Plasma exchange device based on intelligent monitoring of line pressure

Abstract

The application discloses a plasma replacement device based on pipeline pressure intelligent monitoring and belongs to the technical field of medical instruments. The plasma replacement device based on pipeline pressure intelligent monitoring comprises a side support plate, a clamping block is arranged on the inner side of the side support plate, an extraction pipeline and an input pipeline are respectively arranged on the clamping block, an extrusion assembly is arranged in the middle of the extraction pipeline and the input pipeline, the extraction pipeline is connected with a centrifugal assembly, and the input pipeline is connected with a replacement assembly. The application solves the problem that the prior art cannot detect the pressure of the pipeline, thereby causing the pipeline to leak or the blood flow to be abnormal and the problem that the abnormality cannot be found in time, the application can automatically identify the pipeline leakage or blood flow abnormality risk and timely adjust, the pipeline leakage and blood flow abnormality in the process of plasma replacement cannot be found in time, thereby causing damage to the health of the patient, the monitoring data is consistent with the actual physiological state, and the medical effect of plasma replacement is improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a plasma exchange device based on intelligent monitoring of pipeline pressure. Background Technology

[0002] Plasma exchange is one of the important methods for purifying blood in the field of modern biomedical engineering. Its basic principle is to use a blood separator to separate the patient's blood into plasma and blood cell components (red blood cells, white blood cells, and platelets) in vitro. Then, the plasma containing harmful and pathogenic substances is discarded, and an equal amount of replacement fluid is used to replace the plasma. Finally, the blood cell components and plasma replacement fluid are returned to the patient's body.

[0003] Chinese patent publication number CN221731803U discloses a plasma exchange device that can simultaneously shut down the inlet and outlet pipes in case of an emergency.

[0004] In actual use, the aforementioned patents cannot detect the pressure of the pipeline, which may lead to the failure to detect pipeline leaks or abnormal blood flow in a timely manner, thus harming the patient's health. Summary of the Invention

[0005] The purpose of this invention is to provide a plasma exchange device based on intelligent pipeline pressure monitoring. By monitoring the pressure dynamics of connecting pipelines at different locations in real time, it automatically identifies risks such as pipeline leaks or abnormal blood flow and makes timely adjustments. This avoids the failure to detect pipeline leaks and abnormal blood flow during plasma exchange, which could harm the patient's health. Through intelligent pressure monitoring, it calibrates the matching between pressure thresholds and clinical parameters, ensuring that the monitoring data is consistent with the actual physiological state, thereby improving the medical efficacy of plasma exchange and solving the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a plasma exchange device based on intelligent monitoring of pipeline pressure, comprising a mounting frame and side support plates. Side support plates are installed on both sides of the bottom of the mounting frame, and clamping blocks are installed on the inner side of the side support plates. An extraction pipeline and an input pipeline are respectively installed on the clamping blocks. A squeezing assembly is provided between the extraction pipeline and the input pipeline. The squeezing assembly is installed on the mounting frame. The extraction pipeline is connected to a centrifugation assembly, and the input pipeline is connected to a replacement assembly. The replacement assembly is connected to the centrifugation assembly, and both the replacement assembly and the centrifugation assembly are installed on the mounting frame.

[0007] The extrusion assembly includes a motor, a rotating shaft, an elastic component, a support plate, a movable block, an electric lifting rod, and a limit block. The motor is mounted on the outside of the mounting frame, and the output end of the motor passes through the mounting frame and connects to the rotating shaft. A support plate is fixed on the rotating shaft, and electric lifting rods are mounted on both sides of the support plate. The extended ends of the electric lifting rods are mounted on the movable block, which is movably mounted on the rotating shaft. An elastic component is provided on the movable block, and a limit block is provided at the tail end of the rotating shaft.

[0008] The elastic component includes a first fixed tube, a movable sleeve, a spring, an inner sleeve, a mounting shaft, and a roller. The first fixed tube is fixed to the movable block. A spring is installed inside the first fixed tube. The spring is supported by the movable sleeve. The end of the spring away from the first fixed tube is fixed to the inner sleeve. The end of the inner sleeve is provided with a mounting shaft, and a roller is movably mounted on the mounting shaft.

[0009] The mounting bracket has a support column fixed at the bottom, and the bottom of the support column is fixed to the base. The base has casters at the bottom, and the back of the mounting bracket has a support rod with a controller mounted on it.

[0010] The centrifugation assembly includes a waste liquid tank, a first connecting pipe, a second connecting pipe, and a plasma centrifuge. The waste liquid tank is connected to the plasma centrifuge via the first connecting pipe, and the plasma centrifuge is connected to the replacement assembly via the second connecting pipe.

[0011] The replacement assembly includes a storage tank, a third connecting pipe, a mixing tank, a filter tank, and an adjustment component. The storage tank is connected to the mixing tank via the third connecting pipe, and the bottom of the mixing tank is connected to the filter tank via the adjustment component. Flow pumps are installed on the first, second, and third connecting pipes, the extraction pipe, and the input pipe. Pressure sensors are installed on the extraction pipe, the input pipe, the second connecting pipe, and the third connecting pipe. The flow pumps, motors, and pressure sensors are all connected to the monitoring system. A protein adsorbent membrane is installed inside the filter tank.

