Lung structure injury degree evaluation method, device, equipment, medium and product
Through stereoscopic methods, the morphological parameters of the lung parenchyma after mechanical ventilation were counted and the average linear intercept of the alveolar was calculated, which solved the problem that the degree of lung structural damage caused by mechanical ventilation was difficult to evaluate, and the accurate assessment of the degree of lung structural damage was achieved, providing an auxiliary decision-making basis for clinical treatment.
Patent Information
- Application Number
- CN202510361536.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-26
- Publication Date
- 2025-07-01
AI Technical Summary
The degree of lung structural damage caused by mechanical ventilation is difficult to accurately evaluate, which affects clinical treatment decisions.
Stereovision methods were used to count the lung parenchymal morphological parameters at different scales after mechanical ventilation, including the volume of the lung, the total volume of the alveolar surface area density, and the cavity volume of the alveolar and airway. The average linear intercept of the alveolar and airway were calculated through these parameters to evaluate the degree of damage to the lung structure.
Accurate assessment of the degree of lung structural damage after mechanical ventilation is achieved, providing doctors with a basis for assisting decision-making and helping to optimize mechanical ventilation modes and parameters.
Smart Images
Figure CN120236762A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of intelligent medicine, and particularly to a method, device, equipment, medium and product for evaluating the degree of lung structure damage. Background Art
[0002] Mechanical ventilation is to assist or completely replace the spontaneous breathing of a person through a ventilator to complete gas exchange, improve the patient's respiratory function, provide time for the treatment of the primary disease, and promote the recovery of the disease; ventilators are widely used in clinical practice and are one of the important means to save critically ill patients. While saving the lives of patients, ventilators also cause ventilator-associated lung injury. And lung volume change is an independent pathogenic mechanism of ventilator-associated lung injury and has important clinical significance.
[0003] In the process of quantitatively evaluating the effect of mechanical ventilation modes and parameters, quantitatively evaluating the impact of lung volume changes on lung structure and establishing a relatively accurate evaluation method for quantifying lung structure can further judge the impact of different mechanical ventilation modes and parameters on lung structure. Summary of the Invention
[0004] The purpose of the present application is to provide a method, device, equipment, medium and product for evaluating the degree of lung structure damage, which can evaluate the degree of damage to the lung structure caused by mechanical ventilation.
[0005] To achieve the above purpose, the present application provides the following solutions.
[0006] In the first aspect, the present application provides a method for evaluating the degree of lung structure damage, including the following steps.
[0007] Using stereology methods to statistically analyze the morphological parameters of the lung parenchyma at different scales after mechanical ventilation; the lung parenchyma morphological parameters include the volume of the lung, the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, the number of test points falling on the alveoli, the length of the test lines contained in the diaphragm, the number of times the test lines intersect with the alveoli, and the cavity volume of the alveoli and airways.
[0008] Determine the total alveolar volume based on the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0009] Determine the alveolar surface area density based on the length of the test lines contained in the diaphragm and the number of times the test lines intersect with the alveoli.
[0010] Determine the total alveolar surface area based on the total alveolar volume, the alveolar surface area density, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0011] Determine the alveolar mean linear intercept based on the total alveolar surface area and the cavity volume of the alveoli and the airways.
[0012] Evaluate the degree of damage to the lung structure based on the alveolar mean linear intercept.
[0013] In a second aspect, the present application provides an apparatus for evaluating the degree of damage to a lung structure, including the following modules.
[0014] A lung parenchyma morphological parameter statistics module for statistically analyzing the lung parenchyma morphological parameters at different scales after mechanical ventilation using a stereological method; the lung parenchyma morphological parameters include the volume of the lung, the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, the number of test points falling on the alveoli, the length of the test lines contained in the diaphragm, the number of times the test lines intersect the alveoli, and the cavity volume of the alveoli and the airways.
