Application of traditional Chinese medicine composition in preparation of medicine for treating coronary heart disease complicated with anxiety and depression

Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating coronary heart disease complicated with anxiety and depression, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from coptis chinensis, rhizoma pinelliae preparata, caulis bambusae in taeniam, fried fructus aurantii, pericarpium citri reticulatae, poria cocos, vinegar-processed curcuma zedoary, astragalus membranaceus, cassia twig, angelica sinensis, ligusticum wallichii, cortex albiziae, vinegar-processed rhizoma cyperi and fried semen raphani. The traditional Chinese medicine composition has the effects of tonifying qi, activating blood and soothing liver-qi stagnation, and has a good treatment effect on coronary heart disease combined with anxiety depression through test verification.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to the application of a traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression. Background Technology

[0002] Coronary artery disease complicated by anxiety and depression is a complex pathological state resulting from the comorbidity of coronary atherosclerotic heart disease and mood disorders, falling under the research scope of "dual-heart medicine." Patients with coronary artery disease are prone to anxiety and depression due to long-term myocardial ischemia and chest pain. Anxiety and depression, in turn, exacerbate cardiovascular damage through mechanisms such as sympathetic nerve excitation and the release of inflammatory factors, creating a vicious cycle. Statistics show that the incidence of depression among patients with coronary artery disease is as high as 34.6%-51%, and the incidence of anxiety is also significantly higher than in the general population, seriously affecting treatment outcomes and quality of life.

[0003] In the preparation of drugs for treating coronary heart disease complicated with anxiety and depression, traditional Chinese medicine (TCM) drug compositions mainly achieve "dual treatment of both hearts" through multi-target synergistic effects. TCM compound formulas based on classic prescriptions such as Xiaoyao San, Ganmai Dazao Tang, and Xuefu Zhuyu Tang not only contain liver-soothing and blood-activating components like Chaihu and Danshen to improve coronary artery blood flow, but also combine heart-nourishing and calming herbs like Suanzaoren and Baihe to regulate neurotransmitters (such as serotonin and dopamine). Simultaneously, they reduce vascular endothelial damage and neuroinflammatory responses through anti-inflammatory and antioxidant mechanisms. For example, TCM preparations such as Jieyu Wan and Xinkeshu Pian have been proven to simultaneously reduce patients' HAMD depression scores and improve the frequency of angina attacks, and compared to Western medicine, they have the advantages of fewer adverse reactions and higher compliance. These compositions, through a holistic regulatory model of "regulating Qi and blood, balancing Yin and Yang, and harmonizing emotions," overcome the limitations of traditional single-treatment of cardiovascular or mental symptoms.

[0004] Although traditional Chinese medicine (TCM) compositions demonstrate advantages in multi-system regulation in the treatment of heart and cardiovascular diseases, their standardized application still faces significant bottlenecks. Current clinical research often employs self-formulated prescriptions or empirically adapted formulas, lacking unified diagnostic standards and quality control systems. This leads to significant differences in formulation schemes among different studies and unclear mechanisms of action of active ingredients. This lack of standardization not only affects the stability and reproducibility of efficacy but also hinders the accumulation of large-scale evidence-based medicine, becoming a major obstacle to the internationalization and standardization of TCM compound prescriptions. Summary of the Invention

[0005] The purpose of this invention is to provide an application of a traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, which has the advantage of being able to significantly treat coronary heart disease complicated with anxiety and depression.

[0006] The above-mentioned technical objective of the present invention is achieved through the following technical solution:

[0007] The application of a traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, wherein the raw materials of the traditional Chinese medicine composition include:

[0008] Coptis chinensis, Pinellia ternata, Bambusa textilis, stir-fried Citrus aurantium, Citrus reticulata peel, Poria cocos, Curcuma zedoaria (processed with vinegar), Astragalus membranaceus, Cinnamomum cassia, Angelica sinensis, Ligusticum chuanxiong, Albizia julibrissin bark, Cyperus rotundus (processed with vinegar), and stir-fri

[0009] Preferably, the raw materials for the traditional Chinese medicine composition are: 5-15 parts by weight of Coptis chinensis, 6-18 parts by weight of Pinellia ternata, 8-20 parts by weight of bamboo shavings, 5-15 parts by weight of stir-fried Citrus aurantium, 6-15 parts by weight of Citrus reticulata peel, 20-35 parts by weight of Poria cocos, 6-13 parts by weight of vinegar-processed Curcuma zedoaria, 25-35 parts by weight of Astragalus membranaceus, 10-18 parts by weight of Cinnamomum cassia, 1-18 parts by weight of Angelica sinensis, 10-18 parts by weight of Ligusticum chuanxiong, 6-12 parts by weight of Albizia julibrissin bark, 5-15 parts by weight of vinegar-processed Cyperus rotundus, and 6-15 parts by weight of stir-fried Raphanus sativus seeds.

