Oral care composition, mouth wash and preparation method of mouth wash

Abstract

The invention relates to the technical field of daily chemical products, and provides an oral care composition, mouth wash and a preparation method thereof. The oral care composition provided by the invention is prepared from 1.5 to 5 parts of humic acid, 1.5 to 5 parts of biological glycolipid, 0.5 to 3 parts of ampelopsis grossedentata enzyme, 0 to 1 part of alcohol-water extract of chrysanthemum flowers and 0 to 0.3 part of chelating agent. The oral care composition provided by the invention can effectively soften, decompose and chelate components in dental calculus, and has a remarkable removal effect on mature dental calculus; meanwhile, the composition can effectively remove food residues in the oral cavity and inhibit mass propagation of oral bacteria so as to reduce the formation of dental plaque, has the effects of diminishing inflammation, preventing decayed teeth, refreshing breath and the like, and has a wide application prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemical products, in particular to an oral care composition, a mouthwash and a preparation method thereof. Background Art

[0002] Dental calculus (also known as dental plaque) is the calcified or calcified plaque and sediment deposited on the surface of teeth. Poor oral hygiene can easily lead to the mixing of oral bacteria and food proteins to form dental plaque. Plaque that is not promptly removed continues to accumulate and mixes with food debris to form tartar. Minerals in the tartar continue to accumulate and gradually calcify, forming tartar.

[0003] The speed, distribution, and hardness of calcified plaque, which forms tartar, vary from person to person. Generally, calcification begins within 1 to 14 days of plaque formation, gradually forming tartar. Mature tartar is hard and firmly attached to the tooth surface. It takes months to years to develop into hard, solid, old tartar. Tartar not only affects one's appearance but can also cause other oral diseases, such as bad breath, red, swollen, or bleeding gums, and gum atrophy. Mature tartar usually requires removal at a professional dental clinic using handheld instruments or ultrasonic equipment.

[0004] Nowadays, there are a large number of products on the market for removing tartar, such as mouthwash, toothpaste, etc., but these products are usually only effective for early soft plaque and have little effect on removing mature tartar. Summary of the Invention

[0005] In view of this, the present invention provides an oral care composition, a mouthwash, and a preparation method thereof. The oral care composition provided by the present invention can reduce the formation of dental plaque, decompose dental plaque, and particularly remove mature dental calculus. It also has anti-inflammatory, antibacterial, caries-preventing, and breath-freshening effects.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] An oral care composition comprises the following components in parts by mass: 1.5-5 parts of humic acid, 1.5-5 parts of bioglycolipids, 0.5-3 parts of rattan tea enzyme, 0-1 part of an alcohol-water extract of Globenia chrysantha flowers, and 0-0.3 part of a chelating agent, wherein the amount of the chelating agent and the alcohol-water extract of Globenia chrysantha flowers is 0 at the same time.

[0008] Preferably, the preparation method of the alcohol-water extract of the chrysanthemum flower comprises: mixing crushed chrysanthemum flower material and ethanol aqueous solution for extraction to obtain an extract; concentrating the extract to obtain the alcohol-water extract of the chrysanthemum flower; the volume fraction of ethanol in the ethanol aqueous solution is 70-80%, and the amount ratio of the crushed chrysanthemum flower material and the ethanol aqueous solution is 1g:10-15mL; the extraction temperature is 50-55°C, the number of extractions is 2-3 times, and the time of each extraction is 3-4h.

[0009] Preferably, the preparation method of the rattan tea enzyme comprises:

[0010] Mixing the stems and leaves of Camellia oleifera with water and performing homogenous crushing to obtain a homogeneous crushed product;

[0011] The homogenized crushed material, sugar source and yeast are mixed and fermented to obtain rattan tea enzyme;

[0012] The speed of the homogenizing crushing is 2000-3000 rpm; the time of the homogenizing crushing is 5-8 minutes;

[0013] The fermentation temperature is 28-33° C. and the fermentation time is 45-53 hours.

[0014] Preferably, the chelating agent includes one or more of tetrasodium glutamate diacetate, sodium phytate, trisodium alanine diacetate and sodium α-glucoheptonate.

[0015] Preferably, the bioglycolipids include one or more of rhamnolipids, sophorolipids, trehalolipids and mannose-erythritol lipids.

[0016] The present invention also provides the use of the oral care composition described in the above solution in oral cleaning products for non-therapeutic purposes.

