Traditional Chinese medicine composition for oral care of nasal feeding patient and application of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and provides a traditional Chinese medicine composition for oral care of nasal feeding patients and application of the traditional Chinese medicine composition in order to solve the problem that existing oral care products are high in price. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-15 parts of agastache rugosus, 3-9 parts of coptis chinensis, 5-15 parts of radix angelicae, 5-15 parts of radix cyathulae, 5-15 parts of flos farfarae, 5-15 parts of mint and 5-15 parts of raw liquorice. The compatibility of the traditional Chinese medicine composition has the following characteristics that cold and warm are used together: the wrinkled gianthyssop herb (micro-warm) and the coptis chinensis (large cold) are used, so that yang injury caused by over-cold can be avoided, and heat clearing and dampness eliminating are both considered. The mint raises (dispels wind and heat) and the radix cyathulae descends (leads fire to the origin), so that qi movement can be balanced, and repeated internal heat of the oral cavity is reduced. The tussilago farfara can moisten the lung (tonify lung yin) and the raw liquorice can tonify qi, so that the disadvantage of body fluid consumption of the damp clearing medicine can be alleviated.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition for oral care of patients with nasal feeding and application thereof. BACKGROUND

[0002] The oral cavity is one of the routes for pathogenic microorganisms to invade the human body. Studies have shown that 0.1 mL of oropharyngeal secretions contains 106-108 bacteria, of which about 67% of the bacterial species are consistent with those causing bronchitis and pneumonia. Patients with nasal feeding cannot eat orally, and the oral self-cleaning ability, mucosal protection and pH value of the patients are all decreased, so bacteria can multiply in the oral cavity in large quantities. In addition, the body's resistance is significantly decreased when the patient is ill, which increases the opportunity for bacterial multiplication and infection. For patients with nasal feeding, oral care is particularly important.

[0003] Currently, for oral care of patients with nasal feeding, Western medicine uses 0.9% sodium chloride solution for oral wiping, which only achieves mechanical cleaning. Chemical mouthwash such as chlorhexidine can easily cause irritation of the oral mucosa and disturbance of the bacterial flora. The physiological saline cannot adjust the pH value of the oral cavity (the average pH value of the patients with nasal feeding is only 5.2±0.3), and the chemical bacteriostatic agent destroys the normal bacterial flora in the oral cavity (such as a decrease of >60% of lactobacillus). The existing traditional Chinese medicine nursing uses single scutellaria or honeysuckle decoction gargling, which lacks an oral care solution for reducing oropharyngeal pathogenic bacteria, inhibiting gastric acid reflux, improving oral hygiene and improving oral comfort. If an imported enzyme-containing care solution is used, the cost is more than 50 yuan / time, which is difficult to popularize. SUMMARY

[0004] The present application aims to overcome the deficiencies of the prior art and provide a traditional Chinese medicine composition for oral care of patients with nasal feeding and application thereof.

[0005] The monarch drug is herba agastachis (eliminating dampness and invigorating the spleen, inhibiting the formation of fungal biofilm); The ministerial drugs are rhizoma coptidis (clearing heat and drying dampness, purging stomach fire, targeting inhibiting G+ bacteria and inhibiting gastric acid reflux) and radix angelicae dahuricae (resolving swelling and pus, promoting mucosal repair), which form an antibacterial-repair synergistic mechanism and embody the thought of treating both the symptoms and the root cause; The auxiliary drugs are radix cyathulae (directing fire downward to reduce oral ulcers caused by gastric tube irritation of rhizoma coptidis), flos callicephalae 5-15 parts (containing mucilaginous substances to form an oral moisturizing film, relieve throat itching and expand the indications), herba menthae 5-15 parts (aromatic invigorating the spleen, stimulating saliva secretion, enhancing local cooling sensation and improving breath freshening degree) and radix glycyrrhizae 5-15 parts (neutralizing the bitter and cold of rhizoma coptidis, regulating the medicinal properties, reducing the irritability of rhizoma coptidis and protecting the oral mucosa).

[0006] The indications of the present composition are: Halitosis of stomach fire upward flaming type: oral odor accompanied by red tongue and yellow fur.

[0007] Wet heat type gingival swelling and pain: gingival redness, swelling, bleeding, mouth sticky.

[0008] Chronic pharyngitis or oral ulcer: sore throat, ulcer recurrence (need to add external application).

[0009] To achieve the above-mentioned goal, the first aspect of the present application provides a traditional Chinese medicine composition for oral care of nasogastric feeding patients, which is composed of the following raw materials in parts by weight: Huoxiang 5-15 parts, Huanglian 3-9 parts, Baizhi 5-15 parts, Chuan Niuxi 5-15 parts, Kuan Donghua 5-15 parts, Bohe 5-15 parts, Sheng Gancao 5-15 parts.

