A traditional Chinese medicine composition for treating anxiety and a preparation method thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating anxiety and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: cassia 10-20 parts, acanthopanax 7-12 parts, rhodiola 8-15 parts, spina date seed 5-10 parts, raw dragon tooth 3-8 parts, polygala 2-8 parts, money grass 1-5 parts, sweet draba 1-5 parts, schisandra 5-10 parts, and fried licorice 3-5 parts. The traditional Chinese medicine composition for treating anxiety prepared by the application has the effects of warming the middle and activating blood, benefiting essence and reducing water, calming the nerves and benefiting intelligence, can obviously relieve anxiety, and has a wide application prospect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating anxiety disorder and its preparation method. Background Technology

[0002] Anxiety disorders are among the most common mental illnesses in my country, with major types including generalized anxiety disorder (GAD), panic disorder, specific phobias, and social anxiety disorder. While the symptoms vary among different types of anxiety disorders, they often involve symptoms of autonomic nervous system dysfunction, such as palpitations, shortness of breath, and excessive sweating. These symptoms significantly negatively impact patients' quality of life. In Traditional Chinese Medicine (TCM) diagnosis, anxiety disorders are primarily characterized by mental anxiety such as worry and tension, accompanied by physical anxiety symptoms such as palpitations, chest tightness, and excessive sweating, as well as fear, irritability, restlessness, and insomnia. Heart and gallbladder qi deficiency syndrome is a common TCM syndrome type for anxiety disorders, with typical symptoms including palpitations, timidity, shortness of breath, excessive sweating, and fatigue. Therefore, from the perspective of TCM syndrome differentiation and treatment, finding formulas that can effectively alleviate the mental anxiety and physical symptoms of autonomic nervous system dysfunction in anxiety disorders is an urgent problem to be solved.

[0003] Currently, while commonly used anti-anxiety medications can alleviate symptoms to some extent, they often have adverse reactions such as excessive sedation, gastrointestinal reactions, and cardiovascular reactions. Furthermore, SSRIs require 2-3 weeks to take effect and need to be taken long-term to maintain efficacy. Moreover, relapse or recurrence of anxiety often occurs after discontinuation, making a fundamental cure difficult. In contrast, Traditional Chinese Medicine (TCM) has unique advantages in the treatment of anxiety disorders and has become a current research hotspot. However, there is currently a lack of TCM preparations specifically for treating anxiety disorders on the market. Most practitioners believe that TCM preparations with liver-soothing, mood-lifting, and mind-calming effects can exert an anti-anxiety effect to some extent. Therefore, for patients with anxiety disorders whose main symptoms include anxiety, timidity, palpitations, shortness of breath, excessive sweating, and fatigue, seeking effective TCM preparations for treating anxiety disorders caused by heart and gallbladder qi deficiency is an urgent need in clinical practice. Based on the above objectives, this invention provides a TCM composition for treating anxiety disorders caused by heart and gallbladder qi deficiency. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, one of the objectives of this invention is to provide a traditional Chinese medicine composition for treating anxiety disorder.

[0005] One of the objectives of this invention is achieved through the following technical solution:

[0006] A traditional Chinese medicine composition for treating anxiety disorder, the composition comprising the following raw materials in parts by weight: 10-20 parts cinnamon, 7-12 parts Acanthopanax senticosus, 8-15 parts Rhodiola rosea, 5-10 parts Ziziphus jujuba var. spinosa, 3-8 parts fossilized teeth, 2-8 parts Polygala tenuifolia, 1-5 parts Lysimachia christinae, 1-5 parts Lepidium apetalum, 5-10 parts Schisandra chinensis, and 3-5 parts prepared licorice root.

[0007] Furthermore, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts cinnamon, 9 parts Acanthopanax senticosus, 11 parts Rhodiola rosea, 7 parts Ziziphus jujuba var. spinosa, 5 parts fossilized teeth, 5 parts Polygala tenuifolia, 3 parts Lysimachia christinae, 3 parts Lepidium apetalum, 7 parts Schisandra chinensis, and 4 parts prepared licorice root.

[0008] The second objective of this invention is to provide a method for preparing a traditional Chinese medicine composition for treating anxiety disorders.

