Anti-radiation protection device for animal experiment

Abstract

The invention relates to the technical field of radiation experiments, and discloses an animal experiment anti-radiation protection device which comprises a base and a neutron moderation plate fixed on the base, and further comprises a neutron reflection plate arranged on the base in a sliding manner, and a neutron absorption plate is embedded in one surface of the neutron moderation plate and is octagonal; the self-hooping part is arranged in the mouse sleeve; the protecting part is arranged on the mouse sleeve and is connected with the self-hooping part; the cleaning and spraying part is arranged in the mouse sleeve and is connected with the protecting part; the dose of thermal neutrons is optimized through the neutron moderation plate, the upper sleeve and the lower sleeve are matched to ensure that only tumors are exposed to a thermal neutron area, irradiation damage to other parts of a mouse is reduced, push-pull of the upper sleeve drives the L plate to move along the guide groove, the T sleeve rotates in a matched mode, the strap is controlled to be tightened or loosened, and during tightening, the strap and the lower sleeve form a constraint space to fix the mouse; when the mouse is relaxed, the rubber band elastic auxiliary hoop rebounds, the mouse is released, manual binding is not needed, and the operation process is simplified.

Description

Technical Field

[0001] The present invention relates to the technical field of radiation experiments, and in particular to an anti-radiation protection device for animal experiments. Background Art

[0002] In animal experiments, mice are usually used as experimental subjects for radiation experiments. Mice with specific tumors are bred and placed in mouse sleeves to provide radiation protection for the mice. The mouse tumors are then exposed. The accelerator's boron neutron capture therapy device uses high-speed protons to hit the target to produce primary neutrons. The primary neutrons are shaped and slowed down by the beam shaper BSA to obtain an epithermal neutron beam. The epithermal neutron beam is used to irradiate the mouse tumors for experiments. During the experiment, it is used to fix and reduce the radiation dose of the normal tissues of small animals, thereby reducing toxic and side effects.

[0003] As a binary targeted radiotherapy method, boron content plays a vital role, but normal tissues still contain a small amount of boron. In order to reduce damage to normal tissues, it is necessary to design a shield that absorbs thermal neutrons to minimize irradiation to normal tissues while having a fixing effect.

[0004] During the entire experiment, the lost epithermal neutron beam will pass through the mouse sleeve, resulting in a large loss of thermal neutrons.

[0005] Existing mouse sleeves usually require staff to place the mouse into the mouse sleeve and then use a bandage to wrap it to secure it. The mouse cannot be automatically released when the mouse sleeve is opened, and the mouse cannot be automatically secured when the mouse sleeve is closed, which reduces operational efficiency and convenience. Summary of the Invention

[0006] The present invention provides an animal experiment radiation protection device, which can provide radiation protection for mice, automatically fix the mice, further slow down thermal neutrons, obtain thermal neutrons with a larger reaction interface, and improve irradiation effect, operation efficiency and convenience.

[0007] In order to solve the above technical problems, the technical solutions of the present invention are as follows: In a first aspect, a radiation protection device for animal experiments comprises a base and a neutron moderator plate fixed to the base, wherein eight radiation-protective mouse sleeves are fixed to one side of the neutron moderator plate. The device further comprises: a neutron reflector slidably disposed on the base, the neutron reflector being located on a side of the mouse sleeves away from the neutron moderator plate; and a neutron absorption plate inlaid on one side of the neutron moderator plate, the neutron absorption plate being located between the eight mouse sleeves and having an octagonal shape. The self-hoop portion is arranged in the mouse sleeve to automatically fix the mouse in the mouse sleeve; The taking and protecting portion is provided on the mouse sleeve and is connected to the self-hoop portion to separate the mouse from the mouse sleeve when the mouse sleeve is opened; The cleaning spray part is arranged in the mouse sleeve and connected to the taking and protecting part to spray and wipe the mouse sleeve clean when it is opened; The self-hoop part includes a pushing member and a supporting member, wherein the pushing member is provided on the mouse sleeve, and the supporting member is connected to the pushing member and is located in the mouse sleeve; The protection part includes a protection piece and a pull-connecting piece, wherein the protection piece is arranged at one end of the mouse sleeve, and the pull-connecting piece connects the protection piece with the pushing piece; The cleaning and spraying part includes a spraying and wiping part and a storage part. The spraying and wiping part is connected with the receiving and protecting part and the pushing and driving part. The storage part is communicated with the spraying and wiping part.

[0008] Furthermore, the mouse sleeve comprises: The lower sleeve has eight parts, each of which is fixed on one side of the neutron moderator plate and corresponds to the eight sides of the neutron absorption plate; The upper sleeve is plugged into the side of the lower sleeve away from the neutron absorption plate; A breathing hole is provided through a side of the upper sleeve away from the neutron absorption plate; The exposure hole is opened through one side of the lower sleeve close to the central absorption edge.