[0010] Preferably, it is composed of the following raw materials in parts by weight: Huoxiang 10 parts, Huanglian 3 parts, Baizhi 5 parts, Chuan Niuxi 5 parts, Kuan Donghua 5 parts, Bohe 5 parts, Sheng Gancao 5 parts.

[0011] The second aspect of the present application provides a traditional Chinese medicine composition for preparing a medicine for oral care of nasogastric feeding patients.

[0012] Preferably, the medicine for oral care of nasogastric feeding patients is an external preparation, which is selected from any one of granules, tablets, capsules, powders, decoctions or pills.

[0013] Preferably, the medicine for oral care of nasogastric feeding patients further comprises auxiliary materials.

[0014] The third aspect of the present application provides a decoction for oral care of nasogastric feeding patients, which comprises a main drug component and a pharmaceutically acceptable auxiliary material; the main drug component is prepared by processing the traditional Chinese medicine composition for oral care of nasogastric feeding patients described in the first aspect.

[0015] Preferably, the preparation method of the main drug component comprises the following steps: S1, Kuan Donghua 5 parts, Bohe parts are weighed and put into sterile gauze bags, and cold water extraction is carried out, and finally multi-layer gauze is used for filtration, and the filtrate is collected; S2, Huoxiang 10 parts, Huanglian 3 parts, Baizhi 5 parts, Chuan Niuxi 5 parts, Sheng Gancao 5 parts are weighed and soaked in cold water, and decocted twice, and the filtrates of the two times are combined.

[0016] Compared with the prior art, the technical scheme provided by the present application has the following beneficial effects or advantages: The composition of the present application has the effects of antifungal, antibacterial spectrum expansion, mucosal repair and moisture innovation. The compatibility of the present application has the following characteristics: This formula is an original creation. Its characteristics are the use of pungent and bitter herbs to regulate the ascending and descending functions, and the combination of attacking and tonifying to achieve the same effect on the five internal organs, improve oral flora imbalance, and enhance the disease resistance of the oral mucosa in patients receiving nasogastric feeding.

[0017] The formula combines pungent and bitter herbs, and uses both warm and cold herbs: Patchouli (pungent and slightly warm) + Coptis chinensis (bitter and cold, strengthens the kidneys and drains the heart) → avoids excessive cold that damages Yang, and takes into account both clearing heat and resolving dampness.

[0018] The formula balances the ascending and descending functions: Peppermint disperses wind-heat, while Achyranthes bidentata descends (bitter, sweet, sour, and neutral in nature, guiding fire back to its source) → balancing the Qi mechanism, reducing recurring oral inflammation, and reducing esophageal reflux.

[0019] A combination of tonifying and purging: Coltsfoot flower moistens the lungs (pungent and slightly bitter, moistens the lungs and lowers qi) + raw licorice root is sweet and mild, harmonizing the effects of other herbs → mitigating the depletion of body fluids caused by dampness-removing herbs. Attached Figure Description

[0020] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the embodiments of the invention to explain the invention and do not constitute a limitation thereof.

[0021] In the attached diagram: Figure 1 This is a flowchart of the processing method of the present invention. Detailed Implementation

[0022] The following is in conjunction with the appendix Figure 1 The preferred embodiments of the present invention will be described herein. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0023] Example 1: A traditional Chinese medicine composition for oral care of patients receiving nasogastric feeding, the composition comprising the following raw materials in parts by weight: 5-15 parts of agastache rugosa, 3-9 parts of coptis chinensis, 5-15 parts of angelica dahurica, 5-15 parts of achyranthes bidentata, 5-15 parts of coltsfoot flower, 5-15 parts of peppermint, and 5-15 parts of raw licorice.

[0024] The optimal ratio is as follows: composed of the following parts by weight of active pharmaceutical ingredient: 10 parts of agastache rugosa, 3 parts of coptis chinensis, 5 parts of angelica dahurica, 5 parts of achyranthes bidentata, 5 parts of coltsfoot flower, 5 parts of mint, and 3 parts of raw licorice root.

[0025] Agastache rugosa, Coptis chinensis, Angelica dahurica, Achyranthes bidentata, Tussilago farfara, Mentha haplocalyx, Glycyrrhiza uralensis.

