Endothelialization-promoting antifouling developing coating material as well as preparation method and application thereof
By reacting the siloxane-modified developer with the modified phosphorylcholine polymer, a composite coating with anti-fouling, developing and endothelialization-promoting functions is formed, which solves the problems of developer dissolution and biological inertness of the developing coating during long-term implantation, and achieves the synergistic effect of developing signal stability and endothelial cell adhesion.
Patent Information
- Application Number
- CN202510892695.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-30
- Publication Date
- 2025-09-23
AI Technical Summary
Existing developing coatings suffer from developer dissolution, poor biocompatibility, and lack of active anti-fouling capabilities during long-term implantation. In addition, the biological inertness of the coating surface inhibits endothelial cell adhesion and proliferation, making it difficult to meet the synergistic needs of implantable devices for developing monitoring, anti-fouling and anti-thrombosis, and rapid endothelial repair.
A siloxane-modified developer is reacted with a modified phosphorylcholine polymer to form a composite coating with anti-fouling, developing and endothelialization promoting functions. The developer stability and endothelial cell adhesion are improved through covalent bonding, and specific polymer monomers are selected to combine anti-fouling, developing and endothelialization promoting functions.
The developer is embedded in the coating network in the form of chemical bonds to avoid water-soluble loss and stabilize the development signal; the coating promotes endothelial cell adhesion and proliferation through covalent bonding, significantly improving anti-fouling performance and reducing the risk of infection, achieving a synergistic effect of development and endothelialization.