Nicotine substitute liquid preparation as well as preparation method and application thereof

Abstract

The invention relates to the technical field of electronic atomization, in particular to a nicotine substitute liquid preparation and a preparation method and application thereof. The invention provides a nicotine substitution liquid preparation. The nicotine substitution liquid preparation comprises the following raw material components: a nicotine throat hitting feeling simulation additive, a nicotine head feeling simulation additive and an atomization solvent, the nicotine throat hitting feeling simulation additive is selected from at least one of piperine and 6-methyl nicotine; the nicotine head feeling simulation additive is selected from at least one of cytisine, magnolol and 6-methyl nicotine. The nicotine replaces a liquid preparation to simulate the feeling of feeling on the head and the feeling of hitting the throat caused by the nicotine, the feeling of feeling on the head and the feeling of hitting the throat of the nicotine-free atomized preparation are improved, the satisfaction of a user is improved, the aim of physiologically relieving addiction is achieved, meanwhile, the toxicity and addiction of the nicotine-free atomized preparation are far lower than those of the nicotine, and health damage can be reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of electronic atomization, and particularly relates to a nicotine replacement liquid preparation, a preparation method thereof, and an application thereof. Background Art

[0002] An e-cigarette nicotine atomization device is a tobacco-free product that delivers nicotine in the form of aerosol. Its working principle is that a battery powers a nebulizer to heat the e-liquid in the e-liquid tank, enabling consumers to inhale an aerosol containing or without nicotine, thereby achieving the effect of smoking traditional tobacco products and realizing "exhaling clouds and puffing mists". Currently, electronic atomization preparations generally contain propylene glycol, glycerol, edible flavors, and nicotine, which are used in a certain proportion. Propylene glycol, glycerol, and edible flavors are all permitted food additives. Compared with traditional cigarettes, the e-cigarette nicotine atomization device does not require combustion, and the atomization process will not produce various harmful substances such as tar, polycyclic aromatic hydrocarbons, and carbon monoxide generated by high-temperature combustion. At the same time, it hardly causes the impact of second-hand smoke. It is a potential nicotine substitute and can achieve a certain smoking cessation effect.

[0003] The e-cigarette nicotine atomization device can be used as a means to relieve addiction. On the one hand, nicotine is added because nicotine is addictive and is the main substance for the formation of nicotine addiction, which can relieve the addiction of smokers physiologically. On the other hand, the suction behavior of the e-cigarette nicotine atomization device is similar to that of cigarette smoking, exhaling clouds and puffing mists, which can relieve the addiction of smokers psychologically. However, nicotine has high toxicity and addiction, and long-term inhalation will affect human health. Currently, the market supervision of nicotine is continuously strengthened, and various countries have begun to limit the nicotine content in e-cigarettes to not exceed 20 mg / g. Based on the consideration of public health and safety, many countries have also promoted zero-nicotine e-cigarette atomization devices. Zero-nicotine products do not have the problem of nicotine addiction. Currently, the zero-nicotine atomization preparation products used in this device mainly feature rich flavors and a cooling sensation. However, because they do not contain nicotine, the existing zero-nicotine atomization preparations do not have the throat hit and the feeling of being high brought by nicotine, and the product satisfaction is weak, and they cannot relieve the addiction of consumers physiologically. Summary of the Invention

[0004] The purpose of the present invention is to overcome the defects of the existing zero-nicotine atomization preparations that do not have the throat hit and the feeling of being high brought by nicotine, have weak product satisfaction, and cannot relieve the addiction of consumers physiologically, and further provide a nicotine replacement liquid preparation, a preparation method thereof, and an application thereof.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] The present invention provides a nicotine replacement liquid preparation, and the raw material components of the nicotine replacement liquid preparation include a nicotine throat hit simulation additive, a nicotine high simulation additive, and an atomization solvent;

[0007] The nicotine throat hit simulation additive is selected from at least one of piperine and 6-methylnicotine;

[0008] The nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine.

[0009] Preferably, the total mass content of the nicotine throat hit simulation additive and the nicotine head rush simulation additive in the nicotine replacement liquid preparation is 2.1 - 61 mg / g.

[0010] Preferably, the mass ratio of the nicotine throat hit simulation additive to the nicotine head rush simulation additive is (0.1 - 11) : (2 - 50).

[0011] Preferably, the raw material components of the nicotine replacement liquid preparation include 6-methylnicotine and an atomization solvent.

[0012] Preferably, the mass ratio of the 6-methylnicotine to the atomization solvent is (0.3 - 5) : (40 - 95).

[0013] Preferably, the raw material components of the nicotine replacement liquid preparation include a nicotine throat hit simulation additive, a nicotine head rush simulation additive, and an atomization solvent;

[0014] The nicotine throat hit simulation additive is selected from at least one of piperine and 6-methylnicotine;

[0015] The nicotine head rush simulation additive is selected from at least one of cytisine and magnolol.

[0016] Preferably, when the nicotine throat hit simulation additive is piperine, the nicotine head rush simulation additive is cytisine and / or magnolol;

[0017] Or, when the nicotine throat hit simulation additive is 6-methylnicotine, the nicotine head rush simulation additive is cytisine and / or magnolol.

[0018] Preferably, when the nicotine throat hit simulation additive is piperine, the nicotine head rush simulation additive is cytisine and magnolol, and the mass ratio of the cytisine to the magnolol is (5 - 40) : (5 - 30);

[0019] Or, when the nicotine throat hit simulation additive is 6-methylnicotine, the nicotine head rush simulation additive is cytisine and magnolol, and the mass ratio of the cytisine to the magnolol is (1 - 25) : (1 - 5).

[0020] Preferably, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the atomization solvent is (0.3 - 5):(40 - 95).

[0021] Preferably, the atomization solvent includes at least one of propylene glycol and glycerol.

[0022] Preferably, the atomization solvent is propylene glycol and glycerol;

[0023] The mass ratio of the propylene glycol to the glycerol is (1 - 50):(1 - 50).

[0024] Preferably, in the nicotine replacement liquid preparation, the mass content of the nicotine throat hit simulation additive is 0.1 - 11 mg / g, and the mass content of the nicotine head rush simulation additive is 2 - 50 mg / g;

[0025] Preferably, the raw material components of the nicotine replacement liquid preparation further include organic acids.