[0012] The regulating assembly includes a control housing, which is connected to the bottom of the mixing tank via a connecting flange at the top. The top of the control housing has a liquid inlet and a pressure boosting fixture is fixed in the center. The top of the control housing extends downward to form a cleaning channel. A blocking ball is movable in the cleaning channel. The bottom of the cleaning channel has a threaded interface. A spray ring is installed on the pressure boosting fixture, and the cleaning channel is connected to the spray ring.

[0013] The spray ring has several sets of spray holes. An adjusting component is installed inside the control housing, dividing the housing into a main chamber and a secondary chamber. The outer wall of the adjusting component extends outward to form a first control section and a second control section. The adjusting component has threaded grooves and two sets of limiting grooves. A threaded rod is installed within the threaded grooves. An annular drive component is movably sleeved on the outer wall of the threaded rod. The top of the annular drive component has two sets of vertical limiting sections, each movably positioned within its corresponding limiting groove. The annular drive component extends horizontally to both sides to form horizontal blocking sections, located above the through holes. The threaded rod extends into the threaded grooves. Part of the threaded rod is connected to the threaded groove by threads. The outer wall of the threaded rod is provided with an annular part that matches the annular drive component. The bottom of the threaded rod is fixedly connected to the output shaft of the micro motor. The micro motor is embedded in the control housing. The outer wall of the control housing is provided with a guide groove for the horizontal sliding of the first connecting rod. One end of the first connecting rod is fixedly connected to the annular drive component. The other end of the first connecting rod extends out of the control housing and is fixedly provided with a handle. The control housing extends outward to provide a liquid outlet channel. A second connecting flange is provided at the outlet of the liquid outlet channel. The liquid outlet channel is connected to the filter box through a second fixed pipe. A through hole is provided at the connection between the liquid outlet channel and the secondary chamber.

[0014] The monitoring system includes:

[0015] The pressure data monitoring module is used to acquire the data monitored by the pressure sensor in real time and to mark the pressure data acquired from different parts.

[0016] The pressure analysis module is used to analyze pressure fluctuation patterns in pressure data acquired from different parts based on artificial intelligence algorithms.

[0017] The risk identification module is used to identify the risk of leakage or abnormal blood flow in different connecting pipelines by using the results analyzed by the pressure analysis module.

[0018] The pressure regulation module is used to control the pump speed of the corresponding flow pump based on the identification results of the risk identification module until the pressure in the connecting pipeline returns to a safe range.

[0019] Preferably, the step of analyzing pressure fluctuation patterns in pressure data acquired from different locations based on artificial intelligence algorithms includes:

[0020] Based on the pressure data, pressure change curves for different locations are constructed, and the pressure change trends for different locations are determined based on the pressure change curves.

[0021] The pressure fluctuation pattern of different parts is determined based on the pressure change trend, and the pressure change attributes of different parts are determined based on the pressure fluctuation pattern. The pressure change attributes include: steady-state attributes and dynamic attributes.

[0022] Identify multiple adaptive pressure fluctuation patterns for the target location where the pressure change attribute is dynamic, and obtain the set pressure fluctuation frequency for each adaptive pressure fluctuation pattern.

[0023] The target pressure fluctuation frequency is determined based on the target pressure data of the target location. The matching degree between the target location and each adapted pressure fluctuation mode is calculated based on the target pressure fluctuation frequency and the set pressure fluctuation frequency of each adapted pressure fluctuation mode.

[0024]

[0025] in, This represents the degree of matching between the target location and the i-th adaptive pressure fluctuation pattern. This is expressed as the target pressure fluctuation frequency. This represents the set pressure fluctuation frequency for the i-th adaptive pressure fluctuation mode. Let ln be the pressure detection error factor, and ln be the natural logarithm. This is expressed as the forced response deviation factor of the target location to pressure feedback. This is represented by the matching degree balance factor, where D represents the pressure change sequence corresponding to the target pressure data of the target location. This is represented as the pressure change sequence of the i-th adapted pressure fluctuation pattern;

[0026] The target pressure fluctuation pattern with the highest matching degree is selected as the matching pressure fluctuation pattern for the target part.

[0027] Compared with the prior art, the beneficial effects of the present invention are:

[0028] This invention employs a high-precision pipeline pressure sensor to monitor the pressure dynamics of connecting pipelines at different locations in real time. It then utilizes artificial intelligence algorithms to analyze pressure fluctuation patterns, automatically identifying risks such as pipeline leaks or abnormal blood flow. Based on the pressure data, it adjusts the pump speed or valve opening in real time to maintain pipeline pressure within safe thresholds. This prevents pipeline leaks and abnormal blood flow from going undetected during plasma exchange, thus avoiding potential harm to the patient's health. Through intelligent pressure monitoring, the matching of pressure thresholds with clinical parameters is calibrated, ensuring that the monitored data is consistent with the actual physiological state, thereby improving the medical efficacy of plasma exchange. Attached Figure Description

[0029] Figure 1 This is a rear view of the plasma exchange device based on intelligent pipeline pressure monitoring according to the present invention.

