Handheld nitric oxide treatment device for preventing and treating skin diseases

Abstract

The invention discloses a handheld nitric oxide treatment device for preventing and treating skin diseases. The rotating gliding arc discharge technology is adopted, and a high-density local energy field is formed in air, so that nitrogen and oxygen molecules efficiently react to generate NO and NO2. NO gas flow with stable concentration can be generated under the condition of low-voltage power supply, and in-situ treatment of the skin surface is realized. The USB PD standard power supply is applied to the NO treatment device for the first time, so that the energy required by discharge driving is ensured, and the safety risk of high-voltage direct supply is avoided. In addition, a discharge module, an airflow channel and a heat dissipation structure in the device adopt an integrated layout, and triple cooperation of airflow driving, discharge generation and cooling is realized. The adjustability of the proportion of the active components is realized by controlling the discharge power and the airflow speed, and the treatment effect and the biological safety can be both considered. The invention can be widely applied to the scenes of home nursing, adjuvant therapy of skin diseases, wound disinfection, post-medical and post-art recovery and the like.

Description

Technical Field

[0001] This invention belongs to the field of skin treatment technology, and in particular to a handheld nitric oxide treatment device for the prevention and treatment of skin diseases. Background Technology

[0002] Nitric oxide (NO) is an important signaling molecule involved in various physiological processes in the human body, including vasodilation, antibacterial and immune regulation, cell proliferation, and tissue repair. In recent years, numerous studies have demonstrated the significant therapeutic effects of NO in the prevention and treatment of skin diseases, particularly in bacterial and fungal infections, inflammatory diseases (such as eczema and psoriasis), skin wound healing, and the repair of diabetic foot ulcers. NO exerts a comprehensive effect through mechanisms such as promoting local blood flow, regulating immune responses, and clearing pathogenic microorganisms, thereby achieving anti-inflammatory, antiviral, antibacterial, and tissue regeneration-promoting effects.

[0003] Currently, most clinically used nitric oxide therapy devices are geared towards treating respiratory diseases such as acute respiratory distress syndrome and pulmonary hypertension. These devices typically use high-pressure cylinders to store NO gas, which is then diluted and inhaled by the patient. For example, patents CN201910446603.7 and CN202410152872.3 disclose a portable NO therapy device that generates NO through electric arc discharge and filters it before inhalation therapy. While such devices can achieve controllable NO output, they are complex, bulky (usually exceeding 5 kg), and primarily used for inhalation therapy, making them unsuitable for the prevention and treatment of local skin diseases.

[0004] To achieve on-demand nitric oxide generation, existing research has attempted to utilize plasma discharge technologies (such as spark discharge, arc discharge, or dielectric barrier discharge) to directly generate NO gas through the reaction of nitrogen and oxygen in the air. For example, patent CN201480027851 discloses a device for generating inhaled NO through spark discharge, which can adjust the ratio of NO to nitrogen oxides by controlling airflow and temperature. However, this device is mainly aimed at respiratory therapy, requiring an airtight system and complex airflow path, and is not suitable for targeted skin treatment. Furthermore, its high-voltage power supply design is not conducive to device miniaturization and safe low-voltage operation. Patent CN103997840 discloses a handheld portable sliding arc low-temperature plasma device, but it still requires an external miniature air pump and high-voltage power supply, which remains inconvenient for home use and travel.

[0005] Our team has previously developed a plasma nitric oxide therapy device (Patent No.: CN118203451B, entitled "A Nitric Oxide Therapy Device for Animal Disease Prevention and Treatment") in the field of animal disease treatment. This device generates a gas stream rich in NO and NO2 through sliding arc discharge for animal wound disinfection, anti-infection, and tissue repair. This approach verifies the feasibility of efficiently generating NO in air using low-temperature sliding arc discharge and achieves good anti-inflammatory and bactericidal effects in animal models. However, this system is mainly designed for treating large-area wounds on the animal's body surface; its volume is relatively large, and its structure relies on an external airflow drive and an independent power supply module, making it unsuitable for the refined and localized treatment of human skin.