[0009] The second objective of this invention is achieved by the following technical solution:

[0010] The preparation method of the traditional Chinese medicine composition for treating anxiety disorder described above includes the following specific steps:

[0011] (1) Weigh out each ingredient according to the weight proportions: cinnamon, Acanthopanax senticosus, Rhodiola rosea, Ziziphus jujuba var. spinosa, fossilized teeth, Polygala tenuifolia, Lysimachia christinae, Lepidium apetalum, Schisandra chinensis, and prepared licorice root. Grind them into powder and sieve them to obtain Chinese medicine powder for later use.

[0012] (2) Soak the Chinese medicine powder prepared in step (1) in water, then decoct it; filter, centrifuge, and collect the first filtrate and the first filter residue;

[0013] (3) Then add water to the first filter residue to soak, and then decoct; after filtration and centrifugation, collect the second filtrate, combine the first filtrate and the second filtrate, concentrate and freeze dry to obtain the traditional Chinese medicine composition.

[0014] Furthermore, the mesh size of the sieve in step (1) is 50-60.

[0015] Furthermore, in step (2), the amount of water added is 6-8 times the total weight of the Chinese medicine powder.

[0016] Furthermore, the soaking time in step (2) is 2-4 hours; the decocting time is 4-6 hours.

[0017] Furthermore, the amount of water added in step (3) is 4-6 times the total weight of the filter residue.

[0018] Furthermore, the soaking time in step (3) is 1-3 h; the decocting time is 3-5 h.

[0019] To facilitate a better understanding of this invention, the effects of each ingredient are explained below:

[0020] Cinnamon: pungent and sweet, with extremely hot properties. It enters the kidney, spleen, heart, and liver meridians. Functions and indications: warms the middle jiao and tonifies the kidneys, assists yang and promotes qi transformation. The *Shennong Bencao Jing* records: it treats all diseases, nourishes the spirit, improves complexion, benefits joints, and replenishes the middle jiao and boosts qi.

[0021] Acanthopanax senticosus: pungent, slightly bitter, and warm in nature. It enters the spleen, kidney, and heart meridians. Functions and indications: tonifies the middle jiao and replenishes essence, invigorates qi and strengthens the spleen, tonifies the kidneys and calms the mind. The *Mingyi Bielu* records: tonifies the middle jiao and replenishes essence, strengthens muscles and bones, and enhances willpower.

[0022] Rhodiola rosea: Sweet and bitter, neutral in nature. It enters the lung and heart meridians. Functions and indications: Tonifies qi and invigorates blood circulation, unblocks meridians and relieves asthma. The Compendium of Materia Medica records: Strengthens muscles and bones, benefits essence and qi.

[0023] Sour jujube seed: sweet and sour, neutral in nature. It enters the heart, liver, and gallbladder meridians. Functions and indications: calms the mind and aids sleep, reduces sweating. The *Compendium of Materia Medica* records: nourishing and moistening, reduces sweating and calms the mind.

[0024] Raw dragon teeth: Sweet and astringent, cold in nature. Enters the heart and liver meridians. Functions and indications: Calms the nerves and relieves anxiety, clears the heart and eliminates irritability. The *Shennong Bencao Jing* records: Treats infantile and adult epilepsy, mania, chest tightness, shortness of breath, and various spasms.

[0025] Polygala tenuifolia: Bitter and pungent, warm in nature. It enters the heart, kidney, and lung meridians. Functions and indications: Calms the mind and improves intelligence. According to *Diannan Materia Medica*, it nourishes heart blood, calms the nerves, soothes the mind, and dispels phlegm.

[0026] Lysimachia christinae: Sweet and slightly bitter, cold in nature. It enters the liver, gallbladder, kidney, and bladder meridians. Functions and indications: Soothes the liver and relieves depression, clears heat and promotes diuresis, and improves joint mobility. According to *Compendium of Materia Medica*, it detoxifies, reduces swelling, and promotes urination.

[0027] Sweet Lepidium seed: pungent, bitter, and extremely cold in nature. It enters the Lung and Bladder meridians. Functions and indications: Clears lung heat and relieves asthma, promotes diuresis and reduces swelling. The *Shennong Bencao Jing* records: It treats abdominal masses and stagnation of qi, imbalances of hot and cold in food, breaks up hard masses and expels pathogens, and promotes urination.