[0030] Figure 2 A front view of the plasma exchange device based on intelligent pipeline pressure monitoring of the present invention;

[0031] Figure 3This is a schematic diagram of the squeezing component of the plasma exchange device based on intelligent pipeline pressure monitoring according to the present invention;

[0032] Figure 4 This is a schematic diagram of the electric lifting rod compression assembly after lifting and lowering according to the present invention;

[0033] Figure 5 This is a schematic diagram of the elastic component of the plasma exchange device based on intelligent pipeline pressure monitoring according to the present invention;

[0034] Figure 6 This is a schematic diagram of the adjustment component of the present invention;

[0035] Figure 7 This is a flowchart of the plasma exchange device based on intelligent pipeline pressure monitoring according to the present invention.

[0036] In the diagram: 1. Mounting frame; 2. Side support plate; 3. Clamping block; 4. Compression assembly; 41. Motor; 42. Rotating shaft; 43. Elastic assembly; 431. First fixed tube; 432. Movable sleeve; 433. Spring; 434. Inner sleeve; 435. Mounting shaft; 436. Roller; 44. Support plate; 45. Movable block; 46. Electric lifting rod; 47. Limiting block; 5. Centrifuge assembly; 51. Waste liquid tank; 52. First connecting pipe; 53. Second connecting pipe; 54. Plasma centrifuge; 6. Replacement assembly; 61. Storage tank; 62. Third connecting pipe; 63. Mixing tank; 64. Filter tank; 65. Adjustment assembly; 66. Second fixed tube; 7. Flow pump; 8. Pressure sensor; 9. Extraction pipe 10. Input pipeline; 11. Control housing; 12. Connecting flange one; 13. Pressure boosting fixing component; 14. Liquid inlet; 15. Spray ring; 16. Spray hole; 17. Cleaning channel; 18. Sealing ball; 19. Threaded interface; 20. Main chamber; 21. Secondary chamber; 22. First control unit; 23. Adjusting component; 24. Second control unit; 25. Threaded groove; 26. Limiting groove; 27. Vertical limiting part; 28. Annular part; 29. ​​Horizontal blocking part; 30. Through hole; 31. Annular drive component; 32. Connecting flange two; 33. Liquid outlet channel; 34. Threaded rod; 35. Handle; 36. First connecting rod; 37. Micro motor; 38. Support column; 39. Base; 40. Casters; 48. Controller. Detailed Implementation

[0037] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] To address the problem that existing technologies cannot detect pipeline pressure during practical use, leading to undetected leaks or abnormal blood flow that could harm patient health, please refer to [link to relevant documentation]. Figures 1-7 This embodiment provides the following technical solution:

[0039] The plasma exchange device based on intelligent pipeline pressure monitoring includes a mounting frame 1 and side support plates 2. Side support plates 2 are mounted on both sides of the bottom of the mounting frame 1. Clamping blocks 3 are mounted on the inner sides of the side support plates 2. An extraction tube 9 and an input tube 10 are respectively mounted on the clamping blocks 3. A squeezing assembly 4 is located between the extraction tube 9 and the input tube 10, and the squeezing assembly 4 is mounted on the mounting frame 1. The extraction tube 9 is connected to a centrifugation assembly 5, and the input tube 10 is connected to a replacement assembly 6. The replacement assembly 6 is connected to the centrifugation assembly 5, and both the replacement assembly 6 and the centrifugation assembly 5 are mounted on the mounting frame 1. During plasma exchange, needles mounted on the extraction tube 9 and the input tube 10 are inserted into the patient's two arteries, driving a flow pump 7 at the extraction tube 9 to pump plasma from the patient's blood vessels. Blood is drawn from the body and transferred to the plasma centrifuge 54 for centrifugation. The plasma is then pumped into the waste tank 51 using the flow pump 7 on the first connecting pipe 52. Blood cells are mixed with new plasma through the second connecting pipe 53 and filtered through the filter box 64. The mixture is then injected into the patient's body through the flow pump 7 on the input pipe 10, thereby achieving the purpose of plasma exchange. A support column 38 is fixed to the bottom of the mounting frame 1, and the bottom of the support column 38 is fixed to the base 39. Casters 40 are provided below the base 39. A support rod is provided on the back of the mounting frame 1, and a controller 48 is installed on the support rod. The controller 48 can be adjusted along the support rod. The controller 48 is used to control the operation of the plasma exchange device and display the monitored data.

[0040] The compression assembly 4 includes a motor 41, a rotating shaft 42, an elastic component 43, a support plate 44, a movable block 45, an electric lifting rod 46, and a limiting block 47. The motor 41 is mounted on the outside of the mounting frame 1, and the output end of the motor 41 passes through the mounting frame 1 and is connected to the rotating shaft 42. The support plate 44 is fixed on the rotating shaft 42, and electric lifting rods 46 are mounted on both sides of the support plate 44. The extended ends of the electric lifting rods 46 are mounted on the movable block 45, which is movably mounted on the rotating shaft 42. The movable block 45 is equipped with the elastic component 43, and the tail end of the rotating shaft 42 is equipped with a limiting block 47. When a pipeline leak or abnormal blood flow is detected and plasma exchange needs to be stopped immediately, the motor 41 is started to rotate the rotating shaft 42, which rotates the elastic component 43 by 90 degrees. At this time, the elastic component 43 compresses the extraction pipeline 9 and the input pipeline 10. Since the extraction tube 9 and the input tube 10 are made of rubber, under the action of the spring 433, the extraction tube 9 and the input tube 10 are squeezed to fit tightly against the clamp 3, thereby achieving the purpose of immediately closing the extraction tube 9 and the input tube 10. When it is necessary to close one of the tubes, the electric lifting rod 46 is activated to move the elastic component 43 on the side that does not need to be closed away from the tube that does not need to be closed. Then the motor 41 is activated to rotate the rotating shaft 42, moving the elastic component 43 corresponding to the tube that needs to be closed to the tube that needs to be closed. Under the compression of the spring 433, the tube is closed. This can achieve rapid closure of the extraction tube 9 and the input tube 10, avoiding serious tube leakage or abnormal blood flow. Failure to close in time will not only affect the plasma exchange effect, but also harm the patient's health.