[0026] Preferably, the organic acid includes at least one of C3 - C8 organic carboxylic acids;

[0027] Optionally, the organic acid includes at least one of C3 - C8 monobasic organic carboxylic acids, C3 - C8 dibasic organic carboxylic acids, and C3 - C8 tribasic organic carboxylic acids.

[0028] Preferably, the organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid;

[0029] Optionally, the organic acid is benzoic acid.

[0030] Preferably, calculated by carboxyl group, the molar ratio of the organic acid to 6 - methyl nicotine is 1:(0.98 - 1.5);

[0031] Preferably, calculated by carboxyl group, the molar ratio of the organic acid to 6 - methyl nicotine is 1:1.

[0032] Preferably, the raw material components of the nicotine replacement liquid preparation further include fragrance.

[0033] Preferably, the fragrance includes at least one of tobacco fragrance, fruit fragrance, and mint fragrance;

[0034] Optionally, the fruit fragrance includes at least one of mango fragrance, blueberry fragrance, and grape fragrance.

[0035] Preferably, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the fragrance is (0.3 - 5):(20 - 45).

[0036] The nicotine replacement liquid preparation of the present invention is used to enhance satisfaction, and further, to enhance the satisfaction of consumers.

[0037] The present invention provides a preparation method of the nicotine replacement liquid preparation as claimed in the above claims, comprising the following steps:

[0038] Mix the nicotine throat hit simulation additive, the nicotine head rush simulation additive and the atomization solvent, and then heat and stir evenly to obtain the product.

[0039] Preferably, the preparation method of the nicotine replacement liquid preparation further comprises the step of adding essence.

[0040] Preferably, the preparation method of the nicotine replacement liquid preparation further comprises the step of adding organic acid.

[0041] The present invention does not make specific limitations on the stirring method. Optionally, the stirring method is selected from mechanical stirring, mechanical oscillation or ultrasonic oscillation.

[0042] The present invention provides an application of the above-mentioned nicotine replacement liquid preparation or the nicotine replacement liquid preparation prepared by the above-mentioned preparation method in an atomization device.

[0043] Preferably, the atomization device is an electronic atomization device.

[0044] The beneficial effects of the present invention:

[0045] The nicotine replacement liquid preparation provided by the present invention has raw material components including a nicotine throat hit simulation additive, a nicotine head rush simulation additive, and an atomization solvent; the nicotine throat hit simulation additive is selected from at least one of piperine and 6-methylnicotine; the nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine. The nicotine head rush simulation additive (at least one of cytisine, magnolol, and 6-methylnicotine) in the present invention can make the brain produce an effect similar to the head rush of nicotine, and can partially replace the activation effect of nicotine. The nicotine throat hit simulation additive (at least one of piperine and 6-methylnicotine) can bring feelings such as pain, irritation, itching, etc. to the human throat, forming a throat hit feeling. Among them, 6-methylnicotine has a certain effect similar to both the nicotine head rush and the throat hit. Therefore, the nicotine replacement liquid preparation formed by compounding a specific nicotine throat hit simulation additive and a nicotine head rush simulation additive with an atomization solvent in a specific ratio synergistically simulates the head rush and throat hit brought by nicotine, improves the head rush and throat hit of the zero-nicotine atomization preparation, enhances the satisfaction generated by users, thereby achieving the purpose of physiological addiction relief. At the same time, its toxicity and addiction are much lower than nicotine, and it can reduce health damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for use in the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0047] Figure 1 Average normalized heart rate diagrams of Example 1, Example 2, Example 11, and Comparative Example 1 of the present invention;

[0048] Figure 2 Normalized heart rate diagrams of Example 1, Example 2, Example 11, and Comparative Example 1 of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0049] The following embodiments are provided to better further understand the present invention. It is not limited to the best embodiment, and does not limit the content and protection scope of the present invention. Any product that is the same or similar to the present invention obtained by anyone under the inspiration of the present invention or by combining the features of the present invention with other prior art features falls within the protection scope of the present invention.

[0050] For those without specific experimental procedures or conditions indicated in the examples, the operations or conditions of the conventional experimental procedures described in the literature in this field can be followed. For reagents or instruments without the manufacturer indicated, they are all conventional reagent products that can be obtained through commercial purchases.

[0051] The core component in the nicotine liquid preparation is nicotine. When the power supply heats the atomizer, the nicotine in the nicotine liquid preparation will be atomized into aerosol and then inhaled by the human body. Part of the aerosol is transmitted to the larynx, causing a throat hit feeling by stimulating the larynx. Another part of the aerosol will enter the lungs to participate in the pulmonary vein circulation, and then enter the arterial circulation, quickly transmitting the nicotine to the brain, binding to the acetylcholine receptors in the brain, promoting the release of neurotransmitters (dopamine) in the brain. The release of dopamine is a pleasant experience, which will enhance the reward function of the brain, produce a high feeling, and make smokers feel satisfied. However, nicotine has high toxicity and addiction, and long-term inhalation will affect human health. Satisfaction is a comprehensive evaluation of the high feeling and the throat hit feeling. An appropriate throat hit feeling helps to improve the comprehensive satisfaction. However, if the throat hit feeling is too strong, it will cause too high suction irritation and physical discomfort, thus reducing the satisfaction. At present, in order to prevent the abuse of nicotine and ensure the health and safety of the public, the strict supervision of nicotine in e-cigarette products in various countries has prompted many countries to promote zero-nicotine products to avoid the problem of nicotine addiction. Zero-nicotine atomization preparation products mainly feature rich flavors and a cooling sensation. However, because they do not contain nicotine, the existing zero-nicotine atomization preparations do not have the throat hit feeling and high feeling brought by nicotine, and the product satisfaction is weak, and they cannot relieve the addiction of consumers physiologically.

[0052] Cytisine is a natural bioactive compound, mainly isolated from leguminous plants (especially the seeds of honeysuckle), and is used as an auxiliary tool for the clinical management of smoking cessation. The main action target of cytisine is the neuronal nicotinic acetylcholine receptor (nAChRs), and binding to this receptor can produce neurotransmitters such as dopamine, and its onset effect is similar to that of nicotine.

