Inonotus photoneus mycelium polysaccharide as well as preparation method and application thereof

By extracting and purifying the polysaccharide CMSP from the mycelium of Cellobacteria, the problem of insufficient research on biological activity of Cellobacteria was solved, efficient anti-tumor activity was achieved, and important medical application prospects were provided.

CN120505382APending Publication Date: 2025-08-19HUNAN INST OF MICROBIOLOGY
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Patent Information

Application Number
CN202510634548.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-16
Publication Date
2025-08-19

AI Technical Summary

Technical Problem

The prior art research on the biological activity of Cellobacteria photobiota has not yet been thorough, and the lack of effective anti-tumor active substance development has limited its application potential in the medical field.

Method used

The mycelium of Cellobacteria was used as raw material, and the mycelium polysaccharide of Cellobacteria was extracted and purified by ultrasonic crushing, water alcohol deposition, column chromatography, etc., and the interference of exogenous polysaccharides in the culture medium was eliminated to obtain high-purity, low molecular weight and high activity intracellular polysaccharides.

Benefits of technology

The high-efficiency anti-tumor activity of CMSP, the mycelial polysaccharide of Cellobacter optofiber, has a broad-spectrum inhibitory effect, especially the significant inhibitory effect on Hep-3B, Hela and B16 tumor cells, providing a precursor for the development of anti-tumor drugs.

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Abstract

The invention discloses inonotus ocellatus mycelium polysaccharide as well as a preparation method and application thereof, and relates to the technical field of edible mushroom processing. According to the method, the inonotus photo-nucleuses mycelium is used as a preparation raw material for the first time, the uniform polysaccharide CMSP is obtained by sequentially adopting multiple methods such as ultrasonic disruption, water extraction and alcohol precipitation and column chromatography, and the CMSP is composed of glucose, galactose, mannose, glucuronic acid, fucose and glucosamine. The monosaccharides comprise the following components in percentage by mass: 49.52% of glucose, 25.56% of galactose, 14.85% of mannose, 6.85% of glucuronic acid, 2.29% of fucose and 0.93% of glucosamine. The polysaccharide CMSP provided by the invention has a relatively good inhibition effect on various tumor cells such as Hep-3B, Hela and B16, and can provide a precursor substance for development of antitumor drugs.
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