[0010] Further preferred, the raw materials of the traditional Chinese medicine composition are: 8-13 parts by weight of Coptis chinensis, 9-15 parts by weight of Pinellia ternata, 9-18 parts by weight of bamboo shavings, 8-11 parts by weight of stir-fried Citrus aurantium, 8-14 parts by weight of Citrus reticulata peel, 22-32 parts by weight of Poria cocos, 8-11 parts by weight of vinegar-processed Curcuma zedoaria, 28-32 parts by weight of Astragalus membranaceus, 12-16 parts by weight of Cinnamomum cassia, 8-17 parts by weight of Angelica sinensis, 13-16 parts by weight of Ligusticum chuanxiong, 8-11 parts by weight of Albizia julibrissin bark, 8-13 parts by weight of vinegar-processed Cyperus rotundus, and 8-13 parts by weight of stir-fried Raphanus sativus seeds.

[0011] The preferred raw materials for the traditional Chinese medicine composition are: 9 parts by weight of Coptis chinensis, 10 parts by weight of Pinellia ternata, 10 parts by weight of bamboo shavings, 10 parts by weight of stir-fried Citrus aurantium, 10 parts by weight of Citrus reticulata peel, 24 parts by weight of Poria cocos, 10 parts by weight of vinegar-processed Curcuma zedoaria, 30 parts by weight of Astragalus membranaceus, 15 parts by weight of Cinnamomum cassia, 15 parts by weight of Angelica sinensis, 15 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Albizia julibrissin bark, 9 parts by weight of vinegar-processed Cyperus rotundus, and 12 parts by weight of stir-fried Raphanus sativus seeds.

[0012] Alternatively, Coptis chinensis 9 parts by weight, Pinellia ternata 12 parts by weight, Bambusa textilis 15 parts by weight, Citrus aurantium 10 parts by weight, Citrus reticulata 12 parts by weight, Poria cocos 30 parts by weight, Curcuma zedoaria 10 parts by weight, Astragalus membranaceus 30 parts by weight, Cinnamomum cassia 15 parts by weight, Angelica sinensis 15 parts by weight, Ligusticum chuanxiong 15 parts by weight, Albizia julibrissin 10 parts by weight, Cyperus rotundus 9 parts by weight, and Raphanus sativus 12 parts by weight.

[0013] In the above technical solution, the traditional Chinese medicine composition can be any form of the above-mentioned raw materials, including: a composition formed by pulverizing, grinding and sieving the raw materials into powder and then mixing them.

[0014] Preferably, the dosage form of the drug includes powder, pills, tablets, granules, capsules, ointments, oral preparations, gels, or decoctions.

[0015] Preferably, the drug also includes a pharmaceutically acceptable carrier.

[0016] In summary, the present invention has the following beneficial effects:

[0017] The traditional Chinese medicine composition provided by this invention comprises the following raw materials: Coptis chinensis, Pinellia ternata, Bambusa textilis, Citrus aurantium (fried), Citrus reticulata peel, Poria cocos, Curcuma zedoaria (vinegar-processed), Astragalus membranaceus, Cinnamomum cassia, Angelica sinensis, Ligusticum chuanxiong, Albizia julibrissin bark, Cyperus rotundus (vinegar-processed), and Raphanus sativus seeds (fried). Among the above-mentioned combinations of traditional Chinese medicine, Astragalus membranaceus combined with bamboo shavings has the effect of clearing heat and resolving phlegm; Curcuma zedoaria combined with vinegar and Ligusticum chuanxiong has the effect of breaking up blood stasis and eliminating masses; Cyperus rotundus combined with vinegar and stir-fried radish seeds has the effect of regulating qi and relieving depression; Angelica sinensis combined with cinnamon twig has the effect of activating blood and unblocking collaterals; Astragalus membranaceus combined with Poria cocos has the effect of strengthening the spleen and eliminating dampness; Albizia julibrissin bark combined with tangerine peel has the effect of soothing the liver and calming the mind; stir-fried Citrus aurantium combined with vinegar and Cyperus rotundus has the effect of regulating qi; Ligusticum chuanxiong combined with Angelica sinensis has the effect of activating blood; bamboo shavings combined with Pinellia ternata can resolve phlegm; Coptis chinensis combined with vinegar and Curcuma zedoaria can attack pathogens; Astragalus membranaceus combined with Poria cocos can support the body's resistance and prevent pathogens from harming the body's resistance; stir-fried radish seeds combined with tangerine peel can regulate the spleen; Albizia julibrissin bark combined with vinegar and Cyperus rotundus can soothe the liver and improve digestive disorders related to emotions. Therefore, the traditional Chinese medicine composition of this application, through the synergistic combination of the above-mentioned drugs, has the effects of invigorating qi and promoting blood circulation, soothing the liver and relieving depression. Experimental verification shows that it has a good therapeutic effect on coronary heart disease complicated with anxiety and depression. In addition, it has a good therapeutic effect on anxiety insomnia, depression and irritability, epigastric fullness and loss of appetite, and dyslipidemia. Detailed Implementation

