 1 did not liquefy.

[0098] After aging for 1 month at 50° C., the paste of Comparative Example 2-3 liquefied, that is, the paste structure of Comparative Example 2-3 after adding fluoride was unstable.

[0099] After aging for 1 month at 50° C., the paste of Example 1-2 did not liquefy.

[0100] It can be seen that although EDTA.2Na and BHT can improve the stability of hydrogen peroxide, EDTA.2Na cannot improve the stability of the paste structure of the composition, while BHT can not only improve the stability of hydrogen peroxide, but also improve the stability of the paste structure of the composition.

[0101] After the preparation of the above-mentioned Example 1-2 was completed, it was aged at 50° C. for 2 months, and the paste structure of the composition was observed. The results are shown in Table 4:

[0102] Table 4:

[0103] Example 1 Example 2 Is the paste liquefied? yes no

[0104] From Table 4 we can see that:

[0105] After aging for 2 months at 50° C., the paste of Example 1 also liquefied. However, after aging for 2 months at 50° C., the paste of Example 2 still did not liquefy, that is, the structure of the composition was still stable.

[0106] It can be seen that although EDTA.2Na cannot improve the structural stability of the composition, the combination of EDTA.2Na and BHT can further improve the structural stability of the composition.

[0107] Comparative Examples 4-8

[0108] According to the formula in Table 5, oral care compositions of Comparative Examples 4-8 were prepared. For the convenience of comparison, Example 1 was included in Table 5. The data in the table are all parts by weight, totaling 100 parts.

[0109] Table 5

[0110]

[0111]

[0112] As can be seen from Table 5, BHT was added to Example 1 and Comparative Examples 4-8, and the viscosity of the pastes was similar when the preparation was completed, but different types of additives were added, among which:

[0113] Example 1 added 20% poloxamer as a thickener;

[0114] Comparative Example 4 added 12% PVP (polyvinyl pyrrolidone) as a thickener;

[0115] Comparative Example 5 added 0.8% xanthan gum as a thickener;

[0116] Comparative Example 6 added 0.8% cellulose gum as a thickener;

[0117] Comparative Example 7 added 0.5% of carbomer as a thickener;

[0118] Comparative Example 8 added 0.9% carrageenan as a thickener;

[0119] After the preparation of the above comparative examples 4-8 was completed, the composition was aged at 50°C for 1 month and the paste structure was observed. The results are shown in Table 6:

[0120] Table 6:

[0121] Example 1 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Is the paste liquefied? no yes yes yes yes yes

[0122] From Table 6 we can see that:

[0123] After aging for one month at 50° C., the paste of Example 1 did not liquefy.

[0124] After aging for 1 month at 50° C., the pastes of Comparative Examples 4-8 all liquefied.

[0125] It can be seen that the selection of thickener in the composition will affect the stability of the paste structure. Even if BHT is added to the composition, when the thickener is PVP, xanthan gum, cellulose gum, carbomer or carrageenan, the paste of the composition will also liquefy. Only when poloxamer is used as the thickener, the paste of the composition will not liquefy.

[0126] Comparative Examples 9-13

[0127] According to the formula in Table 7, oral care compositions of Comparative Examples 9-13 were prepared. For the convenience of comparison, Example 2 was included in Table 7. The data in the table are all parts by weight, totaling 100 parts.

[0128] Table 7

[0129]

[0130] As can be seen from Table 7, Example 2 and Comparative Examples 9-13 all added EDTA.2NA and BHT, and the viscosity of the pastes was similar when the preparation was completed, but different types of additives were added, among which:

[0131] Example 2 added 20% poloxamer as a thickener;

[0132] Comparative Example 9 added 12% PVP (polyvinyl pyrrolidone) as a thickener;

[0133] Comparative Example 10 added 0.8% xanthan gum as a thickener;

[0134] Comparative Example 11 added 0.8% cellulose gum as a thickener;

[0135] Comparative Example 12 added 0.5% of carbomer as a thickener;

[0136] Comparative Example 13 added 0.9% carrageenan as a thickener;

[0137] After the preparation of the above comparative examples 9-13 was completed, they were aged at 50°C for 1 month and the paste structure of the composition was observed. The results are shown in Table 8:

[0138] Table 8

[0139] Example 2 Comparative Example 9 Comparative Example 10 Comparative Example 11 Comparative Example 12 Comparative Example 13 Is the paste liquefied? no yes yes yes yes yes

[0140] From Table 8 we can see that:

[0141] After aging for 1 month at 50° C., the paste of Example 2 did not liquefy.

