A radiation protection device for animal experiments

Abstract

This invention relates to the field of radiation experiment technology and discloses an animal experiment radiation protection device, including a base and a neutron moderator plate fixed on the base. It further includes: a neutron reflector plate slidably disposed on the base, with an octagonal neutron absorber plate embedded on one side of the moderator plate; a self-closing part disposed inside a mouse sleeve; a removal part disposed on the mouse sleeve and connected to the self-closing part; and a cleaning spray part disposed inside the mouse sleeve and connected to the removal part. This invention optimizes the thermal neutron dose through the neutron moderator plate, and, in conjunction with the upper and lower sleeves, ensures that only the tumor is exposed to the thermal neutron region, reducing radiation damage to other parts of the mouse. The push-pull mechanism of the upper sleeve drives the L-plate to move along the guide groove, and the T-tube rotates accordingly, controlling the tightening or loosening of the closing strap. When tightened, the closing strap and the lower sleeve form a restraint space to fix the mouse; when loosened, the elastic band assists the closing strap to rebound and release the mouse, eliminating the need for manual binding and simplifying the operation process.

Description

Technical Field

[0001] This invention relates to the field of radiation experiment technology, and specifically to a radiation protection device for animal experiments. Background Technology

[0002] In animal experiments, mice are commonly used as experimental subjects for radiation experiments. Mice with specific tumors are bred and placed in a mouse sleeve to provide radiation protection while exposing the tumor. Through the boron neutron capture therapy device of an accelerator, high-speed protons strike the target to produce primary neutrons. After the primary neutrons are shaped and slowed down by the beam shaper BSA, a superheated neutron beam is obtained. The superheated neutron beam is used to irradiate the mouse tumor for the experiment. In this experiment, it is used to fix and reduce the radiation dose to normal tissues of small animals and reduce toxic side effects.

[0003] As a binary targeted radiotherapy method, boron content plays a crucial role. However, normal tissues still contain a small amount of boron. To reduce damage to normal tissues, it is necessary to design a shield that can absorb thermal neutrons, minimize irradiation of normal tissues, and at the same time have a fixation function.

[0004] Throughout the experiment, the lost ultrathermal neutron beam passes through the mouse sleeve, resulting in significant thermal neutron loss.

[0005] Existing mouse snares typically require staff to place the mouse inside and then secure it with bandages. They cannot automatically release the mouse when the snare is opened or automatically secure it when the snare is closed, thus reducing operational efficiency and convenience. Summary of the Invention

[0006] This invention provides an animal experiment radiation protection device that can provide radiation protection for mice, automatically fix the mice, further slow down thermal neutrons, obtain thermal neutrons with a larger reaction interface, and improve irradiation effect, operation efficiency and convenience.

[0007] To solve the above-mentioned technical problems, the technical solution of the present invention is as follows:

[0008] In a first aspect, an animal experiment radiation protection device includes a base and a neutron moderator plate fixed on the base. Eight mouse sleeves for radiation protection are fixed on one side of the neutron moderator plate. The device also includes a neutron reflector plate slidably disposed on the base, with the neutron reflector plate located on the side of the mouse sleeves away from the neutron moderator plate. A neutron absorber plate is embedded on one side of the neutron moderator plate, and the neutron absorber plate is located between the eight mouse sleeves and is octagonal.

[0009] The self-clamping part is set inside the mouse sleeve to automatically fix the mouse inside the mouse sleeve;

[0010] The protective part is set on the mouse sleeve and connected to the self-closing part to separate the mouse protective sleeve when the mouse sleeve is opened;

[0011] The cleaning spray section is located inside the mouse sleeve and connected to the retrieval section, so as to spray and wipe the mouse clean when the mouse sleeve is opened;

[0012] The self-clamping part includes a push-drive component and a support component. The push-drive component is disposed on the mouse sleeve, and the support component is connected to the push-drive component and located inside the mouse sleeve.

[0013] The protective part includes a protective retractor and a connecting member. The protective retractor is located at one end of the mouse sleeve, and the connecting member connects the protective retractor to the pusher.

[0014] The cleaning spray unit includes a spraying component and a storage and supply component. The spraying component is connected to a receiving and protection component and a pushing component. The storage and supply component is in communication with the spraying component.

[0015] Furthermore, the mouse sleeve includes:

[0016] The lower sleeve has eight parts, each fixed to one side of the neutron moderating plate and corresponding to one of the eight sides of the neutron absorbing plate.

[0017] The upper sleeve is inserted into the side of the lower sleeve away from the neutron absorber plate;

[0018] The breathing hole is opened through the side of the upper sleeve away from the neutron absorption plate;

[0019] An exposure hole is provided, which is made through the lower sleeve on the side near the center absorption edge.

