Traditional Chinese medicine compound with pelvic inflammation treatment function, pharmaceutical preparation and preparation method

Abstract

The invention provides a traditional Chinese medicine compound with a pelvic inflammation treatment function, a pharmaceutical preparation and a preparation method. The traditional Chinese medicine compound with the pelvic inflammation treatment function comprises at least one of ligusticum wallichii, radix bupleuri, fennel, salvia miltiorrhiza and cassia twig, peach kernel, safflower and red paeony root. Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention can be used for safely and effectively relieving the inflammation symptoms of pelvic inflammation without obvious side effects by virtue of mutual cooperation of multiple traditional Chinese medicines.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound having the function of treating pelvic inflammatory disease, a pharmaceutical preparation for treating pelvic inflammatory disease and a preparation method of the pharmaceutical preparation for treating pelvic inflammatory disease. BACKGROUND

[0002] Pelvic inflammatory disease is an infectious disease involving the female upper genital tract, including endometritis, salpingitis, tubo-ovarian abscess and pelvic peritonitis. It is one of the common diseases in gynecology and poses a serious threat to women's health and fertility.

[0003] Currently, in the treatment of pelvic inflammatory disease, drug therapy, surgical treatment and / or physical therapy are usually adopted. Drug therapy is the main means of treating pelvic inflammatory disease, especially for acute pelvic inflammatory disease, a broad-spectrum antibiotic is usually selected by a physician based on experience to cover possible pathogenic microorganisms, and oral, intramuscular or intravenous administration is selected according to the severity of the disease. When drug therapy is ineffective or there are complications such as tubal abscess or pelvic abscess, surgical treatment can be adopted by laparotomy or laparoscopic surgery. Physical therapy is to use short wave, ultrashort wave for high frequency electrotherapy, to improve local blood circulation, promote inflammation subsidence, and relieve pain and muscle spasm through thermal effect or non-thermal effect.

[0004] However, drug therapy is highly dependent on the use of antibiotics, which can easily lead to bacterial strain resistance, allergic reactions, liver and kidney function damage and a series of side effects, and cannot effectively deal with mycoplasma, viruses and other pathogens. The invasive operation of surgical treatment can bring intraoperative bleeding, anesthesia risk, postoperative complications and many other risks to patients. Physical therapy is usually used to treat chronic pelvic inflammatory disease, and the thermal effect of short wave and ultrashort wave can aggravate local congestion, leading to the spread of inflammation, and physical therapy is not suitable for patients with tumors, coagulation disorders, heart disease, diabetes, thrombosis, AIDS and other diseases. SUMMARY

[0005] The present application mainly provides a traditional Chinese medicine compound having the function of treating pelvic inflammatory disease, a pharmaceutical preparation for treating pelvic inflammatory disease and a preparation method of the pharmaceutical preparation for treating pelvic inflammatory disease, which can be used to safely, effectively and without obvious side effects relieve the inflammatory symptoms of pelvic inflammatory disease.

[0006] To solve the above technical problems, one technical solution adopted by the present application is to provide a traditional Chinese medicine compound having the function of treating pelvic inflammatory disease, which comprises at least one of Szechuan lovage rhizome, bupleurum, cumin, salvia miltiorrhiza, cassia twig and peach kernel, safflower and red peony root.

[0007] In a specific embodiment, the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease comprises peach kernel, safflower, red peony root, Szechuan lovage rhizome, bupleurum, cumin, salvia miltiorrhiza and cassia twig.

[0008] In one embodiment, the Chinese medicine compound having the function of treating pelvic inflammatory disease comprises, by mass fraction, 5-10 parts of peach kernel, 3-5 parts of safflower, 5-10 parts of red peony root, 5-10 parts of Szechuan lovage rhizome, 5-10 parts of bupleurum, 5-10 parts of Chinese cinnamon or 5-10 parts of Danshen.

[0009] In one embodiment, the Chinese medicine compound having the function of treating pelvic inflammatory disease comprises, by mass fraction, 6 parts of peach kernel, 3 parts of safflower, 6 parts of red peony root, 5 parts of Szechuan lovage rhizome, 6 parts of bupleurum, 6 parts of Chinese cinnamon and 10 parts of Danshen.

[0010] To solve the above technical problem, another technical solution adopted by the present application is to provide a pharmaceutical preparation for treating pelvic inflammatory disease, which comprises the Chinese medicine compound having the function of treating pelvic inflammatory disease in any of the above embodiments and optional pharmaceutically acceptable adjuvants.

[0011] In one embodiment, the pharmaceutical preparation for treating pelvic inflammatory disease comprises an external ointment.

[0012] To solve the above technical problem, another technical solution adopted by the present application is to provide a use of the pharmaceutical preparation for treating pelvic inflammatory disease in any of the above embodiments in treating pelvic inflammatory disease.

[0013] To solve the above technical problem, another technical solution adopted by the present application is to provide a preparation method of a pharmaceutical preparation for treating pelvic inflammatory disease, which comprises mixing and grinding at least one of Szechuan lovage rhizome, bupleurum, Chinese cinnamon, Danshen and peach kernel, safflower and red peony root to prepare a pharmaceutical powder; and mixing the pharmaceutical powder with an ointment base to prepare the pharmaceutical preparation for treating pelvic inflammatory disease.