[0053] Magnolol belongs to the main active ingredient in magnolia extract. Magnolia is a traditional Chinese medicine with various pharmacological activities. In recent years, the research on magnolol at home and abroad has been continuously deepened. It has been found that magnolol has a wide range of pharmacological effects, such as antidepressant, regulating monoamine neurotransmitters, anti-inflammatory, protecting nerves, etc., and magnolol can increase the levels of 5-hydroxytryptamine and dopamine in the frontal cortex of mice.

[0054] 6-Methylnicotine (CAS: 13270-56-9) is a synthetic organic compound and belongs to the nicotine analogues. It has a very similar throat hit to nicotine. The inventors found that the throat hit of 6-methylnicotine is very obvious in the subjective smoking experience. The affinity of nicotine substitutes for nicotinic acetylcholine receptors (nAChRs) is related to the lipophilicity of the 6-position substituents. Related studies further show that as the size of the substituents increases, the affinity decreases. The affinity of nicotine analogues is determined by the lipophilicity of the 6-position substituents and is also related to the size of the substituents. Among them, the 6-position substituent of 6-methylnicotine has the smallest volume and strong lipophilicity, and also has a strong affinity with the nAChR receptor. Therefore, 6-methylnicotine can produce a similar high feeling to nicotine.

[0055] Piperine is an alkaloid, the source of the pungency of pepper and also the most important bioactive ingredient. Piperine is a regulator of human transient receptor potential (TRP) channels. After activating the TRP channels, piperine can bring about throat sensations such as pain, irritation, itching, etc., forming a throat hit feeling similar to nicotine. In addition, it has been scientifically found that piperine can also inhibit enzymes that play an important role in the drug metabolism process of other substances. By inhibiting the drug metabolism process, piperine may increase the bioavailability of many compounds, thereby enhancing the bioactive effects of other alkaloids on the human body and assisting in enhancing the high feeling.

[0056] The inventors unexpectedly found that using piperine and 6-methylnicotine as additives to simulate the throat hit of nicotine, and using cytisine, magnolol, and 6-methylnicotine as additives to simulate the high feeling of nicotine. Through different combinations and adaptations between the additives for simulating the throat hit of nicotine and the additives for simulating the high feeling of nicotine, they cooperate synergistically to simulate the throat hit and high feeling brought by nicotine, improve the throat hit and high feeling of zero-nicotine products, and produce a high sense of satisfaction.

[0057] The present invention provides a nicotine replacement liquid preparation, and the raw material components of the nicotine replacement liquid preparation include a nicotine throat hit simulation additive, a nicotine head rush simulation additive, and an atomization solvent; the nicotine throat hit simulation additive is selected from at least one of piperine and 6-methylnicotine; the nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine. The inventors have found that the nicotine head rush simulation additive (at least one of cytisine, magnolol, and 6-methylnicotine) can cause the brain to produce an effect similar to the head rush of nicotine, and can partially replace the activating effect of nicotine. The nicotine throat hit simulation additive (at least one of piperine and 6-methylnicotine) can bring feelings such as pain, irritation, itching, etc. to the human throat, forming a throat hit feeling, and 6-methylnicotine also has a certain head rush and throat hit effect similar to nicotine. Therefore, the nicotine replacement liquid preparation formed by compounding specific nicotine throat hit simulation additives and nicotine head rush simulation additives with an atomization solvent in a specific ratio synergistically simulates the head rush and throat hit brought by nicotine, improves the head rush and throat hit of the zero-nicotine atomization preparation, enhances the satisfaction generated by the user, thereby achieving the purpose of physiological addiction relief. At the same time, its toxicity and addiction are much lower than nicotine, and it can reduce health damage.

[0058] In some alternative embodiments, the total mass content of the nicotine throat hit simulation additive and the nicotine head rush simulation additive in the nicotine replacement liquid formulation is 2.1 - 61 mg / g. For example, optionally, the total mass content of the nicotine throat hit simulation additive and the nicotine head rush simulation additive in the nicotine replacement liquid formulation is 2.1 mg / g, 2.5 mg / g, 2.6 mg / g, 3 mg / g, 3.5 mg / g, 4 mg / g, 4.5 mg / g, 5 mg / g, 5.6 mg / g, 6 mg / g, 7 mg / g, 8 mg / g, 9 mg / g, 10 mg / g, 11 mg / g, 12 mg / g, 13 mg / g, 14 mg / g, 15 mg / g, 16 mg / g, 17 mg / g, 18 mg / g, 19 mg / g, 20 mg / g, 22 mg / g, 23 mg / g, 24 mg / g, 25 mg / g, 26 mg / g, 27 mg / g, 28 mg / g, 29 mg / g, 30 mg / g, 31 mg / g, 32 mg / g, 33 mg / g, 34 mg / g, 35 mg / g, 36 mg / g, 37 mg / g, 38 mg / g, 39 mg / g, 40 mg / g, 41 mg / g, 42 mg / g, 43 mg / g, 44 mg / g, 45 mg / g, 46 mg / g, 47 mg / g, 48 mg / g, 49 mg / g, 50 mg / g, 51 mg / g, 52 mg / g, 53 mg / g, 54 mg / g, 55 mg / g, 56 mg / g, 57 mg / g, 58 mg / g, 59 mg / g, 60 mg / g, 61 mg / g.

