3D printing medical simulation pathological dummy manufacturing method

Abstract

The invention discloses a manufacturing method of a 3D printing medical simulation pathological dummy. The manufacturing method is characterized by comprising the following steps: step 1, data acquisition and processing; 2, reconstructing a model; step 3, forming the shell; 4, silica gel forming; and 5, assembling the trunk. According to the method, three-dimensional construction is carried out based on three-dimensional reconstruction of real patient data and parameterized design of a pathological anatomical structure through a personalized pathological modeling technology; according to the invention, organ tissue simulation production is carried out through a hollow shell and silica gel filling composite molding technology and an organ tissue hardness gradient simulation method; according to the method, model production can be accurately completed through modular organ positioning and transparent substrate visualization technologies; the model prepared by the method has the advantages that the organ tissue hardness error lt is realized; the method has the advantages that the precision of the anatomical position reaches + / -0.5 mm, the service life is prolonged to 3 times that of a conventional model, the manufacturing cost is reduced by more than 40%, and the performance of the model can be ensured on the premise that the manufacturing cost is improved and reduced.

Description

Technical Field

[0001] The invention belongs to the field of medical teaching model manufacturing, and specifically relates to a method for manufacturing a 3D printed medical simulation pathological dummy. Background Art

[0002] Currently, the use of human body mannequins as teaching aids is becoming increasingly widespread both domestically and internationally. Plastic and rigid mannequins are commonly used for teaching in the domestic market. These mannequins are primarily manufactured using traditional mold-making processes. The human body is complex, and traditional mannequins are completely opaque, making it impossible to visually present the body's internal structure, a significant inconvenience for teaching. Using traditional manufacturing methods to present detailed internal structures would be extremely costly and difficult to implement. Currently, medical schools and various medical institutions mostly use real people as training subjects, posing significant safety risks and potential safety hazards. Therefore, the production of medical simulation pathological mannequins is extremely important. This invention utilizes 3D printing rapid prototyping technology to significantly shorten the model's production cycle, improve teaching efficiency, and shorten the development cycle of surgeons.

[0003] Existing surgical training models have two core flaws:

[0004] 1. Anatomical distortion: Commercial models are mostly based on healthy human anatomical data and cannot simulate pathological conditions such as tumor infiltration and organ adhesions (e.g., varicose veins in cirrhosis and pleural adhesions in lung cancer);

[0005] 2. Interaction limitations: Traditional silicone models lack force feedback authenticity, which can easily lead to instrument motion errors (>2mm) during surgical robot training and cannot support complex surgical procedures (such as laparoscopic organ separation and vascular reconstruction).

[0006] Therefore, traditional medical teaching models have the following shortcomings: standardized models cannot reflect individual pathological characteristics, plaster or plastic models lack real tissue touch, multi-organ integration is poor, anatomical structure is distorted, the cost of pathological structure production is high, and existing silicone models are difficult to achieve precise anatomical positioning. Summary of the Invention

[0007] The present invention provides a 3D printing medical simulation pathological dummy manufacturing method to solve the defects in the prior art.

[0008] The present invention is achieved through the following technical solutions:

[0009] A 3D printed medical simulation pathological dummy manufacturing method is characterized by comprising the following steps:

[0010] Step 1: Data acquisition and processing: Obtain patient CT image data and use 3D-DOCTOR software to reconstruct organ and bone models;

[0011] Step 2: Reconstruct the model: Classify the bone model and organ model, convert them into STL format for 3D printing to produce a hollow shell, and control the shell thickness through the shell thickness control module;

[0012] Step 3: Shell molding: Use MaterialiseMagics software to optimize the model. Use RepetierHost software to slice the optimized STL format file to generate G-code file and use 3D printing for rapid molding.

[0013] Step 4: Silicone molding: Filling with silicone of different parameters and colors according to the tissue characteristics of different organs;

[0014] Step 5: Torso assembly: Make an integral torso shell, establish a three-dimensional positioning system to fix the skeletal organs in relative positions, and inject transparent silicone liquid between the torso shell and the skeletal organs. After cooling, the model is completed.

[0015] As described above, in the method for manufacturing a 3D-printed medical simulation pathological dummy, in step 1, the anatomical structure of the lesion is restored by obtaining patient-specific data, thereby enabling training in tumor resection boundary determination, abnormal blood vessel separation operation drills, organ adhesion lysis technology practice, and the construction of a real surgical environment.

