Aromatic essential oil with carsickness preventing and relieving effects and preparation method

Abstract

The invention discloses aromatic essential oil with carsickness preventing and relieving effects and a preparation method, and relates to the technical field of in-car health, and the aromatic essential oil specifically comprises alpha-pinene, beta-pinene, beta-caryophyllene, limonene, menthol, linalool, ocimene and citronellol. The proportions of the alpha-pinene, the beta-pinene, the beta-caryophyllene, the limonene, the menthol, the linalool, the ocimene and the citronellol are respectively 15 to 25 percent, 15 to 25 percent, 15 to 25 percent, 10 to 20 percent, 10 to 20 percent, 5 to 10 percent, 5 to 10 percent and 8 to 15 percent. Essential oil is adsorbed to pores of the ceramic rod in a vacuum impregnation or low-pressure pressurization impregnation mode, deep penetration of the essential oil on the ceramic rod is promoted, the fragrance carrying amount of the ceramic rod per unit is increased, fragrance release is more uniform and lasting, and therefore the fragrance carrying amount and uniformity are improved.

Description

Technical Field

[0001] This invention relates to the field of in-vehicle health technology, specifically to an aromatic essential oil with motion sickness prevention and relief effects and its preparation method. Background Technology

[0002] Motion sickness is a common physiological discomfort, manifested as dizziness, nausea, and vomiting, which can cause inconvenience to people's daily travel. Currently, the main means of preventing and relieving motion sickness by passengers themselves is through medication, such as taking motion sickness pills or using motion sickness patches. These methods prevent or suppress nausea and vomiting by inhibiting the stimulation of the vomiting center by key neurotransmitters (acetylcholine, histamine, and serotonin).

[0003] However, existing drug-based methods have certain side effects, such as drowsiness / fatigue (especially antihistamines), dry mouth, and blurred vision (especially anticholinergic drugs), posing risks to users.

[0004] Furthermore, traditional impregnation processes have the following problems, negatively impacting the quality of natural plant fragrances: First, the high-temperature stage accelerates the impregnation process, damaging heat-sensitive aroma molecules in the essential oils, leading to distorted, diluted, or even off-odors. Second, prolonged exposure increases the chances of oxidation due to prolonged impregnation, draining, and drying, causing aroma deterioration. Third, low penetration efficiency is a concern; relying solely on atmospheric pressure impregnation makes it difficult for essential oils to efficiently and deeply penetrate the microporous structure of the ceramic rod, affecting fragrance carrying capacity and sustained-release effects. The lack of protection during the process, particularly regarding antioxidant protection of the essential oils, accelerates their deterioration. Fourth, the risk of solvent residue is present; the use of solvents may lead to residue issues, affecting safety, aroma purity, and especially the overall effect. Summary of the Invention

[0005] This invention provides an aromatic essential oil with motion sickness prevention and relief effects and a preparation method thereof, which solves the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: an aromatic essential oil with motion sickness prevention and relief effects, wherein the specific components of the aromatic essential oil include α-pinene, β-pinene, β-caryophyllene, limonene, menthol, linalool, ocimene, and citronellol, and the proportions of α-pinene, β-pinene, β-caryophyllene, limonene, menthol, linalool, ocimene, and citronellol are 15-25%, 15-25%, 15-25%, 10-20%, 10-20%, 5-10%, 5-10%, and 8-15%, respectively.

[0007] A method for preparing an aromatic essential oil with motion sickness prevention and relief effects, comprising the following steps:

[0008] S1, Aromatic Essential Oil Extraction

[0009] Supercritical CO2 extraction was employed, with temperatures controlled at 40–60°C and pressures at 10–35 MPa, to extract active ingredients of different polarities in stages.

[0010] The first stage involves extracting monoterpenoid compounds at 12 MPa and 45°C to ensure effective extraction of low-molecular-weight, highly volatile substances.

