Traditional Chinese medicine composition as well as preparation method and application thereof in prevention and treatment of nephritis

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof in prevention and treatment of nephritis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 30 parts of radix astragali seu hedysari, 10 to 20 parts of radix salviae miltiorrhizae, 10 to 40 parts of radix rehmanniae recen, 10 to 40 parts of fructus corni, 10 to 40 parts of fructus rosae laevigatae, 10 to 15 parts of fructus schisandrae chinensis, 15 to 30 parts of rhizoma imperatae, 10 to 20 parts of herba cepbalanoplosis segeti, 10 to 20 parts of semen cuscutae, 15 to 20 parts of radix achyranthis bidentatae, 10 to 20 parts of radix gentianae, 30 to 40 parts of radix rehmanniae The traditional Chinese medicine composition formed by compatibility of the traditional Chinese medicine raw materials has a good treatment effect on nephritis, especially chronic nephritis. Test results prove that by taking the traditional Chinese medicine composition disclosed by the invention, the total effective rate of treating chronic nephritis is up to 98%.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition and a preparation method thereof, and application thereof in preventing and treating nephritis. Background Art

[0002] Chronic nephritis, also known as chronic glomerulonephritis, refers to a group of glomerular diseases with proteinuria, hematuria, hypertension, and edema as basic clinical manifestations. The onset is different, the disease is prolonged, and the lesions progress slowly. It can cause varying degrees of renal dysfunction and eventually develop into chronic renal failure. Due to the different pathological types and stages of this group of diseases, the main clinical manifestations are different and the disease manifestations are diverse. Based on different clinical manifestations, chronic nephritis can be divided into five subtypes: common type, nephrotic massive proteinuria, hypertension type, mixed type, and acute onset type.

[0003] At present, for the treatment of chronic nephritis, Western medicine mostly uses antihypertensive, anti-infection or diuretic treatment, such as thiazide diuretics, loop diuretics, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers or glucocorticoids and immunosuppressive drugs. However, Western medicine has great side effects, easily causing residues in the body or organs, and a low cure rate. Moreover, it will develop into more serious diseases such as uremia due to long-term incurable diseases, which seriously threatens people's health. There are many drug ingredients in traditional Chinese medicine that have shown a clear therapeutic effect on chronic kidney disease, and their safety has been confirmed through long-term and extensive clinical observations. For example, the tripterygium wilfordii polyglycosides in tripterygium wilfordii preparations have significant effects on reducing proteinuria in patients with nephritis or protecting glomerular podocytes; for example, rhubarb preparations have the effects of delaying the progression of renal function and inhibiting the proliferation of glomerular mesangial cells. Among them, the refined extracted rhein has the effects of regulating blood sugar and inhibiting metabolic abnormalities, which is especially suitable for metabolic-related kidney damage such as diabetic nephropathy. However, there are few traditional Chinese medicines that can be used to treat chronic nephritis in the prior art, and the therapeutic effects of some traditional Chinese medicines are poor. Summary of the invention

[0004] The purpose of the present invention is a Chinese medicine composition and a preparation method thereof and use in preventing and treating nephritis. The Chinese medicine composition has a good therapeutic effect on nephritis, especially chronic nephritis.

[0005] The present invention provides a traditional Chinese medicine composition, comprising the following raw materials in parts by weight:

[0006] 15-30 parts of Astragalus, 10-20 parts of Salvia miltiorrhiza, 10-40 parts of Rehmannia root, 10-40 parts of Cornus officinalis, 10-40 parts of Rosa laevigata, 10-15 parts of Schisandra chinensis, 15-30 parts of Imperata rhizome, 10-20 parts of Cirsium amara, 10-20 parts of Cuscuta australis, 15-20 parts of Achyranthes bidentata, 10-20 parts of Gentiana scabra, 30-40 parts of Rehmannia root and 10-20 parts of Euryale ferox.

[0007] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight:

[0008] 20-25 parts of Astragalus, 15-20 parts of Salvia miltiorrhiza, 20-30 parts of Rehmannia root, 20-30 parts of Cornus officinalis, 15-30 parts of Rosa laevigata, 10-15 parts of Schisandra chinensis, 20-25 parts of Imperata rhizome, 15-20 parts of Cirsium armeniaca, 15-20 parts of Cuscuta australis, 15-20 parts of Achyranthes bidentata, 15-20 parts of Gentiana scabra, 35-40 parts of Rehmannia root and 15-20 parts of Euryale ferox.