[0041] The elastic component 43 includes a first fixed tube 431, a movable sleeve 432, a spring 433, an inner sleeve 434, a mounting shaft 435, and a roller 436. The first fixed tube 431 is fixed to the movable block 45. The spring 433 is installed inside the first fixed tube 431 and is supported by the movable sleeve 432. The end of the spring 433 away from the first fixed tube 431 is fixed to the inner sleeve 434. The end of the inner sleeve 434 is provided with a mounting shaft 435. The roller 436 is movably mounted on the mounting shaft 435. The roller 436 can roll when the extraction pipe 9 and the input pipe 10 are squeezed, so that the elastic component 43 can smoothly close the extraction pipe 9 and the input pipe 10. At the same time, under the action of the roller 436, it can also avoid damage to the extraction pipe 9 and the input pipe 10 due to excessive squeezing force during squeezing.

[0042] Centrifugation assembly 5 includes a waste liquid tank 51, a first connecting pipe 52, a second connecting pipe 53, and a plasma centrifuge 54. The waste liquid tank 51 is connected to the plasma centrifuge 54 via the first connecting pipe 52. The plasma centrifuge 54 is connected to the replacement assembly 6 via the second connecting pipe 53. The replacement assembly 6 includes a storage tank 61, a third connecting pipe 62, a mixing tank 63, a filter tank 64, and an adjustment assembly 65. The storage tank 61 is connected to the mixing tank 63 via the third connecting pipe 62. The bottom of the mixing tank 63 is connected to the filter tank via the adjustment assembly 65. The filter box 64 is connected. Flow pumps 7 are installed on the first connecting pipe 52, the second connecting pipe 53, the third connecting pipe 62, the extraction pipe 9, and the input pipe 10. Pressure sensors 8 are installed on the extraction pipe 9, the input pipe, the second connecting pipe 53, and the third connecting pipe 62. Flow pumps 7, motor 41, and pressure sensors 8 are all connected to the monitoring system. A protein adsorbent membrane is installed inside the filter box 64. Through the pore size screening and electrostatic adsorption of the protein adsorbent membrane, large molecular pathogenic substances can be removed.