[0015] An alveolar total volume determination module for determining the total alveolar volume based on the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0016] An alveolar surface area density determination module for determining the alveolar surface area density based on the length of the test lines contained in the diaphragm and the number of times the test lines intersect the alveoli.
[0017] An alveolar total surface area determination module for determining the total alveolar surface area based on the total alveolar volume, the alveolar surface area density, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0018] An alveolar mean linear intercept determination module for determining the alveolar mean linear intercept based on the total alveolar surface area and the cavity volume of the alveoli and the airways.
[0019] A damage degree evaluation module for evaluating the degree of damage to the lung structure based on the alveolar mean linear intercept.
[0020] In a third aspect, the present application provides a computer device, including: a memory, a processor, and a computer program stored on the memory and executable on the processor, where the processor executes the computer program to implement the method for evaluating the degree of damage to a lung structure as described in any one of the above.
[0021] In a fourth aspect, the present application provides a computer-readable storage medium, on which a computer program is stored, and when the computer program is executed by a processor, the method for evaluating the degree of damage to a lung structure as described in any one of the above is implemented.
[0022] Fifth aspect, the present application provides a computer program product, including a computer program which, when executed by a processor, implements the method for evaluating the degree of lung structure damage described in any one of the above.
[0023] According to the specific embodiments provided by the present application, the following technical effects are disclosed in the present application: The present application uses stereology methods to statistically analyze the morphological parameters of the lung parenchyma at different scales after mechanical ventilation to obtain the volume changes of the alveoli, including the total alveolar volume, the alveolar surface area density, and the total alveolar surface area. The mean linear intercept of the alveoli is determined through the above-mentioned volume changes of the alveoli to evaluate the degree of lung structure damage after mechanical ventilation, thereby providing an auxiliary basis for the doctor's next step of work. BRIEF DESCRIPTION OF THE DRAWINGS
[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.
[0025] Figure 1 It is a flowchart of a method for evaluating the degree of lung structure damage provided in an embodiment of the present application.
[0026] Figure 2 It is a schematic flowchart of using a multi-level hierarchical sampling method with four increasing magnification levels to statistically analyze the morphological parameters of the lung parenchyma at different scales provided in an embodiment of the present application. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, rather than all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present application.
[0028] To make the above objects, features, and advantages of the present application more obvious and understandable, the present application will be further described in detail below with reference to the drawings and specific embodiments.
[0029] The embodiment of the present application provides a method for evaluating the degree of lung structure damage. This method is executed by a computer device, which can be specifically executed by a computer device such as a terminal or a server alone, or jointly executed by a terminal and a server. In the embodiment of the present application, as Figure 1 shown, this method includes the following steps.
[0030] S1: Use stereology methods to statistically analyze the morphological parameters of the lung parenchyma at different scales; the lung parenchymal morphological parameters include the volume of the lung, the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, the number of test points falling on the alveoli, the length of the test lines contained in the diaphragm, the number of intersections of the test lines with the alveoli, and the cavity volume of the alveoli and the airway.
[0031] S2: Determine the total alveolar volume based on the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0032] S3: Determine the alveolar surface area density based on the length of the test lines contained in the diaphragm and the number of intersections of the test lines with the alveoli.
[0033] S4: Determine the total alveolar surface area based on the total alveolar volume, the alveolar surface area density, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0034] S5: Determine the alveolar mean linear intercept based on the total alveolar surface area and the cavity volume of the alveoli and the airway.
[0035] S6: Evaluate the degree of damage to the lung structure based on the alveolar mean linear intercept.
[0036] In an exemplary embodiment, S2 can be replaced by the following steps.
[0037] S21: Use the formula to determine the volume density of the lung parenchyma; where is the volume density of the lung parenchyma p; is the number of test points falling on the lung parenchyma; is the number of test points falling on the lung.
[0038] S22: Use the formula to determine the volume density of the diaphragm; where is the volume density of the diaphragm s; is the number of test points falling on the diaphragm.
[0039] S23: Use the formula to determine the volume density of the alveoli; where is the volume density of the alveoli; is the number of test points falling on the alveoli.