[0009] Furthermore, the pushing member includes: The guide groove is symmetrically arranged on a side of the lower sleeve close to the upper sleeve; An L-plate, guided and arranged in one of the guide grooves; a longitudinal rod, disposed in one of the guide slots, fixedly connected to the lower sleeve, and passing through the L-plate; The T-tube is provided through the L-plate and is rotatably connected to the L-plate and is located outside the longitudinal rod; The push-rotating part is arranged in the guide groove.

[0010] Furthermore, the push-rotate component includes: A spiral groove is provided on the outer side of the longitudinal rod; The ball is rolled and embedded in the inner side of the T-tube and extends into the spiral groove; The socket is opened at one end of the L-board; The plug rod is fixed at a position of the upper sleeve close to the L plate and is inserted into the socket.

[0011] Furthermore, the support hoop comprises: A through-channel is provided on the lower sleeve to connect the inner side of the lower sleeve and the guide groove; One end of the hoop is rolled up on the outside of the T-tube and fixed to the T-tube, and the other end passes through the channel and is fixed on the inside of the lower sleeve; The rubber band is inserted into the upper sleeve and is located on the outside of the hoop.

[0012] Furthermore, the receiving and protecting member includes: A movable groove is provided at one end of the lower sleeve; A rotating rod is disposed in the movable groove and is rotatably connected to the lower sleeve; A coil spring is sleeved on the outside of the rotating rod, with one end fixed to the rotating rod and the other end fixed to the lower sleeve; The soft film is rolled up on the outside of the rotating rod.

[0013] Furthermore, the pull-connector comprises: A support ring is arranged on the inner side of the lower sleeve; One end of the soft film is connected to the support ring and adapted to its curvature; An outer ring, fixed on the outside of the support ring; The connecting rod is arranged through the passage, and one end is fixedly connected to the L-plate, and the other end is fixedly connected to the outer ring.

[0014] Furthermore, the wiping member includes: The liquid channel is opened inside the outer ring; There are multiple nozzles, which are evenly arranged outside the outer ring and connected to the liquid channel; There are two cotton brushes, which are symmetrically fixed on the outside of the outer ring through fixing components and are located outside the nozzle.

[0015] Furthermore, the storage component includes: The liquid capsule has one end fixed to the outside of the T-tube and is located outside the longitudinal rod; A liquid tube, one end of which passes through the end of the liquid sac, and the other end of which passes through the through-channel and is fixed on the outer ring and communicates with the liquid channel; There are two one-way valves, one of which is set through the end of the lower sleeve away from the neutron absorption plate, and the discharge end is connected to the liquid bag, and the other is set through the liquid pipe; A hose is fixedly connected to the input end of one of the one-way valves; The storage and discharge component is arranged in the upper sleeve and is communicated with the hose.

[0016] Furthermore, the storage and drainage parts include: The liquid storage chamber is provided in the upper sleeve and bypasses the breathing hole; L tube, fixed in the liquid storage cavity and connected to the hose; There are multiple liquid holes, evenly distributed throughout the L tube; The filling cylinder is arranged outside the upper sleeve and is communicated with the liquid storage cavity, and the inlet is vertically upward.

[0017] The above solution of the present invention includes at least the following beneficial effects: The thermal neutron dose is optimized through the neutron moderator plate, and the neutron absorption plate shields normal tissue. The upper and lower sleeves work together to ensure that only the tumor is exposed to the thermal neutron zone, minimizing radiation damage to other parts of the mouse. The push-pull of the upper sleeve drives the L-plate to move along the guide groove, and the T-tube rotates in coordination with the ball bearing and the spiral groove of the longitudinal rod to control the tightening or loosening of the cuff. When tightening, the cuff and the lower sleeve form a restraint space to fix the mouse; when loosening, the elasticity of the rubber band assists the cuff to rebound and release the mouse. The push-pull of the upper sleeve drives the cuff to automatically tighten or release, eliminating the need for manual binding and simplifying the operation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 An overall stereoscopic diagram of the animal experiment radiation protection device provided by an embodiment of the present invention; Figure 2 A three-dimensional diagram of a neutron absorption plate provided in an embodiment of the present invention; Figure 3 A top plan view of an upper sleeve and a lower sleeve assembly provided in an embodiment of the present invention; Figure 4 A side sectional plan view of the upper sleeve and the lower sleeve sliding open provided by an embodiment of the present invention; Figure 5 A cross-sectional plan view of an upper sleeve provided in an embodiment of the present invention; Figure 6 A perspective view of the lower sleeve and the upper sleeve sliding open provided in an embodiment of the present invention; Figure 7 The embodiment of the present invention provides Figure 3 Schematic diagram of the structure at A in FIG; Figure 8 The embodiment of the present invention provides Figure 4 Schematic diagram of the structure at B in FIG; Figure 9 A three-dimensional diagram of the unfolded combination of the lower sleeve and the soft film provided in an embodiment of the present invention; Figure 10 A perspective view of a combination of a socket and a filling cylinder provided in an embodiment of the present invention; Figure 11 A three-dimensional diagram of a rubber band and plug assembly provided in an embodiment of the present invention; Figure 12 A cross-sectional view of a guide groove and a stereoscopic view of a lower sleeve assembly provided in an embodiment of the present invention; Figure 13 A three-dimensional diagram of a combination of a support ring, an L-plate, and a soft film provided in an embodiment of the present invention; Figure 14 The embodiment of the present invention provides Figure 9 Schematic diagram of the structure at point C in .

