Oral care solution for treating and preventing ventilator-associated pneumonia and preparation method thereof

Abstract

The invention belongs to the technical field of oral care solutions, and particularly provides an oral care solution for treating and preventing ventilator-associated pneumonia and a preparation method of the oral care solution. Honeysuckle, Chinese lobelia, coptis chinensis, liquorice, fortune eupatorium herb, mint, cinnamon, clove, catechu and aloe are adopted as raw materials and are subjected to proper weight proportioning. Under the combined action of the medicinal components, the traditional Chinese medicine composition has the effects of killing and inhibiting bacteria, clearing away heat and toxic materials and astringing wound. The oral care solution disclosed by the invention adopts pure Chinese herbal medicine components, is high in safety after long-term use, relatively weak in irritation to oral mucosa and very small in influence on a production environment of normal flora, and does not cause disorder of oral strains; the oral care solution provided by the invention is suitable for oral care of critical patients, and can effectively treat and / or prevent the occurrence of ventilator-associated pneumonia of the critical patients.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of oral care solution, and particularly relates to an oral care solution for treating and preventing ventilator-associated pneumonia and a preparation method thereof. BACKGROUND

[0002] Ventilator-associated pneumonia (VAP) is one of the most common infectious diseases in patients with mechanical ventilation in the intensive care unit (ICU). The prerequisite for the occurrence of VAP is that the balance between the host's defense function and the colonization and invasion of microorganisms is destroyed. The inhalation of pathogenic bacteria in the oropharynx or the leakage of bacteria around the tracheal tube cuff is the most important way for bacteria to enter the trachea. Ventilator-associated pneumonia (VAP) refers to pneumonia occurring in patients with tracheal intubation or tracheostomy after receiving mechanical ventilation for 48 hours, and also includes pneumonia occurring within 48 hours after mechanical ventilation and extubation. It is one of the most common infectious diseases in patients with mechanical ventilation in the intensive care unit (ICU). At present, the morbidity and mortality of VAP are relatively high at home and abroad. After the occurrence of VAP, the mechanical ventilation time, ICU stay time and total hospitalization time are prolonged, and the hospitalization cost is increased. Since the treatment of VAP is difficult, the prevention of the formation of VAP has become a great challenge for critical medicine. At present, it is believed that aspiration of bacteria colonized in the oropharynx is an important risk factor for VAP in patients with tracheal intubation. Therefore, maintaining oral hygiene, inhibiting and reducing the colonization of bacteria in the oral cavity and reducing the incidence of VAP are of great importance. The diagnosis, prevention and treatment guidelines for ventilator-associated pneumonia recommend that patients with tracheal intubation use 0.12% chlorhexidine solution for oral care to reduce the incidence of VAP. However, the components containing antibacterial drugs have the characteristics of producing drug resistance, oral ulcer erosion, oral odor, mucosal bleeding, tooth discoloration and other side reactions.

[0003] At present, the oral care solution in the prior art is mainly based on western medicine preparations. Although it can achieve the effects of inhibiting bacteria and cleaning the oral cavity, it has its own blind area in preventing infection, and generally has the disadvantages of unstable efficacy, easy drug resistance, easy change of oral pH value, no effect on fungal infection, destruction of normal beneficial flora in the oral cavity, and inability to change the environment of wet and hot mutual knot in the oral cavity of patients and achieve the effect of eliminating the breeding environment of pathogens. SUMMARY

[0004] In order to solve the above problems existing in the prior art, the present application provides an oral care solution for treating and preventing ventilator-associated pneumonia. The oral care solution uses Chinese herbal medicine as raw material, has weak irritation to oral mucosa, has little effect on the production environment of normal flora, has the effects of bactericidal and bacteriostatic, heat-clearing and detoxifying, and astringing sores, and thus can achieve the effects of treating and preventing ventilator-associated pneumonia.

[0005] The technical solution adopted in the present invention is: A first aspect of the present invention provides an oral care solution for treating and preventing ventilator-associated pneumonia. The raw material components include: 20-40 parts by weight of honeysuckle, 20-40 parts by weight of lobelia, 10-20 parts by weight of coptis chinensis, 10-20 parts by weight of liquorice, 20-40 parts by weight of perilla, 5-15 parts by weight of mint, 5-15 parts by weight of cinnamon, 5-15 parts by weight of cloves, 5-15 parts by weight of catechu, and 10-20 parts by weight of aloe.