[0011] The second stage involves mechanical extraction of oxygen-containing sesquiterpenoids at 15 MPa and 55°C. The pressure and temperature are increased based on the first stage to ensure the extraction effect of high molecular weight and highly polar substances.

[0012] S2, Ceramic rod pretreatment

[0013] The ceramic rod surface is dried after cleaning using vacuum drying or constant temperature drying to remove impurities. The pretreated ceramic rod is then cooled to room temperature before being impregnated.

[0014] S3, Essential Oil Pretreatment

[0015] Adding natural antioxidants and permeation enhancers to essential oils can improve their affinity with ceramics or reduce viscosity.

[0016] S4, Immersion

[0017] Essential oils are adsorbed into the pores of a ceramic rod using vacuum impregnation or low-pressure impregnation.

[0018] S5, drain

[0019] Place the soaked ceramic rod on a perforated drain rack to remove excess essential oil from the surface of the ceramic rod. The draining time is controlled between 10 and 30 minutes, and the draining process is carried out in a low-oxygen environment or a closed space protected by inert gas.

[0020] S6, Post-processing

[0021] The essential oil components are stabilized by vacuum low-temperature drying or natural curing.

[0022] Optionally, the vacuum drying temperature in S2 is set to below 50°C, the constant temperature drying temperature in S2 is set to 40~50°C, and the room temperature in S2 is set to 25~30°C.

[0023] Optionally, the amount of natural antioxidant added in S3 is 0.1% to 0.5%, and the natural antioxidant in S3 is rosemary extract, vitamin E, or tea polyphenols.

[0024] Optionally, the rosemary extract in S3 is rich in caryopsisic acid or caryopsisol, and the vitamin E in S3 is tocopherol.

[0025] Optionally, the amount of the penetration enhancer added in S3 is less than 1%, the penetration enhancer in S3 is a natural lipophilic emulsifier or a low-viscosity natural carrier oil, the natural lipophilic emulsifier in S3 is lecithin, and the low-viscosity natural carrier oil in S3 is distilled coconut oil.

[0026] Optionally, the specific steps of vacuum impregnation in S4 are as follows: the cooled ceramic rod is completely immersed in the impregnation container with the pretreated essential oil, and the vacuum degree of the impregnation container is set to -0.06~-0.09MPa. After impregnating the container, the vacuum is evacuated to the set negative pressure and maintained for 15~45 minutes. Then the vacuum is slowly released to normal pressure and the container is continued to soak at normal pressure for 30~120 minutes.

[0027] Optionally, the specific operation steps of the low-pressure impregnation in S4 are as follows: the ceramic rod is immersed in the impregnation container, and an inert gas of N2 or Ar is introduced to replace the air to form a low-oxygen environment. After pressurization, the low pressure of 0.1~0.3 MPa is maintained for 10~30 minutes, and then the pressure is slowly released and the ceramic rod is immersed at normal pressure for 30~120 minutes. The temperature during the vacuum or pressurization stage of the entire impregnation process is controlled at 25~30°C.

[0028] Optionally, the specific operation steps of vacuum low-temperature drying in S6 are as follows: the drained ceramic rod is placed in a vacuum drying oven, and the interior is evacuated and kept at a low temperature, with the vacuum degree set to -0.08 ~ -0.1 MPa, the temperature set to no higher than 35°C, and the time set to 1~4h.

[0029] Optionally, the specific steps for natural curing in S6 are as follows: let it stand for 24~48 hours in an inert gas protected or sealed, light-proof, and low-temperature environment, with the low temperature set to 25°C.

[0030] The present invention has the following beneficial effects:

[0031] 1. The aromatic essential oil with motion sickness prevention and relief effects and its preparation method are described. By using vacuum impregnation or low-pressure impregnation, the essential oil is adsorbed into the pores of a ceramic rod, which promotes the deep penetration of the essential oil into the ceramic rod, increases the fragrance load per unit ceramic rod, and makes the fragrance release more uniform and lasting, thereby improving the fragrance load and uniformity.