[0019] Description of reference numerals: Figure: 1. Base; 2. Neutron moderator; 3. Lower sleeve; 4. Upper sleeve; 5. Breathing hole; 6. Exposure hole; 7. Neutron absorber; 8. Neutron reflector; 9. Track; 10. Track wheel; 11. Guide groove; 12. L-plate; 13. Longitudinal rod; 14. T-tube; 15. Ball bearing; 16. Socket; 17. Insertion rod; 18. Through-passage; 19. Hoop; 20. Rubber band; 21. Connecting plate ; 22. Pull ring; 23. Socket; 24. Insert block; 25. Movable groove; 26. Rotating rod; 27. Coil spring; 28. Soft membrane; 29. ​​Support ring; 30. Outer ring; 31. Connecting rod; 32. Liquid channel; 33. Nozzle; 34. Cotton brush; 35. Liquid sac; 36. Liquid tube; 37. One-way valve; 38. Hose; 39. Liquid storage chamber; 40. L-tube; 41. Liquid hole; 42. Filling cylinder. DETAILED DESCRIPTION

[0020] Exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0021] like Figures 1 to 14 As shown, an embodiment of the present invention provides an animal experiment radiation protection device, comprising a base 1 and a neutron moderator plate 2 fixed to the base 1, wherein eight mouse sleeves for radiation protection are fixed to one side of the neutron moderator plate 2. The device further comprises: a neutron reflector 8 slidably provided on the base 1, and the neutron reflector 8 is located on a side of the mouse sleeve away from the neutron moderator plate 2; a neutron absorption plate 7 is embedded on one side of the neutron moderator plate 2, and the neutron absorption plate 7 is located between the eight mouse sleeves and is octagonal in shape; The self-hoop portion is arranged in the mouse sleeve to automatically fix the mouse in the mouse sleeve; The taking and protecting portion is provided on the mouse sleeve and is connected to the self-hoop portion to separate the mouse from the mouse sleeve when the mouse sleeve is opened; The cleaning spray part is arranged in the mouse sleeve and connected to the taking and protecting part to spray and wipe the mouse sleeve clean when it is opened; The self-hoop part includes a push-driving part and a support hoop part, the push-driving part is arranged on the mouse sleeve, the support hoop part is connected to the push-driving part and is located in the mouse sleeve; The protection taking part includes a protection receiving part and a pulling connecting part. The protection receiving part is arranged at one end of the mouse sleeve. The pulling connecting part connects the protection receiving part with the pushing part. The cleaning and spraying part comprises a spraying and wiping part and a storage and supply part. The spraying and wiping part is connected with the receiving and protecting part and the pushing and driving part, and the storage and supply part is communicated with the spraying and wiping part.

[0022] Specifically, the mouse sleeve includes: The lower sleeve 3 has eight parts, each of which is fixed on one side of the neutron moderator plate 2 and corresponds to the eight sides of the neutron absorption plate 7; The upper sleeve 4 is inserted into the side of the lower sleeve 3 away from the neutron absorption plate 7; A breathing hole 5 is formed through the upper sleeve 4 on a side away from the neutron absorption plate 7; The exposure hole 6 is opened through one side of the lower sleeve 3 close to the central absorption edge.