[0006] Furthermore, existing portable NO treatment devices still suffer from problems such as complex structure, high power consumption, and low heat dissipation efficiency. Most devices rely on dedicated high-voltage power supplies, which are incompatible with commercially available low-voltage adapters (such as PD power supplies), leading to cumbersome operation and safety hazards in home use scenarios. On the other hand, skin surface treatment requires a moderate and uniform NO concentration, but the gas flow field distribution generated by traditional arc discharge is unstable, easily resulting in hot spots and uneven chemical composition, affecting treatment consistency and safety.

[0007] In summary, existing technologies for nitric oxide therapy devices for skin diseases still have the following shortcomings:

[0008] (1) Complex structure and large size: Most of them are inhalation or tabletop devices, which cannot be handheld or portable;

[0009] (2) Single mode of action: NO gas needs to be transported through a gas path and cannot be generated directly on the skin surface, resulting in a low concentration of action;

[0010] (3) Poor power compatibility: It relies on a dedicated high-voltage power module and is not compatible with commercially available low-voltage adapters;

[0011] (4) Insufficient heat dissipation and safety: The temperature rise in the discharge area is large, which can easily cause skin burns or equipment instability;

[0012] (5) Lack of multi-factor synergistic treatment mechanism: The multi-active factors such as NO, NO2, O3, ultraviolet rays and electric field generated by discharge are not comprehensively utilized. Summary of the Invention

[0013] The purpose of this invention is to address the problems existing in the prior art by providing a handheld nitric oxide therapy device for the prevention and treatment of skin diseases.

[0014] The technical solution to achieve the purpose of this invention is: a handheld nitric oxide treatment device for the prevention and treatment of skin diseases, the device comprising a PD power adapter, a PD trigger, a DC-AC high-frequency oscillation circuit, a fan, a transformer, high-voltage electrodes, a metal casing, and a vortex device;

[0015] The PD power adapter is used to output low-voltage DC power and transmit it to the PD trigger through the power line;

[0016] The PD trigger includes multiple voltage levels for powering the DC-AC high-frequency oscillation circuit and the fan;

[0017] The DC-AC high-frequency oscillation circuit is used to generate high-frequency low-voltage electrical output to the transformer.

[0018] The transformer is used to convert the received low-voltage electricity into high-voltage electricity and output it to the high-voltage electrode;

[0019] The metal casing and the high-voltage electrode constitute a pair of discharge electrodes; the airflow generated by the fan is transformed into a forward-rotating airflow by the swirling device, and the rotated airflow flows through the discharge electrode to push the electric arc between the electrodes to slide and generate a rotating sliding electric arc. The gas generated after the rotating sliding electric arc interacts with the air contains at least a large amount of NO, a small amount of NO2 and a trace amount of O3 mixed gas, while maintaining the gas temperature below a preset threshold; the terms "large amount", "small amount" and "trace amount" are all relative definitions.

[0020] Furthermore, the device also includes a temperature monitoring device for real-time monitoring of the temperature of the metal casing.

[0021] Furthermore, the device also includes a nitrogen oxide measuring device installed at the front end of the swirl device's air inlet for real-time monitoring of nitrogen oxide content.

[0022] Furthermore, the device also includes a numerical display module for displaying in real time the temperature value measured by the temperature monitoring device and the nitrogen oxide content detected in real time by the nitrogen oxide measuring device.

[0023] Furthermore, the multiple voltage levels are controlled by a level selection knob.

[0024] Further, the DC-AC high-frequency oscillation circuit includes a first NMOS transistor, a second NMOS transistor, a third NMOS transistor, a fourth NMOS transistor, a first Zener diode, a second Zener diode, a first to a sixth resistor, a first capacitor, a first inductor, and a second inductor; the positive input of the low-voltage DC power is connected to the gates of the third NMOS transistor and the fourth NMOS transistor respectively through the first resistor and the second resistor; a third resistor and a fourth resistor are connected in series between the gates of the third NMOS transistor and the fourth NMOS transistor, and the negative input of the low-voltage DC power is connected between the third resistor and the fourth resistor; the source of the third NMOS transistor is connected to the gate of the first NMOS transistor and the first Zener diode through a fifth resistor. The cathode of the Zener diode is connected to the gate of the second NMOS transistor and the cathode of the second Zener diode via a sixth resistor. The anode of the first Zener diode is connected to the anode of the second Zener diode. The drain of the first NMOS transistor is connected to the drain of the third NMOS transistor, one end of the first capacitor, one end of the first inductor, the drain of the fourth NMOS transistor, and the drain of the second NMOS transistor. The other end of the first capacitor is connected to the drain of the second NMOS transistor, the drain of the third NMOS transistor, and one end of the second inductor. The other end of the first inductor is connected to the other end of the second inductor, and is also connected to the positive input of the low-voltage DC power. The two ends of the first capacitor output a high-frequency low-voltage power to the transformer.