[0020] Furthermore, the thruster includes:

[0021] Guide grooves are symmetrically formed on the side of the lower sleeve near the upper sleeve;

[0022] The L-plate is guided within one of the guide grooves;

[0023] A longitudinal rod is disposed in one of the guide grooves and is fixedly connected to the lower sleeve, and penetrates the L-plate;

[0024] The T-tube is installed through the L-plate and rotatably connected to the L-plate, and is located on the outside of the longitudinal bar;

[0025] The push-rotating component is located inside the guide groove.

[0026] Furthermore, the push-rotating component includes:

[0027] The outer side of the longitudinal rod is provided with a spiral groove;

[0028] The ball bearings are rolled and embedded inside the T-tube and extend into the spiral groove;

[0029] The connector is located at one end of the L-plate;

[0030] The insert rod is fixed to the upper sleeve near the L-plate and inserted into the socket.

[0031] Furthermore, the support hoop includes:

[0032] A passageway is provided on the lower sleeve to connect the inner side of the lower sleeve with the guide groove;

[0033] The hoop has one end wound around the outside of the T-tube and fixed to the T-tube, and the other end passes through the channel and is fixed to the inside of the lower sleeve.

[0034] The rubber band is inserted into the upper sleeve and is located on the outside of the hoop.

[0035] Furthermore, the receiving and protecting component includes:

[0036] The movable groove is located at one end of the lower sleeve;

[0037] The rotating rod is set in the movable groove and is rotatably connected to the lower sleeve;

[0038] A coil spring is sleeved on the outside of the rotating rod, with one end fixedly connected to the rotating rod and the other end fixedly connected to the lower sleeve;

[0039] The soft membrane is rolled up on the outside of the rotating rod.

[0040] Furthermore, the pull connector includes:

[0041] The support ring is located inside the lower sleeve;

[0042] One end of the PVC membrane is connected to the support ring and is adapted to its curvature;

[0043] The outer ring is fixed to the outside of the support ring;

[0044] The connecting rod is installed through the passageway, with one end fixed to the L-plate and the other end fixed to the outer ring.

[0045] Furthermore, the spraying component includes:

[0046] The fluid channel is located inside the outer ring;

[0047] The nozzles are multiple and evenly distributed on the outer side of the outer ring, and are connected to the liquid channel;

[0048] The cotton brush has two parts, which are symmetrically fixed to the outside of the outer ring by a fixing component and located outside the nozzle.

[0049] Furthermore, the storage and supply component includes:

[0050] The liquid bladder is fixed at one end to the outside of the T-tube and located outside the longitudinal rod;

[0051] The liquid tube has one end passing through the end of the liquid bladder, and the other end passing through the channel and fixed to the outer ring, and is connected to the liquid channel.

[0052] One-way valve, having two, one of which is installed through the lower sleeve away from the neutron absorber plate and the discharge end is connected to the liquid bladder, and the other is installed through the liquid pipe;

[0053] The hose is fixed to the inlet of one of the check valves;

[0054] The storage and discharge components are located inside the upper sleeve and are connected to the hose.

[0055] Furthermore, the storage and discharge components include:

[0056] The liquid storage chamber is located inside the upper sleeve and bypasses the vent hole;

[0057] The L-tube is fixed inside the liquid storage chamber and connected to the flexible tube;

[0058] Multiple liquid orifices are evenly distributed throughout the L-shaped tube.

[0059] The filling cylinder is located outside the upper sleeve and is connected to the liquid storage chamber, with its inlet pointing vertically upwards.

[0060] The above-described solution of the present invention has at least the following beneficial effects:

[0061] The thermal neutron dose is optimized by using a neutron moderation plate, while the neutron absorption plate shields normal tissue. Combined with upper and lower sleeves, this ensures that only the tumor is exposed to the thermal neutron zone, minimizing radiation damage to other parts of the mouse. The push-pull mechanism of the upper sleeve drives the L-plate to move along the guide groove, and the T-tube rotates via a ball bearing and a longitudinal rod helical groove, controlling the tightening or loosening of the clamp. When tightened, the clamp and lower sleeve form a restraint space to fix the mouse; when loosened, the elastic band assists in the clamp's rebound, releasing the mouse. The push-pull mechanism of the upper sleeve automatically tightens or releases the clamp, eliminating the need for manual binding and simplifying the operation. Attached Figure Description

[0062] Figure 1 An overall perspective view of the animal experiment radiation protection device provided in the embodiments of the present invention;

[0063] Figure 2 A perspective view of a neutron absorber plate provided in an embodiment of the present invention;

[0064] Figure 3 A top view of the upper and lower sleeve assembly provided in an embodiment of the present invention;

[0065] Figure 4 A side sectional view of the upper and lower sleeves sliding open according to an embodiment of the present invention;