[0043] The regulating assembly 65 includes a control housing 11, which is connected to the bottom of the mixing tank 63 via a connecting flange 12 at the top. The control housing 11 has a liquid inlet 14 at its top and a pressure-boosting fixing component 13 fixed at its center. The top of the control housing 11 extends downwards to form a cleaning channel 17, within which a sealing ball 18 is movably installed. A threaded interface 19 is located at the bottom of the cleaning channel 17. A spray ring 15 is mounted on the pressure-boosting fixing component 13, and the cleaning channel 17 communicates with the spray ring 15. The spray ring 15 has several sets of spray holes 16. The control housing 11 contains... The control housing 11 is equipped with an adjusting member 23, which divides the housing 11 into a main chamber 20 and a secondary chamber 21. The outer wall of the adjusting member 23 extends outward to form a first control section 22 and a second control section 24. The adjusting member 23 has a threaded groove 25 and two sets of limiting grooves 26. A threaded rod 34 is provided in the threaded groove 25. An annular drive member 31 is movably sleeved on the outer wall of the threaded rod 34. The top of the annular drive member 31 has two sets of vertical limiting sections 27, each set of vertical limiting sections 27 being movably disposed in its corresponding limiting groove 26. The annular drive member 31 extends horizontally to both sides to form horizontal blocking sections 29. Furthermore, the horizontal blocking part 29 is located above the through hole 30, and the portion of the threaded rod 34 extending into the threaded groove 25 is connected to the threaded groove 25 by threads. The outer wall of the threaded rod 34 is provided with an annular part 28 that matches the annular drive member 31. The bottom of the threaded rod 34 is fixedly connected to the output shaft of the micro motor 37, and the micro motor 37 is embedded in the control housing 11. The outer wall of the control housing 11 is provided with a guide groove for the horizontal sliding of the first connecting rod 36, and one end of the first connecting rod 36 is fixedly connected to the annular drive member 31. The other end of the first connecting rod 36 extends out of the control housing 11 and is fixedly provided with a handle 35. 1. An outwardly extending liquid outlet channel 33 is provided, and a connecting flange 32 is provided at the outlet of the liquid outlet channel 33. The liquid outlet channel 33 is connected to the filter box 64 through the second fixed pipe 66. A through hole 30 is provided at the connection between the liquid outlet channel 33 and the auxiliary chamber 21. Based on the flow pump 7, medical personnel fine-tune the flow rate and velocity of the mixed plasma according to the patient's current physical indicators through the adjusting component 65. The mixed plasma in the mixing box 63 enters the main chamber 20 above the control housing 11 through the liquid inlet 14. Since the first control part 22 of the adjusting component 23 is in contact with the inner wall of the control housing 11 in the initial stage (e.g., Figure 5As shown in the diagram, the plasma accumulates in the main chamber 20 and does not fall. When fine-tuning of the plasma flow rate is required, the micro motor 37 is activated and drives the threaded rod 34 to rotate. Due to the restriction of the limiting groove 26 and the vertical limiting part 27, the adjusting member 23 can rise along the threaded rod 34. When the first control part 22 is located in the main chamber 20 and the second control part 24 is not in contact with the inner wall of the control housing 11, the main chamber 20 and the auxiliary chamber 21 are connected, and the plasma in the main chamber 20 will flow through the adjusting member. The plasma flows down the curved outer wall of the regulating member 23 to the bottom of the secondary chamber 21. As the regulating member 23 rises, the plasma flow rate increases (because the gap between the inwardly concave curved outer wall of the regulating member 23 and the inner wall of the control housing 11 reaches its maximum). When it passes the inwardly concave curved outer wall of the regulating member 23 and continues to rise, the second control unit 24 will contact the inner wall of the control housing 11. At this time, the plasma cannot flow. The regulating member 23 is moved up and down by the micro motor 37, thereby controlling the plasma flow rate. Simultaneously, the first connecting rod 36 can be rotated within the horizontal limiting groove by pushing the handle 35, thereby causing the annular drive member 31 to rotate around the threaded rod 34. During this process, the horizontal blocking part 29 can change the area of ​​the blocking through-hole 30, allowing the area of ​​the through-hole 30 to increase from small to large. This alters the flow rate of the plasma under the same suction force of the flow pump 7 (when the suction force of the flow pump 7 remains constant, a larger area of ​​the through-hole 30 results in a slower plasma flow rate). Through these two methods, the flow rate and velocity of the plasma can be controlled while maintaining a constant suction force of the flow pump 7. For fine-tuning, when not in use, saline solution can be pumped into the cleaning channel 17 via an external liquid conduit connected to the threaded interface 19 and a liquid pump. At this time, the sealing ball 18 is impacted and rises to its highest point. Since the diameter of the sealing ball 18 is smaller than the diameter of the cleaning channel 17, the saline solution will enter the spray ring 15 and be sprayed into the control housing 11 through the spray hole 16 to achieve a cleaning effect. After cleaning, the sealing ball 18 falls back and seals the threaded interface 19 (the diameter of the threaded interface 19 is smaller than the diameter of the sealing ball 18), thereby preventing external contamination.

[0044] The regulating component 65 is based on the core working principle of "independent adjustment of flow rate and velocity dual parameters + self-cleaning closed loop". It achieves linear and smooth flow rate adjustment through the raising and lowering of the regulating component 23 (adapting to the physiological needs of different individuals such as children and critically ill patients, and supporting step-by-step treatment). It achieves real-time bidirectional control of flow velocity by adjusting the sealing area of ​​the through hole 30 through the horizontal blocking part 29 (avoiding sudden pressure rise during vasospasm and blood cell damage during turbulence). At the same time, it forms a dual safety mechanism by relying on the mechanical hard limit of the first and second control parts and the "automatic + manual" dual drive mode (preventing parameter loss and responding to electronic system failures). The self-cleaning system removes plasma residue through 360° three-dimensional spraying of the spray ring and seals the sphere to prevent secondary contamination, achieving seamless integration with the treatment process without disassembly and maintenance. It can also link with the original device's pressure monitoring system to optimize pressure control efficiency and provide pretreatment protection for the filter box (extending the filter membrane's lifespan and reducing the clogging rate). Ultimately, it significantly improves the technological maturity and clinical applicability of the plasma exchange device from the perspectives of individualized precision treatment, clinical operation safety, equipment maintenance efficiency, and system synergy, which is significantly different from the existing technology's single-function, manual, and complex adjustment structure.

[0045] In use, needles are installed on the extraction line 9 and the inlet line 10, respectively, and inserted into the patient's two arteries. The flow pump 7 on the extraction line 9 draws blood from the patient and transfers it to the plasma centrifuge 54 for centrifugation. After centrifugation, the flow pump 7 on the first connecting line 52 draws the plasma into the waste tank 51. Blood cells are mixed with fresh plasma through the second connecting line 53, filtered through the filter box 64, and then injected into the patient through the flow pump 7 on the inlet line 10. During plasma exchange, the flow can be adjusted using the regulating component 65. The flow rate and velocity of the plasma are finely adjusted, and the pressure sensor 8 monitors the pressure of the extraction line 9, the input line 10, and the second connecting line 53. The monitored pressure data is transmitted to the monitoring system. The plasma is filtered through the filter box 64 before being introduced into the patient's body to avoid residual bacteria, toxins, metabolic waste, certain inflammatory mediators, and autoantibodies in the plasma, thus ensuring higher quality replacement plasma. The pressure sensor 8 monitors the tubing pressure in real time during blood collection and transfusion, and can make timely adjustments when the pressure is abnormal to ensure that the plasma can be replaced normally.