[0026] Example 2: The application of a traditional Chinese medicine composition in the preparation of a medicament for oral care of a nasogastric feeding patient. The medicament for oral care of a nasogastric feeding patient is in the form of an external preparation selected from any one of granules, tablets, capsules, powders, decoctions or pills. The medicament for oral care of a nasogastric feeding patient also includes auxiliary materials.

[0027] Embodiment 3: A decoction for oral care of a nasogastric feeding patient, the decoction comprising a main medicinal ingredient and a pharmaceutically acceptable auxiliary material; the main medicinal ingredient is prepared by processing the traditional Chinese medicine composition for oral care of a nasogastric feeding patient of the first aspect.

[0028] The preparation method of the main medicinal ingredient comprises the following steps: S1, weigh 1:1.67 of Xuanwudong and Mentha and put them into a sterile gauze bag; according to the ratio of raw material g: water mL, 1:10-1:20 (such as 10g raw material + 100-200 mL water), cold water extraction at 4-25°C for 12-48h; every 2-3 hours, gently stir or shake (promote dissolution, avoid emulsification caused by vigorous stirring).

[0029] This embodiment preferably extracts at 4°C for 24-48 hours, which can reduce the loss of volatile oil at low temperature.

[0030] Finally, filter with multiple layers of gauze, collect the filtrate; the volatile oil in Mentha is easy to oxidize, 0.1% ascorbic acid (antioxidant) can be added or the whole process is operated in the dark; the sesquiterpenes in Xuanwudong have low water solubility, the extraction time can be extended.

[0031] Bacteriostatic treatment: if the filtrate is stored for a long time, 0.05% sodium benzoate can be added.

[0032] S2, weigh 10 parts of Agastache, 3 parts of Coptis, 5 parts of Angelica, 5 parts of Cyathula and 5 parts of raw licorice and soak them at 4-25°C for 30 minutes-2 hours, decoct twice and combine the filtrates of the two times.

[0033] Among them, 5-15 times the amount of water (such as 35g of medicinal materials + 350mL of water) is added for the first decoction, and after boiling with a strong fire, the fire is turned to a weak fire for 20 minutes-1 hour, and then filtered. For the second decoction, 4-12 times the amount of water is added to the residue, and decocted for 15-40 minutes.

[0034] Mix the filtrates of step 1 and step 2 at a ratio of 4:1, and concentrate the filtrate to 25% of the amount of water added.

[0035] Finally, sterilize and package, and ensure that the microbial limit is ≤10 CFU / ml (GB 15979 standard).

[0036] Application case: The effectiveness of oral care was tested at three intervals: before the first oral care session, 24 hours after the first oral care session, 72 hours after the first oral care session, and one week after the first oral care session. Oral pharyngeal swab bacterial culture and oral pH value were measured at these intervals.

[0037] Before the procedure, clear any secretions from the mouth and nasal cavity. The operator uses curved hemostats to hold a cotton ball soaked in traditional Chinese medicine solution to wipe and clean the entire oral cavity. The wiping sequence is as follows: lips - left outer side of teeth - right outer side of teeth - upper inner side of teeth - upper left occlusal surface - lower left inner side - lower left occlusal surface - left cheek - upper right inner side of teeth - upper right occlusal surface - lower right inner side - lower right occlusal surface - right cheek - palate - tongue - sublingual - hard palate - gastric tube contact area. During the wiping process, it is necessary to ensure the comprehensive wiping of the patient's oral cavity environment, and also to pay attention to the meticulous wiping of the patient's oral mucosa.

[0038] Special operating points: Use the "three-zone, six-surface" wiping method: ① buccal mucosa area (bilateral) ② tongue dorsal and ventral areas, hard palate-gastric tube contact area.

[0039] Clinical trials: Case source: All cases in this experiment were patients who required nasogastric feeding and were hospitalized in the Emergency Department of the Eye Hospital of China Academy of Chinese Medical Sciences from January 2024 to December 2026.

[0040] Case selection 2.1 Inclusion criteria ① The patient received nasogastric feeding for ≥ 7 days; ②The patient's Kubota drinking water test grade

[14] >3; ③ The patient is unable to rinse their mouth and brush their teeth on their own; ④ Patients and their families obtained informed consent for this study and signed the informed consent form.

[0041] 2.2 Exclusion Criteria ① Patients with a history of oral surgery; ② Patients with hematological diseases, immune system diseases, malignant tumors, severe infectious diseases, or liver and kidney dysfunction; ③ Patients with contraindications to oral care or those with allergic reactions to the Chinese herbal mouthwash used in this study.

[0042] If any of the above conditions are met, the item will be excluded.