[0032] 2. The aromatic essential oil and its preparation method that have the effect of preventing and relieving motion sickness effectively delay the oxidation and deterioration of the essential oil by adding antioxidants and creating a low-oxygen environment, thereby extending the effective use time and aroma stability of the fragrance stick and thus extending the service life of the ceramic stick. Attached Figure Description

[0033] Figure 1 This is a flowchart of the present invention;

[0034] Figure 2 This is a bar chart showing the degree of motion sickness in Embodiment 1 of the present invention;

[0035] Figure 3 This is a bar chart of the α-wave power in Embodiment 1 of the present invention;

[0036] Figure 4 The MSSQ scale used to screen subjects in Embodiment 2 of this invention;

[0037] Figure 5 The MICS scale for subjectively evaluating the degree of motion sickness in Embodiment 2 of the present invention;

[0038] Figure 6 This is a line graph showing the degree of motion sickness in Embodiment 2 of the present invention;

[0039] Figure 7 This is a line graph showing the blood pressure change trend in Embodiment 2 of the present invention;

[0040] Figure 8 This is a line graph showing the variation in central rate in Embodiment 2 of the present invention;

[0041] Figure 9 This is a bar chart of the α-wave power in Embodiment 2 of the present invention. Detailed Implementation

[0042] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0043] Please see Figures 1 to 9This invention provides a technical solution: an aromatic essential oil with motion sickness prevention and relief effects. The specific components of the aromatic essential oil include α-pinene, β-pinene, β-caryophyllene, limonene, menthol, linalool, ocimene, and citronellol. The proportions of α-pinene, β-pinene, β-caryophyllene, limonene, menthol, linalool, ocimene, and citronellol are 15-25%, 15-25%, 15-25%, 10-20%, 10-20%, 5-10%, 5-10%, and 8-15%, respectively.

[0044] A method for preparing an aromatic essential oil with motion sickness prevention and relief effects includes the following steps:

[0045] S1, Aromatic Essential Oil Extraction

[0046] Essential oils are complex, containing a wide variety of effective chemical substances. Based on their physicochemical properties, they can be divided into monoterpenes and oxygenated sesquiterpenes. Monoterpenes have relatively small molecular weights, are more volatile, and require lower extraction pressures and temperatures. Oxygenated sesquiterpenes have relatively large molecular weights, are more polar, and require more stringent extraction techniques. To ensure efficient extraction of the active ingredients, terpenes with neuromodulatory effects were selected. Based on the bidirectional regulatory properties of terpenes on the autonomic nervous system, such as α-terpineol for sedation, limonene for anti-anxiety, and linalool for parasympathetic nerve activation, a fragrance formula was designed to inhibit sympathetic nerve excitability and enhance parasympathetic nerve activity. The formula achieves a three-step neuromodulatory effect through specific proportions: source inhibition for vestibular nerve excitation, process inhibition for reducing 5-HT3 receptor sensitivity, and auxiliary regulation for relaxation after parasympathetic nerve activation. Supercritical CO2 extraction was used, controlling the temperature at 40-60℃ and the pressure at 10-35 MPa, to extract active ingredients of different polarities in stages.

[0047] The first stage involves extracting monoterpenoid compounds at 12 MPa and 45°C to ensure effective extraction of low-molecular-weight, highly volatile substances.

[0048] The second stage involves mechanical extraction of oxygen-containing sesquiterpenoids at 15 MPa and 55°C. The pressure and temperature are increased based on the first stage to ensure the extraction effect of high molecular weight and highly polar substances.

[0049] S2, Ceramic rod pretreatment

[0050] Vacuum drying or constant temperature drying is used to dry the surface of the ceramic rod after cleaning, instead of traditional high-temperature baking, to remove impurities from the surface of the ceramic rod. After the pre-treated ceramic rod is cooled to room temperature, it is then impregnated to ensure that the ceramic rod is dry and clean, and that there is no moisture or other impurities that may interfere with the adsorption of essential oils.