[0017] The present invention also provides a mouthwash comprising the oral care composition described in the above solution.

[0018] Preferably, the mouthwash comprises the following components in parts by weight:

[0019] 1.5-5 parts of humic acid, 1.5-5 parts of bioglycolipids, 0.5-3 parts of vine tea enzyme, 0-1 part of the alcohol water extract of Globe aquaticum flower, 0-0.3 part of chelating agent, 2-10 parts of moisturizing agent, 0.3-1 part of preservative, 74-95 parts of water, and the amount of chelating agent and the alcohol water extract of Globe aquaticum flower is 0 when they are different.

[0020] Preferably, the moisturizer includes glycerin and sorbitol; and the preservative includes sodium benzoate and potassium sorbate.

[0021] The present invention also provides a method for preparing the mouthwash described in the above scheme, comprising the following steps:

[0022] mixing a moisturizer and water to obtain a moisturizer solution;

[0023] Humic acid, bioglycolipid, vine tea enzyme, an alcohol-water extract of Globenia chrysantha flowers, and a chelating agent are mixed to obtain an oral care composition; when the amount of the alcohol-water extract of Globenia chrysantha flowers or the chelating agent is 0, the addition of the alcohol-water extract of Globenia chrysantha flowers or the chelating agent is omitted;

[0024] mixing the moisturizer solution and the oral care composition to obtain a composite solution;

[0025] The composite solution and the preservative are mixed to obtain the mouthwash.

[0026] The present invention provides an oral care composition comprising the following components by weight: 1.5-5 parts of humic acid, 1.5-5 parts of bioglycolipids, 0.5-3 parts of vine tea enzyme, 0-1 part of an alcohol-water extract of Globe acanthus flowers, and 0-0.3 parts of a chelating agent. In the present invention, the humic acid can decompose dental calculus, provide anti-oxidation, and reduce inflammation; the bioglycolipid can cleanse, reduce inflammation, and soften dental calculus; the vine tea enzyme can soften dental calculus, provide anti-oxidation, reduce inflammation, and alleviate symptoms such as oral ulcers; the alcohol-water extract of Globe acanthus flowers can relieve inflammation and enhance immunity; and the chelating agent can chelate metal ions such as calcium and magnesium in the oral cavity and dental calculus, softening dental calculus and reducing its formation. In summary, the oral care composition provided by the present invention can effectively soften, decompose, and chelate the components in dental calculus, and has a significant effect on removing mature dental calculus; at the same time, the composition of the present invention can also effectively remove food residues in the oral cavity, inhibit the massive reproduction of oral bacteria, thereby reducing the formation of dental plaque, and also has the effects of anti-inflammatory, preventing tooth decay, and freshening breath, and has broad application prospects. DETAILED DESCRIPTION

[0027] The present invention provides an oral care composition, comprising the following components in parts by mass: 1.5 to 5 parts of humic acid, 1.5 to 5 parts of bioglycolipids, 0.5 to 3 parts of vine tea enzymes, 0 to 1 part of an alcohol-water extract of Globenia chrysantha flowers, and 0 to 0.3 parts of a chelating agent, wherein the amounts of the chelating agent and the alcohol-water extract of Globenia chrysantha flowers are not the same and are 0.

[0028] Unless otherwise specified, the oral care compositions provided by the present invention are all commercially available products.

[0029] The oral care composition provided by the present invention comprises 1.5 to 5 parts of humic acid, specifically 2 parts, 3 parts, 4 parts or 5 parts, by mass. The humic acid can decompose dental plaque, and has anti-oxidation and anti-inflammatory effects.

[0030] Based on the mass fraction of the humic acid, the oral care composition includes 1.5 to 5 parts of bioglycolipids, specifically 2 parts, 3 parts, 4 parts or 5 parts; the bioglycolipids preferably include one or more of rhamnolipids, sophorolipids, trehalolipids and mannolipids; the bioglycolipids can play the role of cleaning, anti-inflammatory and softening dental calculus.

[0031] Based on the mass fraction of the humic acid, the oral care composition includes 0.5 to 3 parts of rattan tea enzyme, specifically 1 part, 2 parts or 3 parts.