[0046] The monitoring system includes:

[0047] The pressure data monitoring module is used to acquire the data monitored by the pressure sensor 8 in real time and to mark the pressure data acquired from different parts.

[0048] The pressure analysis module is used to analyze pressure fluctuation patterns in pressure data acquired from different parts based on artificial intelligence algorithms.

[0049] The risk identification module is used to identify the risk of leakage or abnormal blood flow in different connecting pipelines by using the results analyzed by the pressure analysis module.

[0050] The pressure regulating module is used to control the pumping speed of the corresponding flow pump 7 according to the identification result of the risk identification module until the pressure in the connecting pipeline returns to the safe range.

[0051] Working principle: When using the plasma exchange device based on intelligent pipeline pressure monitoring of this invention, according to... Figures 1-6 This includes the following steps:

[0052] Step 1: During plasma exchange, the extraction tubing 9 is connected to one of the patient's veins, and the infusion tubing 10 is connected to another of the patient's arteries. The flow pump 7 at the extraction tubing 9 is driven to draw blood from the patient and transfer it to the plasma centrifuge 54 for centrifugation.

[0053] Step 2: After separation, the plasma is drawn into the waste tank 51 by the flow pump 7 on the first connecting pipe 52. The blood cells are mixed with the new plasma through the second connecting pipe 53, filtered by the filter box 64, and then injected into the patient's body through the flow pump 7 on the input pipe 10.

[0054] Step 3: During the blood extraction and replacement process, pressure sensor 8 is used to monitor the pressure of the connecting tubing at different locations in real time, and pressure data monitoring module is used to acquire the data monitored by pressure sensor 8 in real time and mark the pressure data acquired at different locations.

[0055] Step 4: Using the pressure analysis module and artificial intelligence algorithms, analyze the pressure fluctuation patterns of the pressure data obtained from different parts to determine if there are any anomalies in the pressure data of the connecting pipes at different parts. If there are anomalies, use the risk identification module to identify the risks of the abnormal data and determine the cause of the anomalies in different connecting pipes.

[0056] Step 5: If there is a risk of leakage or abnormal blood flow, control the pump speed of the flow pump 7 corresponding to the risk data until the pressure in the connecting pipeline returns to a safe range. If the pipeline is abnormal and there is no risk of leakage or abnormal blood flow, send an alarm signal to the medical staff.

[0057] Step 6: If adjusting the pump speed of the flow pump 7 cannot bring the pressure of the connecting pipeline back to a safe range, start the motor 41 to rotate the rotating shaft 42, and rotate the elastic component 43 90 degrees. At this time, the elastic component 43 squeezes the extraction pipeline 9 and the input pipeline 10 to immediately close the extraction pipeline 9 and the input pipeline 10.

[0058] In summary, the plasma exchange device based on intelligent pipeline pressure monitoring of the present invention employs a high-precision pipeline pressure sensor 8 to monitor the pressure dynamics of connecting pipelines at different locations in real time. It then utilizes artificial intelligence algorithms to analyze pressure fluctuation patterns, automatically identifying risks such as pipeline leaks or abnormal blood flow. Combined with pressure data, it adjusts the pump speed or valve opening in real time to maintain pipeline pressure within a safe threshold, preventing pipeline leaks and abnormal blood flow from going undetected during plasma exchange and potentially harming the patient's health. Through intelligent pressure monitoring, it calibrates the matching of pressure thresholds with clinical parameters, ensuring that the monitored data is consistent with the actual physiological state, thereby improving the medical efficacy of plasma exchange. The device is activated by starting motor 41... When the elastic component 43 rotates 90 degrees, under the action of the spring 433, the roller 436 squeezes the extraction tube 9 and the input tube 10 to fit tightly against the clamping block 3, thereby achieving the purpose of immediately closing the extraction tube 9 and the input tube 10. This avoids serious issues such as tube leakage or abnormal blood flow. Failure to close in time will not only affect the plasma exchange effect but also harm the patient's health. The roller 436 can roll when squeezing the extraction tube 9 and the input tube 10, allowing the elastic component 43 to smoothly close the extraction tube 9 and the input tube 10. At the same time, the roller 436 can also prevent excessive squeezing force from damaging the extraction tube 9 and the input tube 10.

[0059] In one embodiment, the analysis of pressure fluctuation patterns based on artificial intelligence algorithms on pressure data acquired from different locations includes:

[0060] Based on the pressure data, pressure change curves for different locations are constructed, and the pressure change trends for different locations are determined based on the pressure change curves.

[0061] The pressure fluctuation pattern of different parts is determined based on the pressure change trend, and the pressure change attributes of different parts are determined based on the pressure fluctuation pattern. The pressure change attributes include: steady-state attributes and dynamic attributes.

[0062] Identify multiple adaptive pressure fluctuation patterns for the target location where the pressure change attribute is dynamic, and obtain the set pressure fluctuation frequency for each adaptive pressure fluctuation pattern.

[0063] The target pressure fluctuation frequency is determined based on the target pressure data of the target location. The matching degree between the target location and each adapted pressure fluctuation mode is calculated based on the target pressure fluctuation frequency and the set pressure fluctuation frequency of each adapted pressure fluctuation mode.