[0014] In one embodiment, the ointment base comprises honey.

[0015] In one embodiment, the ratio of the pharmaceutical powder to the ointment base is 30-50 g of the pharmaceutical powder to 3-5 ml of honey.

[0016] The beneficial effects of the present application are: different from the prior art, the Chinese medicine compound provided by the embodiments of the present application has the functions of treating pelvic inflammatory disease, through the use of multiple drugs, the Chinese medicine compound provided by the present application has the effects of activating blood and resolving stasis, warming meridians and relieving pain, and has the effects of antibacterial and anti-inflammatory, which can effectively relieve the symptoms of inflammation and pain caused by pelvic inflammatory disease, and can reduce the infection of pathogenic bacteria and inhibit the recurrence of pelvic inflammatory disease. The multiple components such as peach kernel, safflower and red peony root have the effects of activating blood and resolving stasis and promoting blood circulation, so as to improve local blood circulation and accelerate the subsidence of inflammation.

[0017] Moreover, the Chinese medicine compound with the function of treating pelvic inflammatory disease is composed of natural herbs, is relatively safe and has less side effects, is suitable for long-term and multiple use, and can well deal with the problems of long course of disease and repeated illness during the treatment of pelvic inflammatory disease. Moreover, the treatment with the Chinese medicine compound can avoid the psychological pressure brought to patients by antibiotic and surgical treatment, can improve the compliance of treatment, and is beneficial to the smooth progress of the treatment of pelvic inflammatory disease. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the description of the embodiments will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0019] Figure 1 is a flowchart of an embodiment of a preparation method of a pharmaceutical preparation for treating pelvic inflammatory disease of the present application. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be described in detail below. Obviously, the described embodiments are only some embodiments of the present application, not all embodiments. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as understood by those skilled in the art to which the present application belongs. The terms used in the specification of the present application are only for the purpose of describing the specific embodiments, and are not intended to limit the present application.

[0021] The embodiments of the present application will be described in detail below in conjunction with the embodiments, but those skilled in the art will understand that the following embodiments are only used to illustrate the present application, and should not be regarded as limiting the scope of the present application. The specific conditions are not specified in the examples, and are carried out according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not specified by the manufacturer, and are all conventional products that can be purchased on the market.

[0022] Reference to "an embodiment" herein means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are they necessarily mutually exclusive of one another. As will be apparent to those of ordinary skill in the art, embodiments described herein can be combinable with other embodiments.

[0023] Pelvic inflammation is an infectious disease involving the upper female genital tract, including endometritis, salpingitis, tubo-ovarian abscess and pelvic peritonitis. It is one of the common diseases in gynecology, which poses a serious threat to women's health and fertility.

[0024] Currently, in the treatment of pelvic inflammation, drug therapy, surgical treatment and / or physical therapy are usually used. Drug therapy is the main means of treatment of pelvic inflammation, especially for acute pelvic inflammation, a broad-spectrum antibiotic is usually selected by the physician based on experience to cover possible pathogenic microorganisms, and oral, intramuscular or intravenous administration is selected according to the severity of the disease. When drug therapy is ineffective or there are complications such as tubal abscess or pelvic abscess, surgical treatment can be used. Physical therapy is to use short wave, ultrashort wave for high frequency electrotherapy, to improve local blood circulation, promote inflammation subsidence, relieve pain and muscle spasm through thermal effect or non-thermal effect.

[0025] However, drug therapy is highly dependent on the use of antibiotics, which can easily lead to bacterial strain resistance, allergic reactions, liver and kidney function damage and a series of side effects, and cannot effectively deal with mycoplasma, viruses and other pathogens. The invasive operation of surgical treatment can bring intraoperative bleeding, anesthesia risk, postoperative complications and many other risks to patients. Physical therapy is usually used to treat chronic pelvic inflammation, and the thermal effect of short wave and ultrashort wave can aggravate local congestion, leading to the spread of inflammation, and physical therapy is not suitable for patients with tumors, coagulation disorders, heart disease, diabetes, thrombosis, AIDS and other diseases.

[0026] In order to improve or solve the above technical problems, the inventors of the present application have made long-term research and put forward at least the following embodiments.

[0027] To solve the above technical problems, the specific embodiments of the present application can provide a traditional Chinese medicine compound with the function of treating pelvic inflammation, which comprises at least one of Szechwan lovage rhizome, bupleurum, cumin, salvia miltiorrhiza, cassia twig and peach kernel, safflower and red peony root.

[0028] In the traditional Chinese medicine compound provided in the specific embodiments of the present application and having the function of treating pelvic inflammatory disease, peach kernel is flat in nature, bitter in taste, and is attributed to heart, liver and large intestine channels, and is specialized in treating blood stasis and blockage, relieving lower abdominal stabbing pain, menstrual blood clots and chronic pain caused by pelvic inflammatory disease, and improving local blood circulation. Moreover, peach kernel has the effects of anticoagulation and weak hemolysis, can inhibit the formation of thrombus, can activate blood and remove stasis to resolve abscess, and is helpful to relieve symptoms such as amenorrhea, dysmenorrhea, and mass and mass of pelvic inflammatory disease.