[0028] Schisandra chinensis: Sour and sweet, warm in nature. It enters the lung, heart, and kidney meridians. Functions and indications: Astringent and consolidating, astringes the lungs and generates fluids, tonifies the kidneys and calms the heart. The *Compendium of Materia Medica* records: It astringes qi, generates fluids, and benefits.

[0029] Prepared licorice root: Sweet in taste and neutral in nature. It enters the heart, lung, spleen, and stomach meridians. Functions and indications: Tonifies the spleen and replenishes qi, clears heat and detoxifies, resolves phlegm and relieves cough, alleviates spasms and pain, and harmonizes other herbs. The Compendium of Materia Medica records that licorice root is the chief herb among all medicines, treating seventy-two kinds of mineral poisoning, detoxifying one thousand two hundred kinds of plant poisoning, and effectively harmonizing other herbs; hence, it is known as the "Elder of the Nation."

[0030] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0031] This invention provides a traditional Chinese medicine composition for treating anxiety disorder. The composition uses cinnamon and eleutherococcus senticosus as the principal herbs, which have the effects of warming the middle jiao and tonifying the kidneys, and replenishing essence. Rhodiola rosea, jujube seed, fossilized teeth, and polygala tenuifolia are used as assistant herbs, which have the effects of tonifying qi and blood, calming the mind and aiding sleep, clearing the heart and relieving irritability, and calming the mind and improving intelligence. Lysimachia christinae, Lepidium apetalum, and Schisandra chinensis are used as adjuvant herbs, which have the effects of clearing heat and dampness, promoting diuresis and reducing swelling, and astringing the lungs and generating fluids. Prepared licorice root is used as the guiding herb to harmonize the effects of all the herbs. The overall formula of this invention is rationally formulated, possessing the effects of warming the middle jiao and promoting blood circulation, replenishing essence and promoting diuresis, and calming the mind and improving intelligence. Experimental results show that taking the traditional Chinese medicine composition prepared according to this invention can effectively treat anxiety disorder. Detailed Implementation

[0032] The present invention will now be further described in conjunction with specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments. Specific conditions not specified in the embodiments shall be performed according to conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, all reagents or instruments used are conventional products obtained through commercial channels.

[0033] Example 1

[0034] A traditional Chinese medicine composition for treating anxiety disorder, the composition comprising the following ingredients in parts by weight: 15 parts cinnamon, 9 parts Acanthopanax senticosus, 11 parts Rhodiola rosea, 7 parts Ziziphus jujuba var. spinosa, 5 parts fossilized teeth, 5 parts Polygala tenuifolia, 3 parts Lysimachia christinae, 3 parts Lepidium apetalum, 7 parts Schisandra chinensis, and 4 parts prepared licorice root.

[0035] A method for preparing a traditional Chinese medicine composition for treating anxiety disorder, comprising the following steps:

[0036] (1) Weigh out each ingredient according to the weight proportions: cinnamon, Acanthopanax senticosus, Rhodiola rosea, Ziziphus jujuba var. spinosa, raw fossilized teeth, Polygala tenuifolia, Lysimachia christinae, Lepidium apetalum, Schisandra chinensis, and prepared licorice root. Grind them into powder and pass them through a 55-mesh sieve to obtain Chinese medicine powder for later use.

[0037] (2) Soak the Chinese medicine powder prepared in step (1) in water equal to 7 times the total weight of the Chinese medicine powder for 3 hours, then decoct for 5 hours; filter, centrifuge, and collect the first filtrate and the first filtrate residue;

[0038] (3) Then add water equal to 5 times the total weight of the first filter residue to soak for 2 hours, followed by decoction for 4 hours; after filtration and centrifugation, collect the second filtrate, combine the first and second filtrates, concentrate and freeze dry to obtain the traditional Chinese medicine composition.

[0039] Example 2

[0040] A traditional Chinese medicine composition for treating anxiety disorder, the composition comprising the following ingredients in parts by weight: 10 parts cinnamon, 7 parts Acanthopanax senticosus, 8 parts Rhodiola rosea, 5 parts Ziziphus jujuba var. spinosa, 3 parts fossilized teeth, 2 parts Polygala tenuifolia, 1 part Lysimachia christinae, 1 part Lepidium apetalum, 5 parts Schisandra chinensis, and 3 parts prepared licorice root.

