Dry pesticide suspending agent containing carbendazim and preparation method thereof

Abstract

The invention relates to the technical field of pesticide preparations, and particularly discloses a carbendazim-containing pesticide dry suspending agent and a preparation method thereof. The invention discloses a carbendazim-containing dry pesticide suspending agent. The dry pesticide suspending agent is prepared from the following raw materials in parts by weight: 35-40 parts of an active component, 25-35 parts of a carrier, 3-10 parts of a dispersing agent, 3-5 parts of a wetting agent, 5-10 parts of a stabilizer, 3-7 parts of a synergist, 1-2 parts of a buffering agent and 1-5 parts of a disintegrating agent, the active components are prepared from carbendazim, fluopyram, captan, difenoconazole, azoxystrobin and bacillus amyloliquefaciens freeze-dried powder.

Description

Technical Field

[0001] This application relates to the technical field of pesticide formulations, and particularly to a dry flowable pesticide containing carbendazim and a preparation method thereof. Background Art

[0002] Pesticides are an indispensable part of agricultural production and are used to protect crops from pests and diseases. As a broad-spectrum and highly effective fungicide, carbendazim has been widely used in agricultural production. However, traditional carbendazim formulations have problems such as poor stability, easy decomposition, and inconvenient use. Currently, the existing carbendazim formulations on the market are mostly in the form of emulsifiable concentrates, wettable powders, etc. Although these formulations have solved the problem of using carbendazim to a certain extent, they still have defects such as poor stability, easy moisture absorption and caking, and poor use effects. Summary of the Invention

[0003] In order to improve the use effect of carbendazim, this application provides a dry flowable pesticide containing carbendazim and a preparation method thereof.

[0004] In the first aspect, a dry flowable pesticide containing carbendazim provided by this application adopts the following technical solution: A dry flowable pesticide containing carbendazim, the raw materials of the dry flowable pesticide include the following components in parts by weight: 35 - 40 parts of active ingredient, 25 - 35 parts of carrier, 3 - 10 parts of dispersant, 3 - 5 parts of wetting agent, 5 - 10 parts of stabilizer, 3 - 7 parts of synergist, 1 - 2 parts of buffer, 1 - 5 parts of disintegrant; the active ingredient includes carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens.

[0005] By adopting the above technical solution, fluxapyroxad in the active ingredient inhibits succinic dehydrogenase, forms a dual block of energy metabolism with carbendazim, captan is a multi-site protective fungicide, enhancing the control of resistant strains, difenoconazole can interfere with cell membrane synthesis and expand the fungicidal spectrum, azoxystrobin synergizes with carbendazim to inhibit the mitochondrial respiration of pathogenic bacteria, and the freeze-dried powder of Bacillus amyloliquefaciens will dissolve the fungal cell membrane and produce osmotic synergy with chemical agents, thereby improving the use effect of carbendazim.

[0006] In a specific feasible embodiment, the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredient is 1:(0.2 - 0.3):(0.1 - 0.2):(0.15 - 0.25):(0.1 - 0.2):(0.2 - 0.3).

[0007] By adopting the above technical solution, the ratios of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredient are further defined, thereby improving the use effect of the obtained dry suspension agent.

[0008] In a specific feasible embodiment, the carrier comprises a mixture composed of attapulgite and corn starch.

[0009] By adopting the above technical solution, attapulgite has high adsorbability and can improve the fluidity of particles, and corn starch can enhance the wetting and dispersibility of particles. Therefore, by using the composite carrier composed of attapulgite and corn starch, the use effect of the obtained dry suspension agent can be further improved.

[0010] In a specific feasible embodiment, the dispersant comprises a mixture composed of sodium lignosulfonate and polycarboxylate dispersant.

[0011] By adopting the above technical solution, by using the composite dispersant composed of sodium lignosulfonate and polycarboxylate dispersant, each component in the raw materials can be dispersed evenly.

[0012] In a specific feasible embodiment, the wetting agent comprises alkylnaphthalene sulfonate.