[0009] The present invention also provides a method for preparing the Chinese medicine composition described in the above technical solution, comprising the following steps:

[0010] Mixing astragalus, salvia miltiorrhiza, raw rehmannia root, cornus officinalis, rosa laevigata, schisandra chinensis, rhizoma imperatae, thistle, dodder seed, achyranthes bidentata, gentian, rehmannia root, euryale seed and water for a first decoction to obtain a first medicinal liquid and a first medicinal residue;

[0011] Mixing the first medicinal residue with water for a second decoction to obtain a second medicinal solution and a second medicinal residue;

[0012] The second medicinal residue is mixed with water for a third decoction to obtain a third medicinal liquid and a third medicinal residue;

[0013] The first liquid, the second liquid and the third liquid are combined and filtered to obtain a filtrate;

[0014] The filtrate is concentrated to obtain an extract which is the traditional Chinese medicine composition.

[0015] Preferably, during the first decoction, the weight of the water is 9 to 11 times the total weight of the astragalus, salvia miltiorrhiza, raw rehmannia, cornus officinalis, Rosa laevigata, Schisandra chinensis, Imperata cylindrica, Cirsium armeniaca, Cuscuta australis, Achyranthes bidentata, Gentiana scabra, Rehmannia root and Euryale ferox; and the time of the first decoction is 0.8 to 1.5 hours.

[0016] Preferably, during the second decoction, the weight of the water is 4 to 6 times the weight of the first medicinal residue; and the time of the second decoction is 0.8 to 1.5 hours.

[0017] Preferably, during the third decoction, the weight of the water is 2 to 4 times the weight of the second medicinal residue; and the time of the third decoction is 0.8 to 1.5 hours.

[0018] The present invention also provides the use of the Chinese medicine composition described in the above technical solution or the Chinese medicine composition prepared by the preparation method described in the above technical solution in preparing drugs for preventing and treating nephritis.

[0019] Preferably, the nephritis includes chronic nephritis.

[0020] The present invention also provides a medicine for preventing and treating chronic nephritis, wherein the effective ingredients of the medicine include the Chinese medicine composition described in the above technical solution or the Chinese medicine composition prepared by the preparation method described in the above technical solution.

[0021] Preferably, the dosage form of the drug includes granules, decoction or oral liquid.

[0022] Beneficial effects:

[0023] The present invention provides a Chinese medicine composition, comprising the following raw materials in parts by weight: 15-30 parts of Astragalus, 10-20 parts of Salvia miltiorrhiza, 10-40 parts of Radix Rehmanniae, 10-40 parts of Fructus Corni, 10-40 parts of Fructus Rosae Laevigatae, 10-15 parts of Fructus Schisandrae Chinensis, 15-30 parts of Rhizoma Imperatae, 10-20 parts of Cirsium cyrtonemae, 10-20 parts of Semen Cuscutae, 15-20 parts of Achyranthes bidentatae, 10-20 parts of Gentiana scabrae, 30-40 parts of Radix Rehmanniae Preparata and 10-20 parts of Euryale ferox. The Chinese medicine composition prepared by combining the above Chinese medicine raw materials has a good therapeutic effect on nephritis, especially chronic nephritis. The test results show that by taking the Chinese medicine composition of the present invention, the total effective rate of chronic nephritis is as high as 98%. DETAILED DESCRIPTION

[0024] The invention provides a traditional Chinese medicine composition, comprising the following raw materials in parts by weight: 15-30 parts of astragalus, 10-20 parts of salvia miltiorrhiza, 10-40 parts of raw rehmannia, 10-40 parts of cornus officinalis, 10-40 parts of rosa laevigata, 10-15 parts of schisandra chinensis, 15-30 parts of imperata rhizome, 10-20 parts of thistle, 10-20 parts of dodder seed, 15-20 parts of achyranthes bidentata, 10-20 parts of gentiana, 30-40 parts of rehmannia root and 10-20 parts of euryale ferox.

[0025] In terms of weight, the Chinese medicine composition of the present invention includes 15 to 30 parts of Astragalus. As an embodiment, the weight of the Astragalus can be 20 to 25 parts. In a specific embodiment, the weight of the Astragalus is 15, 20, 25 or 30 parts.