[0023] The base 1 is inlaid with a track 9, and the lower end of the neutron reflector 8 is fixed with a track wheel 10, and the track wheel 10 can cooperate with the track 9 to provide a sliding guide for the neutron reflector 8, so that the protective device can slide the neutron reflector 8 to the side of the upper sleeve 4 away from the neutron moderator 2 during the experiment. The base 1 can provide a stable support for the neutron moderator 2 and the track 9, and the neutron moderator 2 can provide a stable support for the lower sleeve 3. The lower sleeve 3 can provide a placement space for the experimental mice, and the upper sleeve 4 can provide protection for the mice. The upper sleeve 4 Cooperating with the lower sleeve 3, it can cover the mouse and provide radiation protection for the mouse. The neutron moderator 2 can moderate the epithermal neutrons. The exposure hole 6 can provide a placement space for the tumor on the mouse, exposing the tumor to the thermal neutron area. The neutron reflector 8 has the function of reflecting thermal neutrons and can reflect excess thermal neutrons back to the tumor area to supplement the irradiation dose. The neutron absorption plate 7 can absorb thermal neutrons, reduce the neutrons entering the mouse sleeve, and reduce the irradiation of normal tissues. The material of the neutron moderator 2 is MgF2, and the breathing hole 5 can allow the mouse to breathe.

[0024] During actual application of this embodiment: the staff needs to fix the neutron moderator 2 at the beam outlet using the base 1 so that the center point of the neutron absorption plate 7 coincides with the center of the beam outlet, and then place the anesthetized experimental mouse in the mouse sleeve. At the same time, the tumor is aligned with the exposure hole 6 so that the tumor can be placed in the exposure hole 6 and exposed to the thermal neutron area. The upper sleeve 4 needs to be covered on the lower sleeve 3 to protect the mouse and fix the mouse in the mouse sleeve. Then, the neutron reflector 8 is pushed so that it slides along the track 9 using the track wheel 10 to the side of the upper sleeve 4 away from the neutron moderator 2. Then, the irradiation experiment can begin.

[0025] As a preferred embodiment of the present invention, the push member includes: The guide groove 11 is symmetrically provided on a side of the lower sleeve 3 close to the upper sleeve 4; An L-plate 12 is provided for guiding in one of the guide grooves 11; A longitudinal rod 13 is disposed in one of the guide slots 11 and is fixedly connected to the lower sleeve 3 and passes through the L-plate 12; The T-tube 14 is provided through the L-plate 12 and is rotatably connected to the L-plate 12 and is located outside the longitudinal rod 13; The push-rotating component is arranged in the guide groove 11.

[0026] Specifically, the lower sleeve 3 can provide a space for the guide groove 11 , the guide groove 11 can provide a movement guide for the L-plate 12 , provide an installation space for the longitudinal rod 13 , and provide a rotation and movement space for the T-tube 14 .

[0027] Push-and-turn parts include: The outer side of the longitudinal rod 13 is provided with a spiral groove; The ball 15 is rolled and embedded in the inner side of the T-tube 14 and extends into the spiral groove; The socket 16 is provided at one end of the L-plate 12; The insertion rod 17 is fixed to a position of the upper sleeve 4 close to the L-plate 12 and is inserted into the socket 16 .

[0028] Specifically, the longitudinal rod 13 can provide an opening space for the threaded groove, the spiral groove can provide a rolling space for the ball 15, and can provide a moving guide for the ball 15, so that the T-tube 14 can use the ball 15 to move along the longitudinal rod 13 and rotate along the spiral groove under the action of external force, the upper sleeve 4 can provide support for the insertion rod 17, the L-plate 12 can provide an opening space for the socket 16, and the socket 16 can provide a plug-in space for the insertion rod 17.

[0029] The support hoop includes: A through passage 18 is provided on the lower sleeve 3 to connect the inner side of the lower sleeve 3 and the guide groove 11; One end of the band 19 is rolled up on the outside of the T-tube 14 and fixed to the T-tube 14, and the other end passes through the through-channel 18 and is fixed on the inside of the lower sleeve 3; The rubber band 20 is plugged into the upper sleeve 4 and is located outside the hoop 19 .

[0030] Specifically, the lower sleeve 3 can provide a space for the through-channel 18, and the through-channel 18 can provide a through-channel and moving space for the hoop 19. The hoop 19 and the rubber band 20 are elastic and can be deformed under the action of external force. They will rebound after the external force disappears. The rubber band 20 can provide a through-channel and support for the hoop 19.

[0031] One end of the rubber band 20 is fixedly connected to a connecting plate 21, and a pull ring 22 is fixed on the connection. A socket 23 is provided on the side of the upper sleeve 4 away from the lower sleeve 3, and an insert block 24 is fixed on the side of the connecting plate 21 away from the pull ring 22. The insert block 24 has elasticity and curvature, and is squeezed and inserted into the inner side of the socket 23 to fix the connecting plate 21.