[0066] Figure 5A cross-sectional plan view of the upper sleeve provided in an embodiment of the present invention;

[0067] Figure 6 A perspective view of the lower sleeve and upper sleeve sliding open according to an embodiment of the present invention;

[0068] Figure 7 Provided for embodiments of the present invention Figure 3 Schematic diagram of the structure at point A in the diagram;

[0069] Figure 8 Provided for embodiments of the present invention Figure 4 Schematic diagram of the structure at point B in the diagram;

[0070] Figure 9 A perspective view of the lower sleeve and the unfolded soft membrane assembly provided in an embodiment of the present invention;

[0071] Figure 10 A perspective view of the socket and filling cylinder assembly provided in an embodiment of the present invention;

[0072] Figure 11 A perspective view of the rubber band and insert assembly provided in an embodiment of the present invention;

[0073] Figure 12 A cross-sectional view of the guide groove and a perspective view of the lower sleeve assembly provided in an embodiment of the present invention;

[0074] Figure 13 A perspective view of the support ring, L-plate, and soft membrane assembly provided in an embodiment of the present invention;

[0075] Figure 14 Provided for embodiments of the present invention Figure 9 A schematic diagram of the structure at point C.

[0076] Explanation of reference numerals in the attached figures:

[0077] In the diagram: 1. Base; 2. Neutron moderating plate; 3. Lower sleeve; 4. Upper sleeve; 5. Breathing hole; 6. Exposure hole; 7. Neutron absorbing plate; 8. Neutron reflector; 9. Track; 10. Track wheel; 11. Guide groove; 12. L-plate; 13. Longitudinal rod; 14. T-tube; 15. Ball bearing; 16. Insertion port; 17. Insert rod; 18. Through passage; 19. Hoop; 20. Rubber band; 21. Connecting plate 22. Pull ring; 23. Insertion hole; 24. Insertion block; 25. Movable groove; 26. Rotating rod; 27. Coil spring; 28. Soft diaphragm; 29. ​​Support ring; 30. Outer ring; 31. Connecting rod; 32. Liquid channel; 33. Nozzle; 34. Cotton brush; 35. Liquid bladder; 36. Liquid pipe; 37. One-way valve; 38. Hose; 39. Liquid storage chamber; 40. L-tube; 41. Liquid hole; 42. Filling cylinder. Detailed Implementation

[0078] Exemplary embodiments of the invention will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the invention are shown in the drawings, it should be understood that the invention may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this invention will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

[0079] like Figures 1 to 14 As shown, an embodiment of the present invention provides an animal experiment radiation protection device, including a base 1 and a neutron moderator plate 2 fixed on the base 1. Eight mouse sleeves for radiation protection are fixed on one side of the neutron moderator plate 2. The device also includes: a neutron reflector plate 8 slidably disposed on the base 1, and the neutron reflector plate 8 is located on the side of the mouse sleeves away from the neutron moderator plate 2. A neutron absorber plate 7 is embedded on one side of the neutron moderator plate 2, and the neutron absorber plate 7 is located between the eight mouse sleeves and is octagonal.

[0080] The self-clamping part is set inside the mouse sleeve to automatically fix the mouse inside the mouse sleeve;

[0081] The protective part is set on the mouse sleeve and connected to the self-closing part to separate the mouse protective sleeve when the mouse sleeve is opened;

[0082] The cleaning spray section is located inside the mouse sleeve and connected to the retrieval section, so as to spray and wipe the mouse clean when the mouse sleeve is opened;

[0083] The self-clamping part includes a push-drive component and a support component. The push-drive component is set on the mouse sleeve, and the support component is connected to the push-drive component and located inside the mouse sleeve.

[0084] The protective unit includes a protective retractor and a connecting member. The protective retractor is located at one end of the mouse sleeve, and the connecting member connects the protective retractor to the pusher.

[0085] The cleaning spray unit includes a spraying component and a storage and supply component. The spraying component is connected to the receiving and protection component and the push-drive component, and the storage and supply component is connected to the spraying component.

[0086] Specifically, the mouse sleeve includes:

[0087] The lower sleeve 3 has eight parts, which are fixed to one side of the neutron moderating plate 2 and correspond to the eight sides of the neutron absorbing plate 7 respectively.

[0088] The upper sleeve 4 is inserted into the side of the lower sleeve 3 away from the neutron absorption plate 7;

[0089] Breathing hole 5 is opened through the side of the upper sleeve 4 away from the neutron absorption plate 7;

[0090] Exposure hole 6 is opened through the side of the lower sleeve 3 near the center absorption edge.