[0029] Due to the increase in abdominal pressure caused by long-term inflammation or antibiotic use, patients with pelvic inflammatory disease often face the problem of constipation caused by stimulation of the pelvic cavity. Peach kernel has the effect of lubricating the intestines and promoting defecation, and can relieve constipation in patients with pelvic inflammatory disease. Peach kernel also has the effects of anti-inflammatory, analgesic and anti-allergic, which can not only relieve inflammatory reactions, but also reduce allergic reactions caused by other drugs and reduce side effects caused by drug treatment when used in combination with drug treatment methods. Moreover, peach kernel has no abnormal influence on blood glucose, serum protein and liver function tests, and does not cause obvious side effects to patients.

[0030] Specifically, amygdalin in peach kernel can inhibit inflammatory pathways such as NF-κB (nuclear factor kappa-B), COX-2 (cyclooxygenase-2), and reduce the levels of pro-inflammatory factors such as IL-1β (interleukin-1β) and TNF-α (tumor necrosis factor alpha), which can relieve inflammatory reactions and pain caused by pelvic inflammatory disease. Moreover, it can enhance the phagocytic function of macrophages, balance the Th1 / Th2 (helper T cells) cell ratio, and reduce tissue damage.

[0031] Among them, Th1 cells are mainly responsible for mediating cellular immune responses, and can activate macrophages, natural killer cells and cytotoxic T lymphocytes by secreting various cytokines such as interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). These effects help to resist intracellular pathogens such as viruses and bacteria, and are important defense mechanisms in some autoimmune diseases.

[0032] Th2 cells are mainly involved in humoral immune responses, and can promote B cell differentiation and antibody production, especially IgE (immunoglobulin E) antibodies, by secreting cytokines such as interleukin 4 (IL-4), interleukin 5 (IL-5) and interleukin 10 (IL-10). Th2 cells also play an important role in allergic reactions and anti-parasitic infections.

[0033] There is a mutual regulation relationship between Th1 and Th2. If Th1 cell function is hyperactive, it may lead to chronic inflammation and autoimmune diseases; if Th2 cell function is hyperactive, it may trigger allergic reactions and asthma. Maintaining Th1 / Th2 immune balance is crucial for a healthy immune system.

[0034] Safflower tastes pungent and is warm in nature, and belongs to heart and liver channels. It can promote blood circulation and dissipate local stasis, thus having the effects of mildly stimulating heart, reducing coronary resistance, increasing coronary flow and myocardial nutritive blood flow, helping to resist myocardial ischemia, myocardial infarction, arrhythmia, improve peripheral microcirculation disorder, and improve lumbosacral pain and lower abdominal pain caused by pelvic inflammation. Meanwhile, safflower can inhibit platelet aggregation and has anticoagulant effect, thus activating blood and resolving stasis, and having excitatory effect on uterus, helping to treat pelvic inflammation caused by damp-heat and blood stasis, such as blood stasis, dysmenorrhea, postpartum abdominal pain, blood vessel obstruction and purple swelling pain, etc. In addition, safflower has immunocompetence, can regulate Th1 / Th2 (helper T cell) cell ratio, and can remove free radicals to reduce oxidative stress damage.

[0035] Safflower also has anti-inflammatory and analgesic effects, can increase pelvic tissue blood supply by dilating blood vessels, promote inflammation absorption, and improve symptoms such as poor menstruation and dysmenorrhea caused by pelvic inflammation. Safflower yellow pigment contained in safflower can inhibit inflammatory signaling pathways such as NF-κB, and reduce the release of pro-inflammatory factors such as IL-6 (interleukin 6) and TNF-α (tumor necrosis factor-α).

[0036] In addition, safflower also has the effects of reducing blood pressure, resisting hypoxia, supplementing trace elements, regulating reproductive and immune functions, resisting tumors, etc., and can also relieve other diseases suffered by patients.

[0037] Red peony root is slightly cold in nature and belongs to liver channel, and can clear and resolve lower damp-heat, thus relieving fever, local redness, heat and pain in acute pelvic inflammation, and reducing pelvic inflammatory exudation by regulating vascular permeability. Red peony root can also inhibit platelet aggregation to a certain extent, has antithrombotic effect, realizes the effect of activating blood and resolving stasis, improves pelvic blood circulation, and reduces tissue adhesion and chronic pain caused by pelvic inflammation. Paeoniflorin contained in red peony root can inhibit inflammatory pathways such as NF-κB and COX-2, and reduce the levels of pro-inflammatory factors such as TNF-α and IL-6.

[0038] In terms of side effects of drugs, active ingredients such as paeoniflorin, ethyl palmitate and ethyl linoleate in red peony root have the effects of resisting oxidative damage, inhibiting inflammatory factor release, and improving liver microcirculation, can reduce the activities of total nitric oxide synthase (NOS) and inducible nitric oxide synthase (iNOS) in liver and the amount of NO (nitric oxide), and block the damage of NO to liver.

[0039] At the same time, red peony root and its effective components have the effects of resisting tumors, protecting nerves, protecting hearts, reducing blood lipids, resisting arteriosclerosis, relieving intestinal spasm, inhibiting bacteria, etc., and can also relieve other diseases suffered by patients.