[0142] After aging for 1 month at 50° C., the pastes of Comparative Examples 9-13 all liquefied.

[0143] It can be seen that even if EDTA.2NA and BHT are added to the composition at the same time, when the thickener is PVP, xanthan gum, cellulose gum, carbomer or carrageenan, the paste of the composition still liquefies. Only when poloxamer is used as the thickener, the paste of the composition does not liquefy.

[0144] Embodiment 3-5

[0145] According to the formula in Table 9, the oral care compositions of Examples 3-5 were prepared. For the convenience of comparison, Example 1 was included in the table. The data in the table are all parts by weight, totaling 100 parts.

[0146] Table 9

[0147] Example 3 Example 1 Example 4 Example 5 Polyethylene glycol 40 40 40 40 Hydrogen Peroxide 3 3 3 3 Poloxamer 20 20 20 20 Phosphoric acid 0.032 0.018 0.009 0.005 Sodium fluoride 0.221 0.221 0.221 0.221 BHT 0.005 0.005 0.005 0.005 Deionized water Add to 100% Add to 100% Add to 100% Add to 100% pH 3.5 4 5 5.5

[0148] As can be seen from Table 9, Example 1 and Examples 3-5 all use 20% poloxamer as a thickener and add 0.005% BHT. The difference lies in the different pH values ​​of the compositions, wherein:

[0149] The pH value of the composition of Example 3 is 3.5;

[0150] The pH value of the composition of Example 1 is 4;

[0151] The pH value of the composition of Example 4 is 5;

[0152] The pH value of the composition of Example 5 is 5.5;

[0153] After the preparation of the above examples 3-5 was completed, the compositions were aged at 50°C for 1 month and the paste structure was observed. The results are shown in Table 10:

[0154] Table 10

[0155] Example 3 Example 1 Example 4 Example 5 Is the paste liquefied? no no no no

[0156] After the preparation of the above examples 3-5 was completed, the composition was aged at 50° C. for 2 months and the paste structure was observed. The results are shown in Table 11 below:

[0157] Table 11

[0158] Example 3 Example 1 Example 4 Example 5 Is the paste liquefied? yes no no yes

[0159] From Table 10 and Table 11, we can see that:

[0160] After aging for one month at 50°C, the pastes of Examples 1 and 3-4 did not liquefy. However, after aging for two months at 50°C, the paste structures of Examples 1 and 4 were still stable, while the pastes of Examples 3 and 5 liquefied. That is, when the pH of the composition is between 3.5 and 5.5, the composition has better structural stability, especially when the pH of the composition is between 4 and 5, the composition has better structural stability.

[0161] Embodiment 6-8

[0162] According to the formula in Table 12, the oral care compositions of Examples 6-8 were prepared. For the convenience of comparison, Example 1 was included in the table. The data in the table are all parts by weight, totaling 100 parts.

[0163] Table 12

[0164] Example 1 Example 6 Example 7 Example 8 Polyethylene glycol 40 40 40 40 Hydrogen Peroxide 3 3 3 3 Poloxamer 20 20 20 20 Phosphoric acid 0.018 / / / hydrochloric acid / 0.015 / sulfuric acid / / 0.02 / Formic acid / / / 0.04 Sodium fluoride 0.221 0.221 0.221 0.221 BHT 0.005 0.005 0.005 0.005 Deionized water Add to 100% Add to 100% Add to 100% Add to 100% pH 4.1 4 4.1 4

[0165] As can be seen from Table 12, the pH values ​​of the compositions of Example 1 and Examples 6-8 are similar, all around pH 4, and the difference lies in the different pH adjusters of the compositions, wherein:

[0166] The pH regulator of the composition of Example 1 is phosphoric acid;

