Experimental system and method for photodynamic therapy, photothermal therapy and their combination research

By integrating a photodynamic/photothermal experimental system, the problems of uneven illumination conditions and temperature monitoring interference were solved, and experimental results with comparable illumination conditions, quantifiable temperature fields, and transparent data were achieved, thereby improving the reliability and repeatability of the experiment.

CN121647809BActive Publication Date: 2026-06-09XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
Filing Date
2026-02-03
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing photodynamic and photothermal therapy experimental devices lack a unified optical path adjustment mechanism, resulting in uneven and incomparable illumination conditions, temperature monitoring data being affected by environmental background interference, and experimental data lacking synchronous recording, making it difficult to guarantee the reliability and repeatability of experimental results.

Method used

An integrated experimental system is adopted, including an optical illumination module, an optical path position adjustment module, a temperature monitoring module, and a data acquisition and control module. Through components such as collimation components, beam combining components, achromatic lenses, infrared thermal imagers, and fiber optic temperature probes, coaxial optical paths, real-time temperature monitoring, and multi-channel synchronous recording are achieved, ensuring comparable illumination conditions, quantifiable temperature fields, and transparent data.

Benefits of technology

It achieves comparability under different wavelength illumination conditions, eliminates environmental background thermal interference, ensures the accuracy and traceability of experimental data, and improves the reliability and repeatability of experimental results.

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Abstract

This invention relates to experimental systems and methods for research on photodynamic therapy, photothermal therapy, and their combinations. The experimental system includes: an optical irradiation module comprising multiple laser sources, each capable of outputting a collimated beam, which is then combined to form a coaxial optical path and projected onto the surface of the observed object via a beam adjustment component; an optical path position adjustment module including an electric Z-axis displacement mechanism; a temperature monitoring module including an active temperature control substrate, an infrared thermal imager, and a fiber optic temperature probe interface; and a data acquisition and control module configured to: synchronously acquire laser output power, spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of multiple different regions, and fiber optic temperature probe data, and record the above data with a unified timestamp; calculate power density based on the real-time output power and spot area of ​​the laser sources; and automatically control the laser source to shut off its output when the data from any temperature monitoring channel exceeds a preset safety threshold.
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