[0040] S24: Use the formula to determine the total alveolar volume; where is the total alveolar volume; is the volume of the lung L; is the volume density of the alveolus a.
[0041] In an exemplary embodiment, S3 can be replaced by the following steps.
[0042] Using the formula calculate and determine the alveolar surface area density; where is the alveolar surface area density; is the length of the test line contained in the septum; is the number of times the test line intersects the alveolus.
[0043] In an exemplary embodiment, S4 can be replaced by the following steps.
[0044] Using the formula determine the total alveolar surface area; where is the total alveolar surface area.
[0045] In an exemplary embodiment, S5 can be replaced by the following steps.
[0046] Using the formula determine the alveolar mean linear intercept; where is the alveolar mean linear intercept; is the cavity volume of the alveolus and the airway, is the cavity of the alveolus and the airway.
[0047] In an exemplary embodiment, S5 can be replaced by the following steps.
[0048] Judge whether the alveolar mean linear intercept is within the intercept range. If so, determine that the lung structure is not damaged; if not, determine that the lung structure is damaged.
[0049] In the actual operation process, the stereological method is used to statistically analyze the morphological parameters of the lung parenchyma at different scales after mechanical ventilation of the patient, and calculate the volume change of the lung structure according to the morphological parameters of the lung parenchyma, so as to determine the degree of damage to the lung structure and provide an auxiliary basis for the doctor's next work.
[0050] Taking the common animal experiment mouse as an example, in order to more clearly understand the technical solution of the present application, in the following experiment, the lung tissue after mechanical ventilation is sliced to verify the technical solution of the present application through the prepared lung tissue slices.
[0051] 1. Tissue sampling experimental method.
[0052] 1.1 Lung tissue preparation: Before mechanical ventilation, the experimental subject was routinely anesthetized. After tracheostomy with a suitable blunt-tipped thin-walled metal cannula, the subject was connected to a ventilator for ventilation. At the beginning of mechanical ventilation, pancuronium bromide at a dose of 0.8 mg / kg was administered to cause apnea in the experimental subject. Ventilation was carried out for 25 minutes at a pre-tested plateau pressure, positive end-expiratory pressure = 0 cm H2O, respiratory rate = 60 breaths / minute, and inspiratory-expiratory ratio = 1:1.5 to induce secondary mechanical ventilation-related lung injury.
[0053] 1.2 Lung isolation: The lungs were fixed through blood vessels and airways to maintain alveolar surface tension and airway pressure, enabling direct comparison of lung specimens with in vivo lung function data. After mechanical ventilation with preset parameters, bilateral thoracotomy was performed to remove the lungs, and the pulmonary vascular system was flushed with 100 U / ml heparinized saline and 3% 100 kDa dextran at a pressure of 35 cm H2O.
[0054] 1.3 Lung tissue fixation: Three cycles of lung recruitment ventilation at the total lung capacity ventilation level were given, and after maintaining a pressure of 30 cm H2O for 3 seconds, the airway pressure was maintained at the pre-tested pressure level. The lungs were perfused with 5 mL of 4% formaldehyde, 1% glutaraldehyde, and 3% dextran in 0.15 M HEPES buffer. Then, the tissues were carefully sectioned and fixed at 4°C for at least 24 hours.
[0055] 1.4 Preparation of lung tissue sections: The lungs were embedded in 3% agar and cut into 2-mm sections with a blade. The sections were washed in 0.15 M HEPES and degassed under vacuum. Then, the lung sections were washed in 0.1 M cacodylate buffer for 4×5 minutes, fixed in 1% osmium tetroxide at 4°C for 2 hours, washed in 0.1 M cacodylate buffer for 4×5 minutes, washed once in water, and then incubated overnight in 4% uranyl acetate.