[0016] In the above-mentioned method for manufacturing a 3D-printed medical simulation pathological dummy, the silicone filling in step 4 adopts a vacuum infusion process to ensure that no bubbles are generated during the infusion process into the shell, and the shell is destroyed by a low-temperature embrittlement treatment method after the silicone liquid cools.

[0017] In the above-mentioned method for manufacturing a 3D-printed medical simulation pathological dummy, gradient hardness silicone is used for filling in step 4 to provide real tissue penetration resistance and vascular suture tension simulation.

[0018] In the above-mentioned method for manufacturing a 3D-printed medical simulation pathological dummy, the strength of the gradient hardness silicone is 10-80A.

[0019] In the method for manufacturing a 3D-printed medical simulation pathological dummy as described above, the transparent silicone matrix of the model prepared in step five allows for real-time visualization observation during surgery, simulation of bleeding effects, and testing of the use of an electric knife or an ultrasonic knife.

[0020] The advantages of the present invention are: the present invention uses personalized pathology modeling technology and performs three-dimensional construction based on three-dimensional reconstruction of real patient data and parametric design of pathological anatomical structures; the present invention performs organ tissue simulation production through composite molding technology of hollow shell + silicone filling and organ tissue hardness gradient simulation method; the present invention can accurately complete model production through modular organ positioning and transparent matrix visualization technology; the model prepared by the above method has the advantages of achieving organ tissue hardness error <5%, anatomical position accuracy of ±0.5mm, pathological feature restoration degree >90%, service life extended to 3 times that of conventional models, and production cost reduced by more than 40%, thereby ensuring the performance of the model while improving and reducing preparation cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0022] Figure 1 It is a schematic diagram of CT image data of the present invention;

[0023] Figure 2 The schematic diagram of the organ model is generated by three-dimensional reconstruction of the CT image data of the present invention using 3D-DOCTOR software;

[0024] Figure 3 is a schematic diagram of a reconstruction model of the present invention;

[0025] Figure 4 is a schematic diagram of the present invention using MaterialiseMagics software to perform model optimization processing;

[0026] Figure 5 This is a schematic diagram of the present invention using RepetierHost software to slice and generate a g-code file;

[0027] Figure 6 is a cross-sectional view of the shell structure prepared by the present invention;

[0028] Figure 7 This is a schematic diagram of the structure of the silica gel after filling and molding of the present invention;

[0029] Figure 8 This is one of the schematic diagrams of the 3D printed housing of the present invention;

[0030] Figure 9 This is the second schematic diagram of the 3D printed housing of the present invention;

[0031] Figure 10 This is the third schematic diagram of the 3D printed housing of the present invention;

[0032] Figure 11 This is the fourth schematic diagram of the 3D printed housing of the present invention;

[0033] Figure 12 This is the fifth schematic diagram of the 3D printed housing of the present invention;

[0034] Figure 13 Schematic diagram of a liver lesion model produced according to an embodiment of the present invention. DETAILED DESCRIPTION

[0035] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0036] A 3D printed medical simulation pathological dummy manufacturing method comprises the following steps:

[0037] Step 1: Data acquisition and processing: Obtain patient CT image data (such as Figure 1 3D-DOCTOR software was used to generate organ and bone models (as shown) Figure 2 shown);

[0038] like Figure 3 As shown, step 2: Reconstruct the model: classify the bone model and organ model, convert them into STL format for 3D printing to make a hollow shell (the bones and organs are independently formed), and control the shell thickness through the shell thickness control module (to ensure a uniform wall thickness of 2±0.1mm);

[0039] Step 3: Shell molding: Use MaterialiseMagics software to optimize the model (wall thickness 2mm, hollow structure design, such as Figure 4 As shown) Use the RepetierHost software to slice the optimized STL format file and generate g-code (as shown Figure 5 As shown) file using 3D printing rapid prototyping (as shown) Figure 6 and Figure 8-12 shown);

[0040] Step 4: Silicone molding: According to the tissue characteristics of different organs, configure different parameters and different colors of silicone for filling (the bone tissue obtained is as follows Figure 7 shown);

[0041] Step 5: Torso assembly: Make an integral torso shell, establish a three-dimensional positioning system (organ spatial coordinate matching), fix the skeletal organs in relative positions, and inject transparent silicone liquid between the torso shell and the skeletal organs. After cooling, the model is completed.

[0042] Specifically, in step 1 described in this embodiment, the anatomical structure of the lesion (such as pancreatic cancer invading the portal vein and endometriosis adhesions) is restored by obtaining patient-specific data, thereby enabling training in tumor resection boundary determination, abnormal blood vessel separation operation drills, organ adhesion lysis technology practice, and the construction of a real surgical environment.