[0025] Furthermore, the primary and secondary sides of the transformer are connected to form a three-terminal transformer, and one end of the transformer where the primary and secondary sides are connected is connected to a metal casing.

[0026] Furthermore, the transformer includes port 1, port 2 and port 3. Port 2 is a common port for the primary and secondary sides of the transformer. Port 1 and port 2 constitute the primary side of the transformer, and port 3 and port 2 constitute the secondary side of the transformer. Port 1 and port 2 are connected to the output pins of the DC-AC high-frequency oscillation circuit. At the same time, port 2 is connected to the metal casing, and port 3 is connected to the high-voltage electrode.

[0027] Compared with the prior art, the present invention has the following significant advantages:

[0028] (1) Achieve safe and efficient in-situ generation of nitric oxide

[0029] This invention employs rotating sliding arc discharge technology, which creates a high-density local energy field in the air, enabling nitrogen and oxygen molecules to react efficiently to generate NO and NO2. Compared to traditional spark discharge or dielectric barrier discharge methods, rotating sliding arc discharge offers a more stable arc path and higher gas conversion efficiency. It can generate a stable concentration (10–150 ppm) of NO gas flow under low-voltage power supply conditions, achieving in-situ treatment on the skin surface and avoiding the concentration decay problems caused by the large size and long delivery path of traditional gas-based NO devices.

[0030] (2) Realize low-voltage safe drive and intelligent power management

[0031] This invention is the first to apply the USB PD standard power supply to a NO treatment device. Through an intelligent voltage recognition circuit, it enables multi-level power input from 5V to 20V, ensuring the energy required for discharge drive while avoiding the safety risks of direct high-voltage supply. This design lowers the barrier to entry, making the device directly compatible with commercially available PD adapters or power banks, significantly improving its versatility and portability.

[0032] (3) Compact structure and efficient heat dissipation system integration design

[0033] The device integrates the discharge module, airflow channels, and heat dissipation structure. The fan-driven swirling airflow cools the components, electrodes, and reaction zone while maintaining the required reaction airflow rate for NO generation, achieving a triple synergy of "airflow drive—discharge generation—cooling." Actual measurements show that under continuous operating conditions, the device surface temperature remains below 40°C, and the airflow temperature remains below 45°C, effectively preventing skin burns and improving long-term operational stability.

[0034] (4) Stable output and significant synergistic effect of active components

[0035] The sliding arc discharge of this invention not only generates NO, but also produces small amounts of NO2, O3, and low-intensity ultraviolet radiation, among other active factors. The synergistic effect of these multiple active components creates a comprehensive antibacterial and anti-inflammatory environment on the skin surface, promoting tissue repair. Compared to traditional single NO release devices, this invention achieves adjustable proportions of active components by controlling the discharge power and airflow speed, thus balancing therapeutic efficacy and biosafety.

[0036] (5) Easy to operate and flexible in application scenarios

[0037] The device of this invention is lightweight and weighs less than 300g, allowing for one-handed operation. Furthermore, the device requires no professional installation or debugging and can be widely used in home care, adjunctive treatment of skin diseases, wound disinfection, and post-medical aesthetic recovery.

[0038] The present invention will now be described in further detail with reference to the accompanying drawings. Attached Figure Description

[0039] Figure 1 This is a schematic diagram of a handheld nitric oxide therapy device for the prevention and treatment of skin diseases in one embodiment.

[0040] Figure 2 This is a schematic diagram of a handheld nitric oxide therapy device for the prevention and treatment of skin diseases in one embodiment, wherein... Figure 2 (a) in the diagram is an overall external view. Figure 2(b) in the figure is a sectional view.