[0018] The specific embodiments of the present invention will be further described below.

[0019] The technical solution adopted in this invention is:

[0020] The application of a traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, wherein the raw materials of the traditional Chinese medicine composition include:

[0021] Coptis chinensis, Pinellia ternata, Bambusa textilis, stir-fried Citrus aurantium, Citrus reticulata peel, Poria cocos, Curcuma zedoaria (processed with vinegar), Astragalus membranaceus, Cinnamomum cassia, Angelica sinensis, Ligusticum chuanxiong, Albizia julibrissin bark, Cyperus rotundus (processed with vinegar), and stir-fri

[0022] The traditional Chinese medicine composition provided by this invention mainly comprises Coptis chinensis, Pinellia ternata, Bambusa textilis, stir-fried Citrus aurantium, Citrus reticulata peel, Poria cocos, Curcuma zedoaria (processed with vinegar), Astragalus membranaceus, Cinnamomum cassia, Angelica sinensis, Ligusticum chuanxiong, Albizia julibrissin bark, Cyperus rotundus (processed with vinegar), and stir-fried Raphanus sativus seeds. In the above-mentioned combination, the combination of Astragalus membranaceus and Bambusa textilis has the effect of clearing heat and resolving phlegm; the combination of Curcuma zedoaria (processed with vinegar) and Ligusticum chuanxiong has the effect of breaking up blood stasis and eliminating masses; the combination of Cyperus rotundus (processed with vinegar) and stir-fried Raphanus sativus seeds has the effect of regulating qi and relieving depression; and the combination of Angelica sinensis and Cinnamomum cassia has the effect of activating qi and relieving depression. The combination of Astragalus membranaceus and Poria cocos promotes blood circulation and eliminates dampness; the combination of Albizia julibrissin bark and Citrus reticulata peel soothes the liver and calms the mind; the combination of stir-fried Citrus aurantium and vinegar-processed Cyperus rotundus promotes qi circulation; Ligusticum chuanxiong and Angelica sinensis invigorate blood; the combination of Bambusa textilis and Pinellia ternata resolves phlegm; the combination of Coptis chinensis and vinegar-processed Curcuma zedoaria attacks pathogens; the combination of Astragalus membranaceus and Poria cocos strengthens the body and prevents pathogens from harming the body; the combination of stir-fried Raphanus sativus seed and Citrus reticulata peel regulates the spleen; and the combination of Albizia julibrissin bark and vinegar-processed Cyperus rotundus soothes the liver and improves digestive disorders related to emotional state. Therefore, the traditional Chinese medicine composition of this application, through the synergistic combination of the above-mentioned drugs, has the effects of invigorating qi and blood circulation, soothing the liver and relieving depression. Experimental verification shows that it has a good therapeutic effect on coronary heart disease complicated with anxiety and depression, and also has a good therapeutic effect on anxiety insomnia, depression and irritability, epigastric fullness and loss of appetite, and dyslipidemia.

[0023] The term "comprising" as used in this invention means that, in addition to the raw materials mentioned above, it may also include other raw materials acceptable in the field of traditional Chinese medicine, which impart different properties to the traditional Chinese medicine composition. Furthermore, the term "comprising" as used in this invention may also be replaced with the closed-ended phrase "is" or "made from...".