[0059] In some alternative embodiments, the mass ratio of the nicotine throat hit simulation additive to the nicotine head rush simulation additive is (0.1 - 11):(2 - 50); for example, optionally, the mass ratio of the nicotine throat hit simulation additive to the nicotine head rush simulation additive can be: 0.1:2, 0.1:3, 0.1:5, 0.1:9, 0.1:10, 0.1:15, 0.1:19, 0.1:20, 0.1:25, 0.1:26, 0.1:30, 0.1:35, 0.1:37, 0.1:40, 0.1:45, 0.1:50, 0.5:2, 0.5:3, 0.5:5, 0.5:9, 0.5:10, 0.5:15, 0.5:19, 0.5:20, 0.5:25, 0.5:26, 0.5:30, 0.5:35, 0.5:37, 0.5:40, 0.5:45, 0.5:50, 1:2, 1:3, 1:5, 1:9, 1:10, 1:15, 1:19, 1:20, 1:25, 1:26, 1:30, 1:35, 1:37, 1:40, 1:45, 1:50, 3:2, 3:3, 3:5, 3:9, 3:10, 3:15, 3:19, 3:20, 3:25, 3:26, 3:30, 3:35, 3:37, 3:40, 3:45, 3:50, 5:2, 5:3, 5:5, 5:9, 5:10, 5:15, 5:19, 5:20, 5:25, 5:26, 5:30, 5:35, 5:37, 5:40, 5:45, 5:50, 7:2, 7:3, 7:5, 7:9, 7:10, 7:15, 7:19, 7:20, 7:25, 7:26, 7:30, 7:35, 7:37, 7:40, 7:45, 7:50, 10:2, 10:3, 10:5, 10:9, 10:10, 10:15, 10:19, 10:20, 10:25, 10:26, 10:30, 10:35, 10:37, 10:40, 10:45, 10:50, 11:2, 11:3, 11:5, 11:9, 11:10, 11:15, 11:19, 11:20, 11:25, 11:26, 11:30, 11:35, 11:37, 11:40, 11:45, 11:50; The inventors found that by controlling the mass ratio of the nicotine throat hit simulation additive to the nicotine head rush simulation additive within the range of (0.1 - 11):(2 - 50), under their synergistic effect, the satisfaction of users can be improved, reaching or even exceeding the satisfaction of products on the market with benzoic acid as the organic acid and a nicotine content of 10 mg / g.

[0060] The raw material components of the nicotine replacement liquid preparation include 6-methyl nicotine and an atomization solvent. The inventors found that 6-methyl nicotine has both a head rush and throat hit similar to nicotine, which can well improve the satisfaction of users, even better than nicotine. At the same time, its toxicity and addiction are much lower than nicotine, which can reduce damage to human health.

[0061] In some alternative embodiments, the mass ratio of the 6-methyl nicotine to the atomization solvent is (0.3 - 5):(40 - 95). For example, optionally, the mass ratio of 6-methyl nicotine to the atomization solvent can be 0.3:40, 0.3:45, 0.3:47, 0.3:50, 0.3:51, 0.3:55, 0.3:60, 0.3:65, 0.3:70, 0.3:74, 0.3:80, 0.3:85, 0.3:90, 0.3:95, 0.5:40, 0.5:45, 47, 0.5:50, 0.5:51, 0.5:55, 0.5:60, 0.5:65, 0.5:70, 0.5:74, 0.5:80, 0.5:85, 0.5:90, 0.5:95, 1:40, 1:45, 1:47, 1:50, 1:51, 1:55, 1:60, 1:65, 1:70, 1:74, 1:80, 1:85, 1:90, 1:95, 1.5:40, 1.5:45, 1.5:47, 1.5:50, 1.5:51, 1.5:55, 1.5:60, 1.5:65, 1.5:70, 1.5:74, 1.5:80, 1.5:85, 1.5:90, 1.5:95, 2:40, 2:45, 2:47, 2:50, 2:51, 2:55, 2:60, 2:65, 2:70, 2:74, 2:80, 2:85, 2:90, 2:95, 3:40, 3:45, 3:47, 3:50, 3:51, 3:55, 3:60, 3:65, 3:70, 3:74, 3:80, 3:85, 3:90, 3:95, 4:40, 4:45, 4:47, 4:50, 4:51, 4:55, 4:60, 4:65, 4:70, 4:74, 4:80, 4:85, 4:90, 4:95, 5:40, 5:45, 5:47, 5:50, 5:51, 5:55, 5:60, 5:65, 5:70, 5:74, 5:80, 5:85, 5:90, 5:95.

[0062] In some alternative embodiments, the raw material components of the nicotine replacement liquid preparation include a throat hit simulation additive for nicotine, a head rush simulation additive for nicotine, and an atomization solvent; the throat hit simulation additive for nicotine is selected from at least one of piperine and 6-methyl nicotine; the head rush simulation additive for nicotine is selected from at least one of cytisine and magnolol.

[0063] In some alternative embodiments, the nicotine throat hit simulation additive is piperine, and the nicotine head rush simulation additive is cytisine. In some alternative embodiments, the nicotine throat hit simulation additive is piperine, and the nicotine head rush simulation additive is magnolol. In other alternative embodiments, the nicotine throat hit simulation additive is piperine, and the nicotine head rush simulation additives are cytisine and magnolol;The mass ratio of sparteine to magnolol is (5 - 40):(5 - 30). For example, optionally, the mass ratio of sparteine to magnolol can be 5:5, 5:6, 5:8, 10, 5:11, 5:13, 5:15, 5:17, 5:19, 5:20, 5:21, 5:23, 5:25, 5:26, 5:28, 5:29, 5:30, 7:5, 7:6, 7:8, 10, 7:11, 7:13, 7:15, 7:17, 7:19, 7:20, 7:21, 7:23, 7:25, 7:26, 7:28, 7:29, 7:30, 10:5, 10:6, 10:8, 10, 10:11, 10:13, 10:15, 10:17, 10:19, 10:20, 10:21, 10:23, 10:25, 10:26, 10:28, 10:29, 10:30, 15:5, 15:6, 15:8, 10, 15:11, 15:13, 15:15, 15:17, 15:19, 15:20, 15:21, 15:23, 15:25, 15:26, 15:28, 15:29, 15:30, 20:5, 20:6, 20:8, 10, 20:11, 20:13, 20:15, 20:17, 20:19, 20:20, 20:21, 20:23, 20:25, 20:26, 20:28, 20:29, 20:30, 25:5, 25:6, 25:8, 10, 25:11, 25:13, 25:15, 25:17, 25:19, 25:20, 25:21, 25:23, 25:25, 25:26, 25:28, 25:29, 25:30, 30:5, 30:6, 30:8, 10, 30:11, 30:13, 30:15, 30:17, 30:19, 30:20, 30:21, 30:23, 30:25, 30:26, 30:28, 30:29, 30:30, 35:5, 35:6, 35:8, 10, 35:11, 35:13, 35:15, 35:17, 35:19, 35:20, 35:21, 35:23, 35:25, 35:26, 35:28, 35:29, 35:30, 40:5, 40:6, 40:8, 10, 40:11, 40:13, 40:15, 40:17, 40:19, 40:20, 40:21, 40:23, 40:25, 40:26, 40:28, 40:29, 40:30. By compounding piperine, sparteine and magnolol, the improvement of the satisfaction of users is significantly higher than that of compounding sparteine and piperine alone or compounding magnolol and piperine alone.;