[0041] Figure 3 In one embodiment Figure 2 Exploded view and exploded cross-section view, among which Figure 3 (a) in the diagram is an exploded view. Figure 3 (b) in the diagram is an exploded cross-section.

[0042] Figure 4 This is a schematic diagram of a DC-AC high-frequency oscillation circuit in one embodiment.

[0043] Figure 5 This is a schematic diagram of a DC-AC high-frequency oscillation circuit in one embodiment.

[0044] Figure 6 This is a schematic diagram of a three-terminal transformer in one embodiment, wherein... Figure 6 (a) in the diagram is a schematic diagram of the principle. Figure 6 (b) in the diagram is a structural schematic. Detailed Implementation

[0045] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0046] It should be noted that if the embodiments of the present invention involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of the components in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicators will also change accordingly.

[0047] In one embodiment, a handheld nitric oxide therapy device for the prevention and treatment of skin diseases is provided. This handheld nitric oxide therapy device is an integrated plasma discharge system capable of generating nitric oxide in situ in air under low-pressure, safe conditions, and stably releasing it to the skin surface through an airflow guiding structure to achieve local antibacterial, anti-inflammatory, and tissue repair functions. Figure 1 The device includes a PD power adapter, a PD trigger, a DC-AC high-frequency oscillation circuit, a fan, a transformer, high-voltage electrodes, a metal casing, and a vortex device;

[0048] The PD power adapter is used to output low-voltage DC power and transmit it to the PD trigger through the power line;

[0049] The PD trigger includes multiple voltage levels for powering the DC-AC high-frequency oscillation circuit and the fan;

[0050] The DC-AC high-frequency oscillation circuit is used to generate high-frequency low-voltage electrical output to the transformer.

[0051] The transformer is used to convert the received low-voltage electricity into high-voltage electricity and output it to the high-voltage electrode;

[0052] The metal casing and the high-voltage electrode constitute a pair of discharge electrodes; the airflow generated by the fan is transformed into a forward-rotating airflow by the swirling device, and the rotated airflow flows through the discharge electrode to push the electric arc between the electrodes to slide and generate a rotating sliding electric arc. The gas generated after the rotating sliding electric arc interacts with the air contains at least a large amount of NO, a small amount of NO2 and a trace amount of O3 mixed gas, while maintaining the gas temperature below a preset threshold (45°C); the terms "large amount", "small amount" and "trace amount" are relative definitions.

[0053] Here, both the discharge power and the airflow speed in the device can be adjusted and controlled to achieve the adjustability of the proportion of active components, thereby balancing therapeutic efficacy and biosafety.

[0054] Preferably, in some embodiments, the PD power adapter is a power adapter that supports the USB Power Delivery (PD) fast charging protocol and is mainly used for fast charging of devices such as smartphones, tablets, and laptops, supporting a maximum power output of 100W.

[0055] Preferably, in some embodiments, the voltage of the low-voltage DC power supply is controlled by a PD trigger according to the PD communication protocol. The PD communication protocol is a fast charging specification developed by the USB-IF organization, which includes at least voltage levels such as 5V, 9V, 12V, 15V, and 20V.

[0056] Preferably, in some embodiments, the device further includes a temperature monitoring device for real-time monitoring of the temperature of the metal casing.

[0057] Preferably, the temperature monitoring device uses, but is not limited to, a temperature sensor.

[0058] Preferably, in some embodiments, the device further includes a nitrogen oxide measuring device installed at the front end of the swirl device inlet for real-time monitoring of nitrogen oxide content.

[0059] Preferably, the nitrogen oxide measuring device employs, but is not limited to, a nitrogen oxide measuring sensor.

[0060] Preferably, in some embodiments, the device further includes a numerical display module for displaying in real time the temperature value measured by the temperature monitoring device and the nitrogen oxide content detected in real time by the nitrogen oxide measuring device.

[0061] Here, the numerical display module can be a single module that displays all information, or it can be divided into several sub-modules, each installed in a different area to display different information. No special restrictions are imposed here.