[0091] The base 1 is inlaid with a track 9, and the lower end of the neutron reflector 8 is fixed with a track wheel 10, which can cooperate with the track 9 to provide sliding guidance for the neutron reflector 8. This allows the protective device to slide the neutron reflector 8 to the side of the upper sleeve 4 away from the neutron moderating plate 2 during the experiment. The base 1 provides stable support for the neutron moderating plate 2 and the track 9. The neutron moderating plate 2 provides stable support for the lower sleeve 3, which provides a place for the experimental mouse. The upper sleeve 4 provides protection for the mouse. Together with the lower sleeve 3, it can cover the mouse and provide radiation protection. The neutron moderator plate 2 can moderate hyperthermal neutrons. The exposure hole 6 can provide a space for the tumor on the mouse, exposing the tumor to the thermal neutron region. The neutron reflector plate 8 has the function of reflecting thermal neutrons and can reflect excess thermal neutrons back to the tumor region to supplement the irradiation dose. The neutron absorber plate 7 can absorb thermal neutrons, reduce the number of neutrons entering the mouse sleeve, and reduce the irradiation of normal tissues. The material of the neutron moderator plate 2 is MgF2, and the breathing hole 5 can allow the mouse to breathe.

[0092] In practical application of this embodiment: the operator needs to fix the neutron moderator plate 2 to the beam outlet using the base 1, so that the center point of the neutron absorber plate 7 coincides with the center of the beam outlet. Then, the anesthetized experimental mouse is placed in the mouse sleeve, and the tumor is aligned with the position of the exposure hole 6 so that the tumor can be placed in the exposure hole 6 and exposed to the thermal neutron region. The upper sleeve 4 is covered on the lower sleeve 3 to protect the mouse and fix the mouse in the mouse sleeve. Then, the neutron reflector plate 8 is pushed so that it slides along the track 9 using the track wheel 10 to the side of the upper sleeve 4 away from the neutron moderator plate 2. Then, the irradiation experiment can be started.

[0093] In a preferred embodiment of the present invention, the thrust member includes:

[0094] Guide grooves 11 are symmetrically opened on the side of the lower sleeve 3 near the upper sleeve 4;

[0095] L-plate 12, with a guide disposed within one of the guide grooves 11;

[0096] The longitudinal rod 13 is set in one of the guide grooves 11 and is fixedly connected to the lower sleeve 3, and passes through the L plate 12;

[0097] T-tube 14 is installed through L-plate 12 and rotatably connected to L-plate 12, and is located on the outside of longitudinal bar 13;

[0098] The push-rotating component is set inside the guide groove 11.

[0099] Specifically, the lower sleeve 3 provides space for the guide groove 11, the guide groove 11 provides a moving guide for the L plate 12, provides installation space for the longitudinal rod 13, and provides rotation and movement space for the T cylinder 14.

[0100] The push-rotor components include:

[0101] A spiral groove is provided on the outer side of the longitudinal rod 13;

[0102] The ball bearing 15 is rolled and embedded inside the T-cylinder 14 and extends into the spiral groove;

[0103] The connector 16 is located at one end of the L-plate 12;

[0104] The insertion rod 17 is fixed on the upper sleeve 4 near the L plate 12 and inserted into the socket 16.

[0105] Specifically, the longitudinal bar 13 provides space for the threaded groove, the spiral groove provides space for the rolling of the ball 15 and provides a guiding function for the movement of the ball 15, so that the T-cylinder 14 can move along the longitudinal bar 13 and rotate along the spiral groove under the action of external force using the ball 15. The upper sleeve 4 provides support for the insertion rod 17, the L-plate 12 provides space for the insertion port 16, and the insertion port 16 provides space for the insertion rod 17 to be inserted.

[0106] The support hoop includes:

[0107] The passage 18 is opened on the lower sleeve 3 to connect the inner side of the lower sleeve 3 and the guide groove 11;

[0108] The hoop 19 has one end wound around the outside of the T-tube 14 and fixed to the T-tube 14, and the other end passes through the through-channel 18 and is fixed to the inside of the lower sleeve 3.

[0109] The rubber band 20 is inserted into the upper sleeve 4 and is located outside the hoop 19.

[0110] Specifically, the lower sleeve 3 provides space for the passageway 18, the passageway 18 provides a through channel and movement space for the hoop 19, the hoop 19 and the rubber band 20 are elastic and can deform under the action of external force, and will rebound after the external force disappears, the rubber band 20 provides a through channel and support for the hoop 19.

[0111] One end of the rubber band 20 is fixedly connected to a connecting plate 21, and a pull ring 22 is fixedly connected to the connecting plate 20. The upper sleeve 4 has an insertion hole 23 on the side away from the lower sleeve 3. The connecting plate 21 has an insertion block 24 fixed on the side away from the pull ring 22. The insertion block 24 has elasticity and curvature and is pressed and inserted into the inner side of the insertion hole 23 to fix the connecting plate 21.