[0051] S3, Essential Oil Pretreatment

[0052] Adding natural antioxidants and penetration enhancers to essential oils can improve their affinity with ceramics or reduce viscosity, and can also enhance the stability of essential oils, while avoiding the use of irritating chemical solvents.

[0053] S4, Immersion

[0054] The essential oil is adsorbed into the pores of the ceramic rod by vacuum impregnation or low-pressure impregnation, so that the essential oil is adsorbed into the pores of the ceramic rod efficiently, evenly and deeply;

[0055] S5, drain

[0056] Place the soaked ceramic rod on a perforated drain rack to remove excess essential oil from the surface of the ceramic rod. The draining time should be controlled between 10 and 30 minutes to avoid prolonged exposure. The draining process should be carried out in a low-oxygen environment or a closed space protected by inert gas.

[0057] S6, Post-processing

[0058] The essential oil components are stabilized by vacuum low-temperature drying or natural curing.

[0059] The vacuum drying temperature in S2 is set below 50°C, the constant temperature drying temperature in S2 is set to 40~50°C, and the room temperature in S2 is set to 25~30°C.

[0060] The amount of natural antioxidants added in S3 is 0.1%~0.5%, and the natural antioxidants in S3 are rosemary extract, vitamin E, or tea polyphenols.

[0061] The rosemary extract in S3 is rich in caryopsisic acid or caryopsisol, and the vitamin E in S3 is tocopherol.

[0062] The amount of penetration enhancer added in S3 is less than 1%. The penetration enhancer in S3 is a natural lipophilic emulsifier or a low-viscosity natural carrier oil. The natural lipophilic emulsifier in S3 is lecithin, and the low-viscosity natural carrier oil in S3 is distilled coconut oil.

[0063] The specific steps for vacuum impregnation in S4 are as follows: The cooled ceramic rod is completely immersed in the impregnation container with the pre-treated essential oil, and the vacuum degree of the impregnation container is set to -0.06~-0.09MPa. After impregnation, the vacuum is evacuated to the set negative pressure and maintained for 15~45 minutes. Then, the vacuum is slowly released to normal pressure and the container is continued to soak at normal pressure for 30~120 minutes.

[0064] The specific operating steps for low-pressure impregnation in S4 are as follows: The ceramic rod is immersed in the impregnation container, and inert gas such as N2 or Ar is introduced to replace the air and form a low-oxygen environment. Then, pressure is applied to reduce oxidation. The low pressure of 0.1~0.3 MPa is maintained for 10~30 minutes, and then the pressure is slowly released and immersed at normal pressure for 30~120 minutes. The temperature during the vacuum or pressurization stage of the entire impregnation process is controlled at 25~30°C.

[0065] The specific operating steps for vacuum low-temperature drying in S6 are as follows: Place the drained ceramic rod into a vacuum drying oven, evacuate the inside of the oven and maintain the low temperature, with the vacuum degree set to -0.08 ~ -0.1 MPa, the temperature set to no higher than 35°C, and the time set to 1~4h. This step is mainly used to stabilize the system.

[0066] The specific steps for natural curing in S6 are as follows: let it stand for 24~48 hours under inert gas protection or in a sealed, light-proof, and low-temperature environment, with the low temperature set at 25°C. This step is mainly used to stabilize the system.

[0067] Example 1: Investigating the effect of fragrance on preventing motion sickness in passengers.

[0068] I. Research Content

[0069] A comparative study of post-ride conditions with and without fragrance use.

[0070] II. Test Passengers

[0071] Six participants with motion sickness susceptibility were selected through the Motion Sickness Susceptibility Scale (MSSQ). The participants were aged 18-40 years, with a male-to-female ratio of 1:1. Participants were required to be in good health, without other dizziness symptoms or cardiovascular diseases, have a normal sense of smell, and maintain normal daily routines before the experiment, without changing their normal diet or lifestyle for this study.