[0032] In actual application of this embodiment, the staff can pull the upper sleeve 4 in the direction away from the neutron absorption plate 7 as needed, so that the upper sleeve 4 can use external force to drive the L plate 12 to move along the longitudinal rod 13 through the insertion rod 17. At the same time, the L plate 12 will drive the T cylinder 14 and the ball 15 to move together, so that the T cylinder 14 can rotate clockwise by the cooperation of the ball 15 and the spiral groove during the movement, thereby releasing the hoop 19 in the wound and tightened state, and during the movement of the upper sleeve 4, the hoop 19 is pulled through the channel 18 to move into the lower sleeve 3 by the rubber band 20, thereby expanding the distance between the hoop 19 and the lower sleeve 3, and then the staff can place the experimental mouse on the lower sleeve 3. Between the sleeve 3 and the cuff 19, adjust the mouse so that the tumor on its body corresponds to the position of the exposure hole 6, and then push the upper sleeve 4 toward the neutron absorption plate 7, so that the upper sleeve 4 pushes the T-tube 14 to move along the longitudinal rod 13 through the L-plate 12, so that the T-tube 14 can rotate counterclockwise using the ball 15 and the spiral groove, and reel in the released cuff 19 during the rotation, so that the cuff 19 can gradually tighten as the upper sleeve 4 moves toward the neutron absorption plate 7, and after the upper sleeve 4 completely covers the lower sleeve 3, move toward the lower sleeve 3, and pull the rubber band 20 to deform, so that the cuff 19 can make the experimental mouse tightly fixed by the cuff 19 under the support of the lower sleeve 3.

[0033] Afterwards, the staff can pull the connecting plate 21 away from the neutron moderator plate 2 through the pull ring 22 as needed, so that the connecting plate 21 drives the plug block 24 to move together, causing the plug block 24 to deform and be pulled out of the socket 23, thereby releasing the connection between the rubber band 20 and the upper sleeve 4, and then pulling the upper sleeve 4 away from the neutron moderator plate 2, so that the upper sleeve 4 drives the plug rod 17 to be pulled out from the socket 16, thereby removing the upper sleeve 4 and opening the opening of the lower sleeve 3, and then using the rubber band 20 to pull the hoop 19 in the direction close to the upper sleeve 4, so that the hoop 19 is stretched and deformed under the support of the T-tube 14 and the lower sleeve 3, thereby loosening the tightly bound mouse and fine-tuning the position of the mouse so that the tumor on the mouse can be placed in the exposure hole 6, and then loosening the hoop 19, so that the hoop 19 can use the rebound force to re-fix the experimental mouse, and then reset the plug rod 17, the upper sleeve 4 and the plug block 24, and the irradiation experiment can be carried out.

[0034] As a preferred embodiment of the present invention, the protective member includes: A movable groove 25 is provided at one end of the lower sleeve 3; The rotating rod 26 is disposed in the movable groove 25 and is rotatably connected to the lower sleeve 3; The coil spring 27 is sleeved on the outside of the rotating rod 26, with one end fixed to the rotating rod and the other end fixed to the lower sleeve 3; The soft film 28 is rolled up on the outside of the rotating rod 26 .

[0035] Specifically, the exposure hole 6 has an inclined angle to facilitate the tumor to be pushed out of the exposure hole 6. The lower sleeve 3 can provide a space for the movable groove 25 to be opened, and the movable groove 25 can provide a rotation space for the rotating rod 26, the coil spring 27 and the soft membrane 28. The soft membrane 28 is made of transparent material, which can facilitate the staff to observe the corresponding position of the mouse and the exposure hole 6.

[0036] Pull-on parts include: A support ring 29 is provided inside the lower sleeve 3; One end of the soft membrane 28 is connected to the support ring 29 and adapted to its curvature; The outer ring 30 is fixed on the outside of the support ring 29; The connecting rod 31 is disposed through the through passage 18 , and one end is fixedly connected to the L-plate 12 , and the other end is fixedly connected to the outer ring 30 .

[0037] Specifically, the L-plate 12 can provide support for the outer ring 30 through the connecting rod 31, so that the outer ring 30 can support the support ring 29 in the lower sleeve 3, and can drive the outer ring 30 and the support ring 29 to move together through the connecting rod 31 when the L-plate 12 moves, and the support ring 29 can pull one end of the soft membrane 28 to move together.

[0038] In actual application of this embodiment, after the irradiation experiment on the mouse tumor, the staff needs to pull the upper sleeve 4 in the direction away from the neutron absorption plate 7. The upper sleeve 4 will drive the L plate 12 to move together through the insertion rod 17, so that the L plate 12 can drive the outer ring 30 and the support ring 29 to move along the inner side of the mouse sleeve in the direction away from the neutron absorption plate 7 through the connecting rod 31. At the same time, the support ring 29 will pull one end of the soft film 28, so that the soft film 28 can pull the rotating rod 26 to rotate clockwise. During the rotation of the rotating rod 26, the coil spring 27 will be wound to store energy, so that the soft film 28 wound on the outside of the rotating rod 26 can be released and unfolded. During the movement of the support ring 29, it will move between the placed mouse and the lower sleeve 3, and as it moves, the support ring 29 can push the mouse tumor. At the same time, the cuff 19 will be appropriately relaxed, so that the tumor can slide out of the exposure hole 6 by utilizing the inclination angle of the exposure hole 6 under the push of the support ring 29. At the same time, the mouse will move toward the direction close to the upper sleeve 4, and then as the upper sleeve 4 slides open, the support ring 29 drives the soft membrane 28 to expand between the mouse and the lower sleeve 3, so that the mouse and its tumor can be separated from the lower sleeve 3, thereby facilitating the removal and separation of the tumor and the mouse while opening the upper sleeve 4, and protecting the inner wall of the lower sleeve 3 from contamination.