[0064] In some alternative embodiments, the nicotine throat hit simulation additive is 6-methylnicotine, and the nicotine head rush simulation additive is sparteine. In some alternative embodiments, the nicotine throat hit simulation additive is 6-methylnicotine, and the nicotine head rush simulation additive is magnolol. In other alternative embodiments, the nicotine throat hit simulation additive is 6-methylnicotine, and the nicotine head rush simulation additives are sparteine and magnolol. The mass ratio of sparteine to magnolol is (1 - 25):(1 - 5). For example, the mass ratio of sparteine to magnolol can be 1:1, 2:1, 5:1, 7:1, 9:1, 10:1, 12:1, 13:1, 15:1, 18:1, 19:1, 20:1, 21:1, 24:1, 25:1, 1:2, 2:2, 5:2, 7:2, 9:2, 10:2, 12:2, 13:2, 15:2, 18:2, 19:2, 20:2, 21:2, 24:2, 25:2, 1:3, 2:3, 5:3, 7:3, 9:3, 10:3, 12:3, 13:3, 15:3, 18:3, 19:3, 20:3, 21:3, 24:3, 25:3, 1:4, 2:4, 5:4, 7:4, 9:4, 10:4, 12:4, 13:4, 15:4, 18:4, 19:4, 20:4, 21:4, 24:4, 25:4, 1:5, 2:5, 5:5, 7:5, 9:5, 10:5, 12:5, 13:5, 15:5, 18:5, 19:5, 20:5, 21:5, 24:5, 25:5. By compounding 6-methylnicotine, sparteine, and magnolol, the satisfaction of users is significantly improved compared to using only the combination of sparteine and 6-methylnicotine or only the combination of magnolol and 6-methylnicotine alone.

[0065] In some alternative embodiments, the atomizing solvent may be a conventional atomizing solvent in the art, including but not limited to at least one of propylene glycol and glycerol; optionally, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the atomizing solvent is (0.3 - 5):(40 - 95). For example, optionally, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the atomizing solvent is 0.3:40, 0.3:45, 0.3:47, 0.3:50, 0.3:51, 0.3:55, 0.3:60, 0.3:65, 0.3:70, 0.3:74, 0.3:80, 0.3:85, 0.3:90, 0.3:95, 0.5:40, 0.5:45, 47, 0.5:50, 0.5:51, 0.5:55, 0.5:60, 0.5:65, 0.5:70, 0.5:74, 0.5:80, 0.5:85, 0.5:90, 0.5:95, 1:40, 1:45, 1:47, 1:50, 1:51, 1:55, 1:60, 1:65, 1:70, 1:74, 1:80, 1:85, 1:90, 1:95, 1.5:40, 1.5:45, 1.5:47, 1.5:50, 1.5:51, 1.5:55, 1.5:60, 1.5:65, 1.5:70, 1.5:74, 1.5:80, 1.5:85, 1.5:90, 1.5:95, 2:40, 2:45, 2:47, 2:50, 2:51, 2:55, 2:60, 2:65, 2:70, 2:74, 2:80, 2:85, 2:90, 2:95, 3:40, 3:45, 3:47, 3:50, 3:51, 3:55, 3:60, 3:65, 3:70, 3:74, 3:80, 3:85, 3:90, 3:95, 4:40, 4:45, 4:47, 4:50, 4:51, 4:55, 4:60, 4:65, 4:70, 4:74, 4:80, 4:85, 4:90, 4:95, 5:40, 5:45, 5:47, 5:50, 5:51, 5:55, 5:60, 5:65, 5:70, 5:74, 5:80, 5:85, 5:90, 5:95. Preferably, the atomizing solvent is propylene glycol and glycerol.The mass ratio of the propylene glycol to the glycerol is (1 - 50):(1 - 50). Optionally, the mass ratio of the propylene glycol to the glycerol and ethanol is 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:13, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 2:1, 2:3, 2:5, 2:7, 2:9, 2:10, 2:13, 2:15, 2:20, 2:25, 2:30, 2:35, 2:40, 2:45, 2:50, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 12:1, 13:1, 15:1, 18:1, 20:1, 22:1, 25:1, 29:1, 30:1, 32:1, 35:1, 40:1, 43:1, 45:1, 47:1, 50:1. The addition of the atomization solvent in the present invention can better dissolve the raw material components, effectively improve the atomization efficiency of nicotine, and increase the satisfaction.

[0066] In some alternative embodiments, the mass content of the nicotine throat hit sensation simulation additive in the nicotine replacement liquid preparation is 0.1-11 mg / g, and the mass content of the nicotine head rush sensation simulation additive is 2-50 mg / g. For example, optionally, the mass content of A in the nicotine replacement liquid preparation is 0.1 mg / g, 0.5 mg / g, 0.7 mg / g, 0.9 mg / g, 1 mg / g, 1.1 mg / g, 1.5 mg / g, 1.7 mg / g, 2 mg / g, 2.3 mg / g, 2.5 mg / g, 2.7 mg / g, 3 mg / g, 3.5 mg / g, 3.7 mg / g, 4 mg / g, 4.5 mg / g, 4.8 mg / g, 5 mg / g, 5.5 mg / g, 5.8 mg / g, 6 mg / g, 6.5 mg / g, 5.7 mg / g, 7 mg / g, 7.5 mg / g, 7.7 mg / g, 8 mg / g, 8.5 mg / g, 9 mg / g, 9.5 mg / g, 10 mg / g, 10.5 mg / g, 11 mg / g, and the mass content of the nicotine head rush sensation simulation additive is 2 mg / g, 3 mg / g, 4 mg / g, 5 mg / g, 6 mg / g, 7 mg / g, 8 mg / g, 9 mg / g, 10 mg / g, 11 mg / g, 12 mg / g, 13 mg / g, 14 mg / g, 15 mg / g, 16 mg / g, 17 mg / g, 18 mg / g, 19 mg / g, 20 mg / g, 21 mg / g, 22 mg / g, 23 mg / g, 24 mg / g, 25 mg / g, 26 mg / g, 27 mg / g, 28 mg / g, 29 mg / g, 30 mg / g, 31 mg / g, 32 mg / g, 33 mg / g, 34 mg / g, 35 mg / g, 36 mg / g, 37 mg / g, 38 mg / g, 39 mg / g, 40 mg / g, 41 mg / g, 42 mg / g, 43 mg / g, 44 mg / g, 45 mg / g, 46 mg / g, 47 mg / g, 48 mg / g, 49 mg / g, 50 mg / g.