[0072] III. Research Methods

[0073] The evaluation of passengers' motion sickness severity is conducted through a combination of subjective and objective methods. The subjective method uses passenger descriptions (MISC scale) to directly obtain the motion sickness severity level. The objective method uses changes in passengers' physiological indicators as the basis for motion sickness evaluation. The advantage of this method is that the results are not affected by human subjective consciousness and are more objective, but it cannot directly reflect the degree of motion sickness. It is necessary to analyze the passenger's motion sickness state in conjunction with the physiological indicators. Combining the two evaluation methods can make the test results more objective and accurate.

[0074] The experiment was conducted using a controlled method, with the same test subjects undergoing tests without fragrance and tests with fragrance. There were 6 people in each group, and a total of 3 groups. To ensure that the physical condition of the test subjects was not disturbed, the control test was conducted on two separate days (the individual tests with and without fragrance were not conducted on the same day).

[0075] Here, we selected alpha brainwaves (8-13Hz, which indicates a comfortable and relaxed state) as the basis for the selection of physiological indicators with more specific criteria. Other physiological indicators were not selected because they could not guarantee that the baseline data on the day of the control test was consistent and it was difficult to conduct effective analysis through the test results after the ride.

[0076] IV. Experimental Procedure

[0077] 1. Preparation stage

[0078] One electric vehicle, one person in charge of the experiment (driving and explaining the experiment), six subjects, two samples of aromatherapy sticks, a motion sickness severity scale (MISC scale), a suitable road site for conducting the experiment, EEG equipment and consumables (electrode pads, conductive silicone grease), and three experimenters (responsible for equipment operation, data recording, and taking photos / videos of the experimental process).

[0079] 2. Experimental Phase

[0080] Each individual experiment lasts approximately 45 minutes. There are two groups of three people each, conducted in the morning and afternoon.

[0081] ① The person in charge of the experiment explained the experimental procedure, tasks, precautions and health risks to the subjects, signed the informed consent form, and then randomly selected 6 people in sequence to conduct the experiment one by one, with the time set at 10 minutes.

[0082] ② The subjects were seated in the right position in the back row. The equipment operator put the EEG device on the subjects and started baseline measurement before the formal experiment. The measurement time was set to 10 minutes.

[0083] ③ Simulate daily urban traffic conditions, conduct tests on a predetermined route using a prescribed driving method that may cause motion sickness (set acceleration / deceleration methods, distance, speed, etc.), and record subjective evaluation results and objective physiological data, with the time set to 10 minutes;

[0084] ④ Control test content

[0085] a. If fragrance testing is not used, proceed as in ③;

[0086] b. When using fragrance testing, place the fragrance stick at the air conditioning vent inside the vehicle before driving to diffuse it. Do not turn on the air conditioning cooling / heating function, set the fan speed to the maximum, and diffuse for 5 minutes to ensure that passengers can clearly feel the fragrance after opening the door and getting into the vehicle.

[0087] ⑤ After the individual experiment is completed, check the data collection and record completeness. After confirming that there are no errors, allow the staff to relax and rest, and ventilate the vehicle. After 5 minutes, start the next individual experiment. Repeat this cycle 6 times to finish.

[0088] V. Results Analysis

[0089] The three test results share common characteristics; therefore, one set of results will be selected for presentation here.

[0090] 1. Subjective evaluation (level of pain)

[0091] As attached Figure 2 As shown, the baseline measurement of the subjects was defined as pain level 0. Then, during the test, the pain level was obtained through questioning and self-reporting. The results showed that the subjects' motion sickness after riding in the car without fragrance was higher than after using fragrance, with a difference of at least 1 level and a maximum difference of 3 levels. The difference in effect may be due to the difference in subjective feelings of different passengers towards fragrance, as well as the difference in olfactory ability.