[0112] In practical application, the operator can pull the upper sleeve 4 away from the neutron absorber plate 7 as needed. This allows the upper sleeve 4 to move the L-plate 12 along the longitudinal rod 13 via the insert rod 17 using external force. Simultaneously, the L-plate 12 will move the T-tube 14 and the ball bearings 15 together. During this movement, the T-tube 14 can rotate clockwise using the cooperation of the ball bearings 15 and the spiral groove, thereby releasing the coiled and tightened band 19. As the upper sleeve 4 moves, the band 19 is pulled through the passage 18 and into the lower sleeve 3 via the elastic band 20, widening the gap between the band 19 and the lower sleeve 3. The operator can then place the experimental mouse into the lower sleeve 3. Between the sleeve 3 and the band 19, adjust the position of the mouse so that the tumor on its body corresponds to the position of the exposure hole 6. Then push the upper sleeve 4 towards the neutron absorption plate 7, so that the upper sleeve 4 pushes the T cylinder 14 along the longitudinal rod 13 through the L plate 12. The T cylinder 14 can rotate counterclockwise using the ball bearing 15 and the spiral groove. During the rotation, the released band 19 is wound up, so that the band 19 can gradually tighten as the upper sleeve 4 moves towards the neutron absorption plate 7. After the upper sleeve 4 completely covers the lower sleeve 3, it moves towards the lower sleeve 3 and pulls the rubber band 20 to deform. Thus, the band 19 can tightly fix the experimental mouse with the support of the lower sleeve 3.

[0113] Afterwards, the staff can pull the connecting plate 21 away from the neutron slowing plate 2 using the pull ring 22 as needed. This will cause the connecting plate 21 to move the insert block 24 together, deforming the insert block 24 and pulling it out of the insertion hole 23. This will disconnect the rubber band 20 from the upper sleeve 4. Then, the upper sleeve 4 will be pulled away from the neutron slowing plate 2, causing the upper sleeve 4 to pull the insert rod 17 out of the insertion port 16. This will remove the upper sleeve 4, open the opening of the lower sleeve 3, and then use the rubber band 20 to pull the clamp 19 closer to the upper sleeve 4. This will stretch and deform the clamp 19 under the support of the T-tube 14 and the lower sleeve 3, thereby loosening the clamp on the mouse and fine-tuning the position of the mouse so that the tumor on the mouse can be placed in the exposure hole 6. Then, the clamp 19 will be loosened, allowing the clamp 19 to re-fix the experimental mouse using the rebound force. Finally, the insert rod 17, the upper sleeve 4, and the insert block 24 will be reset, and the irradiation experiment can be carried out.

[0114] In a preferred embodiment of the present invention, the receiving and protecting member includes:

[0115] The movable groove 25 is located at one end of the lower sleeve 3;

[0116] The rotating rod 26 is set in the movable groove 25 and is rotatably connected to the lower sleeve 3;

[0117] A coil spring 27 is sleeved on the outside of the rotating rod 26, with one end fixedly connected to the rotating rod and the other end fixedly connected to the lower sleeve 3;

[0118] The diaphragm 28 is wound up on the outside of the rotating rod 26.

[0119] Specifically, the exposure hole 6 has an inclined angle to facilitate the push-out of the tumor from the exposure hole 6. The lower sleeve 3 provides space for the opening of the movable groove 25. The movable groove 25 provides rotation space for the rotating rod 26, the coil spring 27 and the soft membrane 28. The soft membrane 28 is made of transparent material, which allows staff to easily observe the corresponding position of the mouse and the exposure hole 6.

[0120] The pull connector includes:

[0121] Support ring 29 is located inside the lower sleeve 3;

[0122] One end of the diaphragm 28 is connected to the support ring 29 and is adapted to its curvature;

[0123] Outer ring 30 is fixed to the outside of support ring 29;

[0124] The connecting rod 31 is installed through the passage 18, with one end fixedly connected to the L plate 12 and the other end fixedly connected to the outer ring 30.

[0125] Specifically, the L-plate 12 can provide support for the outer ring 30 through the connecting rod 31, so that the outer ring 30 can support the support ring 29 inside the lower sleeve 3, and when the L-plate 12 moves, it can drive the outer ring 30 and the support ring 29 to move together through the connecting rod 31, and the support ring 29 can pull one end of the soft membrane 28 to move together.