[0056] The uranyl acetate-treated tissues were rinsed in distilled water for 4×5 minutes, and then dehydrated successively in 70%, 80%, and 90% acetone. The tissues were infiltrated with 50% acetone and 50% Technovit 7100 for 2 hours, and then infiltrated with 100% Technovit 7100 at 4°C overnight. Finally, the tissues were embedded in Technovit 7100, fixed on a column with Technovit 3040, cut into 1.5-μm sections with a blade, transferred to glass slides, and stained with toluidine blue.
[0057] The preparation of lung tissue sections was completed by the above method.
[0058] The degree of injury to the lung tissue sections was evaluated using the lung structure injury degree evaluation method of the present application, and the specific steps are as follows.
[0059] Using stereological methods, four multi-level hierarchical sampling methods with increasing magnification were used to collect images of 100-200 representative slice regions under the microscope at magnifications of lung level, 10-100 times, 400-600 times, and 1000-5000 times for estimating lung morphological parameters, referring to Figure 2 as shown in Figure 2 in is the number of test points falling on the non-pulmonary parenchyma part np, is the number of test points falling on the epithelial cells ep.
[0060] Stereological methods were used to statistically calculate the morphological parameters of the lung parenchyma. Based on the multi-level hierarchical sampling method, the calculation result of each level is the reference parameter of the next level.
[0061] Figure 2 At medium scale 1, the Cavalieri sampling method can be used to estimate the lung-level parameters. Similarly, statistical calculations are carried out from macroscopic to microscopic. The number of evenly distributed test probes at each level is 100-200 to ensure sufficient sampling. For the measurement of three-dimensional structure quantities such as volume, a uniformly distributed test lattice is used, such as Figure 2 the example of medium scale 2. For the test calculation of two-dimensional structure quantities such as surface area, a set of evenly distributed test line segments is used, such as Figure 2 the examples of medium scale 3 and scale 4.
[0062] 1) Calculate according to the Figure 2 grading calculation for different scales in
[0063] (1) In this experiment, the lung volume , that is, the sum of the areas of each slice A i multiplied by the slice thickness t, where i is the slice area serial number. In actual operation, the lung volume can be directly obtained; the volume density term , that is, the number of test points falling on the lung parenchyma divided by the total number of test points in the lung; similarly, , and , and the result unit is milliliters.
[0064] 2) Calculate the total alveolar surface area.
[0065] First, calculate the surface area density.
[0066] (2) Among them, L ( s ) is the total length of the test lines contained in the septum, To test the number of intersections of the test line with the alveoli, and , d represents the line length of each test point.
[0067] Then, calculate the total surface area of the alveoli according to the following formula, and the result unit is square meters.
[0068] (3) 3) Calculate the mean linear intercept of the alveoli.
[0069] Mean linear intercept of the alveoli L m Can be calculated according to the following formula.
[0070] (4) Among them, airplace represents the alveoli and the airway cavity, V(airplace) is the cavity volume, and S(a) is the alveolar surface area, and the result unit is micrometers.
[0071] 4) Conclusion of the evaluation of lung structure damage.
[0072] The result of the mean linear intercept index of the alveoli should be reported as data on the degree of lung structure damage that depends on time. The mean linear intercept of the alveoli is 200μm - 250μm. When the measured mean linear intercept of the alveoli exceeds this normal range, it indicates that there is tissue structure damage.
[0073] Based on the same inventive concept, the embodiments of the present application also provide a device for evaluating the degree of lung structure damage for implementing the above-mentioned method for evaluating the degree of lung structure damage. The solution provided by this device to solve the problem is similar to the solution recorded in the above method. Therefore, the specific limitations in one or more embodiments of the device for evaluating the degree of lung structure damage provided below can refer to the limitations on the method for evaluating the degree of lung structure damage in the above text, and will not be repeated here.
[0074] In an exemplary embodiment, a device for evaluating the degree of lung structure damage is provided, which includes the following modules.