[0032] In the present invention, the preparation method of the rattan tea enzyme preferably comprises: mixing the rattan tea stems and leaves with water and homogenizing and crushing them to obtain a homogenous crushed product; mixing the homogenized crushed product, a sugar source and a yeast and fermenting them to obtain the rattan tea enzyme; the rattan tea stems and leaves are specifically fresh rattan tea stems and leaves; before mixing the rattan tea stems and leaves with water, the rattan tea stems and leaves are preferably cut into 2-3 cm segments and cleaned; the rotation speed of the homogenizing and crushing is preferably 2000-3000 rpm, specifically 2000 rpm, 2500 rpm and 3000 rpm. or 3000 rpm; the homogenization time is preferably 5 to 8 minutes; the homogenization temperature is room temperature; the ratio of the stems and leaves of the rattan tea to water is preferably 1g:3mL, which is sufficient to immerse the stems and leaves of the rattan tea; the sugar source is preferably concentrated sugarcane juice, and the solid content of the concentrated sugarcane juice is preferably 60 to 65%, specifically 60%, 62% or 65%; the mass ratio of the homogenized product to the concentrated sugarcane juice is preferably 50:1; the inoculum size of the yeast is preferably 1×10 6 ~1×10 7 / mL, the optimal number of viable bacteria is 8×10 5 ~8×10 6 cfu / mL; in the present invention, the concentrated sugarcane juice and the homogenized crushed material are preferably first mixed uniformly, then introduced into a fermentation tank, sterilized, and then introduced into yeast, and then fermented; the fermentation temperature is preferably 30°C and the fermentation time is preferably 48 hours. After the fermentation is completed, the fermentation liquid is preferably centrifuged and then ultrafiltered and sterilized to obtain the vine tea enzyme.

[0033] In the present invention, the main components of the vine tea enzyme include flavonoids, polyphenols, vitamins and enzymes; the vine tea enzyme can soften dental plaque, resist oxidation, resist inflammation, and relieve symptoms such as oral ulcers.

[0034] Based on the mass fraction of the humic acid, the oral care composition includes 0 to 1 parts of the alcohol-water extract of Globenia flowers, specifically 0 parts (i.e., no alcohol-water extract of Globenia flowers is added), 0.2 parts, 0.5 parts, 0.8 parts or 1 parts.

[0035] In the present invention, the preparation method of the alcohol-water extract of the angelica flowers preferably comprises: mixing crushed angelica flowers with an ethanol aqueous solution for extraction to obtain an extract; and concentrating the extract to obtain the alcohol-water extract of the angelica flowers. The particle size of the chrysanthemum flower crushed material is preferably 1-3 mm, and the chrysanthemum flower crushed material is preferably obtained by crushing dried chrysanthemum flowers; the volume fraction of the ethanol aqueous solution is preferably 70-80%, specifically 70%, 75%, 78% or 80%; the amount ratio of the chrysanthemum flower crushed material to the ethanol aqueous solution is preferably 1 g:10-15 mL, specifically 1 g:10 mL, 1 g:12 mL or 1 g:15 mL; the extraction temperature is preferably 50-55° C., and the extraction is preferably carried out under condensation reflux conditions; the number of extractions is preferably 2-3 times, and the time for each extraction is preferably 3-4 hours; in the present invention, the extracts obtained from each extraction are preferably filtered and combined, and then concentrated; the concentration is preferably reduced pressure concentration, and the reduced pressure concentration is preferably carried out in a rotary evaporator. Ethanol is preferably recovered during the concentration process, and the remaining viscous liquid is the alcohol-water extract of chrysanthemum flowers; the content of active ingredients in the alcohol-water extract of chrysanthemum flowers is preferably 10-15wt%, the content of ethanol is 20-25wt%, and the balance is water. In the present invention, the alcohol water extract of the angelica flower can relieve inflammation and enhance immunity.

[0036] Based on the mass fraction of the humic acid, the oral care composition includes 0 to 0.3 parts of a chelating agent, specifically 0 parts (i.e., no chelating agent is added), 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts. The chelating agent is preferably one or more of tetrasodium glutamate diacetate, sodium phytate, trisodium alanine diacetate, and sodium α-glucoheptonate, more preferably tetrasodium glutamate diacetate; the chelating agent can chelate metal ions such as calcium and magnesium in the oral cavity and dental calculus, soften dental calculus, and reduce dental calculus formation.

