Composition for improving sleep memory of children

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a composition for improving sleep memory of children, which comprises the following components in parts by weight: 20-40 parts of codonopsis lanceolata, 10-20 parts of poria cocos, 10-20 parts of gastrodia elata, 10-20 parts of rhizoma polygonati, 5-10 parts of fingered citron, 3-7 parts of edible rose and 1-4 parts of stevia rebaudiana. After the medicine is applied to child patients of 3-14 years old for four weeks, the sleep quality of the child patients is obviously improved, the PSQI score is reduced by about 36%, the sleep time is obviously accelerated (shortened by 52% compared with that before treatment), the sleep time is prolonged (increased by 23% compared with that before treatment), the sleep efficiency is improved by 26%, the occurrence frequency of sleep disorders is reduced, and daylight drowsiness and insufficient energy are obviously improved; the composition has a good effect of improving the sleep memory quality of children and is suitable for popularization and application.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a composition for improving children's sleep and memory. Background Art

[0002] The statements in this section merely provide background information related to the present disclosure and may not constitute prior art.

[0003] With changing lifestyles and increasing academic workloads in modern society, many families face the problem of insufficient sleep for their children. This long-term problem can lead to numerous health risks, including decreased cognitive function, impaired learning and memory, emotional and behavioral problems, hampered growth hormone secretion, impaired height growth, and decreased immunity. Data shows that among all brain health labels, products with "brain health" and "memory enhancement" claim the highest market share, highlighting the market demand for sleep disorders and the urgent need for the development of effective treatments.

[0004] Traditional Chinese medicine treatments for sleep disorders in young children have a rich foundation in both theoretical and practical application. Traditional Chinese medicine believes that sleep disorders in children are often associated with dysfunction of the heart, liver, spleen, and kidneys. In particular, the heart governs the mind, the liver governs the flow of qi, and the spleen governs transportation and transformation. Disharmony among these three organs can easily lead to sleep disorders. Therefore, traditional Chinese medicine treatments typically focus on tonifying deficiency and purging excess, harmonizing yin and yang, and calming the mind and spirit. Treatment is tailored to the specific symptoms of the child. Commonly used compound formulas include Suanzaoren Decoction, Guipi Decoction, Longdan Xiegan Decoction, and Chaihu Shugan Powder.

[0005] Compared to Western medicine, traditional Chinese medicine (TCM) offers advantages such as natural origin, fewer side effects, and a lower incidence of allergic diseases, making it safer for growing children. As research into TCM compositions deepens, developing new TCM compositions for treating sleep disorders in young children is of great significance in promoting the development of TCM resources and its adaptability and specificity to modern symptoms. Summary of the Invention

[0006] The purpose of the present invention is to provide a composition for improving children's sleep and memory, addressing the problem of the current lack of traditional Chinese medicine compositions for treating insomnia, and solving the problem of treating poor sleep quality in children. After a four-week course of treatment, the PSQI score decreased by about 36%, the time to fall asleep was significantly accelerated (shortened by 52% compared with before treatment), the sleep time was prolonged (increased by 23% compared with before treatment), the sleep efficiency was improved by 26%, the frequency of sleep disorders was reduced, daytime sleepiness and lack of energy were significantly improved, and the sleep quality was significantly improved.

[0007] The technical solutions of the present invention are as follows:

[0008] A composition for improving children's sleep and memory comprises the following components in parts by weight: 20-40 parts of blue ginseng, 10-20 parts of poria, 10-20 parts of gastrodia elata, 10-20 parts of polygonatum, 5-10 parts of bergamot, 3-7 parts of edible rose, and 1-4 parts of stevia.

[0009] According to a preferred embodiment, the composition comprises the following components in parts by weight: 20-40 parts of blue ginseng, 10-20 parts of Poria cocos, 10-20 parts of Gastrodia elata, 10-20 parts of Polygonatum sibiricum, 5-10 parts of bergamot, 5-7 parts of edible rose, and 2-4 parts of stevia.

[0010] According to a preferred embodiment, the composition comprises the following components in parts by weight: 20-25 parts of blue ginseng, 10-15 parts of Poria cocos, 10-15 parts of Gastrodia elata, 10-15 parts of Polygonatum sibiricum, 5-7 parts of bergamot, 5-6 parts of edible rose, and 2-4 parts of stevia.