[0013] In a specific feasible embodiment, the stabilizer comprises a mixture composed of nano-silica and polyvinylpyrrolidone.

[0014] In a specific feasible embodiment, the synergist comprises a mixture composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant.

[0015] By adopting the above technical solution, benzothiadiazole can improve the immunity of crops themselves, osthole and matrine can further improve the bactericidal performance of the dry suspension agent, trehalose protects the activity of biological agents and improves stress resistance, and silicone surfactant enhances the spreading property of the liquid medicine. Therefore, by using the composite synergist composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant, the use effect of the dry suspension agent can be further improved.

[0016] In a specific feasible embodiment, the buffer comprises a mixture composed of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate.

[0017] By adopting the above technical solution, by using the buffer composed of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate, the stability of the obtained dry suspension agent can be improved.

[0018] In a specific feasible embodiment, the disintegrant comprises sodium carboxymethyl starch.

[0019] Second aspect, a preparation method of a carbendazim-containing pesticide dry suspension agent provided by the present application adopts the following technical solution: A preparation method of a carbendazim-containing pesticide dry suspension agent includes the following steps: First, uniformly stir and mix the active ingredient, carrier, dispersant, wetting agent, stabilizer, synergist, buffer, and disintegrant, then add water and stir evenly to obtain a mixture, and then subject the mixture to sand grinding treatment to obtain a suspension with a particle size D50 < 2 μm; Use a spray dryer to perform spray granulation on the suspension under the conditions that the inlet hot air temperature is 120 - 150 °C and the outlet hot air temperature is 60 - 90 °C to obtain the pesticide dry suspension agent.

[0020] By adopting the above technical solution, first mix the active ingredient, carrier, dispersant, wetting agent, stabilizer, synergist, buffer, and disintegrant, then add water for mixing and sand grinding, and finally perform spray granulation using a spray dryer to obtain a pesticide dry suspension agent with good stability and good use effect.

[0021] In summary, the present application includes at least one of the following beneficial technical effects: 1. In the present application, fluxapyroxad in the active ingredient inhibits succinate dehydrogenase, forms a dual block of energy metabolism with carbendazim. Captan is a multi-site protective fungicide, enhancing the control of resistant strains. Difenoconazole can interfere with cell membrane synthesis and expand the bactericidal spectrum. Azoxystrobin synergistically enhances the effect with carbendazim, inhibiting the mitochondrial respiration of pathogenic bacteria. The freeze-dried powder of Bacillus amyloliquefaciens will dissolve the fungal cell membrane and produce penetration synergy with chemical agents, thereby improving the use effect of carbendazim; 2. In the present application, benzothiadiazole can improve the immunity of crops themselves. Osthole and matrine can further improve the bactericidal performance of the dry suspension agent. Trehalose protects the activity of biological agents and improves stress resistance. The silicone surfactant enhances the spreading property of the liquid medicine. Therefore, the composite synergist composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant can further improve the use effect of the dry suspension agent; 3. In the method of the present application, first mix the active ingredient, carrier, dispersant, wetting agent, stabilizer, synergist, buffer, and disintegrant, then add water for mixing and sand grinding, and finally perform spray granulation using a spray dryer to obtain a pesticide dry suspension agent with good stability and good use effect. Specific Embodiments

[0022] The following further elaborates on the present application in conjunction with examples.

