Preparation method of aromatic ketone compound

By utilizing the radical-mediated reaction of unsaturated carbonyl compounds with free radical precursors in the presence of molecular oxygen, the limitations of existing aromatic ketone synthesis methods have been overcome, achieving efficient and concise synthesis of aromatic ketone compounds, which is applicable to drug and material synthesis.

CN121377970APending Publication Date: 2026-01-23HUAZHONG UNIV OF SCI & TECH
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Patent Information

Application Number
CN202511506260.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-21
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

Existing methods for synthesizing aromatic ketones suffer from problems such as the use of stoichiometric acids or noble metal catalysts, waste generation, poor functional group compatibility, and difficulty in α-position functionalization, making it difficult to achieve efficient, atom-economical, and simple synthesis.

Method used

A highly efficient synthesis of aromatic ketones is achieved by using unsaturated carbonyl compounds and free radical precursors in the presence of molecular oxygen via a free radical-mediated decarbonylation functionalization reaction. This avoids the use of precious metal catalysts and allows the reaction to proceed in organic solvents under light or heating conditions.

Benefits of technology

It achieves highly selective and concise synthesis of aromatic ketone compounds, featuring high atom economy, simple operation, and environmental friendliness, making it suitable for the fields of drug and material synthesis.

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Abstract

The invention belongs to the technical field of organic synthetic chemistry, and discloses a preparation method of an aromatic ketone compound, which comprises the following steps: by taking an unsaturated carbonyl compound obtained by condensing aryl acetaldehyde / acid and aldehyde / ketone molecules as a precursor, carrying out a reaction on the unsaturated carbonyl compound in the presence of a free radical precursor and molecular oxygen under the conditions of illumination and / or heating to obtain the aromatic ketone compound. And carrying out free radical mediated decarbonylation functionalization reaction in an organic solvent to obtain the aromatic ketone compound. The functional group contained in the free radical precursor is introduced to the alpha position of the ketone compound. By improving reaction participants and a reaction mechanism, the aromatic ketone compounds with various structures can be efficiently and highly selectively constructed in one step, the functionalization of the alpha position of the aromatic ketone compounds is synchronously realized, and the preparation method which is simple and convenient to operate, high in atom economy, green and environment-friendly is provided for the aromatic ketone compounds; the obtained compound is especially applicable to the fields of drug synthesis and synthesis of other materials.
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