[0062] Preferably, in some embodiments, the multiple voltage levels are controlled by, but not limited to, a level selection knob, or by a digital intelligent control device, a voice intelligent control device, etc., as long as they can achieve level adjustment.

[0063] Exemplarily, in some embodiments, such as Figure 2 As shown, the handheld nitric oxide therapy device for the prevention and treatment of skin diseases of the present invention includes an integrated plastic shell 2.0, a fan 2.1, a speed selection button 2.2, a power switch 2.3, a PD trigger 2.4, a printed circuit board of a DC-AC high-frequency oscillation circuit 2.5, two heat sinks 2.6, a vortex device 2.7, a transformer 2.8, a metal shell 2.9, a high-voltage electrode 2.10, and an air outlet 2.11;

[0064] The structure is described with the axial direction of the integrated plastic housing 2.0 along the vertical direction. The fan 2.1 is installed at the bottom of the integrated plastic housing 2.0 to draw external air into the integrated plastic housing 2.0. The gear selection button 2.2, power switch 2.3, and PD trigger 2.4 are respectively installed on the corresponding windows on the side of the integrated plastic housing 2.0. The printed circuit board 3.1 of the DC-AC high-frequency oscillation circuit 2.5 is installed inside the integrated plastic housing 2.0 and is arranged along the axial direction of the integrated plastic housing 2.0, and is located above the fan 2.1. Each heat sink 2.6 is installed inside the integrated plastic housing 2.0 and located on both sides of the printed circuit board 3.1; the transformer 2.8 is embedded in the integrated plastic housing 2.0 along the axial direction and is located on the upper part of the integrated plastic housing 2.0; the airflow guide channel of the swirling device 2.7 causes the gas to form a rotating airflow; the high-voltage electrode 2.10 is installed on the top of the upper end of the transformer 2.8; the metal housing 2.9 is fitted onto the upper part of the integrated plastic housing 2.0; the upper opening of the integrated plastic housing 2.0 serves as an air outlet 2.11;

[0065] The gas that enters the integrated plastic housing 2.0 through the fan 2.1 passes through the radiator 2.6 and the swirling device 2.7 before entering the discharge area formed by the transformer 2.8 and the high-voltage electrode 2.10.

[0066] It should be noted that if the axis of the integrated plastic shell 2.0 is not vertical, the bottom can be referred to as the tail and the top as the head.

[0067] Here, the swirling structure of the swirling device 2.7 extends the residence time of the gas in the arc region, improving the NO generation efficiency; on the other hand, it promotes heat conduction and dispersion, reducing the temperature rise of the transformer and the discharge area.

[0068] Here, airflow enters from the bottom or tail, and flowing through the 2.6 heat sink also reduces the temperature of the components in the DC-AC high-frequency oscillation circuit 2.5.

[0069] Here, the 2.6 heat sink and the 2.7 vortex device serve as both gas channels and the printed circuit board of the DC-AC high-frequency oscillation circuit 2.5 and the supporting structure of the transformer 2.8, respectively.

[0070] Preferably, the voltage selection button 2.2 is a multi-position button switch, which allows the user to select different voltage positions by pressing it, thereby controlling the amount of nitric oxide produced.

[0071] Preferably, the metal housing 2.9 is fitted onto the integral plastic housing 2.0 via, but not limited to, threaded mounting.

[0072] Preferably, the airflow guiding channel is obtained by slotting the inside of the integrated plastic shell 2.0 and is located between the transformer 2.8 and the integrated plastic shell 2.0.

[0073] Preferably, such as Figure 3 As shown, the gear selection button 2.2, power switch 2.3, and PD trigger 2.4 are mounted on the printed circuit board 3.1 as a whole, and are mounted on the integrated plastic shell 2.0 through the "I"-shaped bayonet 3.2. The printed circuit board 3.1 and the two heat sinks 2.6 are mounted on the integrated plastic shell 2.0 through the "U"-shaped bayonet 3.3.

[0074] It should be noted that for components without special structural limitations, any component that can achieve the corresponding function in the existing technology is acceptable.

[0075] It should also be noted that the above-mentioned settings, installations, connections, and fixations can be made using, but are not limited to, bolts, threads, etc. Any existing fixed or movable connection scheme can be adapted, as long as the corresponding function can be achieved.

