Polymorphic form and amorphous form of ziyuglycoside II sodium salt as well as preparation method and application of polymorphic form and amorphous form of ziyuglycoside II sodium salt

By preparing the polymorphic and amorphous forms of Sanguisorba officinalis saponin II sodium salt, the problems of poor water solubility and low bioavailability of ZYG II are solved, its solubility and bioavailability are improved, making it particularly suitable for pulmonary administration and enhancing its efficacy.

CN120818002APending Publication Date: 2025-10-21JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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Patent Information

Application Number
CN202510973899.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2025-06-17
Filing Date
2025-07-15
Publication Date
2025-10-21

AI Technical Summary

Technical Problem

Sanguisorba officinalis saponin II (ZYG II) has poor water solubility and low bioavailability, which affects its clinical efficacy. Existing research mainly focuses on drug delivery systems, and there is a lack of methods to improve its solubility and bioavailability.

Method used

Polymorphic and amorphous forms of sanguisorba officinalis saponin II sodium salt (ZYG-II-Na) were prepared, and their solid forms were optimized through different preparation methods such as solvent evaporation, humidity control, and spray drying to improve solubility and pharmacokinetic behavior.

Benefits of technology

The solubility and bioavailability of ZYG-Ⅱ-Na in water are improved, its efficacy is enhanced, and it is particularly suitable for pulmonary administration, providing application support for polymorphic and amorphous forms.

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Abstract

The invention discloses a polymorphic form and an amorphous form of ziyuglycoside II sodium salt as well as a preparation method and application of the polymorphic form and the amorphous form, and particularly discloses physicochemical properties of the polymorphic form and the amorphous form of the ziyuglycoside II sodium salt (ZYG-II-Na) and application of the ziyuglycoside II sodium salt in preparation of medicines. Compared with ziyuglycoside II, the polymorphic ZYG-II-Na and the amorphous ZYG-II-Na obtained by means of crystal form screening and solid engineering have higher solubility and dissolution rate, and the bioavailability of the ziyuglycoside II in vivo is remarkably improved. In addition, in-vitro evaluation and pharmacokinetic tests show that the ZYG-II-Na has good pharmacokinetic characteristics and treatment potential when being used for treating lung diseases (such as through an inhalation way).
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