[0026] Based on the weight of the Astragalus, the Chinese medicine composition of the present invention includes 10 to 20 parts of Salvia miltiorrhiza; as an embodiment, the weight of Salvia miltiorrhiza is 15 to 20 parts; in a specific embodiment, the weight of Salvia miltiorrhiza is 10 parts, 15 parts or 20 parts.

[0027] Based on the weight of the astragalus, the Chinese medicine composition of the present invention includes 10 to 40 parts of raw rehmannia; as an embodiment, the weight of the raw rehmannia is 20 to 30 parts; in a specific embodiment, the weight of the raw rehmannia is 10 parts, 20 parts, 25 parts or 40 parts.

[0028] Based on the weight of the astragalus, the traditional Chinese medicine composition of the present invention includes 10 to 40 parts of Cornus officinalis; as an embodiment, the weight of the Cornus officinalis is 20 to 30 parts; in a specific embodiment, the weight of the Cornus officinalis is 10 parts, 20 parts, 30 parts or 40 parts.

[0029] Based on the weight proportion of the Astragalus, the Chinese medicine composition of the present invention comprises 10 to 40 parts of Rosa laevigata; as an embodiment, the weight proportion of the Rosa laevigata is 15 to 30 parts; in a specific embodiment, the weight proportion of the Rosa laevigata is 10 parts, 15 parts, 30 parts or 40 parts.

[0030] Based on the weight of the astragalus, the Chinese medicine composition of the present invention includes 10 to 15 parts of Schisandra chinensis; as an embodiment, the weight of Schisandra chinensis is 10 or 15 parts.

[0031] Based on the weight of the astragalus, the Chinese medicine composition of the present invention includes 15 to 30 parts of Imperata root; as an embodiment, the weight of the Imperata root is 20 to 25 parts; in a specific embodiment, the weight of the Imperata root is 15 parts, 20 parts, 25 parts or 30 parts.

[0032] Based on the weight of the astragalus, the Chinese medicine composition of the present invention includes 15 to 30 parts of small thistle; as an embodiment, the weight of the small thistle is 15 to 20 parts; in a specific embodiment, the weight of the small thistle is 10 parts, 15 parts or 20 parts.

[0033] Based on the weight of the astragalus, the traditional Chinese medicine composition of the present invention includes 15 to 20 parts of dodder seeds; as an embodiment, the weight of the dodder seeds is 10 parts, 15 parts or 20 parts.

[0034] Based on the weight of the Astragalus, the Chinese medicine composition of the present invention includes 15 to 20 parts of Achyranthes bidentata; as an embodiment, the weight of the Achyranthes bidentata is 15 or 20 parts.

[0035] Based on the weight of the astragalus, the Chinese medicine composition of the present invention includes 15 to 20 parts of gentian; as an embodiment, the weight of the gentian is 15 to 20 parts; in a specific embodiment, the weight of the gentian is 10 parts, 15 parts or 20 parts.

[0036] Based on the weight of the Astragalus, the Chinese medicine composition of the present invention includes 30 to 40 parts of Rehmannia glutinosa; as an embodiment, the weight of the Rehmannia glutinosa is 35 to 40 parts; in a specific embodiment, the weight of the Rehmannia glutinosa is 30 parts, 35 parts or 40 parts.

[0037] Based on the weight of the astragalus, the Chinese medicine composition of the present invention includes 10 to 20 parts of gorgon fruit; as an embodiment, the weight of the gorgon fruit is 15 to 20 parts; in a specific embodiment, the weight of the gorgon fruit is 10 parts, 15 parts or 20 parts.

[0038] The present invention also provides a method for preparing the Chinese medicine composition described in the above technical solution, comprising the following steps:

[0039] Mixing astragalus, salvia miltiorrhiza, raw rehmannia root, cornus officinalis, rosa laevigata, schisandra chinensis, rhizoma imperatae, thistle, dodder seed, achyranthes bidentata, gentian, rehmannia root, euryale seed and water for a first decoction to obtain a first medicinal liquid and a first medicinal residue;

[0040] Mixing the first medicinal residue with water for a second decoction to obtain a second medicinal solution and a second medicinal residue;

[0041] The second medicinal residue is mixed with water for a third decoction to obtain a third medicinal liquid and a third medicinal residue;

[0042] The first liquid, the second liquid and the third liquid are combined and filtered to obtain a filtrate;

[0043] The filtrate is concentrated to obtain an extract which is the traditional Chinese medicine composition.