[0039] As a preferred embodiment of the present invention, the wiping member includes: The liquid channel 32 is provided inside the outer ring 30; There are multiple nozzles 33, evenly arranged outside the outer ring 30 and connected to the liquid channel 32; There are two cotton brushes 34 , which are symmetrically fixed to the outside of the outer ring 30 through fixing components and are located outside the nozzle 33 .

[0040] Specifically, the outer ring 30 can provide a space for the liquid channel 32, and the liquid channel 32 can provide a channel for the liquid to enter the nozzle 33. The nozzle 33 can atomize and spray the liquid under the action of pressure. The outer ring 30 can provide a stable support for the cotton brush 34, which is relatively soft and has adsorption and elasticity.

[0041] Storage components include: Capsule 35, one end is fixed to the outside of the T-tube 14, and located outside the longitudinal rod 13; The liquid tube 36 has one end passing through the end of the liquid sac 35 and the other end passing through the through-channel 18 and fixed on the outer ring 30 and communicated with the liquid channel 32; There are two one-way valves 37, one of which is set through the end of the lower sleeve 3 away from the neutron absorption plate 7, and the discharge end is connected to the liquid bag 35, and the other is set through the liquid pipe; A hose 38 is fixedly connected to the input end of one of the one-way valves 37; The storage and discharge components are arranged in the upper sleeve 4 and are connected to the hose 38.

[0042] Specifically, the lower sleeve 3 can provide support for the other end of the liquid capsule 35, the T-tube 14 can provide stable support for one end of the liquid capsule 35, the liquid capsule 35 can provide storage space for liquid, and can separate the storage space from the distance between the T-tube 14 and the longitudinal rod 13, and the liquid capsule 35 can bend and twist under the action of external force to reduce the storage space, and can be expanded and reset under the action of external force, the lower sleeve 3 can provide stable support for the one-way valve 37, the one-way valve 37 is a valve type, one of the one-way valves 37 can provide a channel for the liquid to enter the liquid capsule 35, and the other one-way valve 37 can prevent the liquid and gas in the liquid pipe from entering the liquid capsule 35, and prevent the liquid in the liquid capsule 35 from being discharged outside the one-way valve 37, the liquid capsule 35 can provide support for the hose 38, and the hose 38 can provide a channel for the liquid in the liquid capsule 35 to enter the liquid channel 32.

[0043] Storage and drainage parts include: The liquid storage chamber 39 is provided in the upper sleeve 4 and bypasses the breathing hole 5; L tube 40, fixed in the liquid storage chamber 39 and connected to the hose 38; There are multiple liquid holes 41, which are evenly opened throughout the L tube 40; The filling cylinder 42 is arranged outside the upper sleeve 4 and is connected to the liquid storage chamber 39, with the inlet facing vertically upward.

[0044] Specifically, the upper sleeve 4 can provide an opening space for the liquid storage chamber 39, the liquid storage chamber 39 can provide storage space for alcohol liquid, and the upper sleeve 4 can provide stable support for the L-tube 40, the L-tube 40 can provide an opening space for the liquid hole 41, the liquid hole 41 can provide a channel for the liquid to enter the L-tube 40, and the filling cylinder 42 can provide a channel for the liquid to enter the liquid storage chamber 39.