[0023] All raw materials in the examples are commercially available. Among them, the polycarboxylate dispersant is sodium polyacrylate; the alkylnaphthalene sulfonate is sodium alkylnaphthalene sulfonate; the silicone surfactant is Silwet L-77. Example

[0024] Example 1 Example 1 provides a preparation method of a carbendazim-containing pesticide dry suspension, including the following steps: First, 35 kg of active ingredients, 25 kg of carrier, 3 kg of dispersant, 3 kg of wetting agent, 5 kg of stabilizer, 3 kg of synergist, 1 kg of buffer, and 1 kg of disintegrant are stirred and mixed evenly. Then, 125 kg of water is added and stirred evenly to obtain a mixture. Then, the mixture is subjected to sand grinding treatment to obtain a suspension with a particle size D50 < 2 μm; the active ingredients are a mixture composed of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens, and the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens is 1:0.15:0.05:0.1:0.05:0.15; the carrier is a mixture composed of attapulgite and corn starch, and the weight ratio of attapulgite and corn starch is 2:1; the dispersant is a mixture composed of sodium lignosulfonate and polycarboxylate dispersant, and the weight ratio of sodium lignosulfonate and polycarboxylate dispersant is 5:3; the wetting agent is alkylnaphthalene sulfonate; the stabilizer is a mixture composed of nano-silica and polyvinylpyrrolidone, and the weight ratio of nano-silica and polyvinylpyrrolidone is 2:1; the synergist is a mixture composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant, and the weight ratio of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant is 1:2:1:3:2; the buffer is a mixture composed of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate, and the weight ratio of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate is 3:1:2; the disintegrant is sodium carboxymethyl starch; The suspension is spray granulated using a spray dryer under the conditions of an inlet hot air temperature of 135 °C and an outlet hot air temperature of 75 °C to obtain the pesticide dry suspension.

[0025] Example 2 Example 2 provides a preparation method of a carbendazim-containing pesticide dry suspension, including the following steps: First, 37.5 kg of active ingredients, 30 kg of carrier, 6.5 kg of dispersant, 4 kg of wetting agent, 7.5 kg of stabilizer, 5 kg of synergist, 1.5 kg of buffer, and 3 kg of disintegrant are stirred and mixed evenly. Then, 160 kg of water is added and stirred evenly to obtain a mixture. Next, the mixture is subjected to sand grinding treatment to obtain a suspension with a particle size D50 < 2 μm; the active ingredients are a mixture composed of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried Bacillus amyloliquefaciens powder, and the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried Bacillus amyloliquefaciens powder is 1:0.15:0.05:0.1:0.05:0.15; the carrier is a mixture composed of attapulgite and corn starch, and the weight ratio of attapulgite and corn starch is 2:1; the dispersant is a mixture composed of sodium lignosulfonate and polycarboxylate dispersant, and the weight ratio of sodium lignosulfonate and polycarboxylate dispersant is 5:3; the wetting agent is alkylnaphthalenesulfonate; the stabilizer is a mixture composed of nano-silica and polyvinylpyrrolidone, and the weight ratio of nano-silica and polyvinylpyrrolidone is 2:1; the synergist is a mixture composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant, and the weight ratio of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant is 1:2:1:3:2; the buffer is a mixture composed of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate, and the weight ratio of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate is 3:1:2; the disintegrant is sodium carboxymethyl starch; The suspension is spray granulated using a spray dryer under the conditions of an inlet hot air temperature of 135°C and an outlet hot air temperature of 75°C to obtain a dry flowable pesticide.

[0026] Example 3 Example 3 provides a method for preparing a dry flowable pesticide containing carbendazim, comprising the following steps: First, 40 kg of active ingredients, 35 kg of carrier, 10 kg of dispersant, 5 kg of wetting agent, 10 kg of stabilizer, 7 kg of synergist, 2 kg of buffer, and 5 kg of disintegrant are stirred and mixed evenly. Then, 190 kg of water is added and stirred evenly to obtain a mixture. Next, the mixture is subjected to sand grinding treatment to obtain a suspension with a particle size D50 < 2 μm; the active ingredients are a mixture composed of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens, and the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens is 1:0.15:0.05:0.1:0.05:0.15; the carrier is a mixture composed of attapulgite and corn starch, and the weight ratio of attapulgite and corn starch is 2:1; the dispersant is a mixture composed of sodium lignosulfonate and polycarboxylate dispersant, and the weight ratio of sodium lignosulfonate and polycarboxylate dispersant is 5:3; the wetting agent is alkylnaphthalenesulfonate; the stabilizer is a mixture composed of nano-silica and polyvinylpyrrolidone, and the weight ratio of nano-silica and polyvinylpyrrolidone is 2:1; the synergist is a mixture composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant, and the weight ratio of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant is 1:2:1:3:2; the buffer is a mixture composed of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate, and the weight ratio of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate is 3:1:2; the disintegrant is sodium carboxymethyl starch; The suspension is spray granulated using a spray dryer under the conditions of an inlet hot air temperature of 135 °C and an outlet hot air temperature of 75 °C to obtain a dry flowable pesticide.