[0037] The present invention also provides the use of the oral care composition described in the above solution in an oral cleaning product for non-therapeutic purposes. The oral cleaning product preferably includes toothpaste or mouthwash.

[0038] The present invention also provides a mouthwash comprising the oral care composition described in the above solution.

[0039] In the present invention, the mouthwash preferably includes the following components in parts by mass: 1.5 to 5 parts of humic acid, 1.5 to 5 parts of bioglycolipids, 1.5 to 3 parts of vine tea enzyme, 0 to 1 part of alcohol-water extract of chrysanthemum flowers, 0 to 0.3 parts of chelating agent, 2 to 10 parts of moisturizing agent, 0.3 to 1 part of preservative, and 74 to 95 parts of water.

[0040] In the present invention, the humic acid, bioglycolipid, rattan tea enzyme, water-alcohol extract of angelica flowers and chelating agent are the same as those in the above scheme, and will not be described in detail here.

[0041] In the present invention, based on the mass fraction of humic acid, the mouthwash includes 2 to 10 parts of moisturizing agent, specifically 2 parts, 3 parts, 4 parts, 5 parts or 6 parts; the moisturizing agent preferably includes glycerol and sorbitol (also known as sorbitol), specifically, the mass fraction of glycerol in the mouthwash is preferably 1 to 5 parts, and the mass fraction of sorbitol is preferably 1 to 5 parts.

[0042] In the present invention, based on the mass fraction of humic acid, the mouthwash includes 0.3 to 1 parts of preservatives, preferably 0.4 parts, and the preservatives preferably include sodium benzoate and potassium sorbate. The mass ratio of sodium benzoate to potassium sorbate is preferably 1:1; specifically, the mass fraction of sodium benzoate in the mouthwash is preferably 0.15 to 0.5 parts, preferably 0.2 parts, and the mass fraction of potassium sorbate is preferably 0.15 to 0.5 parts, more preferably 0.2 parts.

[0043] In the present invention, based on the mass fraction of humic acid, the mouthwash comprises 74 to 95 parts of water; the water is preferably deionized water.

[0044] The present invention also provides a method for preparing the mouthwash described in the above scheme, comprising the following steps:

[0045] Mixing the moisturizer and water (referred to as the first mixing) to obtain a moisturizer solution;

[0046] Humic acid, bioglycolipid, vine tea enzyme, an alcohol-water extract of schizonepeta tenuifolia flowers, and a chelating agent are mixed (referred to as the second mixture) to obtain an oral care composition; when the amount of the alcohol-water extract of schizonepeta tenuifolia flowers or the chelating agent is 0, the addition of the alcohol-water extract of schizonepeta tenuifolia flowers or the chelating agent is omitted;

[0047] mixing the moisturizer solution and the oral care composition (referred to as the third mixing) to obtain a composite solution;

[0048] The composite solution and the preservative are mixed (referred to as the fourth mixing) to obtain the mouthwash.

[0049] In the present invention, the first mixing, the second mixing and the fourth mixing are preferably stirred mixing. The present invention has no special requirements for the specific conditions of the stirring and mixing, as long as uniform mixing can be achieved; the third mixing is preferably stirred and homogenized in sequence, and the stirring is based on uniform stirring. The speed of the homogenization is preferably 2000 to 3000 rpm, specifically 2000 rpm, 2500 rpm or 3000 rpm, and the homogenization time is preferably 3 to 5 minutes.

[0050] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0051] In the following examples, humic acid was purchased from Guangzhou Binti Biotechnology Co., Ltd.; the bioglycolipid was specifically rhamnolipid, purchased from Yimingtai (Shandong) Biotechnology Co., Ltd.; and tetrasodium glutamate diacetate was purchased from Nanjing Huashi New Materials Co., Ltd.

[0052] The preparation method of the alcohol-water extract of zinnia flowers (hereinafter referred to as zinnia extract) is as follows: the dried zinnia flowers are crushed to a particle size of 1 to 3 mm, an ethanol aqueous solution with a volume fraction of 80% is added, and the ratio of the zinnia flower crushed material to ethanol is 1 g:10 mL. The extract is subjected to condensation reflux extraction at 50° C. for 3 hours each time, filtered, and the filtrate is combined. The filtrate is concentrated by reduced pressure evaporation at a constant temperature of 40° C. using a rotary evaporator, and the ethanol is recovered to obtain a thick liquid, which is the zinnia extract.