[0041] A method for preparing a traditional Chinese medicine composition for treating anxiety disorder, comprising the following steps:

[0042] (1) Weigh out each ingredient according to the weight proportions: cinnamon, Acanthopanax senticosus, Rhodiola rosea, Ziziphus jujuba var. spinosa, raw fossilized teeth, Polygala tenuifolia, Lysimachia christinae, Lepidium apetalum, Schisandra chinensis, and prepared licorice root. Grind them into powder and pass them through a 50-mesh sieve to obtain Chinese medicine powder for later use.

[0043] (2) Soak the Chinese medicine powder prepared in step (1) in water equal to 6 times the total weight of the Chinese medicine powder for 2 hours, then decoct for 4 hours; filter, centrifuge, and collect the first filtrate and the first filtrate residue;

[0044] (3) Then add water equal to 4 times the total weight of the first filter residue to soak for 1 hour, then decoct for 3 hours; after filtration and centrifugation, collect the second filtrate, combine the first and second filtrates, concentrate and freeze dry to obtain the traditional Chinese medicine composition.

[0045] Example 3

[0046] A traditional Chinese medicine composition for treating anxiety disorder, the composition comprising the following ingredients in parts by weight: 20 parts cinnamon, 12 parts Acanthopanax senticosus, 15 parts Rhodiola rosea, 10 parts Ziziphus jujuba var. spinosa, 8 parts fossilized teeth, 8 parts Polygala tenuifolia, 5 parts Lysimachia christinae, 5 parts Lepidium apetalum, 10 parts Schisandra chinensis, and 5 parts prepared licorice root.

[0047] A method for preparing a traditional Chinese medicine composition for treating anxiety disorder, comprising the following steps:

[0048] (1) Weigh out each ingredient according to the weight proportions: cinnamon, Acanthopanax senticosus, Rhodiola rosea, Ziziphus jujuba var. spinosa, fossilized teeth, Polygala tenuifolia, Lysimachia christinae, Lepidium apetalum, Schisandra chinensis, and prepared licorice root. Grind them into powder and pass them through a 60-mesh sieve to obtain Chinese medicine powder for later use.

[0049] (2) Soak the Chinese medicine powder prepared in step (1) in water equal to 8 times the total weight of the Chinese medicine powder for 4 hours, then decoct for 6 hours; filter, centrifuge, and collect the first filtrate and the first filtrate residue;

[0050] (3) Then add water equal to 6 times the total weight of the first filter residue to soak for 3 hours, followed by decoction for 5 hours; after filtration and centrifugation, collect the second filtrate, combine the first and second filtrates, concentrate and freeze dry to obtain the traditional Chinese medicine composition.

[0051] Comparative Example 1

[0052] The difference between Comparative Example 1 and Example 1 is that Lysimachia christinae was omitted from the ingredients of the traditional Chinese medicine composition for treating anxiety disorder, while all other components are the same as in Example 1.

[0053] Comparative Example 2

[0054] The difference between Comparative Example 2 and Example 1 is that the ingredients of the traditional Chinese medicine composition for treating anxiety disorder are omitted from the composition of Sweet Lepidium apetalum, while all other components are the same as in Example 1.

[0055] Comparative Example 3

[0056] The difference between Comparative Example 3 and Example 1 is that the sweet lepidium seed in the traditional Chinese medicine composition for treating anxiety disorder is replaced with poria cocos, while all other components are the same as in Example 1.

[0057] Experimental Example 1

[0058] Pharmacological study of the traditional Chinese medicine composition for treating anxiety disorder prepared in this invention:

[0059] 1.1 Constructing an animal model of anxiety disorder:

[0060] (1) SPF-grade male SD rats were selected as experimental animals, with a weight of about 150g, totaling 80 rats. They were randomly divided into 8 groups: model group, blank control group, low-dose group of Example 1, medium-dose group of Example 1, high-dose group of Example 1, medium-dose group of Comparative Example 1, medium-dose group of Comparative Example 2, and medium-dose group of Comparative Example 3, with 10 rats in each group. They were acclimatized for 3 days and had free access to water and food during the period.