[0126] In practical application, after irradiating a mouse tumor, the operator needs to pull the upper sleeve 4 away from the neutron absorber plate 7. The upper sleeve 4, via the insert rod 17, moves the L-plate 12, causing the L-plate 12 to move along the inner side of the mouse sleeve away from the neutron absorber plate 7 via the connecting rod 31, along with the outer ring 30 and the support ring 29. Simultaneously, the support ring 29 pulls one end of the soft membrane 28, causing the soft membrane 28 to pull the rotating rod 26 clockwise. During rotation, the rotating rod 26 coils the spring 27 to store energy, allowing the soft membrane 28, coiled outside the rotating rod 26, to be released and unfolded. During the movement of the support ring 29, it will move between the placed mouse and the lower sleeve 3. As it moves, the support ring 29 can push the mouse tumor. At the same time, the clamp 19 will be appropriately loosened, allowing the tumor to slide out of the exposure hole 6 under the push of the support ring 29 using the tilt angle of the exposure hole 6. Simultaneously, the mouse will move towards the upper sleeve 4. As the upper sleeve 4 slides open, the support ring 29 will cause the diaphragm 28 to unfold between the mouse and the lower sleeve 3, separating the mouse and its tumor from the lower sleeve 3. This makes it convenient to remove and separate the tumor and the mouse while opening the upper sleeve 4, and protects the inner wall of the lower sleeve 3 from contamination.

[0127] As a preferred embodiment of the present invention, the spraying component includes:

[0128] Liquid channel 32 is located inside the outer ring 30;

[0129] The nozzle 33 has multiple nozzles, which are evenly arranged on the outside of the outer ring 30 and are connected to the liquid channel 32.

[0130] Two cotton brushes 34 are symmetrically fixed to the outside of the outer ring 30 by a fixing component and located outside the nozzle 33.

[0131] Specifically, the outer ring 30 provides space for the liquid channel 32, which in turn provides a channel for the liquid to enter the nozzle 33. The nozzle 33 can atomize and spray the liquid under pressure. The outer ring 30 provides stable support for the cotton brush 34, which is relatively soft and has absorbency and elasticity.

[0132] Storage and supply parts include:

[0133] The liquid bladder 35 is fixed at one end to the outside of the T-tube 14 and is located outside the longitudinal rod 13;

[0134] The liquid tube 36 has one end passing through the end of the liquid bladder 35, and the other end passing through the channel 18 and fixed on the outer ring 30, and is connected to the liquid channel 32.

[0135] One-way valve 37, having two, one of which is installed through the lower sleeve 3 away from the end of the neutron absorption plate 7 and the discharge end is connected to the liquid bladder 35, and the other is installed through the liquid pipe;

[0136] Hose 38 is fixed to the inlet of one of the check valves 37;

[0137] The storage and discharge components are installed inside the upper sleeve 4 and are connected to the hose 38.

[0138] Specifically, the lower sleeve 3 provides support for the other end of the liquid bladder 35, the T-tube 14 provides stable support for one end of the liquid bladder 35, the liquid bladder 35 provides storage space for liquid and separates the storage space from the distance between the T-tube 14 and the longitudinal rod 13, and the liquid bladder 35 can bend and twist to reduce the storage space under the action of external force, and can unfold and reset under the action of external force. The lower sleeve 3 provides stable support for the one-way valve 37. The one-way valve 37 is a valve type. One one-way valve 37 can provide a channel for liquid to enter the liquid bladder 35, while the other one-way valve 37 can prevent liquid and gas in the liquid pipe from entering the liquid bladder 35 and prevent the liquid in the liquid bladder 35 from being discharged out of the one-way valve 37. The liquid bladder 35 provides support for the hose 38, and the hose 38 can provide a channel for the liquid in the liquid bladder 35 to enter the liquid channel 32.

[0139] Storage and drainage components include:

[0140] The liquid storage chamber 39 is located inside the upper sleeve 4 and bypasses the vent hole 5;

[0141] L-tube 40 is fixed inside the liquid storage chamber 39 and is connected to the hose 38;

[0142] Multiple liquid holes 41 are evenly distributed through the L-tube 40;

[0143] The filling cylinder 42 is located outside the upper sleeve 4 and is connected to the liquid storage chamber 39, with its inlet vertically upward.

[0144] Specifically, the upper sleeve 4 provides space for the liquid storage chamber 39, which provides storage space for the alcohol liquid. The upper sleeve 4 also provides stable support for the L-tube 40, which provides space for the liquid hole 41, which provides a channel for the liquid to enter the L-tube 40. The filling cylinder 42 provides a channel for the liquid to enter the liquid storage chamber 39.