[0075] The lung parenchyma morphological parameter statistics module is used to statistically analyze the morphological parameters of the lung parenchyma at different scales after mechanical ventilation by using stereology methods; the morphological parameters of the lung parenchyma include the volume of the lung, the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, the number of test points falling on the alveoli, the length of the test line contained in the diaphragm, the number of intersections of the test line with the alveoli, and the cavity volume of the alveoli and the airway.
[0076] An alveolar total volume determination module, configured to determine the total alveolar volume according to the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0077] An alveolar surface area density determination module, configured to determine the alveolar surface area density according to the length of the test line contained in the diaphragm and the number of times the test line intersects the alveoli.
[0078] An alveolar total surface area determination module, configured to determine the total alveolar surface area according to the total alveolar volume, the alveolar surface area density, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli.
[0079] An alveolar mean linear intercept determination module, configured to determine the alveolar mean linear intercept according to the total alveolar surface area and the cavity volume of the alveoli and the airway.
[0080] An injury degree assessment module, configured to assess the injury degree of the lung structure according to the alveolar mean linear intercept.
[0081] In an exemplary embodiment, a computer device is provided. The computer device may be a server or a terminal. The computer device includes a processor, a memory, an input / output interface (Input / Output, abbreviated as I / O), and a communication interface. Among them, the processor, the memory, and the input / output interface are connected through a system bus, and the communication interface is connected to the system bus through the input / output interface. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program, and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The database of the computer device is used to store lung structure injury degree assessment data. The input / output interface of the computer device is used to exchange information between the processor and external devices. The communication interface of the computer device is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, a lung structure injury degree assessment method is implemented.
[0082] In an exemplary embodiment, a computer device is provided, including a memory and a processor. A computer program is stored in the memory, and when the processor executes the computer program, the above method is implemented.
[0083] In an exemplary embodiment, a computer-readable storage medium is provided, storing a computer program, and when the computer program is executed by a processor, the above method is implemented.
[0084] In an exemplary embodiment, a computer program product is provided, including a computer program which, when executed by a processor, implements the above method.
[0085] Those of ordinary skill in the art can understand that all or part of the processes in the above method embodiments can be completed by instructing relevant hardware through a computer program. The computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the above method embodiments. Among them, any reference to a memory, database, or other medium used in the embodiments provided in this application can include at least one of non-volatile and volatile memories. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetoresistive random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM), etc.
[0086] In this application, all actions of obtaining signals, information, or data are carried out on the premise of complying with the corresponding data protection regulations and policies of the country where it is located and obtaining authorization from the owner of the corresponding device.
[0087] The databases involved in the embodiments provided in this application can include at least one of relational databases and non-relational databases. Non-relational databases can include distributed databases based on blockchain, etc., without limitation. The processors involved in the embodiments provided in this application can be general-purpose processors, central processors, graphics processors, digital signal processors, programmable logic devices, data processing logics based on quantum computing, etc., without limitation.
[0088] The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope recorded in this specification.
[0089] In this article, specific examples are used to elaborate on the principles and implementation manners of the present application. The description of the above embodiments is only used to help understand the method and its core idea of the present application; at the same time, for those of ordinary skill in the art, according to the idea of the present application, there will be changes in the specific implementation manners and application scopes. In summary, the content of this specification should not be construed as a limitation to the present application.
Claims
1. A method for assessing the degree of lung structural damage, characterized in that: The method for assessing the degree of lung structure damage comprises: The morphological parameters of lung parenchyma at different scales after mechanical ventilation were counted by stereology method; the morphological parameters of lung parenchyma included the volume of the lung, the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, the number of test points falling on the alveoli, the length of the test line contained in the diaphragm, the number of intersections between the test line and the alveoli, and the cavity volume of the alveoli and the airway; Determine the total alveolar volume based on the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli; determining an alveolar surface area density based on a length of a test line contained in the septum and a number of times the test line intersects an alveolus; Determine the total alveolar surface area according to the total alveolar volume, the alveolar surface area density, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli; Determining an average alveolar linear intercept according to the total alveolar surface area and the alveolar and airway cavity volumes; The degree of lung structure damage was assessed based on the mean alveolar linear intercept.