[0027] Example 4 The difference between Example 4 and Example 2 is that the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredients is 1:0.2:0.1:0.15:0.1:0.2; the remaining steps are the same as those in Example 2.

[0028] Example 5 The difference between Example 5 and Example 2 is that the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredients is 1:0.25:0.15:0.2:0.15:0.25; the remaining steps are the same as those in Example 2.

[0029] Example 6 Example 6 is different from Example 2 in that the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredient is 1:0.3:0.2:0.25:0.2:0.3; the remaining steps are the same as those in Example 2.

[0030] Example 7 Example 7 is different from Example 2 in that the weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredient is 1:0.35:0.25:0.3:0.25:0.35; the remaining steps are the same as those in Example 2.

[0031] Example 8 Example 8 is different from Example 5 in that the carrier is attapulgite; the remaining steps are the same as those in Example 5.

[0032] Example 9 Example 9 is different from Example 5 in that the carrier is corn starch; the remaining steps are the same as those in Example 5.

[0033] Example 10 Example 10 is different from Example 5 in that the synergist is a mixture of benzothiadiazole, osthole, and matrine, and the weight ratio of benzothiadiazole, osthole, and matrine is 1:2:1; the remaining steps are the same as those in Example 5.

[0034] Example 11 Example 11 is different from Example 5 in that the synergist is a mixture of trehalose and silicone surfactant, and the weight ratio of trehalose and silicone surfactant is 3:2; the remaining steps are the same as those in Example 5.

[0035] Comparative Example Comparative Example 1 Comparative Example 1 is different from Example 1 in that the active ingredient is a mixture of carbendazim, fluxapyroxad, and captan, and the weight ratio of carbendazim, fluxapyroxad, and captan is 1:0.15:0.05; the remaining steps are the same as those in Example 5.

[0036] Comparative Example 2 Comparative Example 2 is different from Example 1 in that the active ingredient is a mixture of carbendazim, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens, and the weight ratio of carbendazim, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens is 1:0.1:0.05:0.15; the remaining steps are the same as those in Example 5.

[0037] Performance detection test of control effect: The dry flowable agent in this application was used to conduct experiments on paddy fields. When in use, it was diluted with ten times the amount of water, and the application rate was 20 g per mu. The control effects 7 days and 14 days after spraying were detected.

[0038] Table 1 Performance detection results of the dry flowable agent Combined with Example 1 and Comparative Examples 1-2, the control effect of the dry flowable agent in Example 1 was the best. It can be seen that when preparing the suspension, the active ingredients are preferably a mixture composed of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens. Fluxapyroxad in the active ingredients inhibits succinate dehydrogenase and forms a double block of energy metabolism with carbendazim. Captan is a multi-site protective fungicide that enhances the control of resistant strains. Difenoconazole can interfere with cell membrane synthesis and expand the bactericidal spectrum. Azoxystrobin and carbendazim have synergistic effects and inhibit the mitochondrial respiration of pathogenic bacteria. The freeze-dried powder of Bacillus amyloliquefaciens will dissolve the fungal cell membrane and produce osmotic synergy with chemical agents. Therefore, using the composite active ingredients composed of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens improves the control effect of the finally obtained dry flowable agent.