[0061] (2) After 3 days of acclimatization, an anxiety model in rats was established. The specific procedures were as follows: Water was provided at set times for 7 days. The animals were given 10 minutes of water at 9 am and 9 pm each day. The water bottles were removed at other times and drinking was prohibited. Starting from 9 pm on the 8th day, the animals were given empty bottle stimulation once or twice at the original water supply time for 20 days. The blank control group was not treated.

[0062] 1.2 Drug intervention:

[0063] Example 1 Low-dose group: Based on crude drug, 0.2 g / kg of the traditional Chinese medicine composition of Example 1 was administered by gavage once a day for 20 consecutive days;

[0064] In Example 1, the dosage group was administered 0.5 g / kg of the traditional Chinese medicine composition of Example 1 by gavage once a day for 20 consecutive days, based on the amount of raw drug.

[0065] Example 1 High-dose group: Based on crude drug, 1 g / kg of the traditional Chinese medicine composition of Example 1 was administered by gavage once a day for 20 consecutive days;

[0066] Comparative Example 1 medium-dose group: Based on crude drug, 0.5 g / kg of the traditional Chinese medicine composition of Comparative Example 1 was administered by gavage once a day for 20 consecutive days;

[0067] Comparative Example 2 medium dose group: Based on crude drug, 0.5 g / kg of the traditional Chinese medicine composition of Comparative Example 2 was administered by gavage once a day for 20 consecutive days;

[0068] Comparative Example 3 medium-dose group: Based on crude drug, 0.5 g / kg of the traditional Chinese medicine composition of Comparative Example 3 was administered by gavage once a day for 20 consecutive days;

[0069] Blank control group and model group: The same volume of physiological saline was administered by gavage once a day for 20 consecutive days.

[0070] 1.3 Test of Effect Indicators

[0071] 1.3.1 Elevated Cross Maze Experiment

[0072] The principle of the elevated cross maze is based on the conflict between the exploratory behavior of rats when faced with new stimuli and their natural tendency to avoid darkness. Rats are curious about new things and will actively explore the open arms, while they have a natural tendency to avoid darkness (closed arms). This conflict between exploration and avoidance leads to anxiety in the rats. The height of the entire maze above the ground is equivalent to a human standing on the edge of a cliff, easily causing fear and unease in the rats. The anxiety level can be evaluated by comparing the time and number of times the rats spend in the open and closed arms. Two hours after the last drug administration, the rats were placed on the central platform of the elevated cross maze and allowed to explore freely for approximately 10 minutes. White noise was played during the experiment to eliminate external noise interference. The video system automatically recorded the number of times the rats entered the open and closed arms (each entry with all four limbs counted as one entry) and the time spent in each arm within 5 minutes. The ratio of the number of times rats entered the open arms to the ratio of the time spent in the open arms was calculated and used as an indicator of the rats' anxiety level. The shorter the number of times and the shorter the time spent in the open arms, the more severe the rats' anxiety symptoms. The experimental results are shown in Table 1.

[0073] Table 1. Percentage of SD rats entering the open arm and percentage of rats remaining in the open arm.

[0074] ;

[0075] The results are shown in Table 1, which represents the proportion of SD rats entering the open arm and the proportion of rats remaining in the open arm for a shorter period. As shown in Table 1, compared to the blank control group, the proportion of rats entering the open arm and the proportion of rats remaining in the open arm were significantly reduced after stimulation in the model group. By administering the corresponding traditional Chinese medicine composition for treating anxiety, compared to comparative groups 1-3, the traditional Chinese medicine compositions for treating anxiety prepared in Examples 1-3 of this invention significantly increased the proportion of rats entering the open arm and the proportion of rats remaining in the open arm. This indicates that the traditional Chinese medicine composition for treating anxiety prepared in this invention can significantly alleviate the anxiety symptoms in rats.

[0076] 1.3.2 Mine Field Experiment

[0077] The open field analysis system assesses an animal's anxiety state by observing its behavior in a new open environment. Animals, fearful of new environments, primarily move to the periphery, with less activity in the central area. However, their exploratory nature motivates them to move to the central area, allowing for observation of the resulting anxiety. Two hours after the last drug administration, rats in each group were placed in an open field box, allowed to acclimatize for 1 minute, then removed and placed back in the center of the box. Animal behavior analysis software was used to automatically record the rats' activity within the box for 15 minutes. The entire experiment was conducted quietly, and the total distance and speed of movement were measured. The anxiety behavior of SD rats was evaluated using total distance and speed; decreased total distance and speed indicated more severe anxiety symptoms. The experimental results are shown in Table 2.