[0044] The present invention mixes astragalus, salvia miltiorrhiza, raw rehmannia, cornus officinalis, rosa laevigata, schisandra, white imperata root, thistle, dodder seed, achyranthes bidentata, gentian, prepared rehmannia, euryale and water for a first decoction to obtain a first medicinal liquid and a first medicinal residue. As an embodiment, during the first decoction, the weight of the water is 9 to 11 times the total weight of the astragalus, salvia miltiorrhiza, raw rehmannia, cornus officinalis, rosa laevigata, schisandra, white imperata root, thistle, dodder seed, achyranthes bidentata, gentian, prepared rehmannia and euryale; as another embodiment, the weight of the water is 10 times the total weight of the astragalus, salvia miltiorrhiza, raw rehmannia, cornus officinalis, rosa laevigata, schisandra, white imperata root, thistle, dodder seed, achyranthes bidentata, gentian, prepared rehmannia and euryale. As an embodiment, the time of the first decoction is 0.8 to 1.5 hours; as another embodiment, the time of the first decoction is 1 hour.

[0045] After obtaining the first medicinal residue, the present invention mixes the first medicinal residue with water for a second decoction to obtain a second medicinal liquid and a second medicinal residue. As an embodiment, during the second decoction, the weight of the water is 4 to 6 times the weight of the first medicinal residue; as another embodiment, the weight of the water is 5 times the weight of the first medicinal residue. As an embodiment, the time of the second decoction is 0.8 to 1.5 hours; as another embodiment, the time of the second decoction is 1 hour.

[0046] After obtaining the second medicinal residue, the present invention mixes the second medicinal residue with water for a third decoction to obtain a third medicinal liquid and a third medicinal residue. As an embodiment, during the third decoction, the weight of the water is 2 to 4 times the weight of the second medicinal residue; as another embodiment, the weight of the water is 3 times the weight of the second medicinal residue. As an embodiment, the time of the third decoction is 0.8 to 1.5 hours; as another embodiment, the time of the third decoction is 1 hour.

[0047] The present invention has no particular limitation on the specific process and method of the first decoction, the second decoction and the third decoction, and conventional decoction methods in the art may be used.

[0048] After obtaining the first liquid, the second liquid and the third liquid, the present invention combines the first liquid, the second liquid and the third liquid and then filters them to obtain a filtrate. The present invention has no particular limitation on the filtering method, and a conventional filtering method in the art can be used.

[0049] After obtaining the filtrate, the present invention concentrates the filtrate to obtain an extract which is the Chinese medicine composition. As an embodiment, the extract has a specific gravity of 1.15 at 60°C.

[0050] The present invention also provides the use of the Chinese medicine composition described in the above technical solution or the Chinese medicine composition prepared by the preparation method described in the above technical solution in the preparation of a drug for preventing and treating nephritis. As an embodiment, the nephritis is chronic nephritis; as another embodiment, the chronic nephritis is common chronic nephritis.

[0051] The present invention also provides a medicine for preventing and treating chronic nephritis, wherein the active ingredient of the medicine comprises the Chinese medicine composition described in the above technical solution or the Chinese medicine composition prepared by the preparation method described in the above technical solution. As an embodiment, the dosage form of the medicine can be granules, decoctions or oral liquids. As an embodiment, the medicine also includes excipients accepted by traditional Chinese medicine; the amount and type of the excipients are not particularly limited, and can be conventionally limited according to the dosage form. The present invention does not specifically limit the preparation method of the granules, decoctions or oral liquids, and can be prepared using conventional preparation methods in the art.

[0052] In order to further illustrate the present invention, the technical solutions provided by the present invention are described in detail below in conjunction with embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0053] Example 1

[0054] A Chinese medicine composition for treating chronic pneumonia, comprising the following medicinal materials in parts by weight:

[0055] 20 parts of Astragalus, 10 parts of Salvia miltiorrhiza, 10 parts of Rehmannia root, 10 parts of Cornus officinalis, 10 parts of Rosa laevigata, 10 parts of Schisandra chinensis, 15 parts of Imperata cylindrica, 15 parts of Cirsium armeniaca, 10 parts of Cuscuta australis, 15 parts of Achyranthes bidentata, 10 parts of Gentiana scabra, 30 parts of Rehmannia root and 10 parts of Euryale ferox.