[0040] Chuanxiong is warm and belongs to liver and gallbladder meridians. It can dredge blood stasis and relieve lower abdominal distention, stabbing pain and lumbosacral pain caused by pelvic inflammatory disease. Ligustilide in Chuanxiong can inhibit the inflammatory signaling pathways such as NF-κB and MAPK (mitogen-activated protein kinase), and reduce the levels of pro-inflammatory factors such as IL-6 and TNF-α. In addition, Chuanxiong can enhance the phagocytic function of macrophages, balance the ratio of Th1 / Th2 cells, and reduce excessive immune response.

[0041] Chuanxiong can improve the blood system by dilating blood vessels and increase pelvic tissue blood flow. Ligustilide can increase renal blood flow and diuresis, thereby promoting drug penetration and metabolic waste removal, and reducing the risk of tissue adhesion caused by pelvic inflammatory disease. Chuanxiong can also relieve chronic pelvic pain by inhibiting prostaglandin synthesis and central nervous pain transmission.

[0042] At the same time, Chuanxiong has certain inhibitory effect on common pathogens of pelvic inflammatory disease such as Staphylococcus aureus and Escherichia coli, and also has inhibitory effect on some pathogenic skin fungi, which can resist pathogens and reduce complications caused by infection of other strains.

[0043] Chaihu is bitter and pungent in taste, slightly cold in nature, and belongs to liver, gallbladder and lung meridians. It can relieve lower abdominal pain, premenstrual breast distension, liver stagnation, chest and rib pain, irregular menstruation and depression caused by liver qi stagnation, and improve blood stasis. Chaihu saponin can also stimulate the adrenal gland, promote the synthesis and release of adrenal cortical hormone, and use adrenaline to achieve anti-inflammatory effect.

[0044] At the same time, Chaihu can resolve fever and can effectively target low fever, alternating fever and cold (body temperature fluctuation) when acute pelvic inflammatory disease or chronic inflammation has an acute attack. Chaihu has the effect of lifting yang qi and can improve the feeling of distension caused by pelvic organ prolapse accompanied by pelvic inflammatory disease.

[0045] Specifically, Chaihu saponin, saponin A and volatile oil in Chaihu are the main material basis for Chaihu to resolve fever. They can directly act on the hypothalamic temperature regulation center, inhibit the production or release of cAMP (cyclic adenosine monophosphate) in neurons, and inhibit the upward shift of body temperature set point, so as to target fever and alternating fever and cold caused by inflammation. At the same time, total saponins and saponin in Chaihu have obvious inhibitory effect on central nervous system, and can inhibit prostaglandin synthesis, thereby relieving fever and chronic pain caused by pelvic inflammatory disease.

[0046] Fennel is warm in nature, and belongs to the meridians of liver, kidney, spleen and stomach. It can warm the meridians, dispel cold, regulate qi and relieve pain, and can dispel cold dampness in the lower jiao, relieve cold pain in the lower abdomen, cold and soreness in the waist and sacrum caused by cold and qi stagnation, especially suitable for patients with obvious pain during menstruation or when cold, and help treat chronic pelvic inflammatory disease of cold-dampness stagnation type or qi stagnation and blood stasis type. Fennel can also regulate qi and blood, improve the stagnation of qi and blood in the pelvic cavity, and relieve the distending and sinking pain caused by pelvic inflammatory disease.

[0047] Specifically, the volatile oil components such as anethole and anisal in fennel can inhibit inflammatory mediators such as COX-2 and PGE2 (prostaglandin E2), and reduce the levels of pro-inflammatory factors such as TNF-α and IL-6. It can also relieve smooth muscle spasm by regulating calcium ion channels, and thus reduce the spastic pain of pelvic tissue. And it can regulate the movement of intestinal smooth muscle, promote gastrointestinal peristalsis, and relieve the symptoms of stress-induced gastric ulcers, abdominal distension, indigestion, loss of appetite and other symptoms associated with pelvic inflammatory disease.

[0048] Salvia miltiorrhiza is slightly cold in nature, and belongs to the meridians of heart and liver. It has the effects of promoting blood circulation, removing blood stasis, cooling blood and resolving abscesses, and is especially suitable for blood stasis type or damp-heat and blood stasis type pelvic inflammatory disease. It can dredge the stagnation of blood and qi in the pelvic cavity, relieve lower abdominal pain, blood clots and chronic pain. It can clear blood heat and toxin, inhibit redness, heat and pain, and reduce purulent secretions in acute inflammatory period. It can also relieve anxiety and insomnia associated with chronic pelvic inflammatory disease.

[0049] Specifically, tanshinone IIA in salvia miltiorrhiza can dilate the arteries, reduce blood viscosity, and repair damaged endothelial cells to achieve the effect of promoting blood circulation and removing blood stasis. Components such as salvianolic acid A, salvianolic acid B, tanshinone IIA and tanshinone I in salvia miltiorrhiza can act on key targets such as thrombin and plasminogen activator inhibitor-1 to achieve the effect of promoting blood circulation and removing blood stasis. Salvia miltiorrhiza total ketone has estrogen-like biological activity, can inhibit excessive progesterone secretion, reduce prostaglandin F2 level, and inhibit uterine smooth muscle contraction, to relieve the pain caused by pelvic inflammatory disease.

[0050] Tanshinone can also inhibit the inflammatory pathways of NF-κB and MAPK, and reduce the levels of pro-inflammatory factors such as IL-1β and TNF-α. It can also enhance the phagocytic ability of macrophages, balance the ratio of Th17 (T helper cell 17) and Treg (Regulatory T cells), and reduce tissue damage.