[0092] 2. Objective evaluation (physiological indicators)

[0093] Alpha brainwaves are the optimal brainwave state for learning and thinking (frequency range 8-13Hz). When a person's brain frequency is in the alpha wave state, their consciousness is clear, but their body is relaxed. It provides a "bridge" between consciousness and subconsciousness. In this state, the energy consumption of the mind and body is minimal, and the brain receives relatively more energy, so it operates faster, smoother, and more acutely.

[0094] As attached Figure 3 As shown, the baseline alpha brain waves of all test passengers were above 8 Hz before the test. After the test, the alpha brain waves of the control group passengers who used fragrance were higher than those of passengers who did not use fragrance, indicating a relatively more comfortable state. Furthermore, the alpha brain waves of passengers 3 and 6 were still above 8 Hz after using fragrance, indicating a comfortable and relaxed state and a lower incidence of motion sickness.

[0095] Example 2: Investigating the effect of active aromatherapy intervention on alleviating motion sickness symptoms in passengers.

[0096] I. Research Content

[0097] A controlled study on the effect of aromatherapy interventions on relieving motion sickness symptoms.

[0098] II. Test Passengers

[0099] The test participants were 6 individuals with motion sickness susceptibility, selected using the Motion Sickness Susceptibility Scale (MSSQ). The participants were aged 18-40 years, with a male-to-female ratio of 1:1. Participants were required to be in good health, without other dizziness symptoms or cardiovascular diseases, and to maintain normal daily routines before the experiment and not to change their normal diet or lifestyle for this study.

[0100] Each test consists of 6 people per group, completed in 1 day, and is conducted in 3 rounds, with a total of 18 people.

[0101] III. Research Methods

[0102] The evaluation of passengers' motion sickness severity is conducted using a combination of subjective and objective methods. The subjective method uses passenger descriptions (MISC scale) to directly obtain the motion sickness severity level. The objective method uses changes in passengers' physiological indicators as the basis for motion sickness evaluation. The advantage of this method is that the results are not affected by human subjective consciousness and are more objective, but it cannot directly reflect the degree of motion sickness. It is necessary to analyze the passenger's motion sickness state in conjunction with the physiological indicators. Combining the two evaluation methods can make the test results more objective and accurate.

[0103] IV. Experimental Procedure

[0104] 1. Preparation stage

[0105] One electric vehicle, one person in charge of the experiment (driving and explaining the experiment), six subjects, two samples of aromatherapy sticks, a motion sickness severity scale (MISC scale), a suitable road site for conducting the experiment, EEG, Holter ECG, Holter blood pressure, consumables (electrode pads, conductive silicone grease), and three experimenters (responsible for equipment operation, data recording, and taking photos / videos of the experimental process).

[0106] 2. Experimental Phase

[0107] The individual experiment lasts approximately 45 minutes. There are two groups of three people each, conducted in the morning and afternoon respectively.

[0108] ① The person in charge of the experiment explained the experimental procedure, tasks, precautions and health risks to the subjects, signed the informed consent form, and then randomly selected 6 people in sequence to conduct the experiment one by one, with the time set at 10 minutes.

[0109] ② The subjects were seated in the right-hand position of the back row. The equipment operator fitted the subjects with devices such as ambulatory blood pressure monitoring, ambulatory electrocardiogram monitoring, and electroencephalogram monitoring. Baseline measurements were taken before the formal experiment and the time was set to 10 minutes.

[0110] ③ Begin the motion sickness experiment by inducing significant motion sickness (motion sickness pain level ≥ 5) through aggressive driving, and record subjective evaluation results and objective physiological data. The recommended time is 10 minutes.

[0111] ④ To begin the relief experiment and restore the driving habit, the subject held the fragrance tablet 3-5cm away from the nose and gently shook it for 15 seconds, then waited for 1 minute. This was repeated 3 times (to avoid olfactory fatigue and weaken the effect of use). Subjective evaluation results and changes in physiological indicators were recorded before the intervention and after each 1 minute of smelling. The time was set to be about 5 minutes. The specific time should be combined with the data sampling point interval requirements.