[0039] Combined with Examples 1-3, the control effect of the dry flowable agent in Example 2 was the best. It can be seen that when preparing the suspension, increasing the usage amount of raw materials shows a trend of first rising and then falling in the control effect of the obtained dry flowable agent.

[0040] Combined with Example 2 and Examples 4-7, the control effects of the dry flowable agents in Examples 4-6 were the best. It can be seen that when adding the active ingredients, the preferred ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredients is 1:(0.2 - 0.3):(0.1 - 0.2):(0.15 - 0.25):(0.1 - 0.2):(0.2 - 0.3), and the control effect of the obtained dry flowable agent is better.

[0041] Combined with Example 5, Example 8 and Example 9, the control effect of the dry flowable agent in Example 5 was the best. It can be seen that when adding the carrier, the carrier is preferably a mixture composed of attapulgite and corn starch, which can further improve the control effect of the obtained dry flowable agent.

[0042] Combined with Example 5, Example 10 and Example 11, the control effect of the dry flowable agent in Example 5 was the best. It can be seen that when adding the synergist, the synergist is preferably a mixture composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant, which can further improve the control effect of the obtained dry flowable agent.

[0043] This specific embodiment is only an interpretation of the present application and does not limit the present application. After reading this specification, those skilled in the art can make modifications to this embodiment without creative contributions as needed, but as long as it is within the scope of the claims of the present application, it is protected by the patent law.

Claims

1. A carbendazim-containing dry flowable pesticide, characterized in that: The raw materials of the pesticide dry suspension include the following components in parts by weight: 35-40 parts of active ingredient, 25-35 parts of carrier, 3-10 parts of dispersant, 3-5 parts of wetting agent, 5-10 parts of stabilizer, 3-7 parts of synergist, 1-2 parts of buffer, and 1-5 parts of disintegrant; the active ingredient includes carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens.

2. The carbendazim-containing dry flowable pesticide according to claim 1, wherein: The weight ratio of carbendazim, fluxapyroxad, captan, difenoconazole, azoxystrobin, and freeze-dried powder of Bacillus amyloliquefaciens in the active ingredient is 1:(0.2-0.3):(0.1-0.2):(0.15-0.25):(0.1-0.2):(0.2-0.3).

3. The dry flowable pesticide containing carbendazim according to claim 1, wherein: The carrier includes a mixture composed of attapulgite and corn starch.

4. A carbendazim-containing dry flowable pesticide according to claim 1, characterized in that: The dispersant includes a mixture composed of sodium lignosulfonate and polycarboxylate dispersant.

5. A carbendazim-containing dry flowable pesticide according to claim 1, wherein: The wetting agent includes alkylnaphthalenesulfonate.

6. A carbendazim-containing dry flowable pesticide according to claim 1, characterized in that: The stabilizer includes a mixture composed of nano-silica and polyvinylpyrrolidone.

7. A dry suspension pesticide containing carbendazim according to claim 1, characterized in that: The synergist includes a mixture composed of benzothiadiazole, osthole, matrine, trehalose, and silicone surfactant.

8. A carbendazim-containing pesticide dry suspension agent according to claim 1, characterized in that: The buffer includes a mixture composed of citric acid, sodium citrate, and disodium ethylenediaminetetraacetate.

9. A dry suspension pesticide containing carbendazim according to claim 1, characterized in that: The disintegrant includes sodium carboxymethyl starch.

10. A preparation method of a carbendazim-containing pesticide dry suspension agent as described in any one of claims 1-9, characterized in that: It includes the following steps: First, stir and mix the active ingredient, carrier, dispersant, wetting agent, stabilizer, synergist, buffer, and disintegrant evenly, then add water and stir evenly to obtain a mixture, and then subject the mixture to sand grinding treatment to obtain a suspension with a particle size D50 < 2 μm; Perform spray granulation on the suspension using a spray dryer under the conditions of an inlet hot air temperature of 120-150 °C and an outlet hot air temperature of 60-90 °C to obtain the pesticide dry suspension.

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