[0024] In a preferred embodiment of the present invention, the raw material of the traditional Chinese medicine composition comprises the following components in parts by mass:

[0025] Coptis chinensis 5-15 parts by weight, Pinellia ternata 6-18 parts by weight, Bambusa textilis 8-20 parts by weight, Citrus aurantium 5-15 parts by weight, Citrus reticulata 6-15 parts by weight, Poria cocos 20-35 parts by weight, Curcuma zedoaria 6-13 parts by weight, Astragalus membranaceus 25-35 parts by weight, Cinnamomum cassia 10-18 parts by weight, Angelica sinensis 1-18 parts by weight, Ligusticum chuanxiong 10-18 parts by weight, Albizia julibrissin bark 6-12 parts by weight, Cyperus rotundus 5-15 parts by weight, Raphanus sativus 6-15 parts by weight.

[0026] Typical but non-limiting weight portions of Coptis chinensis are, for example, 5g, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, and 15g; typical but non-limiting weight portions of Pinellia ternata are, for example, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, and 18g; typical but non-limiting weight portions of Bambusa textilis are, for example, 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g, 19g, and 20g; typical but non-limiting weight portions of Citrus aurantium ...5g, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g, 19g, and 20g; For example, 5g, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g; typical but non-restrictive weight portions of the above-mentioned dried tangerine peel, such as 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g; typical but non-restrictive weight portions of the above-mentioned Poria cocos, such as 20g, 21g, 22g, 23g, 24g, 25g, 26g, 27g, 28g, 29g, 30g, 31g, 32g, 33g, 34g, 35g; typical but non-restrictive weight portions of the above-mentioned vinegar-processed Curcuma zedoaria, such as 6g, 7g, 8g, 9g, 10g. 11g, 12g, 13g; typical but non-restrictive weight portions of Astragalus membranaceus are, for example, 25g, 26g, 27g, 28g, 29g, 30g, 31g, 32g, 33g, 34g, 35g; typical but non-restrictive weight portions of Cinnamomum cassia are, for example, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g; typical but non-restrictive weight portions of Angelica sinensis are, for example, 1g, 2g, 3g, 4g, 5g, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g; above Typical but non-limiting weight portions of Ligusticum chuanxiong are, for example, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, and 18g; typical but non-limiting weight portions of Albizia julibrissin bark are, for example, 6g, 7g, 8g, 9g, 10g, 11g, and 12g; typical but non-limiting weight portions of Cyperus rotundus (processed with vinegar) are, for example, 5g, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, and 15g; typical but non-limiting weight portions of stir-fried radish seeds are, for example, 6g, 7g, 8g, 9g, 10g, 11g, 12g, 13g, 14g, and 15g.

[0027] In another preferred embodiment of the present invention, the raw materials of the traditional Chinese medicine composition, by weight parts, include the following components: 8-13 parts by weight of Coptis chinensis, 9-15 parts by weight of Pinellia ternata, 9-18 parts by weight of Bambusa textilis, 8-11 parts by weight of stir-fried Citrus aurantium, 8-14 parts by weight of Citrus reticulata, 22-32 parts by weight of Poria cocos, 8-11 parts by weight of Curcuma zedoaria (processed with vinegar), 28-32 parts by weight of Astragalus membranaceus, 12-16 parts by weight of Cinnamomum cassia, 8-17 parts by weight of Angelica sinensis, 13-16 parts by weight of Ligusticum chuanxiong, 8-11 parts by weight of Albizia julibrissin bark, 8-13 parts by weight of Cyperus rotundus (processed with vinegar), and 8-13 parts by weight of stir-fried Raphanus sativus seeds.

[0028] Typical, but not limiting, weight portions of Coptis chinensis are, for example, 8g, 9g, 10g, 11g, 12g, and 13g; typical, but not limiting, weight portions of Pinellia ternata are, for example, 9g, 10g, 11g, 12g, 13g, 14g, and 15g; typical, but not limiting, weight portions of Bambusa textilis are, for example, 9g, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, and 18g; typical, but not limiting, weight portions of Citrus aurantium ... and 13g; typical, but not limiting, weight portions of Citrus aurantium are, for example, 9g, 10g, 11g, 12g, and 13g; typical, but not limiting, weight portions of Citrus aurantium are, for example, However, non-restricted weight portions are, for example, 8g, 9g, 10g, and 11g; typical but non-restricted weight portions of the above-mentioned dried tangerine peel are, for example, 68g, 9g, 10g, 11g, 12g, 13g, and 14g; typical but non-restricted weight portions of the above-mentioned Poria cocos are, for example, 222g, 23g, 24g, 25g, 26g, 27g, 28g, 29g, 30g, 31g, and 32g; typical but non-restricted weight portions of the above-mentioned vinegar-processed Curcuma zedoaria are... For example, 8g, 9g, 10g, 11g; typical but non-restrictive weight portions of Astragalus membranaceus, for example, are 28g, 29g, 30g, 31g, 32g; typical but non-restrictive weight portions of Cinnamomum cassia, for example, are 12g, 13g, 14g, 15g, 16g; typical but non-restrictive weight portions of Angelica sinensis, for example, are 8g, 9g, 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g; Typical but non-limiting weight portions of Ligusticum chuanxiong are, for example, 13g, 14g, 15g, and 16g; typical but non-limiting weight portions of Albizia julibrissin bark are, for example, 8g, 9g, 10g, and 11g; typical but non-limiting weight portions of Cyperus rotundus (processed with vinegar) are, for example, 8g, 9g, 10g, 11g, 12g, and 13g; and typical but non-limiting weight portions of stir-fried radish seeds are, for example, 68g, 9g, 10g, 11g, 12g, and 13g.