[0112] ⑤ After the individual experiment is completed, check the data collection and recording for completeness. After confirming that there are no errors, allow the staff to relax and ventilate the vehicle for rest and relief. After 5 minutes, start the next individual experiment. Repeat this cycle 6 times to finish.

[0113] 3. Analysis Phase

[0114] As attached Figure 4 and attached Figure 5 As shown, the collected subjective results and objective data were compared and analyzed. Based on existing research, the characteristic parameters of motion sickness were compared to verify its scientific validity. The results showed that the fragrance had a relieving effect on motion sickness symptoms.

[0115] V. Results Analysis

[0116] The three test results share common characteristics; therefore, one set of results will be selected for presentation here.

[0117] 1. Subjective evaluation (level of pain)

[0118] As attached Figure 6 As shown, the baseline measurement of the subjects was defined as pain level 0. Then, during the modeling and intervention process, the pain level was obtained through questioning and self-reporting. The results showed that the subjects all experienced an increase in pain level during motion sickness, which was relieved after aromatherapy intervention. The highest pain level reached 7, and the lowest level recovered to 1 after intervention.

[0119] 2. Objective evaluation (physiological indicators)

[0120] ① Ambulatory blood pressure monitoring

[0121] As attached Figure 7 As shown, continuous dynamic monitoring revealed that the diastolic blood pressure of the study subjects showed regular changes. After the motion sickness model was successfully established, both systolic and diastolic blood pressure increased, while they decreased after aromatherapy intervention (student #4 reported that his / her daily blood pressure was high).

[0122] ② Heart rate variability

[0123] Heart rate variability (HRV) refers to the variation in the difference between successive heartbeats. It contains information about the regulation of the cardiovascular system by neurohumoral factors. A decreased HRV indicates increased sympathetic tone, which can lower the ventricular fibrillation threshold and is considered an unfavorable factor. An increased HRV indicates increased parasympathetic tone, which raises the ventricular fibrillation threshold and is considered a protective factor.

[0124] As attached Figure 8 As shown, the preliminary results of the study found that the extremely low frequency and total power indices in the time domain trend and frequency domain trend results were higher during baseline measurement and aromatherapy intervention, indicating that the human autonomic nervous system was in a relatively healthy state. However, after severe driving induced motion sickness, the above indicators of the subjects showed a significant decrease, indicating that aromatherapy intervention has a certain alleviating effect on the autonomic nervous system imbalance caused by motion sickness.

[0125] ③ EEG

[0126] Alpha brainwaves (8-13Hz) represent the optimal brainwave state for learning and thinking. When the brain is in an alpha state, the mind is alert, but the body is relaxed. This provides a "bridge" between the conscious and subconscious mind. In this state, the mind and body expend minimal energy, while the brain receives relatively more energy, resulting in faster, smoother, and more acute brain function.

[0127] As attached Figure 9 As shown, the alpha wave power of all subjects was highest at baseline, indicating that the subjects were in a comfortable state. After a motion sickness model was constructed through vigorous driving, the alpha wave power decreased, and the comfortable state was eliminated. After aromatherapy intervention, the alpha wave power increased again, but could not reach the baseline state.

[0128] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An aromatic essential oil with motion sickness prevention and relief effects, characterized in that: The specific components of the aromatic essential oil include α-pinene, β-pinene, β-caryophyllene, limonene, menthol, linalool, ocimene, and citronellol, wherein the proportions of α-pinene, β-pinene, β-caryophyllene, limonene, menthol, linalool, ocimene, and citronellol are 15-25%, 15-25%, 15-25%, 10-20%, 10-20%, 5-10%, 5-10%, and 8-15%, respectively.