[0056] Preparation method:

[0057] Weigh the above-mentioned medicinal materials in proportion, mix them, add water 10 times the total weight of the medicinal materials, boil for 1 hour, and filter to obtain a first medicinal liquid and a first medicinal residue; add water 5 times the weight of the first medicinal residue to the first medicinal residue, boil for 1 hour, and filter to obtain a second medicinal residue and a second medicinal liquid; add water 3 times the weight of the second medicinal residue to the second medicinal residue, boil for 1 hour, and filter to obtain a third medicinal residue and a third medicinal liquid; combine the first medicinal liquid, the second medicinal liquid and the third medicinal liquid, filter, and concentrate the obtained filtrate to obtain an extract with a specific gravity of 1.15 at 60°C.

[0058] Example 2

[0059] A Chinese medicine composition for treating chronic pneumonia, comprising the following medicinal materials in parts by weight:

[0060] 30 parts of Astragalus, 20 parts of Salvia miltiorrhiza, 40 parts of Rehmannia root, 40 parts of Cornus officinalis, 40 parts of Rosa laevigata, 15 parts of Schisandra chinensis, 30 parts of Imperatae rhizome, 20 parts of Cirsium cyrtonema, 20 parts of Cuscuta australis, 20 parts of Achyranthes bidentata, 20 parts of Gentiana scabra, 40 parts of Rehmannia root and 20 parts of Euryale ferox.

[0061] The preparation method is the same as Example 1.

[0062] Example 3

[0063] A Chinese medicine composition for treating chronic pneumonia, comprising the following medicinal materials in parts by weight:

[0064] 25 parts of Astragalus, 15 parts of Salvia miltiorrhiza, 20 parts of Rehmannia root, 20 parts of Cornus officinalis, 15 parts of Rosa laevigata, 10 parts of Schisandra chinensis, 20 parts of Imperatae rhizome, 10 parts of Cirsium cyrtonema, 15 parts of Cuscuta australis, 15 parts of Achyranthes bidentata, 15 parts of Gentiana scabra, 35 parts of Rehmannia root and 15 parts of Euryale ferox.

[0065] The preparation method is the same as Example 1.

[0066] Example 4

[0067] A Chinese medicine composition for treating chronic pneumonia, comprising the following medicinal materials in parts by weight:

[0068] 15 parts of Astragalus, 20 parts of Salvia miltiorrhiza, 25 parts of Rehmannia root, 30 parts of Cornus officinalis, 30 parts of Rosa laevigata, 15 parts of Schisandra chinensis, 25 parts of Imperatae rhizome, 20 parts of Cirsium cyrtonema, 20 parts of Cuscuta australis, 20 parts of Achyranthes bidentata, 20 parts of Gentiana scabra, 40 parts of Rehmannia root and 20 parts of Euryale ferox.

[0069] The preparation method is the same as Example 1.

[0070] Example 5

[0071] A granule for treating chronic pneumonia, wherein the traditional Chinese medicine composition prepared in Example 1 is prepared into granules according to the "Technical Requirements for Quality Control and Standardization of Traditional Chinese Medicine Formula Granules".

[0072] Example 6

[0073] A decoction for treating chronic pneumonia is prepared by preparing the Chinese medicine composition prepared in Example 2 into a decoction according to conventional preparation methods in the art.

[0074] Example 7

[0075] An oral liquid for treating chronic pneumonia is prepared by referring to conventional preparation methods in the art to prepare the Chinese medicine composition prepared in Example 3 into an oral liquid.

[0076] Application Example 1

[0077] The effect of the Chinese medicine composition of the present invention on treating common chronic pneumonia is verified by the following steps:

[0078] 100 patients with clinical diagnosis of common chronic nephritis were selected and the following test was conducted with the patients' informed consent:

[0079] Experimental subjects: 50 male patients and 50 female patients;

[0080] The diagnostic criteria are: mild facial edema, urine protein (+++), and plasma cholesterol >5.7mmol / L (220mg / dL).

[0081] Dosage: Take the Chinese medicine composition granules prepared in Example 5, brew with warm water and take, 50g / time, three times a day, 15 days as a course of treatment.