[0011] According to a preferred embodiment, the composition comprises the following components in parts by weight: 20-23 parts of blue ginseng, 10-13 parts of Poria cocos, 10-13 parts of Gastrodia elata, 10-13 parts of Polygonatum sibiricum, 5-6 parts of bergamot, 5-6 parts of edible rose, and 2-3 parts of stevia.

[0012] According to a preferred embodiment, the composition comprises the following components in parts by weight: 20 parts of blue ginseng, 10 parts of Poria cocos, 10 parts of Gastrodia elata, 10 parts of Polygonatum sibiricum, 5 parts of bergamot, 5 parts of edible rose, and 3 parts of stevia.

[0013] Among them, blue ginseng, Poria cocos, Gastrodia elata, and Polygonatum sibiricum are all authentic Yunnan medicinal materials, and edible roses are a Yunnan specialty. Blue ginseng, Poria cocos, Gastrodia elata, Polygonatum sibiricum, and bergamot are all medicinal and edible. In this composition, blue ginseng strengthens the spleen, nourishes the heart, and calms the mind; Gastrodia elata calms the liver, strengthens the brain, and calms the mind; Poria cocos strengthens the spleen, calms the mind; Polygonatum sibiricum strengthens the spleen, nourishes the brain, and fights fatigue; bergamot and rose soothe the liver and relieve depression; and stevia soothes the stomach and improves taste. It is widely used as a non-nutritive sweetener and herbal supplement. In this composition, blue ginseng and Poria cocos are the main ingredients, nourishing the spleen, nourishing the heart, and calming the mind; Gastrodia elata calms the liver and suppresses yang, and Polygonatum sibiricum is the auxiliary ingredients, while bergamot and rose are the adjuvant ingredients, promoting qi, soothing the liver, and relieving depression; and stevia is the guiding ingredient, harmonizing the medicinal properties.

[0014] Based on the holistic view of Traditional Chinese Medicine and the principles of Five Zang-organ differentiation, this invention targets sleep disorders and memory loss in children caused by heart and spleen deficiency, liver qi stagnation, and academic pressure. By using Chinese medicinal herbs to nourish the spleen and heart, calm the mind and improve intelligence, and soothe the liver and relieve depression, this treatment aims to combat fatigue, improve sleep, and enhance memory. The drug combination has two key characteristics: all drugs are both medicinal and edible; and the primary ingredients are authentic Yunnan medicinal herbs or unique Chinese herbal remedies, representing the development and utilization of local natural medicines.

[0015] According to a preferred embodiment, the preparation method is as follows: the medicine is soaked in water for half an hour, and then decocted three times in succession. The resulting medicinal liquids are combined and filtered to obtain the juice.

[0016] According to a preferred embodiment, the composition is prepared into any oral dosage form acceptable to the human body by conventional Chinese medicine pharmaceutical methods and with medically acceptable excipients.

[0017] According to a preferred embodiment, the oral dosage form includes pills, powders, granules, oral liquids, decoctions, and tablets.

[0018] According to a preferred embodiment, the excipients include one or more of lactose, microcrystalline cellulose, starch, sodium carboxymethyl cellulose, povidone, magnesium stearate, hypromellose or ethyl cellulose.

[0019] Another aspect of the present invention provides use of the aforementioned composition for improving children's sleep and memory in the preparation of a medicament for improving children's sleep disorders and enhancing children's memory.

[0020] Compared with the existing technology, the beneficial effects of the present invention are:

[0021] 1. A composition for improving children's sleep and memory. This new formula, developed using a combination of medicinal and edible drugs and local Yunnan medicinal materials, has a good therapeutic effect on children's sleep disorders. After a four-week course of treatment, this product significantly improved children's sleep quality, with PSQI scores decreasing by approximately 36%, significantly accelerating sleep onset time (52% shorter than before treatment), extending sleep time (23% longer than before treatment), and improving sleep efficiency by 26%. The frequency of sleep disorders decreased, and daytime sleepiness and lack of energy were significantly improved.

