A morindae officinalis polysaccharide, a preparation method thereof and a medicinal use of the polysaccharide for treating inflammation

By extracting and purifying SSP-Ⅱa polysaccharide from the stem of Spatholobus suberectus, the problem of unclear structural characteristics of Spatholobus suberectus polysaccharide was solved, enabling the development of a novel anti-inflammatory drug with anti-inflammatory effects and filling the gap in the field of anti-inflammatory drugs.

CN121319236BActive Publication Date: 2026-07-24ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202511701357.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-11-19
Publication Date
2026-07-24
Estimated Expiration
2045-11-19

AI Technical Summary

Technical Problem

Existing research has failed to systematically elucidate the fine structural features and intrinsic mechanisms of bioactivity of *Spatholobus suberectus* polysaccharides, which limits their development and utilization in the field of anti-inflammatory drugs. Furthermore, existing anti-inflammatory drugs suffer from problems such as significant side effects and drug resistance.

Method used

Crude polysaccharide from *Spatholobus suberectus* stems was extracted by water extraction and alcohol precipitation. Combined with two-stage purification and MH7A cell activity evaluation, *Spatholobus suberectus* polysaccharide SSP-Ⅱa was obtained. Multidimensional characterization, including ultraviolet and infrared spectroscopy, was employed to ensure product purity and structural uniformity, and its primary structure was determined.

Benefits of technology

The obtained Spatholobus suberectus polysaccharide SSP-Ⅱa has a clear monosaccharide composition and molecular weight, and has significant anti-inflammatory effects, and is expected to be developed into a safe and effective new anti-inflammatory drug.

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Abstract

The application belongs to the technical field of plant polysaccharides, and specifically discloses a morindae polysaccharide, a preparation method thereof and a pharmaceutical use of the morindae polysaccharide in treating inflammation. Monosaccharides in the morindae polysaccharide include mannose, glucuronic acid, galacturonic acid, glucose and arabinose, and the molar ratio is 0.5-0.6:0.3-0.5:1-2:1-2:0.5-1.5. The morindae polysaccharide provided by the application is a new type of structural uniform polysaccharide which is first isolated from morindae stems, has a slightly acidic pH value, clear monosaccharide composition, determined molecular weight and clear glycosidic bond linkage mode, has an anti-inflammatory effect and is expected to be developed into a new anti-inflammatory drug. The preparation process is mild, simple to operate and environmentally friendly.
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