[0145] In practical application, before using the radiation protection device, the operator can inject alcohol liquid into the storage chamber 39 from the filling cylinder 42, filling the storage chamber 39 completely and partially submerging the filling cylinder 42. When the operator slides the upper sleeve 4 closer to the neutron absorption plate 7 to close it, the L plate 12 will be driven by the upper sleeve 4, causing the T cylinder 14 to move away from the other end of the liquid bladder 35. During this process, the T cylinder 14 will rotate while moving using the ball bearing 15 and the spiral groove, thereby allowing the T cylinder 14 to drive the liquid bladder 35 to unfold. During the unfolding process, the suction force will open the channel of the one-way valve 37 connected to the hose 38. At the same time, the channel of the one-way valve 37 connected to the liquid pipe will prevent air and liquid in the liquid pipe from entering the liquid bladder 35. The 40 and water holes draw the alcohol liquid in the storage chamber 39 into the inner side of the liquid bladder 35. When the operator slides and opens the upper sleeve 4 away from the neutron absorption plate 7, the L plate 12 will drive the T cylinder 14 to move together, causing the T cylinder 14 to move towards the other end of the liquid bladder 35. During the movement, the T cylinder 14 will rotate using the ball bearing 15 and the spiral groove, so that the T cylinder 14 can squeeze and fold the liquid bladder 35 during the sliding and opening of the upper sleeve 4. At the same time, by rotating and twisting the liquid bladder 35, the alcohol liquid in the liquid bladder 35 can enter the inner side of the water pipe under the squeezing action, and pass through the water pipe into the inner side of the water channel, so that the alcohol liquid can fill the water channel and enter the nozzle 33. Finally, it passes through the nozzle 33 and is sprayed out onto the inner wall of the lower sleeve 3 and the upper sleeve 4 during the sliding and opening of the upper sleeve 4.

[0146] Working principle: Neutron moderator plate 2 moderates hyperthermal neutrons into thermal neutrons; neutron absorber plate 7 absorbs excess neutrons to reduce irradiation of normal mouse tissues; neutron reflector plate 8 adjusts its position by sliding to reflect thermal neutrons to the tumor area, precisely controlling the irradiation dose; mouse sleeve exposes the tumor to the thermal neutron area through exposure hole 6; other parts are shielded from radiation by neutron absorber plate 7 and sleeve structure. MgF2 neutron moderator plate 2 optimizes the thermal neutron dose, and neutron absorber plate 7 shields normal tissues, ensuring that only the tumor is exposed to the thermal neutron area, minimizing irradiation damage to other parts of the mouse.

[0147] The octagonal arrangement design allows for multiple experiments to be conducted in parallel, and the layout of the exposure hole 6 and the breathing hole 5 takes into account both function and the survival needs of mice.

[0148] The L-plate 12 moves along the guide groove 11 via the push-pull motion of the upper sleeve 4. The T-tube 14 rotates through the cooperation of the ball bearing 15 and the spiral groove of the longitudinal rod 13, controlling the tightening or loosening of the clamp 19. When tightened, the clamp 19 and the lower sleeve 3 form a restraint space to fix the mouse. When loosened, the elastic band 20 assists the clamp 19 to rebound and release the mouse. When the upper sleeve 4 is opened, the connecting rod 31 drives the support ring 29 to unfold the soft membrane 28, separating the mouse from the inner wall of the sleeve to avoid contamination. At the same time, it pushes the tumor to slide out of the exposure hole 6 for easy removal. The push-pull motion of the upper sleeve 4 drives the clamp 19 to automatically tighten or release, eliminating the need for manual binding and simplifying the operation process.

[0149] The soft membrane 28 automatically unfolds when the sleeve is opened, physically isolating the mouse from the inner wall and preventing biological contamination.

[0150] The upper sleeve 4 can be removed by pulling the ring 22 to release the insert 24, simplifying the mouse handling process and increasing experimental throughput.

[0151] During the opening and closing of the sleeve, the T-tube 14 rotates and squeezes the liquid bladder 35, atomizing and spraying the alcohol in the storage chamber 39 through the nozzle 33, and the inner wall of the sleeve is wiped by the cotton brush 34 to achieve cleaning and disinfection; when the sleeve is closed, the T-tube 14 rotates and stretches the liquid bladder 35 to draw in alcohol; when the sleeve is opened, the liquid bladder 35 is squeezed to expel the alcohol, achieving automatic cleaning. Each opening and closing of the sleeve triggers alcohol spraying and wiping by the cotton brush 34, maintaining a sterile internal environment and reducing the risk of cross-contamination. No external power is required; the cleaning agent is delivered by mechanically squeezing the liquid bladder 35, which is energy-saving and highly reliable.