[0064]

[0065] in, This represents the degree of matching between the target location and the i-th adaptive pressure fluctuation pattern. This is expressed as the target pressure fluctuation frequency. This represents the set pressure fluctuation frequency for the i-th adaptive pressure fluctuation mode. Let ln be the pressure detection error factor, and ln be the natural logarithm. This is expressed as the forced response deviation factor of the target location to pressure feedback. This is represented by the matching degree balance factor, where D represents the pressure change sequence corresponding to the target pressure data of the target location. This is represented as the pressure change sequence of the i-th adapted pressure fluctuation pattern;

[0066] The target pressure fluctuation pattern with the highest matching degree is selected as the matching pressure fluctuation pattern for the target part.

[0067] In this embodiment, the pressure fluctuation pattern is represented by the fluctuation pattern of pressure data changes at different locations;

[0068] In this embodiment, the pressure detection error factor is expressed as the error factor when performing pressure detection on different parts, including: the feedback deviation of different tissues to the pressure signal, etc.

[0069] In this embodiment, the forced response deviation factor of the target part to pressure feedback is expressed as the data deviation factor of the forced response of the target part to pressure feedback, which is determined by the delay and pressure depth of the target part to pressure signal feedback.

[0070] In this embodiment, the matching balance factor is represented as the matching balance factor between the target site and the adaptive pressure fluctuation pattern, which is determined based on the changes in the physiological characteristics of the target site under the influence of pressure.

[0071] In this embodiment, the pressure change sequence is represented as a dynamic numerical statistical sequence of pressure data changes, with the horizontal axis representing events and the vertical axis representing numerical values.

[0072] The beneficial effects of the above technical solution are as follows: by comprehensively calculating the matching degree between different parts and the appropriate pressure fluctuation mode based on the pressure fluctuation frequency and pressure change sequence, and then selecting the target pressure fluctuation mode with the highest matching degree, the optimal appropriate pressure fluctuation mode for different parts can be accurately determined, ensuring the reliability and stability of the analysis results.

[0073] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0074] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention.

Claims

1. A plasma exchange device based on intelligent pipeline pressure monitoring, comprising a mounting frame (1) and a side support plate (2), characterized in that, Side support plates (2) are installed on both sides of the bottom of the mounting frame (1). Clamping blocks (3) are installed on the inner side of the side support plates (2). Pull-out pipes (9) and input pipes (10) are installed on the clamping blocks (3) respectively. A squeezing assembly (4) is provided in the middle of the pull-out pipes (9) and the input pipes (10). The squeezing assembly (4) is installed on the mounting frame (1). The pull-out pipes (9) are connected to the centrifugal assembly (5). The input pipes (10) are connected to the displacement assembly (6). The displacement assembly (6) is connected to the centrifugal assembly (5). Both the displacement assembly (6) and the centrifugal assembly (5) are installed on the mounting frame (1). The replacement assembly (6) includes a storage tank (61), a third connecting pipe (62), a mixing tank (63), a filter box (64), and an adjustment assembly (65). The storage tank (61) is connected to the mixing tank (63) through the third connecting pipe (62). The bottom of the mixing tank (63) is connected to the filter box (64) through the adjustment assembly (65). Flow pumps (7) are installed on the first connecting pipe (52), the second connecting pipe (53), the third connecting pipe (62), the extraction pipe (9), and the input pipe (10). Pressure sensors (8) are installed on the extraction pipe (9), the input pipe (10), the second connecting pipe (53), and the third connecting pipe (62). The flow pumps (7), the motor (41), and the pressure sensors (8) are all connected to the monitoring system. A protein adsorbent membrane is installed inside the filter box (64). The monitoring system includes: The pressure data monitoring module is used to acquire the data monitored by the pressure sensor (8) in real time and to mark the pressure data acquired from different parts. The pressure analysis module is used to analyze pressure fluctuation patterns in pressure data acquired from different parts based on artificial intelligence algorithms. The risk identification module is used to identify the risk of leakage or abnormal blood flow in different connecting pipelines by using the results analyzed by the pressure analysis module. The pressure regulating module is used to control the pump speed of the corresponding flow pump (7) according to the identification result of the risk identification module until the pressure of the connecting pipeline returns to the safe range; The analysis of pressure fluctuation patterns based on artificial intelligence algorithms for pressure data acquired from different locations includes: Based on the pressure data, pressure change curves for different locations are constructed, and the pressure change trends for different locations are determined based on the pressure change curves. The pressure fluctuation pattern of different parts is determined based on the pressure change trend, and the pressure change attributes of different parts are determined based on the pressure fluctuation pattern. The pressure change attributes include: steady-state attributes and dynamic attributes. Identify multiple adaptive pressure fluctuation patterns for the target location where the pressure change attribute is dynamic, and obtain the set pressure fluctuation frequency for each adaptive pressure fluctuation pattern. The target pressure fluctuation frequency is determined based on the target pressure data of the target location. The matching degree between the target location and each adapted pressure fluctuation mode is calculated based on the target pressure fluctuation frequency and the set pressure fluctuation frequency of each adapted pressure fluctuation mode. in, This represents the degree of matching between the target location and the i-th adaptive pressure fluctuation pattern. This is expressed as the target pressure fluctuation frequency. This represents the set pressure fluctuation frequency for the i-th adaptive pressure fluctuation mode. Let ln be the pressure detection error factor, and ln be the natural logarithm. This is expressed as the forced response deviation factor of the target location to pressure feedback. This is represented by the matching degree balance factor, where D represents the pressure change sequence corresponding to the target pressure data of the target location. This is represented as the pressure change sequence of the i-th adapted pressure fluctuation pattern; The target pressure fluctuation pattern with the highest matching degree is selected as the matching pressure fluctuation pattern for the target part.