[0043] 2.3 Rejection Criteria ① Those who are forced to discontinue treatment during the observation period due to sudden deterioration of their condition or other serious complications that prevent them from continuing the trial; ②Those who die or abandon treatment during the observation period; ③ Those who remove their nasogastric tube themselves or accidentally.

[0044] 3. Research Methods and Experimental Techniques This experiment used a random number table method, numbering patients receiving nasogastric feeding sequentially according to their consultation time: 1, 2, 3, ... 8, 9, 10. The numbers were then entered into SPSS 23.0 statistical software for analysis, generating a set of random numbers and producing a random allocation table. Patients were then randomly divided into a treatment group (prepared traditional Chinese medicine solution) and a control group (physiological saline).

[0045] 4. Comparison of clinical data (n=5 / group) Table 1 Comparison of Clinical Data ;

[0046] 2. Comparison of inhibition zone diameters for different formulation ratios 2.1 Experimental Methods As shown in Table 2, the tested strains in the groups are: Candida albicans (ATCC 90028) and Staphylococcus aureus (ATCC 25923).

[0047] Table 2 Grouping ;

[0048] Detection method: Oxford cup method (incubate at 37℃ for 24h), measure the diameter of the inhibition zone (mm).

[0049] 2. Data Results: Table 3 shows a comparison of the diameter of the inhibition zone (Candida albicans). Table 3 Diameter of inhibition zone ;

[0050] The antibacterial zone of the proportion of the present invention (Group B) was significantly larger than that of other groups (p<0.01), and the use of coltsfoot flower alone (Group D) had almost no antibacterial effect, proving the necessity of the combination.

[0051] 3. Observation on the effect of the traditional Chinese medicine composition in group B for oral care of patients receiving nasogastric feeding Table 4 shows the effects before intervention, Tables 5-7 show the effects of the traditional Chinese medicine composition in Group B for oral care of patients receiving nasogastric feeding, and Table 8 shows the Beck oral score before and after intervention.

[0052] Table 4 Effects before intervention ;

[0053] Table 5. Effects on Day 1 after intervention ;

[0054] Table 6. Effects on day 3 after intervention ;

[0055] Table 7. Effects on day 7 after intervention ;

[0056] Table 8. Beck's oral health scores before and after the intervention. ;

[0057] Case Studies: Case 1 1. General Information Patient Chen, female, 85 years old, Han nationality, was admitted to the ICU on March 9, 2025 at 11:25 AM with a diagnosis of bacterial pneumonia, presenting with "fever for 10 days accompanied by cough and sputum for 3 days". Her past medical history includes hypertension for over 50 years, lacunar infarction for over 10 years, Alzheimer's disease, and epilepsy (diagnosis unclear). She denies any history of diabetes, coronary heart disease, or other chronic diseases; denies any history of hepatitis, tuberculosis, or other infectious diseases. She underwent left nephrectomy for cancer in April 2006; left breast cancer resection in April 2007; and pacemaker implantation in 2018. She denies any other surgical history and any food or other allergies. Currently, the patient is in a dementia state, unable to speak, disabled, aphasic, with normal body temperature, no choking while drinking, cough, expectoration (sputum copious and of unknown color), no wheezing, no nausea or vomiting, no abdominal pain or diarrhea, can consume liquids, sleeps normally, is incontinent and wears adult diapers, and has no bowel movements.

[0058] 2. Ancillary examinations 2.1 First day after admission 2.1.1 Complete blood count analysis: Mean platelet volume: 7.5 fL; 2.1.2 Infectious inflammation combination: Serum amyloid A assay: 24.5 mg / L, interleukin assay (IL-6): 28.5 pg / ml; 2.1.3 Respiratory tract five items: Respiratory syncytial virus IgM antibody ±; 2.2 Before discharge 2.2.1 Complete blood cell count analysis: Platelet distribution width 8.3 fL, mean platelet volume 9.1 fL; 2.2.2 Infectious inflammation combination: serum amyloid A was 16.8 mg / L, and interleukin-6 (IL-6) was 27.8 pg / ml.

[0059] 2.2.3 Respiratory Pathogen Five Items: Respiratory Syncytial Virus IgM Antibody-; 3. Diagnosis Western medicine diagnosis: bacterial pneumonia, reflux esophagitis.

[0060] Traditional Chinese Medicine diagnosis: Cough; syndrome differentiation: Lung heat and Yin deficiency syndrome.