[0051] Th17 cells secrete pro-inflammatory factors such as IL-17 (interleukin 17), IL-22 (interleukin 22), etc., which can aggravate local inflammatory response and cause tissue damage. Treg cells secrete anti-inflammatory factors such as IL-10 (interleukin 10), TGF-β (transforming growth factor-β), etc., which can inhibit excessive immune response and promote tissue repair.

[0052] An excessively high Th17 / Treg cell ratio can cause excessive inflammatory response and aggravate pelvic tissue damage, and is prone to chronic or repeated infection. An excessively low Th17 / Treg cell ratio can cause immune suppression, which can weaken the ability to eliminate pathogens and prolong the course of infection. Therefore, adjusting the Th17 / Treg cell ratio to an appropriate level is an important means of balancing anti-inflammatory effect and immune tolerance in the treatment of pelvic inflammation.

[0053] Cassia twig is warm in nature and is meridian-entering heart, lung and bladder, which can dispel cold dampness in lower Jiao, improve blood circulation, and relieve muscle tension and pain through sweating, and can relieve cold pain in lower abdomen, cold and soreness in waist and sacrum caused by cold and stagnation of QI and blood, and is especially suitable for chronic pelvic inflammation of cold and blood stasis type or QI stagnation and blood stasis type. And cassia twig can also promote the movement of QI and blood, and is used for blood cold amenorrhea and arthralgia, etc., which can improve the stagnation of QI and blood in pelvic cavity, relieve swelling and pain, and relieve blood clots. At the same time, cassia twig can also balance QI and blood, and is suitable for palpitation and galloping, etc., which can reduce the adverse QI and improve the symptoms of anxiety, chest tightness, insomnia, etc. caused by pelvic inflammation.

[0054] Specifically, cinnamaldehyde in cassia twig can inhibit inflammatory pathways such as NF-κB and COX-2, reduce the levels of pro-inflammatory factors such as IL-6 and TNF-α, enhance the activity of macrophages, balance Th1 / Th2 immune response, and thus reduce the tissue damage caused by pelvic inflammation. It can also act on blood vessels to dilate blood vessels, reduce blood viscosity, increase pelvic blood flow, promote inflammation absorption and metabolic waste clearance.

[0055] By using a variety of drugs, the traditional Chinese medicine compound provided by the present application has the effects of promoting blood circulation to remove blood stasis, warming meridians to relieve pain, and has the effects of antibacterial and anti-inflammatory, which can effectively relieve the symptoms of inflammation and pain caused by pelvic inflammation, and can reduce the infection of pathogens and inhibit the repeated condition of pelvic inflammation. Many components such as peach kernel, safflower and red peony root have the effects of promoting blood circulation to remove blood stasis and promoting blood circulation, which can improve local blood circulation and accelerate the subsidence of inflammation.

[0056] Moreover, the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease is composed of natural herbs, is safer and has fewer side effects, is suitable for long-term and multiple use, and can well deal with problems such as long course of disease and repeated illness during the treatment of pelvic inflammatory disease. Moreover, the treatment by using the traditional Chinese medicine compound can avoid the psychological pressure brought to patients by antibiotic and surgical treatment, can improve the compliance of treatment, and is beneficial to the smooth progress of the treatment of pelvic inflammatory disease.

[0057] It should be noted that the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease provided in the present application does not violate the "eighteen incompatibilities" and "nineteen contraindications" of traditional Chinese medicine compatibility. These drugs do not have the possibility of mutual counteraction, so as to ensure the safety and effectiveness of the drug use.

[0058] In an embodiment of the present application, the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease can specifically include peach kernel, safflower, red peony root, Szechuan lovage rhizome, bupleurum, cumin, salvia miltiorrhiza, and cassia twig. Through the mutual cooperation of peach kernel, safflower, red peony root, Szechuan lovage rhizome, bupleurum, cumin, salvia miltiorrhiza, and cassia twig, the use effect of the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease can be further improved, which is suitable for different etiologies and different signs of pelvic inflammatory disease, can more effectively relieve symptoms such as inflammation and pain caused by various pelvic inflammatory diseases, and effectively inhibit the repeated problems of pelvic inflammatory disease with complex causes.

[0059] In an embodiment of the present application, in the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease, the peach kernel is 5-10 parts, the safflower is 3-5 parts, the red peony root is 5-10 parts, the Szechuan lovage rhizome is 5-10 parts, the bupleurum is 5-10 parts, the cumin is 5-10 parts, the salvia miltiorrhiza is 5-10 parts, and the cassia twig is 5-10 parts. According to the mass ratio provided in the embodiment, the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease can balance the medicinal effects of various components, so as to be effectively used to relieve symptoms such as inflammation and pain caused by various pelvic inflammatory diseases.

[0060] Specifically, in clinical use, considering the dose limitation of pelvic inflammatory disease, 6g of peach kernel, 3g of safflower, 6g of red peony root, 5g of Szechuan lovage rhizome, 6g of bupleurum, 6g of cumin, 6g of salvia miltiorrhiza, and 10g of cassia twig are configured into a single dose for use, so as to avoid the pollution problem caused by multiple uses of single dose.