[0006] It is further preferred that the raw material components of the oral care solution include: 30 parts by weight of honeysuckle, 30 parts by weight of lobelia, 15 parts by weight of coptis chinensis, 15 parts by weight of liquorice, 30 parts by weight of euphratica, 10 parts by weight of mint, 10 parts by weight of cinnamon bark, 10 parts by weight of cloves, 10 parts by weight of catechu, and 15 parts by weight of aloe.

[0007] A second aspect of the present invention provides a method for preparing the oral care solution for treating and preventing ventilator-associated pneumonia, comprising the following steps: (1) Take all the raw materials except mint and mix them thoroughly to obtain a mixture; (2) Add water to the mixture and perform the first decoction; (3) Then add mint and a certain amount of water and boil for the second time; (4) After the second decoction, a medicinal liquid is obtained, namely the oral care liquid.

[0008] In step (2), add 6-9 times the mass of water to the mixture.

[0009] In step (2), the first decoction is to first decoct over high heat for 20 minutes and then decoct over low heat for 30 minutes.

[0010] In step (3), before the second decoction, water in an amount of 4-6 times the mass of the mixture is added.

[0011] In step (3), the second decoction is first decocted on high heat for 10 minutes and then decocted on low heat for 30 minutes.

[0012] In step (4), the medicinal liquid after the second decoction is also distilled.

[0013] Honeysuckle is sweet in flavor and cold in nature. It clears away heat and detoxifies, cooling and dispersing wind-heat. It is used for carbuncles, furuncles, sore throat, erysipelas, dysentery caused by heat toxins, wind-heat colds, and fever caused by febrile diseases.

[0014] Lobelia chinensis has a pungent flavor and a neutral nature. It has diuretic and detumescent properties, clearing away heat and detoxifying. It is used for abdominal edema, facial and foot edema, carbuncles, furuncles, snake and insect bites, and ascites in late-stage schistosomiasis.

[0015] Coptis chinensis (Coptis chinensis) is bitter and cold in nature. It clears heat and dampness, purging fire and detoxifying. It is used for damp-heat-induced fullness and distension, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactive heart fire, restlessness and insomnia, vomiting and epistaxis due to blood heat, conjunctivitis, toothache, diabetes, carbuncles, furuncles, and externally for eczema, eczema, and pus discharge from the ear canal.

[0016] Licorice root (Glycyrrhiza uralensis) is sweet and neutral in nature. It tonifies the spleen and replenishes Qi, clears away heat and detoxifies, eliminates phlegm and relieves cough, relieves pain, and harmonizes various medicinal herbs. It is used for spleen and stomach deficiency, fatigue, palpitations and shortness of breath, cough with sputum, acute pain in the abdomen and limbs, carbuncles, sores, and to alleviate drug toxicity and potency.

[0017] Perilla frutescens (Ceilan) has a pungent flavor and a neutral nature. Its aromatic properties eliminate dampness, invigorate the spleen and stimulate the appetite, and relieve summer heat. It is used for dampness and turbidity in the middle abdomen, abdominal distension, nausea, a sweet and greasy taste in the mouth, bad breath, excessive salivation, and symptoms of summer heat and dampness, as well as headache and chest tightness.

[0018] Peppermint is pungent and cooling in nature. It dispels wind-heat, clears the head and eyes, and clears rashes. It is used for wind-heat colds, the initial onset of wind-heat, headaches, red eyes, sore throat, mouth sores, rubella, measles, and chest and flank distension.

[0019] Cinnamon bark is pungent, sweet, and highly hot. It replenishes fire and yang, guides fire back to its source, dispels cold and relieves pain, and promotes blood circulation and menstruation. It is used for impotence, cold uterus, cold pain in the waist and knees, asthma due to kidney deficiency, dizziness due to yang deficiency, red eyes and sore throat, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency-cold, hernia due to cold, dysmenorrhea, amenorrhea, and dysmenorrhea.

[0020] Cloves are pungent and warm in nature. They warm the middle and reduce adverse reactions, tonify the kidneys, and boost yang. They are used to treat spleen and stomach deficiency and cold, hiccups and vomiting, poor appetite, vomiting and diarrhea, cold pain in the heart and abdomen, and impotence due to kidney deficiency.

[0021] Catechu is bitter and astringent, with a slightly cold nature. It absorbs dampness, promotes tissue regeneration, and heals sores. It is used for persistent ulcers, eczema, mouth sores, injuries from falls, and bleeding from trauma.

[0022] Aloe vera is bitter and cold in nature. It clears liver heat and promotes bowel movements. It is used for constipation, infantile malnutrition, and convulsions; it can also be used externally to treat eczema.