[0078] Table 2. Total distance and speed of SD rats in the mine.

[0079] ;

[0080] The results are shown in Table 2, which represents the total distance and speed of SD rats in the mine. As shown in Table 2, compared to the blank control group, the total distance and speed of SD rats in the model group were significantly reduced after stimulation. By administering the corresponding traditional Chinese medicine composition for treating anxiety, compared to comparative groups 1-3, the traditional Chinese medicine compositions for treating anxiety prepared in Examples 1-3 of this invention significantly increased the total distance and speed of SD rats in the mine. This indicates that the traditional Chinese medicine composition for treating anxiety prepared in this invention can alleviate anxiety symptoms.

[0081] Experimental Example 2

[0082] The following are the clinical trial results of the traditional Chinese medicine compositions for treating anxiety disorders obtained in Examples 1-3 and Comparative Examples 1-3:

[0083] (1) This study was conducted from June 2020 to January 2024, enrolling 226 patients with generalized anxiety disorder (GAD) of the heart-gallbladder qi deficiency type, and ultimately completing clinical observation of 210 patients. The inclusion criteria for patients with GAD of the heart-gallbladder qi deficiency type are as follows: ① Age 18–65 years; ② Meeting the anxiety disorder criteria in the clinical research criteria; ③ Meeting the TCM syndrome criteria for heart-gallbladder qi deficiency type; ④ Stable vital signs, clear consciousness, and a certain level of expressive ability; ⑤ Signed informed consent form and agreed to participate in this study; only those who meet all five of the above criteria can be included. The clinical research criteria are shown in Table 3, using the DSM-5 criteria promulgated by the American Mental Health Association in 2013. Patients can only be diagnosed with GAD when they meet all of these criteria. The TCM syndrome criteria for heart-gallbladder qi deficiency type are shown in Table 4. The exclusion criteria for GAD of the heart-gallbladder qi deficiency type are shown in Table 5.

[0084] Table 3 Generalized Anxiety Disorder Patients in Clinical Studies

[0085] ;

[0086] Table 4. TCM syndrome differentiation criteria for heart and gallbladder qi deficiency.

[0087] ;

[0088] Table 5 Exclusion criteria for generalized anxiety disorder due to deficiency of heart and gallbladder qi.

[0089] ;

[0090] (2) The study will adopt the principles of double-blind, randomized, and controlled trials. Participants will be randomly divided into 7 groups, with 30 participants in each group. These groups are: Example 1 Group, Example 2 Group, Example 3 Group, Comparative Example 1 Group, Comparative Example 2 Group, Comparative Example 3 Group, and Control Group (buspirone tablets). Each group will undergo treatment for 6 weeks, taking 1g of the corresponding traditional Chinese medicine composition for treating anxiety twice daily. The control group will take 10mg of buspirone tablets twice daily.

[0091] (3) The scores of various indicators of clinical patients before and after 6 weeks of treatment were assessed using the Traditional Chinese Medicine Syndrome Scale, and the efficacy index was calculated. The formula is: Efficacy Index (n) = [(Pre-treatment score - Post-treatment score) / Pre-treatment score] × 100%. Based on the efficacy index, the evaluation criteria were formulated, as shown in Table 6. Based on this evaluation criteria, the effectiveness rate of treating anxiety disorders in each group was further calculated, and the results are shown in Table 7.

[0092] Table 6 Evaluation Criteria for Therapeutic Effect Index

[0093] ;

[0094] Table 7. Efficacy of different traditional Chinese medicine combinations in treating anxiety disorders

[0095] ;

[0096] The results are shown in Table 7, which presents the efficacy rates of different traditional Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-3 for treating anxiety disorders. As can be seen from the table, compared with the control group and Comparative Examples 1-3, the traditional Chinese medicine compositions prepared in Examples 1-3 of this invention for treating anxiety disorders significantly improve the efficacy rate of treating anxiety disorders.