[0061] In an embodiment of the present application, preferably, in the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease, the peach kernel is 6 parts, the safflower is 3 parts, the red peony root is 6 parts, the Szechuan lovage rhizome is 5 parts, the bupleurum is 6 parts, the cumin is 6 parts, the salvia miltiorrhiza is 6 parts, and the cassia twig is 10 parts.

[0062] Preferably, the single dose includes 6g of peach kernel, 3g of safflower, 6g of red peony root, 5g of Szechuan lovage rhizome, 6g of bupleurum, 6g of cumin, 6g of salvia miltiorrhiza, and 10g of cassia twig.

[0063] The specific embodiments of the present application can also provide a pharmaceutical preparation for treating pelvic inflammatory disease, which comprises the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease and the optional pharmaceutically acceptable adjuvant.

[0064] By using a plurality of drugs in combination, the pharmaceutical preparation for treating pelvic inflammatory disease provided by the present application has the effects of activating blood and resolving stasis, warming meridians and unblocking collaterals, and relieving pain, and has the effects of resisting bacteria and inflammation, and can effectively relieve the symptoms of inflammation and pain caused by pelvic inflammatory disease, and can reduce pathogen infection and inhibit the recurrence of pelvic inflammatory disease. The plurality of ingredients such as peach kernel, safflower and red peony root have the effects of activating blood and resolving stasis and promoting blood circulation, so as to improve local blood circulation and accelerate the subsidence of inflammation.

[0065] Moreover, the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease used in the pharmaceutical preparation for treating pelvic inflammatory disease is composed of natural herbs, is relatively safe and has fewer side effects, is suitable for long-term and multiple use, and can well deal with the problems of long disease course and disease recurrence that are prone to occur in the treatment of pelvic inflammatory disease. Moreover, the treatment with the traditional Chinese medicine compound can avoid the psychological pressure on patients caused by antibiotic and surgical treatment, can improve the compliance of treatment, and is conducive to the smooth progress of the treatment of pelvic inflammatory disease.

[0066] In a specific embodiment of the present application, the pharmaceutical preparation for treating pelvic inflammatory disease can comprise an external ointment. Compared with drug treatment, surgical treatment and physical treatment, the external ointment is only attached to the surface of the skin of a patient, is absorbed by the skin of the patient, does not cause a wound and has fewer side effects, provides a relatively mild treatment means for pelvic inflammatory disease, can reduce the psychological pressure on patients in the treatment process, improves the compliance of the treatment process of pelvic inflammatory disease, and thus can be conducive to the smooth progress of the treatment process of pelvic inflammatory disease.

[0067] Further, the pharmaceutical preparation for treating pelvic inflammatory disease provided by the specific embodiments of the present application is an external ointment, and the attachment site of the external ointment can be the lower abdomen of a patient to approach the pelvic position where the lesion of pelvic inflammatory disease is located.

[0068] The external ointment can also be combined with a physical treatment means to improve the treatment effect. For example, an infrared lamp is placed directly above the position where the external ointment is attached, the distance between the infrared lamp and the skin of the patient is adjusted according to the feeling of the patient to heat, and the infrared lamp is kept irradiating for a period of time to promote the penetration and absorption of the drug, so that the effective ingredients in the drug can efficiently act on the target tissue to play a therapeutic role.

[0069] The time for keeping the infrared lamp irradiating can be 15-45 minutes. Preferably, the time for keeping the infrared lamp irradiating is 30 minutes.

[0070] In order to solve the above technical problems, the specific embodiments of the present application can also provide a use of a pharmaceutical preparation for treating pelvic inflammatory disease as described in any one of the above specific embodiments in treating pelvic inflammatory disease.

[0071] A review of the background art reveals that among common pelvic inflammatory disease treatments, drug therapy relies heavily on the use of antibiotics, which can easily lead to a series of side effects such as bacterial resistance, allergic reactions, and liver and kidney damage, and are ineffective against pathogens such as mycoplasmas and viruses. The invasive nature of surgical treatments can pose numerous risks to patients, including intraoperative bleeding, anesthesia risks, and postoperative complications. Physical therapy is commonly used to treat chronic pelvic inflammatory disease. During the acute infection phase, the thermal effects of shortwave and ultrashortwave radiation can aggravate local congestion and cause the inflammation to spread. Furthermore, physical therapy is not suitable for patients with concurrent conditions such as tumors, coagulation disorders, heart disease, diabetes, thrombosis, and AIDS.

[0072] Therefore, currently common pelvic inflammatory disease treatments are often only effective for specific types of pelvic inflammatory disease and are not well suited for most patients. Furthermore, the treatments are relatively aggressive and can easily cause damage to the patient's body. However, the pharmaceutical preparations for treating pelvic inflammatory disease provided in the present application provide patients with a milder treatment option and can improve the quality of life of patients with pelvic inflammatory disease through therapeutic means.

[0073] Figure 1 This is a schematic flow chart of an embodiment of the method for preparing a pharmaceutical preparation for treating pelvic inflammatory disease. It should be noted that if there is substantially the same result, this embodiment is not based on Figure 1 The process sequence shown is limited. Figure 1 As shown, the specific embodiment of the present application also provides a method for preparing a pharmaceutical preparation for treating pelvic inflammatory disease, and the method for preparing a pharmaceutical preparation for treating pelvic inflammatory disease comprises:

[0074] S100: mixing and grinding at least one of Chuanxiong rhizome, Bupleurum root, cumin, Salvia miltiorrhiza, and cinnamon twig with peach kernel, safflower, and red peony root to prepare a medicinal powder.