[0023] The present invention has the following beneficial effects: The present invention provides an oral care solution for treating and preventing ventilator-associated pneumonia. The solution utilizes honeysuckle, lobelia, coptis root, licorice, perilla, mint, cinnamon bark, clove, catechu, and aloe as raw materials and is appropriately proportioned by weight. The combined action of these medicinal components has the effects of sterilization and inhibition, clearing away heat and detoxification, and astringing wounds. The oral care solution of the present invention utilizes pure Chinese herbal ingredients, is highly safe for long-term use, exhibits minimal irritation to the oral mucosa, and has minimal impact on the production environment of normal flora, thus preventing imbalance of oral flora. The oral care solution of the present invention is suitable for oral care of critically ill patients and can effectively treat and / or prevent the occurrence of ventilator-associated pneumonia in critically ill patients. DETAILED DESCRIPTION

[0024] To make the objectives, technical solutions, and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without inventive effort are within the scope of protection of the present invention.

[0025] Unless otherwise specified, all reagents involved in the specific embodiments of the present invention are commercially available products and can be purchased through commercial channels.

[0026] In the following examples, 1 part by weight represents 1 g.

[0027] Example 1 This embodiment provides an oral care solution for treating and preventing ventilator-associated pneumonia, the raw material components of which include: 20 parts by weight of honeysuckle, 40 parts by weight of lobelia, 10 parts by weight of coptis chinensis, 20 parts by weight of liquorice, 20 parts by weight of ephedrine root, 15 parts by weight of mint, 5 parts by weight of cinnamon bark, 15 parts by weight of cloves, 5 parts by weight of catechu, and 20 parts by weight of aloe.

[0028] The method for preparing the oral care solution for treating and preventing ventilator-associated pneumonia comprises the following steps: (1) Take all the raw materials except mint and mix them thoroughly to obtain a mixture; (2) Add 6 times the weight of water to the mixture and perform the first decoction: first decoct over high heat for 20 minutes, then decoct over low heat for 30 minutes; (3) Then add mint and 4 times the mass of water (compared to the mass of the mixture) and perform a second decoction: first decoct over high heat for 10 minutes, then decoct over low heat for 30 minutes; (4) After the second decoction, the medicinal liquid is obtained, and after distillation, the oral care liquid for treating and preventing ventilator-associated pneumonia is obtained.

[0029] Example 2 This embodiment provides an oral care solution for treating and preventing ventilator-associated pneumonia, the raw material components of which include: 40 parts by weight of honeysuckle, 20 parts by weight of lobelia, 20 parts by weight of coptis root, 10 parts by weight of liquorice, 40 parts by weight of euphratica, 5 parts by weight of mint, 15 parts by weight of cinnamon bark, 5 parts by weight of cloves, 15 parts by weight of catechu, and 10 parts by weight of aloe.

[0030] The method for preparing the oral care solution for treating and preventing ventilator-associated pneumonia comprises the following steps: (1) Take all the raw materials except mint and mix them thoroughly to obtain a mixture; (2) Add 9 times the weight of water to the mixture and perform the first decoction: first decoct over high heat for 20 minutes, then decoct over low heat for 30 minutes; (3) Then add mint and 6 times the mass of water (compared to the mass of the mixture) and perform a second decoction: first decoct over high heat for 10 minutes, then decoct over low heat for 30 minutes; (4) After the second decoction, a medicinal liquid is obtained, namely, the oral care liquid for treating and preventing ventilator-associated pneumonia.

[0031] Example 3 This embodiment provides an oral care solution for treating and preventing ventilator-associated pneumonia, the raw material components of which include: 30 parts by weight of honeysuckle, 30 parts by weight of lobelia, 15 parts by weight of coptis chinensis, 15 parts by weight of liquorice, 30 parts by weight of euphratica, 10 parts by weight of mint, 10 parts by weight of cinnamon bark, 10 parts by weight of cloves, 10 parts by weight of catechu, and 15 parts by weight of aloe.

[0032] The method for preparing the oral care solution for treating and preventing ventilator-associated pneumonia comprises the following steps: (1) Take all the raw materials except mint and mix them thoroughly to obtain a mixture; (2) Add 7 times the weight of water to the mixture and perform the first decoction: first decoct over high heat for 20 minutes, then decoct over low heat for 30 minutes; (3) Then add mint and 5 times the mass of water (compared to the mass of the mixture) and perform a second decoction: first decoct over high heat for 10 minutes, then decoct over low heat for 30 minutes; (4) After the second decoction, the medicinal liquid is obtained, and after distillation, the oral care liquid for treating and preventing ventilator-associated pneumonia is obtained.