[0076] Preferably, in some embodiments, such as Figure 4As shown, the DC-AC high-frequency oscillation circuit includes a first NMOS transistor Q1, a second NMOS transistor Q2, a third NMOS transistor Q3, a fourth NMOS transistor Q4, a first Zener diode D1, a second Zener diode D2, first resistors R1 to R6, a first capacitor C1, a first inductor L1, and a second inductor L2. The positive input of the low-voltage DC power is connected to the gates of the third NMOS transistor Q3 and the fourth NMOS transistor Q4 through the first resistor R1 and the second resistor R2, respectively. The gates of the third NMOS transistor Q3 and the fourth NMOS transistor Q4 are connected in series with the third resistor R3 and the fourth resistor R4, and the negative input of the low-voltage DC power is connected between the third resistor R3 and the fourth resistor R4. The source of the third NMOS transistor Q3 is connected to the gate of the first NMOS transistor Q1 through the fifth resistor R5. The cathode of the first Zener diode D1 is connected to the cathode of the second Zener diode D2 via the sixth resistor R6. The anode of the first Zener diode D1 is connected to the anode of the second Zener diode D2. The drain of the first Zener diode Q1 is connected to the drain of the third Zener diode Q3, one end of the first capacitor C1, one end of the first inductor L1, the drain of the fourth Zener diode Q4, and the drain of the second Zener diode Q2. The other end of the first capacitor C1 is connected to the drain of the second Zener diode Q2, the drain of the third Zener diode Q3, and one end of the second inductor L2. The other end of the first inductor L1 is connected to the other end of the second inductor L2, and is also connected to the positive input of the low-voltage DC power. The two ends of the first capacitor C1 output a high-frequency low-voltage power to the transformer T1.

[0077] Here, the switching frequency of the first NMOS transistor Q1 and the second NMOS transistor Q2 is determined by the oscillation frequency of the oscillation circuit composed of the first capacitor C1 and the magnetizing inductance of the transformer T1.

[0078] The solution in this embodiment does not require an external controller and control chip to generate MOSFET drive signals.

[0079] Preferably, in some embodiments, such as Figure 5 The diagram illustrates another implementation of a DC-AC high-frequency oscillation circuit. The circuit topology is a common H-bridge circuit. The drive signals for the four MOSFETs in the H-bridge are generated by an MCU (Microcontroller Unit) and its associated peripheral circuitry. The MCU generates one PWM signal, which is transmitted to half-bridge driver chip 1 and an inverter. The inverter inverts the PWM signal to generate a complementary signal, which is then fed into half-bridge driver chip 2. The switching frequency of the MOSFETs in this circuit is determined by the MCU.

[0080] It should be noted that the DC-AC high-frequency oscillation circuit is not limited to the two implementation methods mentioned above. Other implementation methods that can achieve the same function are also acceptable, and no further special limitations are imposed here.

[0081] Furthermore, in one embodiment, the primary and secondary sides of the transformer are connected to form a three-terminal transformer, and one end of the transformer where the primary and secondary sides are connected is connected to a metal casing.

[0082] Preferably, in some embodiments, combined with Figure 6 As shown, the transformer includes port 1, port 2 and port 3. Port 2 is a common port for the primary and secondary sides of the transformer. Port 1 and port 2 constitute the primary side of the transformer, and port 3 and port 2 constitute the secondary side of the transformer. Port 1 and port 2 are connected to the output pins of the DC-AC high-frequency oscillation circuit. At the same time, port 2 is connected to the metal casing, and port 3 is connected to the high-voltage electrode.

[0083] This invention can effectively prevent and treat skin diseases and can be widely applied in home care, adjuvant treatment of skin diseases, wound disinfection and post-medical aesthetic recovery.

[0084] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention without departing from its spirit and scope should be included within the protection scope of the present invention.