[0075] S200: Mixing the drug powder with the plaster base to prepare a drug preparation for treating pelvic inflammatory disease.

[0076] By combining multiple drugs, the pharmaceutical preparation provided herein for treating pelvic inflammatory disease has the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredge collaterals to relieve pain, and has antibacterial and anti-inflammatory effects. It can effectively relieve the inflammation, pain, and other symptoms caused by pelvic inflammatory disease, reduce pathogen infection, and inhibit the recurrence of pelvic inflammatory disease. Among them, various ingredients such as peach kernel, safflower, and red peony root have the effects of promoting blood circulation and removing blood stasis, thereby improving local blood circulation and accelerating the resolution of inflammation.

[0077] Moreover, the traditional Chinese medicine compound with the function of treating pelvic inflammatory disease in the pharmaceutical preparation for treating pelvic inflammatory disease is composed of natural herbs, is safer and has fewer side effects, is suitable for long-term and multiple use, and can well deal with problems such as long course of disease and repeated illness in the treatment of pelvic inflammatory disease. Moreover, the treatment with the traditional Chinese medicine compound can avoid the psychological pressure on patients caused by antibiotic and surgical treatment, can improve the compliance of treatment, and is beneficial to the smooth progress of the treatment of pelvic inflammatory disease.

[0078] In an embodiment of the present application, the plaster base can include honey. Honey contains antibacterial components such as hydrogen peroxide, methylglyoxal (MGO), and phenolic acid, can inhibit the growth of common pathogenic bacteria such as Staphylococcus aureus and Escherichia coli, and the high sugar concentration and low pH environment of honey can also inhibit the survival of bacteria, while forming a physical barrier to prevent pathogens from invading the human body through the skin, thereby having the effects of antibiosis and anti-inflammation.

[0079] Since the treatment of pelvic inflammatory disease is a long-term process, long-term and multiple application of the plaster can easily cause the skin to be damaged due to water loss, while the hydrophilicity of honey can maintain a moist environment on the surface of the skin, prevent the skin tissue from being too dry during the application of the plaster, and the mild nature of honey can be suitable for patients of all skin types, thereby expanding the application range of the pharmaceutical preparation for treating pelvic inflammatory disease and reducing the risk of side effects of the pharmaceutical preparation for treating pelvic inflammatory disease.

[0080] Optionally, the plaster base can further include at least one of traditional plant oil bases such as sesame oil, castor oil, and tung oil having good adhesion.

[0081] Optionally, the plaster base can further include at least one of traditional natural resin preparations such as rosin and beeswax having good adhesion.

[0082] Optionally, the plaster base can further include at least one of gel bases prepared by using gel forming agents such as gelatin, gum arabic, pectin, carbomer, xanthan gum, and ammonium alginate. Such a plaster base has good transparency and a cool skin feel, and has good analgesic and antipyretic effects.

[0083] Optionally, the plaster base can further include at least one of water-soluble bases prepared by using high molecular materials such as PVP (polyvinylpyrrolidone), CMC-Na (sodium carboxymethyl cellulose), PVA (polyvinyl alcohol), HEC (hydroxyethyl cellulose), and HPMC (hydroxypropyl methyl cellulose) in combination with plasticizers such as glycerol and propylene glycol. Such a plaster base has good air permeability, is easy to clean after application, has weak irritation, and is suitable for use when the skin is swollen and painful and is sensitive.

[0084] Optionally, the plaster base can also include an emulsion type base mixing the oil phase, the water phase and the emulsifier. Such plaster base has soft texture, good moisturizing effect and can load fat-soluble drugs. The oil phase can include at least one of liquid paraffin and stearic acid. The water phase can include at least one of water, glycerol and propylene glycol. The emulsifier can include at least one of Tween and Span.

[0085] Optionally, the plaster base can also include at least one of acrylate, silicone, natural rubber and other pressure-sensitive adhesive bases.

[0086] Optionally, the plaster base can also include a high polymer material base prepared by mixing EVA (ethylene-vinyl acetate copolymer), PU (polyurethane) and other gum materials with biocompatible materials such as chitosan and hyaluronic acid.

[0087] Optionally, the plaster base can also include biodegradable bases such as PLA (polylactic acid) and PCL (polycaprolactone).

[0088] In a specific embodiment of the present application, the ratio of the drug powder to the plaster base is 30-50 g of the drug powder to 3-5 ml of the honey. By controlling the ratio of the drug powder to the honey, the honey and the drug powder can be uniformly mixed, so that the prepared drug preparation does not have the problems of easy drying, easy falling off, poor ductility and poor adhesion due to too little plaster base, and does not have the problem of limited therapeutic effect due to too much plaster base and too little drug powder, and can balance the usability and efficacy of the drug preparation for treating pelvic inflammatory disease.

[0089] The following is an embodiment of the drug preparation provided by the present application for treating pelvic inflammatory disease.