[0167] The pH adjusting agent of the composition of Example 6 is hydrochloric acid;

[0168] The pH adjusting agent of the composition of Example 7 is sulfuric acid;

[0169] The pH regulator of the composition of Example 8 is formic acid;

[0170] After the preparation of the above Examples 6-8 was completed, the compositions were aged at 50° C. for 1 month and the paste structure was observed. The results are shown in Table 13:

[0171] Table 13:

[0172] Example 1 Example 6 Example 7 Example 8 Is the paste liquefied? no no no no

[0173] After the preparation of the above Examples 6-8 was completed, the compositions were aged at 50° C. for 2 months and the paste structure was observed. The results are shown in Table 14 below:

[0174] Table 14

[0175] Example 1 Example 6 Example 7 Example 8 Is the paste liquefied? no yes yes yes

[0176] From Table 13 and Table 14, we can see that:

[0177] After aging for one month at 50°C, the pastes of Examples 1 and 6-8 did not liquefy. However, after aging for two months at 50°C, the structure of Example 1 remained stable, while the pastes of Examples 6-8 liquefied. That is, when the pH of the composition was adjusted with an acidic pH adjuster, the composition had good structural stability, especially when the pH adjuster of the composition was phosphoric acid, the composition had better structural stability.

[0178] Examples 9-11

[0179] According to the formulation in Table 15, the oral care compositions of Examples 9 to 11 were prepared. For the convenience of comparison, Example 1 was included in the table. The data in the table are all parts by weight, totaling 100 parts.

[0180] Table 15:

[0181] Example 9 Example 10 Embodiment 11 Polyethylene glycol 40 40 40 Hydrogen Peroxide 0.5 7 12 Poloxamer 15 25 25 Phosphoric acid 0.18 0.18 0.18 Sodium fluoride 0.221 0.221 0.221 EDTA.2Na 0.01 0.2 0.5 BHT 0.005 0.05 0.1 Deionized water Add to 100% Add to 100% Add to 100%

[0182] From Table 15 we can see that:

[0183] Example 9 added 0.5% hydrogen peroxide, 15% poloxamer, 0.01% EDTA.2Na and 0.005% BHT;

[0184] Example 10 added 7% hydrogen peroxide, 25% poloxamer, 0.2% EDTA.2Na and 0.05% BHT;

[0185] Example 11 added 12% hydrogen peroxide, 25% poloxamer, 0.5% EDTA.2Na and 0.1% BHT;

[0186] After the preparation of the above Examples 6-8 was completed, the composition was aged at 50°C for 2 months and the paste structure was observed. The results are shown in Table 16:

[0187] Table 16

[0188] Example 9 Example 10 Embodiment 11 Is the paste liquefied? no no no

[0189] From Table 16 we can see that:

[0190] After aging for two months at 50° C., the composition pastes of Examples 9-11 did not liquefy.

[0191] It can be seen that when the added amount of hydrogen peroxide in the composition is 7-12%, the added amount of EDTA.2NA is 0.05-0.5%, and the added amount of BHT is 0.005-0.1%, the structure of the paste of the composition can maintain good stability.

[0192] Comparative Examples 14-16

[0193] According to the formula in Table 17 below, oral care compositions of Comparative Examples 14-16 were prepared. The data in the table are all parts by weight, and the total amount is 100 parts.

[0194] Table 17

[0195] Comparative Example 14 Comparative Example 15 Comparative Example 16 Polyethylene glycol 40 40 40 Sodium Percarbonate 4 / / PAP / 10 / Carbamide Peroxide / / 8 Poloxamer 17 17 17 Phosphoric acid 0.18 0.18 0.18 Sodium monofluorophosphate 0.76 0.76 0.76 Deionized water Add to 100% Add to 100% Add to 100%

[0196] It can be seen from Table 17 that different peroxides were added to Comparative Examples 14-16, and EDTA.2Na and BHT were not added.