Claims

1. A handheld nitric oxide therapy device for the prevention and treatment of skin diseases, characterized in that, The device includes a PD power adapter, a PD trigger, a DC-AC high-frequency oscillation circuit, a fan, a transformer, high-voltage electrodes, a metal casing, and a vortex device. The PD power adapter is used to output low-voltage DC power and transmit it to the PD trigger through the power line; The PD trigger includes multiple voltage levels for powering the DC-AC high-frequency oscillation circuit and the fan; The DC-AC high-frequency oscillation circuit is used to generate high-frequency low-voltage electrical output to the transformer. The transformer is used to convert the received low-voltage electricity into high-voltage electricity and output it to the high-voltage electrode; The metal casing and the high-voltage electrode constitute a pair of discharge electrodes; the airflow generated by the fan is transformed into a forward-rotating airflow by the swirling device, and the rotated airflow flows through the discharge electrode to push the electric arc between the electrodes to slide and generate a rotating sliding electric arc. The gas generated after the rotating sliding electric arc interacts with the air contains at least a large amount of NO, a small amount of NO2 and a trace amount of O3 mixed gas, while maintaining the gas temperature below a preset threshold; the terms "large amount", "small amount" and "trace amount" are all relative definitions.

2. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 1, characterized in that, The device also includes a temperature monitoring device for real-time monitoring of the temperature of the metal casing.

3. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 2, characterized in that, The device also includes a nitrogen oxide measuring device installed at the front end of the cyclone device's air inlet for real-time monitoring of nitrogen oxide content.

4. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 3, characterized in that, The device also includes a numerical display module, which is used to display in real time the temperature value measured by the temperature monitoring device and the nitrogen oxide content detected in real time by the nitrogen oxide measuring device.

5. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 1, characterized in that, The voltage of the low-voltage DC power supply is controlled by the PD trigger according to the PD communication protocol.

6. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 1, characterized in that, The multiple voltage levels are controlled by a level selection knob.

7. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 1, characterized in that, The DC-AC high-frequency oscillation circuit includes a first NMOS transistor (Q1), a second NMOS transistor (Q2), a third NMOS transistor (Q3), a fourth NMOS transistor (Q4), a first Zener diode (D1), a second Zener diode (D2), first resistors (R1) to sixth resistors (R6), a first capacitor (C1), a first inductor (L1), and a second inductor (L2). The positive input of the low-voltage DC power is connected to the gates of the third NMOS transistor (Q3) and the fourth NMOS transistor (Q4) through the first resistor (R1) and the second resistor (R2), respectively. The gates of the third NMOS transistor (Q3) and the fourth NMOS transistor (Q4) are connected in series with the third resistor (R3) and the fourth resistor (R4), and the negative input of the low-voltage DC power is connected between the third resistor (R3) and the fourth resistor (R4). The source of the third NMOS transistor (Q3) is connected to the gate of the first NMOS transistor (Q1) through the fifth resistor (R5). The cathode of the first Zener diode (D1) is connected to the cathode of the second Zener diode (D2) via the sixth resistor (R6). The anode of the first Zener diode (D1) is connected to the anode of the second Zener diode (D2). The drain of the first Zener diode (Q1) is connected to the drain of the third Zener diode (Q3), one end of the first capacitor (C1), one end of the first inductor (L1), the drain of the fourth Zener diode (Q4), and the drain of the second Zener diode (Q2). The other end of the first capacitor (C1) is connected to the drain of the second Zener diode (Q2), the drain of the third Zener diode (Q3), and one end of the second inductor (L2). The other end of the first inductor (L1) is connected to the other end of the second inductor (L2) and is also connected to the positive input of the low-voltage DC power. The high-frequency low-voltage power output from the two ends of the first capacitor (C1) is supplied to the transformer (T1).

8. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 1, characterized in that, The primary and secondary sides of the transformer are connected to form a three-terminal transformer, and one end of the transformer where the primary and secondary sides are connected is connected to the metal casing.

9. The handheld nitric oxide therapy device for the prevention and treatment of skin diseases according to claim 8, characterized in that, The transformer includes port 1, port 2 and port 3. Port 2 is a common port for the primary and secondary sides of the transformer. Port 1 and port 2 constitute the primary side of the transformer, and port 3 and port 2 constitute the secondary side of the transformer. Port 1 and port 2 are connected to the output pins of the DC-AC high-frequency oscillation circuit. At the same time, port 2 is connected to the metal casing, and port 3 is connected to the high-voltage electrode.

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