Application of CCDC71L in diagnosis and treatment of radiation enteritis

By detecting and inhibiting CCDC71L, a diagnostic and treatment method for radiation enteritis is provided, which solves the problem of poor treatment effect in existing technologies, realizes effective diagnosis and treatment of radiation enteritis, reduces the expression of inflammatory factors, and improves the quality of life of patients.

CN121380331APending Publication Date: 2026-01-23核工业四一六医院
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Patent Information

Application Number
CN202511879535.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2025-01-03
Filing Date
2025-12-12
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

In the current technology, the treatment effect of radiation enteritis is not good, and there is a lack of effective prevention and treatment methods. This leads to symptoms such as abdominal pain and diarrhea in patients, and even causes complications such as intestinal obstruction and intestinal perforation. As the number of patients undergoing radiotherapy for malignant tumors increases, the incidence of radiation enteritis is also rising.

Method used

Using CCDC71L as a diagnostic and therapeutic target, we screen therapeutic drugs by detecting CCDC71L expression levels using reagents and CCDC71L inhibitors, and construct a computer model and system for radiation enteritis to achieve the diagnosis and treatment of radiation enteritis.

Benefits of technology

The application of CCDC71L in the diagnosis and treatment of radiation enteritis is demonstrated, which can achieve effective diagnosis and treatment, reduce the expression of inflammatory factors, reduce the symptoms of radiation enteritis, and improve the quality of life of patients.

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Abstract

The invention discloses an application of CCDC71L in diagnosis and treatment of radiation enteritis, and provides an application of a reagent for detecting the expression level of the CCDC71L in preparation of a product for diagnosing radiation enteritis and an application of an inhibitor of the CCDC71L in preparation of a medicine for treating radiation enteritis. The invention further provides a method for screening candidate drugs for treating or preventing radiation enteritis and a method for inhibiting the expression level of inflammatory factors in macrophages. Experiments prove that the CCDC71L can realize diagnosis of radiation enteritis, and discovers that inhibition of the CCDC71L can inhibit infiltration and polarization of macrophages so as to inhibit radiation-induced inflammatory reaction, and the CCDC71L marker provided by the invention provides a new idea for diagnosis and treatment of radiation enteritis, and has a wide application prospect.
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