[0097] Further analysis revealed that, compared to Example 1, the traditional Chinese medicine composition in Comparative Example 1 omitted Lysimachia christinae; the traditional Chinese medicine composition in Comparative Example 2 omitted Lepidium apetalum; and the traditional Chinese medicine composition in Comparative Example 3 replaced Lepidium apetalum with Poria cocos. The anxiety-reducing effects of the three traditional Chinese medicine compositions in treating anxiety disorder in rats were significantly reduced. In this invention, the traditional Chinese medicine formula uses Cinnamomum cassia and Acanthopanax senticosus as the principal herbs, possessing the effects of warming the middle jiao and tonifying the kidneys, replenishing the middle jiao and benefiting the essence; Rhodiola rosea, Ziziphus jujuba var. spinosa, fossilized teeth, and Polygala tenuifolia as the assistant herbs, possessing the effects of replenishing qi and blood, calming the mind and aiding sleep, clearing the heart and relieving irritability, calming the mind and improving intelligence; Lysimachia christinae, Lepidium apetalum, and Schisandra chinensis are added as adjuvant herbs, possessing the effects of clearing heat and dampness, promoting diuresis and reducing swelling, astringing the lungs and generating fluids; and prepared Glycyrrhiza uralensis is used as the guiding herb to harmonize the various herbs. The entire formula, when combined, has the effects of warming the middle jiao and promoting blood circulation, benefiting the essence and promoting diuresis, calming the mind and improving intelligence, and can effectively treat anxiety symptoms.

[0098] The above embodiments are merely preferred embodiments of the present invention and should not be construed as limiting the scope of protection of the present invention. Any non-substantial changes and substitutions made by those skilled in the art based on the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A traditional Chinese medicine composition for treating anxiety disorder, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 10-20 parts cinnamon, 7-12 parts Acanthopanax senticosus, 8-15 parts Rhodiola rosea, 5-10 parts Ziziphus jujuba var. spinosa, 3-8 parts fossilized teeth, 2-8 parts Polygala tenuifolia, 1-5 parts Lysimachia christinae, 1-5 parts Lepidium apetalum, 5-10 parts Schisandra chinensis, and 3-5 parts prepared licorice root.

2. The traditional Chinese medicine composition for treating anxiety disorder according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 15 parts cinnamon, 9 parts Acanthopanax senticosus, 11 parts Rhodiola rosea, 7 parts Ziziphus jujuba var. spinosa, 5 parts fossilized teeth, 5 parts Polygala tenuifolia, 3 parts Lysimachia christinae, 3 parts Lepidium apetalum, 7 parts Schisandra chinensis, and 4 parts prepared licorice root.

3. A method for preparing a traditional Chinese medicine composition for treating anxiety disorder according to any one of claims 1-2, characterized in that, The specific steps include: (1) Weigh out each ingredient according to the weight proportions: cinnamon, Acanthopanax senticosus, Rhodiola rosea, Ziziphus jujuba var. spinosa, fossilized teeth, Polygala tenuifolia, Lysimachia christinae, Lepidium apetalum, Schisandra chinensis, and prepared licorice root. Grind them into powder and sieve them to obtain Chinese medicine powder for later use. (2) Soak the Chinese medicine powder prepared in step (1) in water, then decoct it; filter, centrifuge, and collect the first filtrate and the first filter residue; (3) Then add water to the first filter residue to soak, and then decoct; after filtration and centrifugation, collect the second filtrate, combine the first filtrate and the second filtrate, concentrate and freeze dry to obtain the traditional Chinese medicine composition.

4. The method for preparing a traditional Chinese medicine composition for treating anxiety disorder according to claim 3, characterized in that, The mesh size of the sieve in step (1) is 50-60.

5. The method for preparing a traditional Chinese medicine composition for treating anxiety disorder according to claim 3, characterized in that, In step (2), the amount of water added is 6-8 times the total weight of the Chinese medicine powder.

6. The method for preparing a traditional Chinese medicine composition for treating anxiety disorder according to claim 3, characterized in that, The soaking time in step (2) is 2-4 hours; the decocting time is 4-6 hours.

7. The method for preparing a traditional Chinese medicine composition for treating anxiety disorder according to claim 3, characterized in that, In step (3), the amount of water added is 4-6 times the total weight of the filter residue.

8. The method for preparing a traditional Chinese medicine composition for treating anxiety disorder according to claim 3, characterized in that, The soaking time in step (3) is 1-3 hours; the decocting time is 3-5 hours.