[0033] Experimental example Fifty-nine patients admitted to the ICU of a Beijing hospital between December 2015 and March 2019 were randomly assigned to an observation group and a control group. The observation group consisted of 28 patients (13 males and 15 females aged 50-92 years) who were treated with the oral care solution described in Example 3 of the present invention. The control group consisted of 31 patients (19 males and 12 females aged 48-90 years) who were not treated with the oral care solution. The incidence of oral ulceration and bleeding, as well as ventilator-associated pneumonia (VAP), was measured in both groups, as shown in Tables 1 and 2, respectively.

[0034] Table 1- Comparison of oral ulceration and bleeding in two groups of patients P<0.05, the difference in the incidence of oral bleeding and ulceration between the observation group and the control group was statistically significant.

[0035] Table 2 - Comparison of the incidence of VAP (ventilator-associated pneumonia) between the two groups of patients P<0.05, the difference in the incidence of VAP between the observation group and the control group was statistically significant.

[0036] It can be seen from Table 1 and Table 2 that the use of the oral care solution of the present invention can effectively reduce the incidence of oral bleeding and ulceration and the incidence of VAP in critically ill patients.

[0037] In summary, the oral care solution described in the present invention utilizes honeysuckle, lobelia, coptis root, liquorice, perilla, mint, cinnamon bark, clove, catechu, and aloe as raw materials and is appropriately proportioned by weight. The combined action of these medicinal components has the effects of sterilization and inhibition, clearing away heat and detoxification, and astringing wounds. The oral care solution described in the present invention utilizes pure Chinese herbal ingredients, is highly safe for long-term use, has minimal irritation to the oral mucosa, and has minimal impact on the production environment for normal flora, preventing oral bacterial imbalance. The oral care solution described in the present invention is suitable for oral care of critically ill patients and can effectively treat and / or prevent the occurrence of ventilator-associated pneumonia in critically ill patients.

Claims

1. An oral care solution for treating and preventing ventilator-associated pneumonia, characterized in that: The raw material components include: 20-40 parts by weight of honeysuckle, 20-40 parts by weight of lobelia, 10-20 parts by weight of coptis chinensis, 10-20 parts by weight of liquorice, 20-40 parts by weight of ephedrine root, 5-15 parts by weight of mint, 5-15 parts by weight of cinnamon bark, 5-15 parts by weight of cloves, 5-15 parts by weight of catechu, and 10-20 parts by weight of aloe.

2. The oral care solution for treating and preventing ventilator-associated pneumonia according to claim 1, characterized in that The raw material components include: 30 parts by weight of honeysuckle, 30 parts by weight of lobelia, 15 parts by weight of coptis chinensis, 15 parts by weight of liquorice, 30 parts by weight of euphratica, 10 parts by weight of mint, 10 parts by weight of cinnamon bark, 10 parts by weight of cloves, 10 parts by weight of catechu and 15 parts by weight of aloe.

3. The method for preparing an oral care solution for treating and preventing ventilator-associated pneumonia according to claim 1, characterized in that the steps include: (1) Take all the raw materials except mint and mix them thoroughly to obtain a mixture; (2) Add water to the mixture and perform the first decoction; (3) Then add mint and a certain amount of water and boil for the second time; (4) After the second decoction, a medicinal liquid is obtained, namely the oral care liquid.

4. The method for preparing an oral care solution for treating and preventing ventilator-associated pneumonia according to claim 3, wherein: In step (2), add 6-9 times the mass of water to the mixture.

5. The method for preparing an oral care solution for treating and preventing ventilator-associated pneumonia according to claim 3, wherein: In step (2), the first decoction is to first decoct over high heat for 20 minutes and then decoct over low heat for 30 minutes.

6. The method for preparing an oral care solution for treating and preventing ventilator-associated pneumonia according to claim 3, wherein: In step (3), before the second decoction, add 4-6 times the mass of water of the mixture.

7. The method for preparing an oral care solution for treating and preventing ventilator-associated pneumonia according to claim 3, wherein: In step (3), the second decoction is first decocted on high heat for 10 minutes and then decocted on low heat for 30 minutes.

8. The method for preparing an oral care solution for treating and preventing ventilator-associated pneumonia according to claim 3, wherein: In step (4), the medicinal liquid after the second decoction is also distilled.

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