[0061] 4. Treatment Plan 4.1 Plan: Routine emergency internal medicine nursing care, Level I nursing care, treatment for severe cases, low-salt and low-fat diet, monitoring and oxygen therapy, allowance for a caregiver, and further relevant examinations after admission; 4.2 Treatment measures using both traditional Chinese and Western medicine: 1) Western medicine treatment included acid suppression to protect the gastric mucosa, regulation of intestinal flora, clearing heat and resolving phlegm, anti-infection treatment, blood pressure control, anti-platelet aggregation, and potassium supplementation. 2) Traditional Chinese medicine treatment included intradermal acupuncture at bilateral Hegu, Neiguan, and Zusanli points to strengthen the body's foundation and nourish its vital energy, and auricular acupuncture patches on both ears to regulate the liver, heart, spleen, lungs, kidneys, and endocrine system, thus regulating the yin and yang of the internal organs.

[0062] 4.3 Traditional Chinese Medicine Care: Avoid wind and cold, regulate diet, and maintain emotional well-being.

[0063] Case 2 1. General Information Patient Ji, female, 63 years old, Han nationality, was admitted to the hospital on August 1, 2024 at 14:32 with a diagnosis of "cerebral infarction" due to "weakness in left limbs for more than one year, worsening in the past three months". Her past medical history includes years of "depression" and "anxiety", more than three years of peripheral arteriosclerosis, and more than five years of rheumatoid arthritis. She denies any other chronic diseases, infectious diseases such as hepatitis and tuberculosis, and allergies to food or other substances. Currently, the patient experiences weakness in left limbs, slurred speech, occasional dizziness, but no headache, double vision, nausea, vomiting, or pain in the precordial region or back. Her appetite is good, but her sleep is poor, and her bowel movements are normal.

[0064] 2. Ancillary examinations 2.1 First day after admission 2.1.1 Complete blood cell count: ★ Red blood cell count 3.68 * 10^12 / L, ★ Hemoglobin 85g / L, ★ Hematocrit 26.9%, Mean corpuscular volume 73.1fL, Mean corpuscular hemoglobin 23pg; 2.2 Before discharge 2.2.1 Complete blood cell count analysis: ★ Hemoglobin 89 g / L, ★ Hematocrit 28.9%, mean corpuscular volume 73.5 fL, mean corpuscular hemoglobin 22.6 pg, mean corpuscular hemoglobin concentration 308 g / L; 3. Diagnosis Western medicine diagnosis: Cerebral infarction, grade 3 hypertension (very high risk).

[0065] Traditional Chinese Medicine diagnosis: stroke; syndrome differentiation: qi stagnation and blood stasis syndrome.

[0066] 4 Treatment Plan 4.1. Plan: Further improve relevant inspections.

[0067] 4.2. Treatment measures of traditional Chinese and Western medicine: 1) Routine nursing care in the geriatric department, Level II nursing care, low-salt and low-fat diet; 2) Treatment: antiplatelet therapy; improvement of depression and sleep disorders; 3) Traditional Chinese medicine treatment: intradermal acupuncture (bilateral Neiguan, Waiguan, Taixi, Zusanli) to promote blood circulation, calm the mind and relieve dizziness; auricular acupressure (heart, kidney, liver, endocrine) to tonify the liver and kidneys and regulate metabolism; Chinese herbal decoction to regulate qi and promote blood circulation.

[0068] 4.3. Traditional Chinese Medicine Care: Avoid wind and cold, maintain emotional well-being, regulate diet, and be mindful of daily routines.

[0069] Case 3 1 General Information The patient, Mr. Jiao, male, 83 years old, Han nationality, was admitted to the hospital at 13:09 on May 28, 2024, with a diagnosis of "acute brainstem infarction" due to "speech impairment accompanied by dysphagia for 1 day". He has a history of hypertension for over 5 years, and a history of reflux esophagitis, chronic bronchitis, and benign prostatic hyperplasia for over 5 years. He underwent "right eye ciliary body photocoagulation surgery" on May 27, 2024. He denies any history of drug, food, or other allergies. Currently, the patient experiences speech impairment, dysphagia, choking when drinking, and feels excessive phlegm that is difficult to expectorate. He also experiences dizziness but no headache. Since the onset of the illness, he has been in a poor mood, has a reduced appetite, sleeps poorly, has constipation (absent for 2 days), and experiences urinary frequency and urgency but no dysuria.

[0070] 2. Ancillary examinations 2.1 First day after admission 2.1.1 Complete blood count + CRP: White blood cell count 11.2*10*9 / L, neutrophils 81.4%, red blood cell count 3.94*10*9 / L, hemoglobin 128.0g / L, hematocrit 8.8%; lymphocyte percentage 11.1%.