[0067] In some alternative embodiments, the raw material components of the nicotine replacement liquid preparation further include organic acids. Optionally, the organic acid includes at least one of C3-C8 organic carboxylic acids; further optionally, the organic acid includes at least one of C3-C8 monobasic organic carboxylic acids, C3-C8 dibasic organic carboxylic acids, and C3-C8 tribasic organic carboxylic acids. Still further optionally, the organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid; still further optionally, the organic acid is benzoic acid. By further adding a specific organic acid to the raw material components to form a nicotine salt in the present invention, the satisfaction of users can be further ensured.

[0068] In some alternative embodiments, based on the carboxyl group, the molar ratio of the organic acid to 6-methyl nicotine is 1:(0.98 - 1.5); for example, optionally, based on the carboxyl group, the molar ratio of the organic acid to 6-methyl nicotine can be 1:0.98, 1:0.99, 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5. After adding 6-methyl nicotine in the nicotine throat hit simulation additive and / or nicotine head rush simulation additive, the inventors further found that the organic acid and its addition amount can affect the satisfaction. Changing the molar ratio of the organic acid to 6-methyl nicotine can change the acid-base environment in the throat and regulate the throat hit during the aerosol entering the lungs. Preferably, based on the carboxyl group, the molar ratio of the organic acid to 6-methyl nicotine is 1:1.

[0069] In some alternative embodiments, the raw material components of the nicotine replacement liquid preparation further include fragrance. The fragrance can be a conventional existing fragrance material in the art, which can be obtained commercially or prepared by conventional components through conventional methods. For example, it can be selected as a single fragrance raw material or a mixture of various extracts. It includes but is not limited to tobacco fragrance, fruit fragrance, and mint fragrance. Further, the fruit fragrance includes at least one of mango fragrance, blueberry fragrance, and grape fragrance; optionally, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the fragrance is (0.3 - 5):(20 - 45). For example, optionally, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the fragrance can be 0.3:20, 0.3:25, 0.3:30, 0.3:35, 0.3:40, 0.3:45, 0.5:20, 0.5:25, 0.5:30, 0.5:35, 0.5:40, 0.5:45, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1.5:20, 1.5:25, 1.5:30, 1.5:35, 1.5:40, 1.5:45, 2:20, 2:25, 2:30, 2:35, 2:40, 2:45, 3:20, 3:25, 3:30, 3:35, 3:40, 3:45, 4:20, 4:25, 4:30, 4:35, 4:40, 4:45, 5:20, 5:25, 5:30, 5:35, 5:40, 5:45.

[0070] The present invention also provides a preparation method of the above-mentioned nicotine replacement liquid preparation, which includes the following steps: mixing the nicotine throat hit simulation additive, the nicotine head rush simulation additive, and the atomization solvent, and then heating and stirring evenly to obtain the product.

[0071] In some alternative embodiments, the method for preparing the nicotine replacement liquid preparation further includes the step of adding flavoring essence.

[0072] In some alternative embodiments, the method for preparing the nicotine replacement liquid preparation further includes the step of adding organic acid.

[0073] The present invention does not specifically limit the heating and stirring temperature and time, as long as the raw materials can be dissolved. Optionally, the dissolution temperature is not higher than 100°C. Optionally, the heating and stirring temperature is 40 - 65°C, and the heating and stirring time is 20 - 30 min. The present invention does not specifically limit the mixing method and the mixing order. Optionally, in the present invention, all the raw materials can be mixed and then heated for dissolution, or some of the raw materials can be mixed and dissolved first, and then the remaining raw materials can be mixed and dissolved.

[0074] In some alternative embodiments, the method for preparing the nicotine replacement liquid preparation includes the following steps: Mix the nicotine head feeling simulation additive, nicotine throat hit feeling simulation additive, organic acid and part of the atomization solvent, heat at 40 - 65°C for 20 - 30 minutes to dissolve and mix evenly, cool to 10 - 35°C, add flavoring essence and stir for 5 - 40 min to mix evenly, to obtain the nicotine replacement liquid preparation.

[0075] In some alternative embodiments, the method for preparing the nicotine replacement liquid preparation includes the following steps: Mix the nicotine head feeling simulation additive, nicotine throat hit feeling simulation additive, organic acid and part of the atomization solvent, heat at 40 - 65°C for 20 - 30 minutes to dissolve and mix evenly, cool to room temperature, add flavoring essence and stir for 5 - 40 min to mix evenly, to obtain the nicotine replacement liquid preparation.

[0076] The present invention also provides an application of the above-mentioned nicotine replacement liquid preparation or the nicotine replacement liquid preparation prepared by the above-mentioned preparation method in an atomization device. Optionally, the atomization device is an electronic atomization device.

[0077] Example 1

[0078] This example provides a method for preparing a nicotine replacement liquid preparation, including the following steps:

[0079] Mix 0.6 g of 6-methyl nicotine, 1 g of magnolol, 0.42 g of benzoic acid, 12.98 g of propylene glycol and 40 g of glycerol, stir at 60°C for 20 min to mix evenly, cool to room temperature, add 45 g of blueberry flavoring essence and stir for 20 min to mix evenly, to obtain the nicotine replacement liquid preparation.