[0090] Embodiment One

[0091] 6 g of peach kernel, 3 g of safflower, 6 g of red peony root, 5 g of chuanxiong, 6 g of bupleurum, 6 g of cumin, 6 g of salvia miltiorrhiza and 10 g of cassia twig are mixed and ground into a drug powder, and then 4 ml of honey is mixed with the drug powder to prepare a paste, thereby preparing a drug preparation for treating pelvic inflammatory disease. The drug preparation is applied to the lower abdomen of the patient with pelvic inflammatory disease to a thickness of about 1 cm, and the lower abdomen of the patient is heated by infrared lamp irradiation for 30-60 minutes.

[0092] After the patient is treated for one course of treatment by the method provided in Embodiment One, the therapeutic effect of the drug preparation for treating pelvic inflammatory disease provided by the present application is observed by the patient's clinical symptoms, gynecological examination and B-ultrasound conditions and other indicators.

[0093] The evaluation criteria for the therapeutic effect are as follows:

[0094] 1. Markedly: clinical symptoms mostly disappear or completely disappear, gynecological signs are negative or significantly improved compared with before treatment, and B-ultrasound shows normal pelvic cavity.

[0095] 2. Effective: clinical symptoms and signs are improved.

[0096] 3. Ineffective: clinical symptoms and signs are not improved or even aggravated.

[0097] Table 1 is a statistical table of the treatment effect of patients with pelvic inflammatory disease.

[0098]

[0099]

[0100] Table 1

[0101] According to Table 1, the age distribution of patients ranges from 25 to 67 years old, and the disease diagnosis includes five kinds of conditions, including missed abortion, pelvic inflammatory disease, abdominal pain, abdominal mass, and failed drug abortion, and the syndrome types include blood stasis and qi stagnation and blood stasis, so it is not difficult to find that the patient's condition is very diverse. For the diversified conditions, the use of the pharmaceutical preparation for treating pelvic inflammatory disease provided by the present application for treatment can obtain significant therapeutic effect, which shows that the pharmaceutical preparation for treating pelvic inflammatory disease provided by the present application has obvious effect in treating pelvic inflammatory disease related aspects, and can effectively relieve the symptoms such as inflammation and pain caused by pelvic inflammatory disease.

[0102] The above only describes some embodiments of the present application, and does not limit the protection scope of the present application, and any equivalent device or equivalent process transformation using the content of the specification and drawings, or direct or indirect application in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A Chinese medicinal compound for treating pelvic inflammatory disease, characterized in that: The invention comprises at least one of Chuanxiong, Bupleurum, Fennel, Salvia miltiorrhiza, and Cinnamon Twig, as well as Peach Kernel, Carthamus tinctorius, and Paeonia lactiflora.

2. The Chinese medicinal compound for treating pelvic inflammatory disease according to claim 1, characterized in that: Including peach kernel, safflower, red peony root, Chuanxiong, bupleurum, fennel, salvia miltiorrhiza, and cinnamon twig.

3. The Chinese medicinal compound for treating pelvic inflammatory disease according to claim 2, characterized in that: Calculated by mass, in the traditional Chinese medicine compound with the function of treating pelvic inflammatory disease, peach kernel is 5-10 parts, safflower is 3-5 parts, red peony root is 5-10 parts, Chuanxiong is 5-10 parts, bupleurum is 5-10 parts, fennel is 5-10 parts, salvia miltiorrhiza is 5-10 parts, and cassia twig is 5-10 parts.

4. The Chinese medicinal compound for treating pelvic inflammatory disease according to claim 3, characterized in that: Calculated by mass, in the traditional Chinese medicine compound with the function of treating pelvic inflammatory disease, there are 6 parts of peach kernel, 3 parts of safflower, 6 parts of red peony root, 5 parts of Chuanxiong, 6 parts of bupleurum, 6 parts of fennel, 6 parts of salvia miltiorrhiza, and 10 parts of cassia twig.

5. A pharmaceutical preparation for treating pelvic inflammatory disease, characterized in that: The pharmaceutical preparation for treating pelvic inflammatory disease comprises the traditional Chinese medicine compound having the function of treating pelvic inflammatory disease according to any one of claims 1 to 4 and optional pharmaceutically acceptable excipients.

6. The pharmaceutical preparation for treating pelvic inflammatory disease according to claim 5, characterized in that The pharmaceutical preparation for treating pelvic inflammatory disease includes an external ointment.

7. Use of the pharmaceutical preparation for treating pelvic inflammatory disease according to claim 5 or claim 6 in treating pelvic inflammatory disease.

8. A method for preparing a pharmaceutical preparation for treating pelvic inflammatory disease, characterized in that: include: Mixing and grinding at least one of Chuanxiong, Bupleurum, Fennel, Salvia miltiorrhiza, and Cinnamon Twig with Peach Kernel, Carthamus tinctorius, and Paeonia lactiflora to prepare a medicinal powder; The drug powder is mixed with a plaster base to prepare the drug preparation for treating pelvic inflammatory disease.

9. The method for preparing the pharmaceutical preparation for treating pelvic inflammatory disease according to claim 8, characterized in that: The plaster base includes honey.

10. The method for preparing the pharmaceutical preparation for treating pelvic inflammatory disease according to claim 9, characterized in that: The ratio of the drug powder to the plaster matrix is ​​3-5 ml of honey for every 30-50 g of the drug powder.

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