[0053] The preparation method of vine tea enzyme is as follows: fresh vine tea stems and leaves are cut into 2-3 cm segments, cleaned and placed in a homogenizer, water is added until the vine tea fragments are submerged (the ratio of vine tea fragments to water is 1g:3mL), and homogenization is carried out at 3000 rpm for 5 minutes at room temperature. Concentrated sugarcane juice (solid content of 60%) is then added, with the mass ratio of homogenized fragments to concentrated sugarcane juice being 50:1. The mixture is stirred evenly and placed in a fermentation tank. After sterilization, yeast is inoculated with an inoculum of 1×10 6 / mL, the number of viable bacteria is 8×10 5 cfu / mL. Fermented at 30°C for 48 hours, the vine tea enzyme was obtained after centrifugation, ultrafiltration, and sterilization.

[0054] Example 1

[0055] 1) Dissolve 3 kg of glycerol and 3 kg of sorbitol in 79.3 kg of deionized water to obtain a moisturizing solution.

[0056] 2) 5 kg of humic acid, 5 kg of bioglycolipid, 3 kg of rattan tea enzyme, 1 kg of schizonepeta tenuifolia extract and 0.3 kg of tetrasodium glutamate diacetate were mixed to obtain an oral care composition.

[0057] 3) adding the oral care composition in step 2) to the moisturizer solution in step 1), stirring evenly, and homogenizing at 2000 rpm for 3 minutes to obtain a composite solution.

[0058] 4) adding 0.2 kg of sodium benzoate and 0.2 kg of potassium sorbate to the composite solution of step 3), stirring and dissolving them uniformly to obtain a mouthwash.

[0059] Examples 2 to 9

[0060] The preparation method is the same as that in Example 1, and the amounts of the raw materials are shown in Table 1.

[0061] Comparative Examples 1 to 4

[0062] The preparation method is the same as that in Example 1, and the amounts of the raw materials are shown in Table 1.

[0063] Table 1 Raw material dosage of Examples 1 to 9 and Comparative Examples 1 to 4 (unit: kg)

[0064]

[0065]

[0066] The total amount of each raw material is 100 kg, and the mass of water is calculated by subtracting the mass of the remaining raw materials from 100 kg.

[0067] Test Example 1 Inhibition Zone Test

[0068] The inhibition zone test is a commonly used microbiological experimental method used to evaluate the inhibitory effect of antimicrobial substances on microorganisms. The specific steps of the inhibition zone test are as follows:

[0069] Materials preparation:

[0070] Culture medium: nutrient agar culture medium; bacterial strain: Escherichia coli; antibacterial substance: mouthwash prepared in Examples 1 to 9 and Comparative Examples 1 to 4.

[0071] Sterile equipment: culture dishes, pipettes, sterile cotton swabs, etc. Constant temperature incubator: used for culturing microorganisms.

[0072] Experimental steps:

[0073] 1. Preparation of Bacterial Suspension

[0074] Escherichia coli was inoculated into a liquid culture medium (Tryptone: 10 g / L, Yeast Extract: 5 g / L, Sodium Chloride (NaCl): 10 g / L) and cultured to the logarithmic growth phase.

[0075] Adjust the concentration of bacterial suspension to 10 6 ~10 8 CFU / mL.

[0076] 2. Apply bacterial solution:

[0077] Take 0.1 mL of bacterial suspension and spread it evenly on the surface of the agar medium. Let it stand for 10 minutes to allow the bacterial suspension to be absorbed by the medium.

[0078] 3. Add antibacterial substances (mouthwash):

[0079] Use sterile tweezers to stick a paper disc (about 6 mm in diameter) containing mouthwash on the surface of the culture medium and distribute it evenly.

[0080] 4. Cultivation:

[0081] The culture dish was placed upside down in a constant temperature incubator and cultured at 37°C for 12 hours.

[0082] 5. Observation and measurement:

[0083] After the incubation period, observe the surface of the culture medium to see if there is a zone of inhibition. Use a vernier caliper or ruler to measure the diameter of the zone of inhibition and record the data.

[0084] 6. Results Analysis

[0085] Size of inhibition zone: The larger the diameter of the inhibition zone, the stronger the inhibitory effect of the mouthwash on the microorganism.

[0086] No inhibition zone: If there is no inhibition zone, it means that the mouthwash has no inhibitory effect on the microorganism.