[0045] During the actual application of this embodiment, the staff can inject alcohol liquid into the liquid storage chamber 39 from the filling cylinder 42 before using the radiation protection device, so that the alcohol liquid fills the liquid storage chamber 39 and half-submerges the filling cylinder 42. When the staff slides and closes the upper sleeve 4 in the direction close to the neutron absorption plate 7, the L plate 12 will be driven by the upper sleeve 4 to drive the T cylinder 14 to move in the direction away from the other end of the liquid capsule 35. During this process, the T cylinder 14 will use the ball 15 and the spiral groove to rotate while moving, so that the T cylinder 14 can drive the liquid capsule 35 to expand, and generate suction during the expansion process to open the channel of the one-way valve 37 connected to the hose 38. At the same time, the channel of the one-way valve 37 connected to the liquid pipe will block the air and liquid in the liquid pipe from entering the liquid capsule 35 through the hose 38 and the L tube. 40 and the water hole suck the alcohol liquid in the liquid storage chamber 39 into the inner side of the liquid capsule 35. When the staff slides and opens the upper sleeve 4 in the direction away from the neutron absorption plate 7, the L plate 12 will drive the T-tube 14 to move together, so that the T-tube 14 moves toward the other end of the liquid capsule 35, and the T-tube 14 will rotate in conjunction with the ball 15 and the spiral groove during the movement, so that the T-tube 14 can squeeze the liquid capsule 35 to fold during the sliding opening of the upper sleeve 4, and at the same time, the liquid capsule 35 is twisted by rotation, so that the alcohol liquid in the liquid capsule 35 can enter the inner side of the water pipe under the action of squeezing, and pass through the water pipe into the inner side of the waterway, so that the alcohol liquid can fill the waterway and enter the nozzle 33, and finally pass through the nozzle 33 and be sprayed to the inner wall of the lower sleeve 3 and the upper sleeve 4 as the upper sleeve 4 slides and opens.

[0046] Working principle: the neutron moderator plate 2 slows down epithermal neutrons into thermal neutrons, the neutron absorption plate 7 absorbs excess neutrons to reduce irradiation to normal tissues of the mouse, and the neutron reflector 8 adjusts its position by sliding to reflect thermal neutrons to the tumor area, accurately controlling the irradiation dose. The mouse sleeve exposes the tumor to the thermal neutron zone through the exposure hole 6, and other parts are shielded from radiation by the neutron absorption plate 7 and the sleeve structure. The MgF2 neutron moderator plate 2 optimizes the thermal neutron dose, and the neutron absorption plate 7 shields normal tissues to ensure that only the tumor is exposed to the thermal neutron zone, minimizing irradiation damage to other parts of the mouse.

[0047] The octagonal arrangement design is suitable for conducting multiple experiments in parallel, and the layout of 6 exposure holes and 5 breathing holes takes into account both functionality and the survival needs of mice.

[0048] The upper sleeve 4 is pushed and pulled to drive the L plate 12 to move along the guide groove 11, and the T cylinder 14 rotates in coordination with the spiral groove of the longitudinal rod 13 through the ball 15 to control the tightening or loosening of the cuff 19. When tightened, the cuff 19 and the lower sleeve 3 form a restraining space to fix the mouse; when loosened, the rubber band 20 elastically assists the cuff 19 to rebound and release the mouse. When the upper sleeve 4 is opened, the connecting rod 31 drives the support ring 29 to unfold the soft membrane 28 to separate the mouse from the inner wall of the sleeve to avoid contamination; at the same time, the tumor is pushed out of the exposure hole 6 for easy removal. The upper sleeve 4 pushes and pulls to drive the cuff 19 to automatically tighten or release, without the need for manual binding, thereby simplifying the operation process.

[0049] The soft membrane 28 automatically unfolds when the sleeve is opened, physically isolating the mouse from the inner wall to avoid biological contamination.

[0050] The upper sleeve 4 can be removed by releasing the insert 24 through the pull ring 22, which simplifies the mouse taking and placing process and improves the experimental throughput.

[0051] During the opening and closing process of the sleeve, the T-cylinder 14 rotates and squeezes the liquid capsule 35, and the alcohol in the liquid storage chamber 39 is atomized and sprayed through the nozzle 33, and the cotton brush 34 wipes the inner wall of the sleeve to achieve cleaning and disinfection; when the sleeve is closed, the T-cylinder 14 rotates and stretches the liquid capsule 35 to inhale alcohol; when the sleeve is opened, the liquid capsule 35 is squeezed out to discharge alcohol, achieving automatic cleaning. Each opening and closing of the sleeve triggers the alcohol spray and cotton brush 34 to wipe, maintaining a sterile internal environment and reducing the risk of cross contamination. No external power is required, and the liquid capsule 35 is squeezed by mechanical movement to complete the detergent delivery, which is energy-saving and highly reliable.