[0029] In the above preferred embodiment, the raw materials of the traditional Chinese medicine composition are, by weight, 9 parts Coptis chinensis, 10 parts Pinellia ternata, 10 parts Bambusa textilis, 10 parts Citrus aurantium (fried), 10 parts Citrus reticulata peel, 24 parts Poria cocos, 10 parts Curcuma zedoaria (vinegar-processed), 30 parts Astragalus membranaceus, 15 parts Cinnamomum cassia, 15 parts Angelica sinensis, 15 parts Ligusticum chuanxiong, 10 parts Albizia julibrissin bark, 9 parts Cyperus rotundus (vinegar-processed), and 12 parts Raphanus sativus seeds (fried).

[0030] Alternatively, Coptis chinensis 9 parts by weight, Pinellia ternata 12 parts by weight, Bambusa textilis 15 parts by weight, Citrus aurantium 10 parts by weight, Citrus reticulata 12 parts by weight, Poria cocos 30 parts by weight, Curcuma zedoaria 10 parts by weight, Astragalus membranaceus 30 parts by weight, Cinnamomum cassia 15 parts by weight, Angelica sinensis 15 parts by weight, Ligusticum chuanxiong 15 parts by weight, Albizia julibrissin 10 parts by weight, Cyperus rotundus 9 parts by weight, and Raphanus sativus 12 parts by weight.

[0031] Based on the application of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, the traditional Chinese medicine composition is: a composition formed by pulverizing, grinding and sieving the raw materials into powder, and then mixing them together.

[0032] In a preferred embodiment of the invention, the drug further includes a pharmaceutically acceptable carrier.

[0033] As a preferred method, the dosage form of the drug includes powder, pill, tablet, granule, capsule, ointment, oral preparation, gel or decoction.

[0034] The present invention relates to the application of a traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression. The drug comprises the above-mentioned traditional Chinese medicine composition. Given that the above-mentioned traditional Chinese medicine composition has the effects of soothing the liver and strengthening the spleen, invigorating qi and promoting blood circulation, it has been experimentally verified to have a good therapeutic effect on coronary heart disease complicated with anxiety and depression.

[0035] Based on the corresponding patient cases mentioned above:

[0036] Mr. Zhang, male, 55 years old, chief complaint: chest tightness for 3 days due to coronary heart disease. Present medical history: chest tightness for 3 days, history of post-PCI for coronary heart disease; shortness of breath for several days, dark purple tongue with yellow and greasy coating, and deep and slippery pulse.

[0037] Diagnosis: Coronary atherosclerotic heart disease, chest tightness, phlegm-blood stasis syndrome, shortness of breath, chronic obstructive pulmonary disease, diabetes, hyperlipidemia, and qi deficiency and blood stasis syndrome. A routine 12-channel electrocardiogram was performed at our hospital.

[0038] Prescription: Coptis chinensis 9g, Pinellia ternata 10g, Bambusa textilis 10g, Ligusticum chuanxiong 15g, Curcuma zedoaria (processed with vinegar) 10g, Poria cocos 24g, Astragalus membranaceus 30g, Cinnamomum cassia 15g, Albizia julibrissin bark 10g, Citrus reticulata peel 10g, Cyperus rotundus (processed with vinegar) 9g, Citrus aurantium (processed with vinegar) 10g, Raphanus sativus (processed with vinegar) 12g, Angelica sinensis 15g. The medicine was decocted mechanically. The patient showed significant improvement after taking the medicine.

[0039] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention in any way. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention shall fall within the scope of the invention.