[0152] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. An animal experiment radiation protection device, comprising a base and a neutron moderator plate fixed on the base, wherein eight mouse sleeves for radiation protection are fixed on one side of the neutron moderator plate, characterized in that, Also includes: A neutron reflector is slidably disposed on the base, and the neutron reflector is located on the side of the mouse sleeve away from the neutron slowing plate. A neutron absorbing plate is embedded on one side of the neutron slowing plate, and the neutron absorbing plate is located between the eight mouse sleeves and is octagonal. The self-clamping part is set inside the mouse sleeve to automatically fix the mouse inside the mouse sleeve; The mouse sleeve includes: eight lower sleeves, which are fixed to one side of the neutron slowing plate and correspond to the eight sides of the neutron absorbing plate respectively; and an upper sleeve is inserted into the side of the lower sleeve away from the neutron absorbing plate. The protective part is set on the mouse sleeve and connected to the self-closing part to separate the mouse protective sleeve when the mouse sleeve is opened; The cleaning spray section is located inside the mouse sleeve and connected to the retrieval section, so as to spray and wipe the mouse clean when the mouse sleeve is opened; The self-clamping part includes a push-drive component and a support component. The push-drive component is disposed on the mouse sleeve, and the support component is connected to the push-drive component and located inside the mouse sleeve. The protective part includes a protective retractor and a connecting member. The protective retractor is located at one end of the mouse sleeve, and the connecting member connects the protective retractor to the pusher. The cleaning spray unit includes a spraying component and a storage and supply component. The spraying component is connected to a receiving and protection component and a pushing component. The storage and supply component is in communication with the spraying component. The thruster includes: Guide grooves are symmetrically formed on the side of the lower sleeve near the upper sleeve; The L-plate is guided within one of the guide grooves; A longitudinal rod is disposed in one of the guide grooves and is fixedly connected to the lower sleeve, and penetrates the L-plate; The T-tube is installed through the L-plate and rotatably connected to the L-plate, and is located on the outside of the longitudinal bar; The push-rotating component is located inside the guide groove; The push-rotating component includes: The outer side of the longitudinal rod is provided with a spiral groove; The ball bearings are rolled and embedded inside the T-tube and extend into the spiral groove; The connector is located at one end of the L-plate; The insert rod is fixed to the upper sleeve near the L-plate and inserted into the socket; The support hoop includes: A passageway is provided on the lower sleeve to connect the inner side of the lower sleeve with the guide groove; The hoop has one end wound around the outside of the T-tube and fixed to the T-tube, and the other end passes through the channel and is fixed to the inside of the lower sleeve. The rubber band is inserted into the upper sleeve and is located on the outside of the hoop. The hoop and the elastic band are elastic.

2. The animal experiment radiation protection device according to claim 1, characterized in that, The mouse sleeve also includes; The breathing hole is opened through the side of the upper sleeve away from the neutron absorption plate; An exposure hole is created by penetrating the lower sleeve on the side closest to the neutron absorber plate.

3. The animal experiment radiation protection device according to claim 2, characterized in that, The protective component includes: The movable groove is located at one end of the lower sleeve; The rotating rod is set in the movable groove and is rotatably connected to the lower sleeve; A coil spring is sleeved on the outside of the rotating rod, with one end fixed to the rotating rod and the other end fixed to the lower sleeve; The soft membrane is rolled up on the outside of the rotating rod.

4. The animal experiment radiation protection device according to claim 3, characterized in that, The connecting member includes: The support ring is located inside the lower sleeve; One end of the PVC membrane is connected to the support ring and is adapted to its curvature; The outer ring is fixed to the outside of the support ring; The connecting rod is installed through the passageway, with one end fixed to the L-plate and the other end fixed to the outer ring.

5. The animal experiment radiation protection device according to claim 4, characterized in that, The spraying component includes: The fluid channel is located inside the outer ring; The nozzles are multiple and evenly distributed on the outer side of the outer ring, and are connected to the liquid channel; The cotton brush has two parts, which are symmetrically fixed to the outside of the outer ring by a fixing component and located outside the nozzle.

6. The animal experiment radiation protection device according to claim 5, characterized in that, The storage and supply components include: The liquid bladder is fixed at one end to the outside of the T-tube and located outside the longitudinal rod; The liquid tube has one end passing through the end of the liquid bladder, and the other end passing through the channel and fixed to the outer ring, and is connected to the liquid channel. One-way valve, having two, one of which is installed through the lower sleeve away from the neutron absorber plate and the discharge end is connected to the liquid bladder, and the other is installed through the liquid tube; The hose is fixed to the inlet of one of the check valves; The storage and discharge components are located inside the upper sleeve and are connected to the hose.

7. The animal experiment radiation protection device according to claim 6, characterized in that, The storage and discharge components include: The liquid storage chamber is located inside the upper sleeve and bypasses the vent hole; The L-tube is fixed inside the liquid storage chamber and connected to the flexible tube; Multiple liquid orifices are evenly distributed throughout the L-shaped tube. The filling cylinder is located outside the upper sleeve and is connected to the liquid storage chamber, with its inlet pointing vertically upwards.

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