[0080] Example 2

[0081] This embodiment provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0082] Mix 0.6 g of 6-methylnicotine, 1 g of cytisine, 0.42 g of benzoic acid, 12.98 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0083] Example 3

[0084] This embodiment provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0085] Mix 0.01 g of piperine, 4.5 g of cytisine, 10.49 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0086] Example 4

[0087] This embodiment provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0088] Mix 0.01 g of piperine, 4.5 g of magnolol, 10.49 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0089] Example 5

[0090] This embodiment provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0091] Mix 3 g of cytisine, 1.5 g of magnolol, 0.01 g of piperine, 10.49 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0092] Example 6

[0093] This embodiment provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0094] Mix 3.0 g of anabasine, 1.5 g of magnolol, 0.05 g of piperine, 10.45 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0095] Example 7

[0096] This example provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0097] Mix 3.0 g of anabasine, 1.5 g of magnolol, 0.1 g of piperine, 10.4 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0098] Example 8

[0099] This example provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0100] Mix 0.3 g of 6-methylnicotine, 0.21 g of benzoic acid, 14.49 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0101] Example 9

[0102] This example provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0103] Mix 0.6 g of 6-methylnicotine, 0.42 g of benzoic acid, 13.98 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0104] Example 10

[0105] This example provides a preparation method of a nicotine replacement liquid preparation, including the following steps:

[0106] Mix 1.0 g of 6-methylnicotine, 0.69 g of benzoic acid, 13.31 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0107] Example 11

[0108] This example provides a method for preparing a nicotine replacement liquid preparation, which includes the following steps:

[0109] Mix 0.6 g of 6-methylnicotine, 0.5 g of cytisine, 0.5 g of magnolol, 0.42 g of benzoic acid, 12.98 g of propylene glycol, and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly. After cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0110] Example 12

[0111] This example provides a method for preparing a nicotine replacement liquid preparation, which includes the following steps:

[0112] Mix 0.6 g of 6-methylnicotine, 3.0 g of cytisine, 1.5 g of magnolol, 0.42 g of benzoic acid, 9.48 g of propylene glycol, and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly. After cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0113] Example 13

[0114] Mix 1.0 g of 6-methylnicotine, 3.0 g of cytisine, 1.5 g of magnolol, 0.69 g of benzoic acid, 8.81 g of propylene glycol, and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly. After cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0115] Comparative Example 1

[0116] This comparative example provides a method for preparing a nicotine replacement liquid preparation, which includes the following steps:

[0117] Mix 15 g of propylene glycol and 40 g of glycerol, stir at 60 °C for 20 min to mix evenly. After cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0118] Comparative Example 2

[0119] This comparative example provides a method for preparing a nicotine liquid preparation, which includes the following steps:

[0120] Mix 1 g of nicotine, 0.75 g of benzoic acid, 13.25 g of propylene glycol, and 40 g of glycerol, stir for 20 min at 60 °C to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0121] Comparative Example 3

[0122] This comparative example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0123] Mix 2 g of nicotine, 1.5 g of benzoic acid, 11.5 g of propylene glycol, and 40 g of glycerol, stir for 20 min at 60 °C to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0124] Comparative Example 4

[0125] This comparative example provides a method for preparing a nicotine liquid preparation, including the following steps:

[0126] Mix 3 g of nicotine, 2.26 g of benzoic acid, 9.74 g of propylene glycol, and 40 g of glycerol, stir for 20 min at 60 °C to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine liquid preparation.

[0127] Comparative Example 5

[0128] This comparative example provides a method for preparing a nicotine replacement liquid preparation, including the following steps:

[0129] Mix 3.0 g of cytisine, 12 g of propylene glycol, and 40 g of glycerol, stir for 20 min at 60 °C to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0130] Comparative Example 6

[0131] This comparative example provides a method for preparing a nicotine replacement liquid preparation, including the following steps:

[0132] Mix 1.5 g of magnolol, 13.5 g of propylene glycol, and 40 g of glycerol, stir for 20 min at 60 °C to mix evenly, after cooling to room temperature, add 45 g of blueberry essence and stir for 20 min to mix evenly to obtain the nicotine replacement liquid preparation.

[0133] Test Example

[0134] The present invention scores each puffing index of the liquid preparations of Examples 1-13 and the liquid preparations of Comparative Examples 1-6 by means of subjective puffing. The puffing team consists of 15 people, all of whom have more than 3 years of experience in puffing traditional cigarettes or e-cigarettes and have nicotine withdrawal 10 hours before puffing.

[0135] Each puffing person is provided with a puffing evaluation form, and uses the method of blind evaluation to puff on the nicotine replacement liquid preparations or nicotine liquid preparations of different examples and comparative examples. The puffing method is as follows: The puffing person undergoes nicotine withdrawal for 10 hours the night before puffing, and conducts a puffing test at 9:00 am on the day of puffing. Use a RELX 5th generation e-cigarette rod (equipped with samples of different examples and comparative examples) to puff a total of 10 mouthfuls of smoke (each puff lasts for 3 seconds, and the interval between each puff is 27 seconds). After puffing, score and evaluate according to the evaluation indexes in Table 1. After puffing one sample of e-liquid, withdraw for 2 hours and then conduct the puffing test on the next sample of e-liquid. The puffing test results are shown in Table 2 (the scoring value is the average score).

[0136] Table 1 Evaluation Indexes

[0137]

[0138] Table 2 Puffing Scoring Data

[0139]

[0140]

[0141] Perform a heart rate test during the puffing process on the liquid preparations (hereinafter referred to as samples) prepared in Example 1, Example 2, Example 11 and Comparative Example 1. The test method is as follows: The puffing person undergoes nicotine withdrawal the night before the puffing test and conducts a heart rate test during the puffing process at 9:00 am on the day of puffing. Before puffing, wear the heart rate test instrument (the heart rate test instrument is Lepu Xin'anbao ER1), and monitor the real-time change of the heart rate throughout the puffing process. After the heart rate instrument is worn and debugged, conduct a 2-minute baseline heart rate test. After the heart rate is stable, start monitoring the heart rate during the puffing process. Use a RELX 5th generation e-cigarette rod (equipped with samples of different examples and comparative examples), and puff a total of 5 mouthfuls of smoke (each puff lasts for 3 seconds, and the interval between adjacent two mouthfuls is 27 seconds). The total puffing time is about 2.5 minutes, and record the time when each mouthful of smoke starts to be puffed. After puffing, continue to monitor the heart rate change for 1 minute, and then end the experiment. After finishing one sample, withdraw for 2 hours and then conduct the heart rate test during the puffing process on the next sample. The test results are as Figure 1 and 2 shown, where Figure 1 the average normalized heart rate is the ratio of the average monitored heart rate during the puffing process to the average baseline heart rate, Figure 2The normalized heart rate is the ratio of the real-time monitored heart rate during puffing to the average reference heart rate within the above-mentioned 2 minutes.