[0197] Comparative Example 14 added 4%% sodium percarbonate;

[0198] Comparative Example 15 added 10% PAP;

[0199] Comparative Example 16 added 8% urea peroxide;

[0200] Comparative Example 13 added 0.9% carrageenan as a thickener;

[0201] After the preparation of the above comparative examples 14-16 was completed, they were aged at 50° C. for 1 month, and the paste structure of the composition was observed. The results are shown in Table 18 below:

[0202] Table 18

[0203] Comparative Example 14 Comparative Example 15 Comparative Example 16 Is the paste liquefied? yes yes yes

[0204] From Table 18 we can see that:

[0205] After aging for 1 month at 50° C., the pastes of Comparative Examples 14-16 liquefied.

[0206] It can be seen that when different peroxides are added to the oral care composition containing peroxide and a fluoride ion source, the structure of the paste is not very stable when EDTA.2Na and BHT are not added.

[0207] Examples 12-14

[0208] The oral care compositions of Examples 12-14 were prepared according to the formulation in Table 19, where all data are in parts by weight, totaling 100 parts.

[0209] Table 19

[0210] Example 12 Embodiment 13 Embodiment 14 Polyethylene glycol 40 40 40 Sodium Percarbonate 3 / / PAP / 10 / Carbamide Peroxide / / 8 Poloxamer 17 17 17 Phosphoric acid 0.18 0.18 0.18 Sodium monofluorophosphate 0.76 0.76 0.76 BHT 0.005 0.005 0.005 Deionized water Add to 100% Add to 100% Add to 100%

[0211] It can be seen from Table 19 that Examples 12-14 added 0.005% BHT on the basis of Comparative Examples 14-16 respectively.

[0212] After the preparation of the above Examples 12-14 was completed, the compositions were aged at 50° C. for 1 month and the paste structure was observed. The results are shown in Table 20:

[0213] Table 20

[0214] Example 12 Embodiment 13 Embodiment 14 Is the paste liquefied? no no no

[0215] From Table 20 we can see that:

[0216] After aging for one month at 50° C., the composition pastes of Examples 12-14 did not liquefy.

[0217] It can be seen that adding different peroxides to the oral care composition can significantly improve the structural stability of the paste when a small amount of BHT (eg, 0.005 wt %) is added.

[0218] Examples 15-17

[0219] The oral care compositions of Examples 15-17 were prepared according to the formulation in Table 21. The data in the table are all parts by weight, totaling 100 parts.

[0220] Table 21:

[0221] Embodiment 15 Example 16 Embodiment 17 Polyethylene glycol 40 40 40 Sodium Percarbonate 3 / / PAP / 10 / Carbamide Peroxide / / 8 Poloxamer 17 17 17 Phosphoric acid 0.18 0.18 0.18 Sodium monofluorophosphate 0.76 0.76 0.76 BHT 0.005 0.005 0.005 EDTA.2Na 0.05 0.05 0.05 Deionized water Add to 100% Add to 100% Add to 100%

[0222] As can be seen from Table 21, Examples 15-17 added 0.005% BHT and 0.05% EDTA.2Na respectively on the basis of Comparative Examples 14-16.

[0223] After the preparation of the above Examples 15-17 was completed, the compositions were aged at 50° C. for 2 months and the paste structure was observed. The results are shown in Table 22:

[0224] Table 22

[0225] Embodiment 15 Example 16 Embodiment 17 Is the paste liquefied? no no no

[0226] From Table 22 we can see that:

[0227] After aging for 2 months at 50° C., the composition pastes of Examples 15-17 did not liquefy.

[0228] It can be seen that when different peroxides are added to the oral care composition, adding a small amount of BHT (for example, 0.005 wt %) and EDTA.2Na can significantly improve the structural stability of the paste.

[0229] Examples 18-19

[0230] According to the formula in Table 23 below, the oral care compositions of Examples 18-19 were prepared. The data in the table are all in parts by weight, totaling 100 parts. In the present invention, the oral care compositions prepared according to the formula can be mixed uniformly in a conventional manner. For the convenience of comparison, Comparative Example 2 is included in Table 23.