Claims

1. The application of a traditional Chinese medicine composition in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, characterized in that: The raw materials of the traditional Chinese medicine composition include: Coptis chinensis, Pinellia ternata, Bambusa textilis, stir-fried Citrus aurantium, Citrus reticulata peel, Poria cocos, Curcuma zedoaria (processed with vinegar), Astragalus membranaceus, Cinnamomum cassia, Angelica sinensis, Ligusticum chuanxiong, Albizia julibrissin bark, Cyperus rotundus (processed with vinegar), and stir-fri 2. The application of the traditional Chinese medicine composition according to claim 1 in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, characterized in that: The raw materials of the traditional Chinese medicine composition are: Coptis chinensis 5-15 parts by weight, Pinellia ternata 6-18 parts by weight, Bambusa textilis 8-20 parts by weight, Citrus aurantium 5-15 parts by weight, Citrus reticulata 6-15 parts by weight, Poria cocos 20-35 parts by weight, Curcuma zedoaria 6-13 parts by weight, Astragalus membranaceus 25-35 parts by weight, Cinnamomum cassia 10-18 parts by weight, Angelica sinensis 1-18 parts by weight, Ligusticum chuanxiong 10-18 parts by weight, Albizia julibrissin bark 6-12 parts by weight, Cyperus rotundus 5-15 parts by weight, and Raphanus sativus 6-15 parts by weight.

3. The application of the traditional Chinese medicine composition according to claim 2 in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, characterized in that: The raw materials of the traditional Chinese medicine composition are: 8-13 parts by weight of Coptis chinensis, 9-15 parts by weight of Pinellia ternata, 9-18 parts by weight of bamboo shavings, 8-11 parts by weight of stir-fried Citrus aurantium, 8-14 parts by weight of Citrus reticulata peel, 22-32 parts by weight of Poria cocos, 8-11 parts by weight of vinegar-processed Curcuma zedoaria, 28-32 parts by weight of Astragalus membranaceus, 12-16 parts by weight of Cinnamomum cassia, 8-17 parts by weight of Angelica sinensis, 13-16 parts by weight of Ligusticum chuanxiong, 8-11 parts by weight of Albizia julibrissin bark, 8-13 parts by weight of vinegar-processed Cyperus rotundus, and 8-13 parts by weight of stir-fried Raphanus sativus seeds.

4. The application of the traditional Chinese medicine composition according to claim 3 in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, characterized in that: The raw materials of the traditional Chinese medicine composition are: 9 parts by weight of Coptis chinensis, 10 parts by weight of Pinellia ternata, 10 parts by weight of bamboo shavings, 10 parts by weight of stir-fried Citrus aurantium, 10 parts by weight of Citrus reticulata peel, 24 parts by weight of Poria cocos, 10 parts by weight of vinegar-processed Curcuma zedoaria, 30 parts by weight of Astragalus membranaceus, 15 parts by weight of Cinnamomum cassia, 15 parts by weight of Angelica sinensis, 15 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Albizia julibrissin bark, 9 parts by weight of vinegar-processed Cyperus rotundus, and 12 parts by weight of stir-fried Raphanus sativus seeds. Alternatively, Coptis chinensis 9 parts by weight, Pinellia ternata 12 parts by weight, Bambusa textilis 15 parts by weight, Citrus aurantium 10 parts by weight, Citrus reticulata 12 parts by weight, Poria cocos 30 parts by weight, Curcuma zedoaria 10 parts by weight, Astragalus membranaceus 30 parts by weight, Cinnamomum cassia 15 parts by weight, Angelica sinensis 15 parts by weight, Ligusticum chuanxiong 15 parts by weight, Albizia julibrissin 10 parts by weight, Cyperus rotundus 9 parts by weight, and Raphanus sativus 12 parts by weight.

5. The use of the traditional Chinese medicine composition as described in any one of claims 1-4 in the preparation of a medicament for treating coronary heart disease complicated with anxiety and depression, characterized in that: The traditional Chinese medicine composition is a composition made by pulverizing, grinding, and sieving the raw materials into powder, and then mixing them together.

6. The application of the traditional Chinese medicine composition according to claim 5 in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, characterized in that: The dosage forms of the drug include powder, pills, tablets, granules, capsules, ointments, oral preparations, gels, or decoctions.

7. The application of the traditional Chinese medicine composition according to claim 5 in the preparation of a drug for treating coronary heart disease complicated with anxiety and depression, characterized in that: The drug also includes a pharmaceutically acceptable carrier.