2. The plasma exchange device based on intelligent pipeline pressure monitoring according to claim 1, characterized in that, The extrusion assembly (4) includes a motor (41), a rotating shaft (42), an elastic component (43), a support plate (44), a movable block (45), an electric lifting rod (46), and a limiting block (47). The motor (41) is installed on the outside of the mounting frame (1). The output end of the motor (41) passes through the mounting frame (1) and is connected to the rotating shaft (42). The support plate (44) is fixed on the rotating shaft (42). Electric lifting rods (46) are installed on both sides of the support plate (44). The extended end of the electric lifting rod (46) is installed on the movable block (45). The movable block (45) is movably installed on the rotating shaft (42). The movable block (45) is provided with an elastic component (43). A limiting block (47) is provided at the tail end of the rotating shaft (42).

3. The plasma exchange device based on intelligent pipeline pressure monitoring according to claim 2, characterized in that, The elastic component (43) includes a first fixed tube (431), a movable sleeve (432), a spring (433), an inner sleeve (434), a mounting shaft (435), and a roller (436). The first fixed tube (431) is fixed on the movable block (45). The first fixed tube (431) is provided with a spring (433). The spring (433) is supported by the movable sleeve (432). The end of the spring (433) away from the first fixed tube (431) is fixed on the inner sleeve (434). The end of the inner sleeve (434) is provided with a mounting shaft (435). The roller (436) is movably mounted on the mounting shaft (435).

4. The plasma exchange device based on intelligent pipeline pressure monitoring according to claim 1, characterized in that, The bottom of the mounting bracket (1) is fixed with a support column (38), the bottom of the support column (38) is fixed on the base (39), the base (39) is provided with a moving wheel (40), the back of the mounting bracket (1) is provided with a support rod, and a controller (48) is installed on the support rod.

5. The plasma exchange device based on intelligent pipeline pressure monitoring according to claim 1, characterized in that, The centrifugation assembly (5) includes a waste liquid tank (51), a first connecting pipe (52), a second connecting pipe (53), and a plasma centrifuge (54). The waste liquid tank (51) is connected to the plasma centrifuge (54) through the first connecting pipe (52), and the plasma centrifuge (54) is connected to the replacement assembly (6) through the second connecting pipe (53).

6. The plasma exchange device based on intelligent pipeline pressure monitoring according to claim 1, characterized in that, The regulating component (65) includes a control housing (11), which is connected to the bottom of the mixing tank (63) via a connecting flange (12) provided at the top. The control housing (11) has a liquid inlet (14) at the top and a pressure-boosting fixing component (13) fixed at the center. The top of the control housing (11) extends downward to form a cleaning channel (17). A sealing ball (18) is movably provided in the cleaning channel (17). A threaded interface (19) is provided at the bottom of the cleaning channel (17). A spray ring (15) is installed on the pressure-boosting fixing component (13), and the cleaning channel (17) is connected to the spray ring (15).

7. The plasma exchange device based on intelligent pipeline pressure monitoring according to claim 6, characterized in that, The spray ring (15) is provided with several sets of spray holes (16). An adjusting member (23) is installed in the control housing (11), and the adjusting member (23) divides the control housing (11) into a main chamber (20) and a secondary chamber (21). The outer wall of the adjusting member (23) extends outward to form a first control part (22) and a second control part (24). The adjusting member (23) is provided with a threaded groove (25) and two sets of limiting grooves (26). A threaded rod (34) is provided in the threaded groove (25). The annular drive member (31) is movably sleeved on the outer wall of the threaded rod (34). The top of the annular drive member (31) is provided with two sets of vertical limiting parts (27). Each set of vertical limiting parts (27) is movably provided in its corresponding limiting groove (26). The annular drive member (31) extends horizontally to both sides to form a horizontal blocking part (29). The horizontal blocking part (29) is located above the through hole (30). The threaded rod (34) extends to the threaded part. The part inside the groove (25) is connected to the threaded groove (25) by threads. The outer wall of the threaded rod (34) is provided with an annular part (28) that matches the annular drive (31). The bottom of the threaded rod (34) is fixedly connected to the output shaft of the micro motor (37). The micro motor (37) is embedded in the control housing (11). The outer wall of the control housing (11) is provided with a guide groove for the horizontal sliding of the first connecting rod (36). One end of the first connecting rod (36) is fixedly connected to the annular drive (31). The other end of the first connecting rod (36) extends out of the control housing (11) and is fixedly provided with a handle (35). The control housing (11) extends outward to provide a liquid outlet channel (33). A connecting flange (32) is provided at the outlet of the liquid outlet channel (33). The liquid outlet channel (33) is connected to the filter box (64) through the second fixed pipe (66). A through hole (30) is provided at the connection between the liquid outlet channel (33) and the secondary chamber (21).

Images