[0022] 2. A composition for improving children's sleep and memory, promoting the development and use of local medicinal resources, providing new Chinese medicine formulas, ensuring safety for children, and reducing the risk of side effects;

[0023] 3. A composition for improving children's sleep memory, which is simple to prepare, uses common materials, and is suitable for promotion and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a diagram showing the PSQI scores of children before and after using a composition for improving children's sleep and memory;

[0025] Figure 2 This is a comparison of the scores of various dimensions of PSQI before and after treatment with a composition for improving children's sleep memory. DETAILED DESCRIPTION

[0026] The specific embodiments listed in the present invention are only examples of the present invention, and the present invention is not limited to the specific embodiments described below. For those skilled in the art, any equivalent modifications and substitutions to the embodiments described below are also within the scope of the present invention. Therefore, equivalent transformations and modifications made without departing from the spirit and scope of the present invention should be included within the scope of the present invention. If specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. All reagents or instruments without the manufacturer specified are conventional products that can be purchased commercially. In order to better illustrate the present invention, numerous specific details are given in the specific embodiments below. Those skilled in the art should understand that the present invention can also be implemented without certain specific details. In other embodiments, methods, means, equipment and steps well known to those skilled in the art are not described in detail in order to highlight the main purpose of the present invention.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. Unless otherwise specified, the units used in this specification are International Standard Units, and the numerical values and numerical ranges appearing in this invention should be understood to include the inevitable systematic errors in industrial production.

[0028] The features and performance of the present invention are further described in detail below with reference to the embodiments.

[0029] Example 1 A composition for improving children's sleep memory and its preparation

[0030] A composition for improving children's sleep and memory comprises 20g of blue ginseng, 10g of Poria cocos, 10g of Gastrodia elata, 10g of Polygonatum sibiricum, 5g of Citron, 5g of Edible Rose, and 3g of Stevia rebaudiana. The ingredients are soaked for 30 minutes, boiled over high heat, then simmered over low heat for 150 minutes. The decoction is repeated three times, and the resulting liquids are combined, filtered, and the juice is collected.

[0031] Example 2 Interventional effect of a self-prepared Yunnan medicine formula of a medicinal and edible composition on children's sleep disorders

[0032] A clinical observation was conducted on 30 children with sleep disorders, and the main findings are as follows:

[0033] 1. Source of Cases

[0034] The cases collected in this study were from children aged ≤14 years who visited the pediatric outpatient clinic of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine from November 2022 to December 2023 and met the inclusion criteria for sleep disorders. A total of 30 SD children with complete case data were collected.

[0035] 2. Diagnostic Criteria

[0036] Based on the diagnostic criteria for non-organic sleep disorders in the CCMD-3 Chinese Classification and Diagnostic Criteria for Mental Disorders and the characteristics of children's sleep clinical manifestations, the following diagnostic criteria are formulated:

[0037] ① Difficulty falling asleep and maintaining sleep, easy awakening, early awakening, and frequent dreams: time to fall asleep > 30 minutes or number of night awakenings ≥ 2 times;

[0038] ② Sleep rhythm disorder: wakefulness at night and daytime sleepiness;

[0039] ③ Parasomnias: crying at night, talking in sleep, and night terrors;

[0040] ④ Emotional instability, irritability, daytime sleepiness, fatigue, decreased concentration and memory, and other problems may occur, which may hinder social function.

[0041] The above symptoms occur ≥ 2 times / week and last for > 2 weeks. Those with any of the above conditions are diagnosed with a sleep disorder.

[0042] III. Eligible patients: Patients aged 3 to 14 years who met the above diagnostic criteria, had no serious primary organic disease, and had not received any treatment related to the disease in the past week. Patients with sleep disorders secondary to other diseases or medications, as well as heart, brain, liver, or kidney dysfunction, were excluded.

[0043] IV. Treatment Method: Administer 100-200 mL of the composition for improving sleep and memory prepared in Example 1 to children. For children aged 3-6, take 50 mL each time; for children aged 7-10, take 80 mL each time; and for children aged 11-14, take 100 mL each time, twice a day, 30 minutes after meals, morning and evening. One week constitutes one course of treatment. Clinical efficacy will be evaluated after four consecutive courses of treatment.

[0044] 5. Efficacy Evaluation Indicators: Before treatment and in the fourth week of treatment, parents filled out the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality based on symptoms and sleep conditions. Higher scores indicate worse sleep quality. GraphPad Prism 10.2.3 software was used for statistical analysis of the data. The PSQI scores of the included cases were quantitative data, and the data were expressed as mean ± standard deviation. The paired t-test was used to compare the PSQI scores before and after medication and the scores of sleep onset time, sleep time, sleep efficiency, sleep disorders, and daytime dysfunction in the PSQI items. The differences were considered statistically significant when P < 0.05.