[0052] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. An animal experiment radiation protection device, comprising a base and a neutron moderator plate fixed to the base, wherein eight mouse sleeves for radiation protection are fixed on one side of the neutron moderator plate, characterized in that: Also includes: A neutron reflector is slidably provided on the base, and the neutron reflector is located on a side of the mouse sleeve away from the neutron moderator. A neutron absorption plate is inlaid on one side of the neutron moderator, and the neutron absorption plate is located between the eight mouse sleeves and is in an octagonal shape. The self-hoop portion is arranged in the mouse sleeve to automatically fix the mouse in the mouse sleeve; The taking and protecting portion is provided on the mouse sleeve and is connected to the self-hoop portion to separate the mouse from the mouse sleeve when the mouse sleeve is opened; The cleaning spray part is arranged in the mouse sleeve and connected to the taking and protecting part to spray and wipe the mouse sleeve clean when it is opened; The self-hoop part includes a pushing member and a supporting member, wherein the pushing member is provided on the mouse sleeve, and the supporting member is connected to the pushing member and is located in the mouse sleeve; The protection part includes a protection piece and a pull-connecting piece, wherein the protection piece is arranged at one end of the mouse sleeve, and the pull-connecting piece connects the protection piece with the pushing piece; The cleaning and spraying part includes a spraying and wiping part and a storage part. The spraying and wiping part is connected with the receiving and protecting part and the pushing and driving part. The storage part is communicated with the spraying and wiping part.

2. The animal experiment radiation protection device according to claim 1, characterized in that: The mouse sleeve comprises: The lower sleeve has eight parts, each of which is fixed on one side of the neutron moderator plate and corresponds to the eight sides of the neutron absorption plate; The upper sleeve is plugged into the side of the lower sleeve away from the neutron absorption plate; A breathing hole is provided through a side of the upper sleeve away from the neutron absorption plate; The exposure hole is opened through one side of the lower sleeve close to the central absorption edge.

3. The animal experiment radiation protection device according to claim 2, characterized in that: The push drive member comprises: The guide groove is symmetrically arranged on a side of the lower sleeve close to the upper sleeve; An L-plate, guided and arranged in one of the guide grooves; a longitudinal rod, disposed in one of the guide slots, fixedly connected to the lower sleeve, and passing through the L-plate; The T-tube is provided through the L-plate and is rotatably connected to the L-plate and is located outside the longitudinal rod; The push-rotating part is arranged in the guide groove.

4. The animal experiment radiation protection device according to claim 3, characterized in that: The push-rotate part comprises: A spiral groove is provided on the outer side of the longitudinal rod; The ball is rolled and embedded in the inner side of the T-tube and extends into the spiral groove; The socket is opened at one end of the L-board; The plug rod is fixed at a position of the upper sleeve close to the L plate and is inserted into the socket.

5. The animal experiment radiation protection device according to claim 4, characterized in that: The support hoop comprises: A through-channel is provided on the lower sleeve to connect the inner side of the lower sleeve and the guide groove; One end of the hoop is rolled up on the outside of the T-tube and fixed to the T-tube, and the other end passes through the channel and is fixed on the inside of the lower sleeve; The rubber band is inserted into the upper sleeve and is located on the outside of the hoop.

6. The animal experiment radiation protection device according to claim 5, characterized in that: The receiving and protecting part comprises: A movable groove is provided at one end of the lower sleeve; A rotating rod is disposed in the movable groove and is rotatably connected to the lower sleeve; A coil spring is sleeved on the outside of the rotating rod, with one end fixed to the rotating rod and the other end fixed to the lower sleeve; The soft film is rolled up on the outside of the rotating rod.

7. The animal experiment radiation protection device according to claim 6, characterized in that: The pull-connector comprises: A support ring is arranged on the inner side of the lower sleeve; One end of the soft film is connected to the support ring and adapted to its curvature; An outer ring, fixed on the outside of the support ring; The connecting rod is arranged through the passage, and one end is fixedly connected to the L-plate, and the other end is fixedly connected to the outer ring.

8. The animal experiment radiation protection device according to claim 7, characterized in that: The wiping member comprises: The liquid channel is opened inside the outer ring; There are multiple nozzles, which are evenly arranged outside the outer ring and connected to the liquid channel; There are two cotton brushes, which are symmetrically fixed on the outside of the outer ring through fixing components and are located outside the nozzle.

9. The animal experiment radiation protection device according to claim 8, characterized in that: The storage component includes: The liquid capsule has one end fixed to the outside of the T-tube and is located outside the longitudinal rod; A liquid tube, one end of which passes through the end of the liquid sac, and the other end of which passes through the through-channel and is fixed on the outer ring and communicates with the liquid channel; There are two one-way valves, one of which is set through the end of the lower sleeve away from the neutron absorption plate, and the discharge end is connected to the liquid bag, and the other is set through the liquid pipe; A hose is fixedly connected to the input end of one of the one-way valves; The storage and discharge component is arranged in the upper sleeve and is communicated with the hose.

10. The animal experiment radiation protection device according to claim 9, characterized in that: The storage and drainage parts include: The liquid storage chamber is provided in the upper sleeve and bypasses the breathing hole; L tube, fixed in the liquid storage cavity and connected to the hose; There are multiple liquid holes, evenly distributed throughout the L tube; The filling cylinder is arranged outside the upper sleeve and is communicated with the liquid storage cavity, and the inlet is vertically upward.

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