Construction and evaluation method of PM2.5 induced chronic obstructive pulmonary disease acute exacerbation mouse model

By constructing a PM2.5-induced COPD acute exacerbation model in a mouse model, the unknown question of whether PM2.5 can directly induce COPD acute exacerbation was solved, the role of PM2.5 in COPD acute exacerbation was revealed, and an experimental basis was provided.

CN120643339APending Publication Date: 2025-09-16THE SECOND AFFILIATED HOSPITAL OF ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE (ACUPUNCTURE AND MOXIBUSTION HOSPITAL OF ANHUI PROVINCE)
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Patent Information

Application Number
CN202510934615.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-08
Publication Date
2025-09-16

AI Technical Summary

Technical Problem

Existing technologies lack systematic experimental data and research, and the mechanism by which PM2.5 can directly induce acute exacerbation of chronic obstructive pulmonary disease (COPD) is still unclear.

Method used

A COPD mouse model was established by combined treatment with smoke and lipopolysaccharide, and PM2.5 was exposed to the mouse nasal drops to construct a PM2.5-induced COPD acute exacerbation model. The inductive effect of PM2.5 was evaluated by combining lung function testing and pathological analysis.

Benefits of technology

A PM2.5-induced COPD acute exacerbation mouse model was successfully constructed, revealing the important role of PM2.5 in COPD acute exacerbation, providing an experimental reference for studying air pollution-induced AECOPD, and showing that PM2.5 can further aggravate lung function damage and inflammation, providing a new research platform.

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Abstract

The invention discloses a construction and evaluation method of a PM2.5 induced chronic obstructive pulmonary disease acute exacerbation mouse model, and relates to the technical field of disease animal models. The invention aims to evaluate whether PM2.5 can induce acute exacerbation of COPD through a mouse model, a COPD model is established by adopting combined treatment of smoking and lipopolysaccharide (LPS), and an infectious AECOPD model is established by using common klebsiella pneumoniae (KP) nasal drop on the basis. Meanwhile, PM2.5 processing is added on the basis of the COPD model, and the effect of PM2.5 on acute exacerbation of COPD is evaluated. Through comparison with a classical model (an infectious AECOPD model), the potential effect of PM2.5 in induction of acute exacerbation of COPD is evaluated, and an important reference is provided for future research on an AECOPD animal model induced by air pollution.
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