[0071] 2.1.2 Infectious inflammation profile: Interleukin-6 (IL-6): 39.8 pg / ml, C-reactive protein: 17.6 mg / L, serum amyloid A: 85 mg / L 2.1.3 Chest (CT) plain scan + thin scan: 1. Bilateral emphysema; 2. Localized thickening of the interlobar pleura in both lungs; 3. Scattered linear lesions in both lungs; 4. Bilateral pleural thickening with calcification; 5. Sclerosis of aortic and coronary artery branches; 6. Changes after gastric tube placement; 7. Nodule in the right lobe of the thyroid gland, ultrasound is recommended; 8. Gallstones.

[0072] 2.2 Before discharge Complete blood count: White blood cell count 7.7*10*9 / L, neutrophils 72.9%, red blood cell count 3.5*10*9 / L, hemoglobin 112.0g / L, hematocrit 34.4%; lymphocyte percentage 19.5%. Infectious inflammation profile: Interleukin-6 (IL-6): <1.5 pg / ml, C-reactive protein: 8.7 mg / L, serum amyloid A: 26.4 mg / L; Chest CT scan (plain + thin scan): 1. Multiple bronchitis foci with pulmonary infection in both lungs, significantly reduced compared to previous scan; interlobar pleural effusion and left pleural effusion have both reduced compared to previous scan, with the left pleural effusion showing more significant reduction. Follow-up scan after consolidation treatment is recommended. 3. Emphysema in both lungs; 4. Scattered linear opacities in both lungs; 5. Bilateral pleural thickening with calcification; 6. Sclerosis of aortic and coronary artery branches; 7. Nodule in the right lobe of the thyroid gland, ultrasound is recommended; 8. Gallstones, and the inflammatory lesions of the gallbladder have improved compared to previous scan.

[0073] 3. Diagnosis Western medicine diagnosis: Acute brainstem infarction (left dorsal medulla oblongata), hypertension (grade 3, very high risk).

[0074] Traditional Chinese Medicine diagnosis: stroke; syndrome differentiation: Qi deficiency and blood stasis syndrome.

[0075] 4 Treatment Plan 4.1 Treatment Plan: Emergency room intensive care, completion of relevant laboratory tests, and integrated traditional Chinese and Western medicine treatment. The patient suffered an acute ischemic stroke, the source of the thrombus is unknown, and the patient underwent eye surgery yesterday, which does not meet the indications for thrombolysis; therefore, conservative treatment will be administered temporarily.

[0076] 4.2 Treatment with Traditional Chinese Medicine and Western Medicine: 1) Emergency internal medicine intensive care, monitoring vital signs and intraocular pressure, and using an air mattress to prevent bedsores. 2) Low-salt, low-fat diet, tube feeding. 3) Treatments including acid suppression and gastric protection, improvement of neurological deficits, blood circulation and stasis removal, lipid regulation, antiplatelet therapy, blood pressure reduction, bowel lubrication, improvement of benign prostatic hyperplasia, and clearing heat and resolving phlegm; for patients with urinary retention and difficulty urinating, wax application was applied to the lower abdomen once daily to improve local symptoms, and a urinary catheter was inserted; Traditional Chinese medicine treatment included intradermal acupuncture at Waiguan, Neiguan, Zusanli, and Sanyinjiao to unblock meridians, strengthen the body's foundation, and apply ear acupuncture to the bilateral Shenmen points of the heart and lungs to regulate the Yin and Yang of the internal organs, and direct moxibustion (seven stroke points: Fengchi, Dazhui, Jianjing, Jianshi, Quchi, Zusanli, and Baihui) 5 times a week to unblock meridians and improve speech and swallowing difficulties. 4) Traditional Chinese medicine treatment focused on unblocking meridians, stasis removal, and phlegm removal.

[0077] 4.3 Traditional Chinese Medicine Care: Avoid wind and cold, regulate diet, eat light meals, avoid spicy foods, maintain good mood, be careful with daily routines, and avoid overwork.

[0078] Case 4 1 General Information Patient Liu, female, 92 years old, Han nationality, was admitted to the hospital on July 3, 2024 at 11:21 AM with a chief complaint of "cough and sputum for more than one month, worsening for one day," diagnosed as "acute exacerbation of bronchial asthma (mild)." She has a history of hypertension, coronary heart disease, diabetes, and hyperlipidemia for more than 10 years. She underwent cataract surgery on her right eye in 2023. She denies any history of drug, food, or other allergies. Currently, the patient experiences shortness of breath, wheezing, cough with copious, white, thin, easily expectorated sputum, palpitations, chest tightness, and hearing loss in both ears. She has no dizziness, headache, acid reflux, heartburn, nausea, vomiting, abdominal pain, or diarrhea. Since the onset of the illness, her mood has been stable, her appetite is good, but her sleep is poor, and her bowel movements are normal.