[0043] Specifically, the silica gel filling in step 4 of this embodiment adopts a vacuum infusion process to ensure that no bubbles are generated during the infusion process into the shell, and the shell is destroyed by a low-temperature embrittlement treatment method after the silica gel liquid cools down.

[0044] More specifically, in step 4 of this embodiment, gradient hardness silicone is used for filling to provide real tissue penetration resistance (such as liver puncture force value matching: 1.8±0.3N) and vascular suture tension simulation (silicone ductility ≥300%).

[0045] Furthermore, the strength of the gradient hardness silicone described in this embodiment is 10-80A.

[0046] Furthermore, the transparent silicone matrix of the model prepared in step five of this embodiment allows for real-time visual observation during surgery (simulating an endoscopic perspective), simulation of bleeding effects (the hollow vascular network can be connected to an artificial circulatory system), and testing of the use of an electric knife or an ultrasonic knife (the silicone temperature resistance is above 200°C).

[0047] Example Liver lesion model preparation

[0048] First, CT data of patients with cirrhosis of the liver were obtained through clinical cases. After processing, the data were converted into a three-dimensional solid model to extract and reconstruct the three-dimensional liver model (the shell wall thickness was 2mm). The data was converted into STL format, and then a g-code file was generated through 3D printing slicing software such as Repetier Host. PLA material was used for 3D printing and liquid silicone was poured (different organs used different hardness and color silicone). After the silicone cooled and solidified, the PLA shell was removed to obtain a silicone liver model entity. The above method was used to make other organs, bones and the human torso contour shell. Finally, according to the relative positions of the organs and bones, they were fixed in the torso shell and transparent silicone liquid was poured between the torso shell and each organ and bone to obtain a liver lesion model (such as Figure 13As shown in the figure, actual use has proved that the liver lesion model prepared by the present invention has an organ tissue hardness error of 2.8%, an anatomical position accuracy of ±0.4mm, a pathological feature restoration degree of 93%, and a production cost reduced by 43%. Thus, while ensuring the simulation degree of the prepared model, the production cost can be greatly reduced, thereby facilitating wide promotion and use.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A method for manufacturing a 3D printed medical simulation pathological dummy, characterized by: The steps include: Step 1: Data acquisition and processing: Obtain patient CT image data and use 3D-DOCTOR software to reconstruct organ and bone models; Step 2: Reconstruct the model: Classify the bone model and organ model, convert them into STL format for 3D printing to produce a hollow shell, and control the shell thickness through the shell thickness control module; Step 3: Shell molding: Use MaterialiseMagics software to optimize the model. Use RepetierHost software to slice the optimized STL format file to generate G-code file and use 3D printing for rapid molding. Step 4: Silicone molding: Filling with silicone of different parameters and colors according to the tissue characteristics of different organs; Step 5: Torso assembly: Make an integral torso shell, establish a three-dimensional positioning system to fix the skeletal organs in relative positions, and inject transparent silicone liquid between the torso shell and the skeletal organs. After cooling, the model is completed.

2. A 3D printed medical simulation pathological dummy manufacturing method according to claim 1, characterized in that: In step 1, the anatomical structure of the lesion is restored by acquiring patient-specific data, thereby enabling training in tumor resection boundary determination, abnormal blood vessel separation operation drills, organ adhesion lysis technology practice, and the construction of a real surgical environment.

3. The method for manufacturing a 3D printed medical simulation pathological dummy according to claim 1, characterized in that: The silica gel filling in the fourth step adopts a vacuum infusion process to ensure that no bubbles are generated during the infusion process into the shell. After the silica gel liquid cools down, the shell is destroyed by a low-temperature embrittlement treatment method.

4. The method for manufacturing a 3D printed medical simulation pathological dummy according to claim 1, characterized in that: In step 4, gradient hardness silicone is used for filling to provide real tissue penetration resistance and vascular suture tension simulation.

5. The method for manufacturing a 3D printed medical simulation pathological dummy according to claim 4, characterized in that: The strength of the gradient hardness silica gel is 10-80A.

6. The method for manufacturing a 3D printed medical simulation pathological dummy according to claim 1, characterized in that: The transparent silicone matrix of the model prepared in step 5 allows for real-time visualization observation during surgery, simulation of bleeding effects, and testing of the use of an electric knife or an ultrasonic knife.

Images