2. A method for preparing an aromatic essential oil with motion sickness prevention and relief effects, used to prepare the aromatic essential oil with motion sickness prevention and relief effects as described in claim 1, characterized in that, The following steps are included: S1, Aromatic Essential Oil Extraction Supercritical CO2 extraction was employed, with temperatures controlled at 40–60°C and pressures at 10–35 MPa, to extract active ingredients of different polarities in stages. The first stage involves extracting monoterpenoid compounds at 12 MPa and 45°C to ensure effective extraction of low-molecular-weight, highly volatile substances. The second stage involves mechanical extraction of oxygen-containing sesquiterpenoids at 15 MPa and 55°C. The pressure and temperature are increased based on the first stage to ensure the extraction effect of high molecular weight and highly polar substances. S2, Ceramic rod pretreatment The ceramic rod surface is dried after cleaning using vacuum drying or constant temperature drying to remove impurities. The pretreated ceramic rod is then cooled to room temperature before being impregnated. S3, Essential Oil Pretreatment Adding natural antioxidants and penetration enhancers to essential oils can improve their affinity with ceramics or reduce viscosity. S4, Immersion Essential oils are adsorbed into the pores of a ceramic rod using vacuum impregnation or low-pressure impregnation. S5, drain Place the soaked ceramic rod on a perforated drain rack to remove excess essential oil from the surface of the ceramic rod. The draining time is controlled between 10 and 30 minutes, and the draining process is carried out in a low-oxygen environment or a closed space protected by inert gas. S6, Post-processing The essential oil components are stabilized by vacuum low-temperature drying or natural curing.

3. The method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The vacuum drying temperature in S2 is set to below 50°C, the constant temperature drying temperature in S2 is set to 40~50°C, and the room temperature in S2 is set to 25~30°C.

4. The method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The amount of natural antioxidant added in S3 is 0.1%~0.5%, and the natural antioxidant in S3 is rosemary extract, vitamin E, or tea polyphenols.

5. The method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The rosemary extract in S3 is rich in caryopsisic acid or caryopsisol, and the vitamin E in S3 is tocopherol.

6. The method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The amount of penetration enhancer added in S3 is less than 1%. The penetration enhancer in S3 is a natural lipophilic emulsifier or a low-viscosity natural carrier oil. The natural lipophilic emulsifier in S3 is lecithin, and the low-viscosity natural carrier oil in S3 is distilled coconut oil.

7. The method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The specific steps of vacuum impregnation in S4 are as follows: the cooled ceramic rod is completely immersed in the impregnation container with the pretreated essential oil, and the vacuum degree of the impregnation container is set to -0.06~-0.09MPa. After impregnation, the vacuum is evacuated to the set negative pressure and maintained for 15~45 minutes. Then the vacuum is slowly released to normal pressure and the soaking continues at normal pressure for 30~120 minutes.

8. The method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The specific operation steps of the low-pressure impregnation in S4 are as follows: the ceramic rod is immersed in the impregnation container, and inert gas of N2 or Ar is introduced to replace the air to form a low-oxygen environment. After pressurization, the low pressure of 0.1~0.3 MPa is maintained for 10~30 minutes. Then the pressure is slowly released and the rod is immersed at normal pressure for 30~120 minutes. The temperature during the vacuum or pressurization stage of the entire impregnation process is controlled at 25~30°C.

9. A method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The specific operation steps of vacuum low-temperature drying in S6 are as follows: the drained ceramic rod is placed in a vacuum drying oven, and the inside is evacuated and kept at a low temperature. The vacuum degree is set to -0.08 to -0.1 MPa, the temperature is set to no higher than 35°C, and the time is set to 1 to 4 hours.

10. A method for preparing an aromatic essential oil with motion sickness prevention and relief effects according to claim 2, characterized in that: The specific steps for natural curing in S6 are as follows: let it stand for 24~48 hours under inert gas protection or in a sealed, light-proof, and low-temperature environment, with the low temperature set to 25°C.

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