[0087] The results of the inhibition zone diameter test are shown in Table 2.

[0088] Test Example 2 Tartar Removal Test

[0089] 1. Simulated plaque removal experiment

[0090] Experimental Materials:

[0091] Several egg shells (simulating tooth surfaces), vinegar (simulating an acidic oral environment), baking soda, mouthwash (Examples 1 to 9, Comparative Examples 1 to 4), a toothbrush, a glass, water, and a timer.

[0092] Experimental steps:

[0093] 1. Simulate Tartar Formation: Place eggshells in a glass and pour vinegar over them, making sure they are completely submerged. Let sit for 24 hours. The acidity of the vinegar will soften the surface of the eggshells, simulating the formation of tartar.

[0094] 2. Tartar Removal: Remove the eggshells and rinse with clean water. The eggshells were divided into three sections and tested using different removal methods: Baking Soda: Mix baking soda and water into a paste. Dip a toothbrush in the paste and gently scrub the eggshells. Mouthwash Group 13 (Examples 1-9, Comparative Examples 1-4): Dip a toothbrush in mouthwash and gently scrub the eggshells. Water: Scrub the eggshells with only water and a toothbrush.

[0095] 3. Observation and recording:

[0096] The effectiveness of each method in removing tartar was recorded, and changes in the eggshell surface were observed. The eggshell surface was scored based on its brightness (0-5 points, with higher scores indicating brighter eggshell surfaces).

[0097] The specific test results are shown in Table 2.

[0098] 2. Trial test

[0099] Thirty volunteers aged between 25 and 45 years old with similar oral hygiene conditions and mature dental calculus were selected to try the mouthwashes in Examples 1 to 9 and Comparative Examples 1 to 4. The mouthwashes were rinsed for 30 seconds (20 mL each time) every morning and evening for 8 weeks. The results showed that the mouthwashes in Examples 1 to 9 could significantly remove mature dental calculus, while the mouthwashes in Comparative Examples 1 to 4 had poor removal effect.

[0100] Test Example 3 Breath Freshening Test

[0101] The concentration of volatile sulfur compounds (VSCs) in the mouth was measured using a Halimete sulfide monitor to assess oral health.

[0102] method:

[0103] 1) Preparation: Avoid eating and smoking for 1 hour before the test. The patient should sit quietly with their mouth closed for 3 minutes to allow VSCs to accumulate in the mouth.

[0104] 2) Sampling: Insert a disposable straw into the patient's mouth, avoiding contact with the tongue or saliva, and slowly extract oral gas (about 10-15 seconds).

[0105] 3) Reading: Record the sulfide concentration (ppb) displayed by the instrument.

[0106] 4) Gargle with the mouthwash prepared in Examples 1 to 9 or Comparative Examples 1 to 3 for 30 seconds and then spit it out. Sampling is performed again and the sulfide concentration displayed by the instrument is recorded.

[0107] 5) After an interval of 1 hour, repeat the above steps 1 to 4 and test the mouthwashes of each embodiment and comparative example in turn to ensure the rationality and scientificity of the results as much as possible.

[0108] Reference values: <100 ppb: Normal. 100-180 ppb: Mild bad breath. >180 ppb: Significant bad breath. See Table 3 for specific test results.

[0109] Table 2 Test results of inhibition zone test and simulated plaque removal test

[0110] Inhibition zone test Simulated plaque removal test Example 1 15mm 5 Example 2 10mm 3 Example 3 12mm 4 Example 4 15mm 5 Example 5 11mm 3 Example 6 10mm 4 Example 7 11mm 3 Example 8 11mm 5 Example 9 15mm 4 Comparative Example 1 9mm 1 Comparative Example 2 9mm 1 Comparative Example 3 10mm 3 Comparative Example 4 8mm 3

[0111] Table 3 Breath freshness test results

[0112]

[0113]

[0114] The inhibition zone experiment showed that humic acid, bioglycolipids, vine tea enzyme, and schisandra chinensis extract all had good antibacterial effects. In terms of effect and cost, Example 4 had the best antibacterial effect.

[0115] The simulated tartar removal test showed that humic acid, bioglycolipids, vine tea enzyme, and tetrasodium glutamate diacetate all had good tartar removal effects, especially humic acid. In terms of effect and cost, Example 4 had the best removal effect.