[0231] Table 23

[0232] Comparative Example 2 Embodiment 18 Embodiment 19 Polyethylene glycol 40 40 40 Hydrogen Peroxide 3 3 3 Poloxamer 20 20 20 Phosphoric acid 0.018 0.018 0.018 Sodium fluoride 0.221 0.221 0.221 EDTA.2Na / / 0.05 BHA / 0.005 0.005 Deionized water Add to 100% Add to 100% Add to 100%

[0233] From Table 23 we can see that:

[0234] Example 18 adds 0.005% BHA on the basis of Comparative Example 2;

[0235] Example 19 adds 0.05% EDTA.2Na and 0.005% BHA to the comparative example 2;

[0236] After the preparation of the above Examples 18-19 was completed, they were aged at 50°C for 1 month, and the recovery rate of hydrogen peroxide in the above comparative example and example compositions was tested. The results are shown in Table 24.

[0237] Table 24

[0238] Comparative Example 2 Embodiment 18 Embodiment 19 Is the paste liquefied? yes no no

[0239] From Table 24 we can see that:

[0240] After aging for 1 month at 50° C., the paste of Comparative Example 2 liquefied, that is, the paste structure of Comparative Example 2 after adding fluoride was unstable.

[0241] After aging for 1 month at 50° C., the pastes of Examples 18-19 did not liquefy.

[0242] This shows that BHA can also improve the stability of the paste structure of the composition.

[0243] After the preparation of the above Examples 18-19 was completed, the composition was aged at 50° C. for 2 months and the paste structure was observed. The results are shown in Table 25:

[0244] Table 25:

[0245] Embodiment 18 Embodiment 19 Is the paste liquefied? yes no

[0246] From Table 25 we can see that:

[0247] After aging at 50° C. for 2 months, the paste of Example 18 also liquefied. However, after aging at 50° C. for 2 months, the paste of Example 19 still did not liquefy, that is, the structure of the composition was still stable.

[0248] It can be seen that the combination of EDTA.2Na and BHA can further improve the stability of the composition structure.

[0249] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the embodiment of this specification. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example.

[0250] In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction. The above description is only an embodiment of the embodiment of this specification and is not intended to limit the embodiment of this specification. For those skilled in the art, the embodiment of this specification may have various changes and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the embodiment of this specification shall be included in the scope of the claims of the embodiment of this specification.

Claims

1. An oral care composition comprising hydrogen peroxide and a fluoride ion source, characterized in that include: 1) Peroxide; 2) fluoride ion source; 3) Antioxidants; 4) thickener; 5) an orally acceptable carrier; Wherein, the antioxidant comprises one or both of butylated hydroxytoluene or butylated hydroxyanisole; The thickening agent comprises poloxamer.

2. The oral care composition according to claim 1, characterized in that: The peroxide is one or more of hydrogen peroxide, sodium percarbonate, phthalimidoperoxycaproic acid (PAP), and urea peroxide.

3. The oral care composition according to claim 1, characterized in that: The mass proportion of the peroxide in the oral care composition is 0.05-12%.

4. The oral care composition according to claim 1, characterized in that: The fluoride ion source is one or more of stannous fluoride, sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, olafluor, and zinc fluoride.

5. The oral care composition according to claim 1, characterized in that: The antioxidant accounts for 0.005-0.1% by weight in the oral care composition.

6. The oral care composition according to claim 1, characterized in that: The oral care composition further comprises ethylenediaminetetraacetic acid or an alkali metal salt thereof.

7. The oral care composition according to claim 6, characterized in that: The mass proportion of the ethylenediaminetetraacetic acid or its alkali metal salt in the oral care composition is 0.01-0.5%.

8. The oral care composition according to claim 1, characterized in that: The pH value of the oral care composition is 3.5-5.5; preferably, the pH value is 4-5.

9. The oral care composition according to claim 1, characterized in that: The oral care composition further comprises an acidic pH adjuster.

10. The oral care composition according to claim 1, characterized in that: The acidic pH value adjuster is phosphoric acid.

11. A method for improving the structural stability of an oral care composition comprising a peroxide and a fluoride ion source, comprising the steps of: Poloxamer as a thickener and antioxidant as a peroxide stabilizer are added to an oral care composition comprising hydrogen peroxide and a fluoride ion source.

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