[0079] 2. Ancillary examinations 2.1 First day after admission 2.1.1 Complete blood count: Red blood cell count 3.66 L * 10^12 / L; Mean corpuscular volume 100.5 H fL; Platelet count 119 L * 10^9 / L; 2.1.2 Chest CT: 1. Interstitial changes in the lungs, please correlate with clinical findings; 2. Small amount of pleural effusion bilaterally, and a small amount of pneumothorax in the left pleural cavity; 3. Multiple small nodules in both lungs, with no significant changes compared to the CT scan on 2022-9-23; 4. Multiple cystic cavities in both lungs, with slight thickening of the paravertebral cyst wall in the right lower lung compared to the CT scan on 2022-9-23; 5. Linear shadows in the left lung; 6. Calcification of the walls of the aorta and coronary arteries.

[0080] 2.1.3 Infectious inflammation combination: Interleukin assay (IL-6): 8.6 pg / ml.

[0081] 2.2 Before discharge 2.2.1 Complete blood cell count: Red blood cell count: 3.1*10^12 / L, mean corpuscular volume: 102.6 fL, hemoglobin: 104 g / L, platelet count: 112*10^9 / L; 2.2.2 Chest CT: 1. Bilateral pleural effusion and pulmonary consolidation have been significantly reduced compared to the previous findings; 2. Multiple small nodular shadows in both lungs, with the nodule in the upper lobe of the left lung being smaller than before; 3. Multiple air-filled cavities in both lungs; 4. Calcification of the walls of the aorta and coronary arteries.

[0082] 2.2.3 Infectious inflammation combination: Interleukin assay (IL-6): 2.4 pg / ml.

[0083] 3. Diagnosis Western medicine diagnosis: acute exacerbation of bronchial asthma (mild), hypertension (grade 3, very high risk).

[0084] Traditional Chinese Medicine diagnosis: Asthma; syndrome differentiation: Phlegm-heat accumulation syndrome.

[0085] 4. Treatment Plan 4.1 Plan: Complete all relevant laboratory tests and treatments, combining traditional Chinese and Western medicine. The patient is an elderly woman with profuse cough and sputum production; therefore, complete the female tumor marker testing to rule out tumor as a cause.

[0086] 4.2 Treatment with Traditional Chinese Medicine and Western Medicine: 1) Emergency Level I internal medicine nursing care, critically ill patient, ECG monitoring, and continuous low-flow oxygen therapy. 2) Low-salt, low-fat, diabetic diet. 3) Treatment with anti-infection, antispasmodic and bronchodilator, acid-suppressing and gastric-protecting, antihypertensive, antiplatelet, lipid-lowering and plaque-stabilizing, cardiac function-improving, and hypoglycemic agents. Auricular acupressure (liver, spleen, endocrine, and Shenmen) 5 times / week to regulate organ function; intradermal acupuncture (bilateral Neiguan, Hegu, Zusanli, and Sanyinjiao) 3 times / week to promote blood circulation and improve local symptoms. 4) Traditional Chinese medicine treatment to clear heat, resolve phlegm, and relieve asthma. The prescription is modified Ma Xing Shi Gan Tang, 4 doses, decocted in water and taken once a day, divided into morning and evening doses.

[0087] 4.3 Traditional Chinese Medicine Care: Avoid wind and cold, regulate diet, maintain emotional well-being, and avoid overwork.

[0088] Case 5 1 General Information Patient Zhang, female, 89 years old, Han nationality, was admitted to the hospital on May 18, 2024 at 9:31 AM with a diagnosis of "aspiration pneumonia" due to "intermittent cough and sputum production for more than 3 years, which worsened and was accompanied by shortness of breath for 1 day". Her past medical history included "bacterial pneumonia and hypostatic pneumonia" for more than 2 years, "chronic bronchitis" for more than 3 years, "atrial fibrillation" for more than 2 years, "hyperlipidemia" for more than 3 years, "lacunar infarction and osteoporosis" for more than 2 years, "Alzheimer's disease" for more than 2 years, and "cerebral thrombosis" for 3 years. She denied any history of drug, food, or other allergies. The patient is currently in a state of dementia, coughing and expectorating phlegm, but with difficulty expectorating. The phlegm is yellow, sticky, and copious, and difficult to cough up. There is no nausea or vomiting, wheezing or shortness of breath, and the patient breathes through their mouth. They can lie flat. Due to the dementia, the patient is unable to speak. A nasogastric tube and urinary catheter are in place. There is no fever or sweating. The patient is fed through a nasogastric tube. The patient sleeps well. The patient has one bowel movement per day, which is small in quantity and soft in consistency. The patient's urine is yellow and scanty, and a small amount of white flocculent material can be seen in the urinary catheter.