[0045] 6. Efficacy judgment criteria: GraphPad Prism 10.2.3 software was used for statistical analysis of the data. The PSQI scores of the included cases were quantitative data, and the data were expressed as mean ± standard deviation. The paired t-test was used to compare the PSQI scores and PSQI-related items before and after medication, and the difference was considered statistically significant when P < 0.05.

[0046] 7. Results

[0047] Table 1 Comparison of PSQI scores before and after treatment in 30 included cases ( point)

[0048]

[0049] Table 2 Comparison of PSQI scores in each dimension after 4 weeks of treatment ( paired t-test)

[0050]

[0051] After 4 weeks of medication, the children's PSQI scores were significantly lower than before medication, the time to fall asleep was faster (shortened by 52% compared with before treatment), the sleep time was prolonged (increased by 23% compared with before treatment), the sleep efficiency was improved by 26%, the frequency of sleep disorders decreased, and daytime functional disorders (daytime sleepiness and lack of energy) were significantly improved. The paired t-test analysis showed statistically significant differences, indicating that the preparation has a significant improvement effect on sleep disorders. No adverse reactions were observed in the cases during the medication period, and it is worthy of clinical promotion and application.

[0052] The above-described embodiments merely represent specific implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of protection of the present application. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the technical concept of the present application, and all such variations and improvements fall within the scope of protection of the present application.

Claims

1. A composition for improving children's sleep memory, characterized in that: The invention comprises the following components in parts by weight: 20-40 parts of blue ginseng, 10-20 parts of poria cocos, 10-20 parts of gastrodia elata, 10-20 parts of polygonatum, 5-10 parts of bergamot, 3-7 parts of edible rose and 1-4 parts of stevia.

2. A composition for improving children's sleep memory according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 20-40 parts of blue ginseng, 10-20 parts of poria cocos, 10-20 parts of gastrodia elata, 10-20 parts of polygonatum, 5-10 parts of bergamot, 5-7 parts of edible rose and 2-4 parts of stevia.

3. A composition for improving children's sleep memory according to claim 2, characterized in that: The invention comprises the following components in parts by weight: 20-25 parts of blue ginseng, 10-15 parts of poria cocos, 10-15 parts of gastrodia elata, 10-15 parts of polygonatum, 5-7 parts of bergamot, 5-6 parts of edible rose and 2-4 parts of stevia.

4. A composition for improving children's sleep memory according to claim 3, characterized in that: The invention comprises the following components in parts by weight: 20-23 parts of blue ginseng, 10-13 parts of poria cocos, 10-13 parts of gastrodia elata, 10-13 parts of polygonatum, 5-6 parts of bergamot, 5-6 parts of edible rose and 2-3 parts of stevia.

5. A composition for improving children's sleep memory according to claim 4, characterized in that: The invention comprises the following components in parts by weight: 20 parts of blue ginseng, 10 parts of poria cocos, 10 parts of gastrodia elata, 10 parts of polygonatum, 5 parts of bergamot, 5 parts of edible rose and 3 parts of stevia.

6. A composition for improving children's sleep memory according to claim 1, characterized in that: The preparation method is as follows: after the medicine is soaked in water for half an hour, it is decocted three times in a row, the medicinal liquids obtained three times are combined and filtered to obtain the juice.

7. A composition for improving children's sleep memory according to claim 6, characterized in that: The composition can also be prepared into any oral dosage form acceptable to the human body by conventional Chinese medicine pharmaceutical methods and with medically acceptable excipients.

8. A composition for improving children's sleep memory according to claim 7, characterized in that: The oral dosage forms include pills, powders, granules, oral liquids, decoctions, and tablets.

9. The composition for improving children's sleep memory according to claim 7, characterized in that: The excipients include one or more of lactose, microcrystalline cellulose, starch, sodium carboxymethyl cellulose, povidone, magnesium stearate, hypromellose or ethyl cellulose.

10. Use of the composition for improving children's sleep and memory according to any one of claims 1 to 9 in the preparation of a medicament for improving children's sleep disorders and enhancing children's memory.

Images