[0082] Criteria for judging treatment effect: Cured: TCM clinical symptoms and signs disappeared or basically disappeared; Markedly effective: TCM clinical symptoms and signs changed significantly; Effective: TCM clinical symptoms and signs improved; Ineffective: TCM clinical symptoms and signs did not improve significantly.

[0083] The calculation formula for the total effective rate is: total effective rate (%) = (number of cured patients + number of significantly effective patients + number of effective patients) / total number of patients participating in the treatment × 100%.

[0084] After taking 3 courses of treatment, the total effective rate of the treatment trial was determined. The results are shown in Table 1.

[0085] Table 1 Results of the treatment of common chronic nephritis with the Chinese medicine composition granules of Example 5

[0086] Group Number of people treated cure Significant effect efficient invalid Total Effectiveness Treatment Group 100 80 8 10 2 98％

[0087] It can be concluded from the above examples that the Chinese medicine composition of the present invention can effectively treat chronic nephritis, and the total efficiency can reach 98%.

[0088] Although the above embodiment describes the present invention in detail, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The invention comprises the following raw materials in parts by weight: 15-30 parts of Astragalus, 10-20 parts of Salvia miltiorrhiza, 10-40 parts of Rehmannia root, 10-40 parts of Cornus officinalis, 10-40 parts of Rosa laevigata, 10-15 parts of Schisandra chinensis, 15-30 parts of Imperata rhizome, 10-20 parts of Cirsium amara, 10-20 parts of Cuscuta australis, 15-20 parts of Achyranthes bidentata, 10-20 parts of Gentiana scabra, 30-40 parts of Rehmannia root and 10-20 parts of Euryale ferox.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 20-25 parts of Astragalus, 15-20 parts of Salvia miltiorrhiza, 20-30 parts of Rehmannia root, 20-30 parts of Cornus officinalis, 15-30 parts of Rosa laevigata, 10-15 parts of Schisandra chinensis, 20-25 parts of Imperata rhizome, 15-20 parts of Cirsium armeniaca, 15-20 parts of Cuscuta australis, 15-20 parts of Achyranthes bidentata, 15-20 parts of Gentiana scabra, 35-40 parts of Rehmannia root and 15-20 parts of Euryale ferox.

3. The method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: The steps include: Mixing astragalus, salvia miltiorrhiza, raw rehmannia root, cornus officinalis, rosa laevigata, schisandra chinensis, rhizoma imperatae, thistle, dodder seed, achyranthes bidentata, gentian, rehmannia root, euryale seed and water for a first decoction to obtain a first medicinal liquid and a first medicinal residue; Mixing the first medicinal residue with water for a second decoction to obtain a second medicinal solution and a second medicinal residue; The second medicinal residue is mixed with water for a third decoction to obtain a third medicinal liquid and a third medicinal residue; The first liquid, the second liquid and the third liquid are combined and filtered to obtain a filtrate; The filtrate is concentrated to obtain an extract which is the traditional Chinese medicine composition.

4. The preparation method according to claim 3, characterized in that: During the first decoction, the weight of the water is 9 to 11 times the total weight of the astragalus, salvia miltiorrhiza, raw rehmannia, cornus officinalis, Rosa laevigata, Schisandra chinensis, Imperata cylindrica, Cirsium armeniaca, Cuscuta australis, Achyranthes bidentata, Gentiana scabra, Rehmannia root and Euryale ferox; and the time of the first decoction is 0.8 to 1.5 hours.

5. The preparation method according to claim 3, characterized in that: During the second decoction, the weight of the water is 4 to 6 times the weight of the first medicinal residue; and the time of the second decoction is 0.8 to 1.5 hours.

6. The preparation method according to claim 3, characterized in that: During the third decoction, the weight of the water is 2 to 4 times the weight of the second medicinal residue; and the time of the third decoction is 0.8 to 1.5 hours.

7. Use of the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 3 to 6 in the preparation of drugs for preventing and treating nephritis.

8. The use according to claim 7, characterized in that: The nephritis includes chronic nephritis.

9. A drug for preventing and treating chronic nephritis, characterized in that: The effective ingredients of the medicine include the traditional Chinese medicine composition according to claim 1 or 2 or the traditional Chinese medicine composition prepared by the preparation method according to any one of claims 3 to 6.

10. The drug according to claim 9, characterized in that The dosage form of the medicine includes granules, decoction or oral liquid.