2. The method for assessing the degree of lung structural damage according to claim 1, characterized in that: Determining the total alveolar volume according to the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli specifically includes: Using the formula Determine the volume density of the lung parenchyma; where, is the volume density of lung parenchyma p; is the number of test points falling on the lung parenchyma; is the number of test points falling on the lung; Using the formula Determine the bulk density of the diaphragm; where, is the volume density of the diaphragm s; is the number of test points falling on the diaphragm; Using the formula Determine the volume density of the alveoli; where, is the volume density of alveoli; is the number of test points falling on the alveoli; Using the formula Determine the total alveolar volume; where, is the total alveolar volume; is the volume of lung L.
3. The method for assessing the degree of lung structural damage according to claim 2, characterized in that: Determining the alveolar surface area density according to the length of the test line contained in the diaphragm and the number of times the test line intersects the alveoli includes: Using the formula Calculate and determine the alveolar surface area density; where, is the alveolar surface area density; is the length of the test wire contained in the diaphragm; is the number of times the test line intersects the alveoli.
4. The method for assessing the degree of lung structural damage according to claim 3, characterized in that: Determining the total alveolar surface area according to the total alveolar volume, the alveolar surface area density, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli specifically includes: Using the formula Determine the total alveolar surface area; where, is the total alveolar surface area.
5. The method for assessing the degree of lung structural damage according to claim 4, characterized in that: Determining the average linear intercept of the alveoli according to the total surface area of the alveoli and the cavity volume of the alveoli and the airways, specifically includes: Using the formula Determine the alveolar mean linear intercept; where, is the mean linear intercept of alveoli; is the volume of the alveoli and airway cavities, It is the cavity between the alveoli and airways.
6. The method for assessing the degree of lung structural damage according to claim 1, characterized in that: The degree of damage to the lung structure is assessed based on the alveolar average linear intercept, specifically including: Determine whether the alveolar average linear intercept is within the intercept range to obtain a first determination result; If the first judgment result indicates that the average linear intercept of the alveoli is within the intercept range, it is determined that the lung structure is not damaged; If the first judgment result indicates that the average linear intercept of the alveoli is not within the intercept range, it is determined that the lung structure is damaged.
7. A device for assessing the degree of lung structure damage, characterized in that: The lung structure damage degree assessment device comprises: A lung parenchyma morphological parameter statistics module is used to use a stereological method to count the lung parenchyma morphological parameters at different scales after mechanical ventilation; the lung parenchyma morphological parameters include the volume of the lung, the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, the number of test points falling on the alveoli, the length of the test line contained in the diaphragm, the number of intersections between the test line and the alveoli, and the cavity volume of the alveoli and the airway; a total alveolar volume determination module, configured to determine the total alveolar volume according to the number of test points falling on the lung parenchyma, the number of test points falling on the lung, the number of test points falling on the diaphragm, and the number of test points falling on the alveoli; an alveolar surface area density determination module, for determining the alveolar surface area density according to the length of the test line contained in the diaphragm and the number of times the test line intersects with the alveoli; an alveolar total surface area determination module, configured to determine the alveolar total surface area according to the alveolar total volume, the alveolar surface area density, the number of the test points falling on the diaphragm, and the number of the test points falling on the alveoli; An alveolar average linear intercept determination module, used to determine the alveolar average linear intercept according to the alveolar overall surface area and the alveolar and airway cavity volume; The damage degree assessment module is used to assess the damage degree of the lung structure according to the alveolar average linear intercept.
8. A computer device comprising: A memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the computer program to implement the method for assessing the degree of lung structure damage according to any one of claims 1 to 6.
9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the method for assessing the degree of lung structure damage according to any one of claims 1 to 6 is implemented.
10. A computer program product, comprising a computer program, characterized in that When the computer program is executed by a processor, the method for assessing the degree of lung structure damage according to any one of claims 1 to 6 is implemented.