[0089] 2. Ancillary examinations 2.1 First day after admission 2.1.1 Infectious inflammation combination: C-reactive protein 13.3 mg / L, serum amyloid A 55.7 mg / L; 2.1.2 Complete blood count: Lymphocyte percentage 15.5%, neutrophil percentage 76.2%; 2.2 Before discharge 2.2.1 Infectious inflammation combination: C-reactive protein 6.4 mg / L, serum amyloid A 12.6 mg / L 2.2.2 Complete blood count: Lymphocyte percentage 22.2%, Neutrophil percentage 68.7%; 3. Diagnosis Western medicine diagnosis: aspiration pneumonia.

[0090] Traditional Chinese Medicine Diagnosis: Cough Disease Syndrome Differentiation: Phlegm-Heat Accumulation Syndrome.

[0091] 4 Treatment Plan 4.1 Plan: Complete relevant examinations and provide integrated traditional Chinese and Western medicine treatment.

[0092] 4.2 Treatment with Traditional Chinese Medicine and Western Medicine: 1) Level 1 nursing care in internal medicine, including blood pressure monitoring, continuous ECG monitoring, and continuous low-flow oxygen therapy for severe cases. 2) Low-salt, low-fat diet. 3) Western medicine treatment: Based on the patient's bacterial culture results, treatment included: anti-infection; clearing heat and resolving phlegm, relieving cough and asthma; regulating heart rhythm and controlling heart rate; regulating intestinal flora imbalance; lipid regulation; anticoagulation; improving osteoporosis, etc.; bladder irrigation to alleviate urinary symptoms. 4) Traditional Chinese medicine treatment focused on resolving phlegm and relieving asthma.

[0093] 4.3 Traditional Chinese Medicine Care: Avoid wind and cold, regulate diet, and maintain emotional well-being.

[0094] As described above, the basic principles, main features, and advantages of the present invention have been well described. The above embodiments and specifications are merely descriptions of preferred embodiments of the present invention, and the present invention is not limited to the above embodiments. Various changes and improvements made to the technical solutions of the present invention by those skilled in the art without departing from the spirit and scope of the present invention should fall within the protection scope defined by the present invention.

Claims

1. A traditional Chinese medicine composition for oral care of patients receiving nasogastric feeding, characterized in that, The pharmaceutical composition comprises the following parts by weight of active pharmaceutical ingredients: 5-15 parts of agastache rugosa, 3-9 parts of coptis chinensis, 5-15 parts of angelica dahurica, 5-15 parts of achyranthes bidentata, 5-15 parts of coltsfoot flower, 5-15 parts of peppermint, and 5-15 parts of raw licorice.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Composed of the following parts by weight of active pharmaceutical ingredient: 10 parts of agastache rugosa, 3 parts of coptis chinensis, 5 parts of angelica dahurica, 5 parts of achyranthes bidentata, 5 parts of coltsfoot flower, 5 parts of mint, and 5 parts of raw licorice root.

3. The use of the traditional Chinese medicine composition according to any one of claims 1-2 in the preparation of a medicament for oral care of patients receiving nasogastric feeding.

4. The application according to claim 3, characterized in that, The drug dosage form for oral care of patients receiving nasogastric feeding is a topical preparation, which is selected from any one of granules, tablets, capsules, powders, decoctions, or pills.

5. The application according to claim 4, characterized in that, The medication used for oral care of patients receiving nasogastric feeding also includes excipients.

6. A decoction for oral care of patients receiving nasogastric feeding, said decoction comprising a main pharmaceutical ingredient and pharmaceutically acceptable excipients; characterized in that, The main pharmaceutical ingredient is obtained by processing the traditional Chinese medicine composition for oral care of patients receiving nasogastric feeding as described in claim 1 or 2.

7. The decoction for oral care of patients receiving nasogastric feeding according to claim 6, characterized in that, The preparation method of the active pharmaceutical ingredient includes the following steps: S1. Weigh 5 parts of Tussilago farfara and 5 parts of peppermint, put them into a sterile gauze bag, and extract them with cold water. Finally, filter them with multiple layers of gauze and collect the filtrate. S2. Weigh out 10 parts of agastache rugosa, 3 parts of coptis chinensis, 5 parts of angelica dahurica, 5 parts of achyranthes bidentata, and 5 parts of licorice root. Soak in cold water, decoct twice, and combine the two filtrates.

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