[0142] Obviously, the above embodiments are merely examples given for clear illustration and are not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or alterations can be made based on the above description. It is not necessary and impossible to enumerate all implementation manners here. And the obvious changes or alterations derived therefrom still fall within the protection scope of the present invention.

Claims

1. A nicotine replacement liquid preparation, characterized in that, the raw material components of the nicotine replacement liquid preparation include a nicotine throat hit simulation additive, a nicotine head rush simulation additive, and an atomization solvent; the nicotine throat hit simulation additive is selected from at least one of piperine and 6-methylnicotine; the nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine.

2. The nicotine replacement liquid preparation according to claim 1, characterized in that, the total mass content of the nicotine throat hit simulation additive and the nicotine head rush simulation additive in the nicotine replacement liquid preparation is 2.1 - 61 mg / g.

3. The nicotine replacement liquid preparation according to claim 1 or 2, characterized in that, the mass ratio of the nicotine throat hit simulation additive to the nicotine head rush simulation additive is (0.1 - 11):(2 - 50).

4. The nicotine replacement liquid preparation according to any one of claims 1 - 3, characterized in that, the raw material components of the nicotine replacement liquid preparation include 6-methylnicotine and an atomization solvent.

5. The nicotine replacement liquid preparation according to claim 4, characterized in that, the mass ratio of the 6-methylnicotine to the atomization solvent is (0.3 - 5):(40 - 95).

6. The nicotine replacement liquid preparation according to any one of claims 1 - 3, characterized in that, the raw material components of the nicotine replacement liquid preparation include a nicotine throat hit simulation additive, a nicotine head rush simulation additive, and an atomization solvent; the nicotine throat hit simulation additive is selected from at least one of piperine and 6-methylnicotine; the nicotine head rush simulation additive is selected from at least one of cytisine and magnolol.

7. The nicotine replacement liquid preparation according to claim 6, characterized in that, when the nicotine throat hit simulation additive is piperine, the nicotine head rush simulation additive is cytisine and / or magnolol; or, when the nicotine throat hit simulation additive is 6-methylnicotine, the nicotine head rush simulation additive is cytisine and / or magnolol.

8. The nicotine replacement liquid preparation according to claim 7, characterized in that, when the nicotine throat hit simulation additive is piperine, the nicotine head rush simulation additive is cytisine and magnolol, and the mass ratio of the cytisine to the magnolol is (5 - 40):(5 - 30); or, when the nicotine throat hit simulation additive is 6-methylnicotine, the nicotine head rush simulation additive is cytisine and magnolol, and the mass ratio of the cytisine to the magnolol is (1 - 25):(1 - 5).

9. The nicotine replacement liquid preparation according to any one of claims 1 - 8, characterized in that, the mass ratio of the total mass of the nicotine throat hit simulation additive and the nicotine head rush simulation additive to the mass of the atomization solvent is (0.3 - 5):(40 - 95).

10. The nicotine replacement liquid preparation according to any one of claims 1 - 9, characterized in that, the atomization solvent includes at least one of propylene glycol and glycerol.

11. The nicotine replacement liquid preparation according to any one of claims 1-10, characterized in that, the atomizing solvent is propylene glycol and glycerol; the mass ratio of the propylene glycol to the glycerol is (1-50):(1-50).

12. The nicotine replacement liquid preparation according to any one of claims 1-11, characterized in that, the mass content of the nicotine throat hit sensation simulation additive in the nicotine replacement liquid preparation is 0.1-11 mg / g, and the mass content of the nicotine head rush sensation simulation additive is 2-50 mg / g.

13. The nicotine replacement liquid preparation according to any one of claims 1-12, characterized in that, the raw material components of the nicotine replacement liquid preparation further include organic acids.

14. The nicotine replacement liquid preparation according to claim 13, characterized in that, the organic acid includes at least one of C3-C8 organic carboxylic acids; optionally, the organic acid includes at least one of C3-C8 monobasic organic carboxylic acids, C3-C8 dibasic organic carboxylic acids, and C3-C8 tribasic organic carboxylic acids.

15. The nicotine replacement liquid preparation according to claim 13 or 14, characterized in that, the organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid; optionally, the organic acid is benzoic acid.

16. The nicotine replacement liquid preparation according to any one of claims 13-15, characterized in that, calculated by carboxyl group, the molar ratio of the organic acid to 6-methylnicotine is 1:(0.98-1.5); preferably, calculated by carboxyl group, the molar ratio of the organic acid to 6-methylnicotine is 1:

1.

17. The nicotine replacement liquid preparation according to any one of claims 1-16, characterized in that, the raw material components of the nicotine replacement liquid preparation further include essence.

18. The nicotine replacement liquid preparation according to claim 17, characterized in that, the essence includes at least one of tobacco essence, fruit essence, and mint essence; optionally, the fruit essence includes at least one of mango essence, blueberry essence, and grape essence.

19. The nicotine replacement liquid preparation according to claim 17 or 18, characterized in that, the mass ratio of the total mass of the nicotine throat hit sensation simulation additive and the nicotine head rush sensation simulation additive to the mass of the essence is (0.3-5):(20-45).

20. A preparation method of the nicotine replacement liquid preparation according to any one of claims 1-19, characterized in that, comprises the following steps: Mix the nicotine throat hit sensation simulation additive, the nicotine head rush sensation simulation additive and the atomizing solvent, and heat and stir evenly to obtain.

21. The preparation method of the nicotine replacement liquid preparation according to claim 20, characterized in that, it further comprises the step of adding essence.

22. The preparation method of the nicotine replacement liquid preparation according to claim 20 or 21, characterized in that, it further comprises the step of adding organic acid.

23. Use of the nicotine replacement liquid preparation according to any one of claims 1-19 or the nicotine replacement liquid preparation prepared by the preparation method according to any one of claims 20-22 in an atomization device.

24. The use according to claim 23, wherein, the atomization device is an electronic atomization device.

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