[0116] The breath freshening experiment shows that the bioglycolipids and rattan tea enzymes have a significant breath freshening effect. In terms of effect and cost, Example 4 is the best.

[0117] In addition, according to Comparative Examples 1 to 4, it can be seen that the amount of humic acid and bioglycolipids used in Comparative Example 1 is relatively small, and the antibacterial effect, tartar removal effect and breath freshening effect of the resulting mouthwash are significantly reduced. Humic acid is omitted in Comparative Example 2, and the antibacterial effect and tartar removal effect of the resulting mouthwash are significantly reduced; bioglycolipids and vine tea enzymes are omitted in Comparative Examples 3 to 4, respectively, and the antibacterial effect and breath freshening effect of the resulting mouthwash are also significantly reduced, indicating that the formula of the oral care composition of the present invention can simultaneously achieve antibacterial effect, tartar removal and breath freshening.

[0118] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. An oral care composition, characterized in that The invention comprises the following components in parts by weight: 1.5 to 5 parts of humic acid, 1.5 to 5 parts of bioglycolipids, 0.5 to 3 parts of vine tea enzyme, 0 to 1 part of ethanol and water extract of Globenia chrysantha flower, and 0 to 0.3 part of chelating agent, and the amount of chelating agent and ethanol and water extract of Globenia chrysantha flower is 0 when they are not used together.

2. The oral care composition according to claim 1, characterized in that The preparation method of the alcohol-water extract of the angelica flowers comprises: mixing crushed angelica flowers and an ethanol-water solution for extraction to obtain an extract; concentrating the extract to obtain the alcohol-water extract of the angelica flowers; the volume fraction of ethanol in the ethanol-water solution is 70-80%, and the amount ratio of the crushed angelica flowers to the ethanol-water solution is 1g:10-15mL; the extraction temperature is 50-55°C, the number of extractions is 2-3, and the time of each extraction is 3-4h.

3. The oral care composition according to claim 1, characterized in that The preparation method of the rattan tea enzyme comprises: Mixing the stems and leaves of Camellia oleifera with water and performing homogenous crushing to obtain a homogeneous crushed product; The homogenized crushed material, sugar source and yeast are mixed and fermented to obtain rattan tea enzyme; The speed of the homogenizing crushing is 2000-3000 rpm; the time of the homogenizing crushing is 5-8 minutes; The fermentation temperature is 28-33° C. and the fermentation time is 45-53 hours.

4. The oral care composition according to claim 1, wherein The chelating agent includes one or more of tetrasodium glutamate diacetate, sodium phytate, trisodium alanine diacetate and sodium α-glucoheptonate.

5. The oral care composition according to claim 1, characterized in that The biological glycolipids include one or more of rhamnolipids, sophorolipids, trehalolipids and mannose erythritol lipids.

6. Use of the oral care composition according to any one of claims 1 to 5 in oral cleaning products for non-therapeutic purposes.

7. A mouthwash, characterized in that The oral care composition comprises the oral care composition according to any one of claims 1 to 5.

8. The mouthwash according to claim 7, characterized in that The composition includes the following parts by weight: 1.5-5 parts of humic acid, 1.5-5 parts of bioglycolipids, 0.5-3 parts of vine tea enzyme, 0-1 part of the alcohol water extract of Globe aquaticum flower, 0-0.3 part of chelating agent, 2-10 parts of moisturizing agent, 0.3-1 part of preservative, 74-95 parts of water, and the amount of chelating agent and the alcohol water extract of Globe aquaticum flower is 0 when they are different.

9. The mouthwash according to claim 8, characterized in that The moisturizers include glycerin and sorbitol; the preservatives include sodium benzoate and potassium sorbate.

10. The method for preparing the mouthwash according to any one of claims 7 to 9, characterized in that: The following steps are involved: mixing a moisturizer and water to obtain a moisturizer solution; Humic acid, bioglycolipid, vine tea enzyme, an alcohol-water extract of Globenia chrysantha flowers, and a chelating agent are mixed to obtain an oral care composition; when the amount of the alcohol-water extract of Globenia chrysantha flowers or the chelating agent is 0, the addition of the alcohol-water extract of Globenia chrysantha flowers or the chelating agent is omitted; mixing the moisturizer solution and the oral care composition to obtain a composite solution; The composite solution and the preservative are mixed to obtain the mouthwash.

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