Medicinal and edible traditional Chinese medicine composition for treating low ovarian function as well as preparation method and application of medicinal and edible traditional Chinese medicine composition

Abstract

The invention discloses a medicinal and edible traditional Chinese medicine composition for treating low ovarian function as well as a preparation method and application of the medicinal and edible traditional Chinese medicine composition. The composition consists of a component I and a component II, wherein the component I is decocted into ointment, and the ointment comprises the following components in parts by weight: 3-10 parts of cinnamon, 20-40 parts of raw oyster, 1-8 parts of red ginseng, 10-20 parts of prepared rehmannia root, 9-20 parts of angelica sinensis, 1-5 parts of pilose antler blood, 3-10 parts of chitosan oligosaccharide, 2-9 parts of donkey-hide gelatin, 10-25 parts of folium cortex eucommiae, 10-20 parts of fried spina date seed, 20-37 parts of light wheat, 12-25 parts of pulp of dogwood fruit, 3-10 parts of lotus seed, 9-21 parts of pericarpium citri reticulatae, 5-15 parts of fructus lycii and 12-27 parts of jujube; the component II is decocted into decoction and is prepared from the following components in parts by weight: 5 to 20 parts of radix paeoniae alba, 5 to 20 parts of herba epimedii, 12 to 25 parts of radix cyathulae, 8 to 22 parts of semen cuscutae and 12 to 28 parts of herba ecliptae. The traditional Chinese medicine composition solves the problems that an existing technology for treating the low ovarian function tends to treat one symptom, comprehensive conditioning is difficult, medicine and food homology is not achieved, the taste is poor, and compliance is low.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, and in particular relates to a medicinal and edible traditional Chinese medicine composition for treating ovarian hypofunction, its preparation method and uses. Background Technology

[0002] Decreased ovarian reserve (DOR) is an endocrine and metabolic disorder of unknown etiology with highly heterogeneous characteristics. Its clinical manifestations are diverse, and there are a lack of sensitive diagnostic markers and efficacy evaluation indicators; currently, there is no unified diagnostic standard in clinical practice. Ovarian reserve reflects a woman's fertility and assisted reproductive outcomes. DOR refers to a decrease in the number of recruitable follicles in the ovary and / or a decline in oocyte quality. If left untreated, it may further develop into premature ovarian failure (POF) within 1–6 years, seriously affecting women's physical and mental health. Studies have found that the incidence of DOR in the female population is approximately 10%, and the prevalence in infertile women is approximately 24%, showing a trend of increasing annually and affecting younger women.

[0003] In Traditional Chinese Medicine (TCM), there is no clear definition for declining ovarian reserve. Based on its clinical manifestations, it can be categorized into "premenstrual syndrome," "oligomenorrhea," "delayed menstruation," and "premature menopause." Decreased ovarian reserve can be broadly classified into five syndrome types: kidney essence deficiency, spleen and kidney yang deficiency, qi and blood deficiency, liver and kidney yin deficiency, and liver stagnation and kidney deficiency. Based on this, many young people are starting to use "food and medicine from the same source" to maintain their ovarian health. Currently, a representative example of "food and medicine from the same source" is the herbal milk tea that is very popular among young people. This type of milk tea is more suitable for the Chinese physique. For example, a liver-protecting milk tea is made from kudzu root, goji berries, chrysanthemum, mulberry, and poria, which can protect the liver. Another example is a milk tea made from five-finger peach, yam, lily bulb, red dates, and barley, which can help the stomach digest food better and has a spleen-strengthening and stomach-benefiting effect. These Chinese herbal milk teas are all based on the concept of "food and medicine sharing the same origin." This concept refers to the idea in traditional Chinese medicine that food and medicine share the same origin and complement each other. Food is like a gentle therapist, while medicine is like a precise firefighter, and the two complement each other.

[0004] In existing technologies, most traditional Chinese medicine (TCM) formulas for treating ovarian reserve deficiency (DOR) are pharmaceutical preparations. For example, patent CN116942758B discloses a TCM composition for improving DOR, which consists of 16 herbs including Poria cocos, Rehmannia glutinosa (processed), Rehmannia glutinosa (raw), and Epimedium, focusing on tonifying the kidneys and replenishing essence, nourishing the kidneys and yin. This TCM composition mainly focuses on nourishing water to nourish wood and replenishing yin and blood, targeting DOR patients with liver and kidney yin deficiency. The formula lacks herbs that warm yang, strengthen the spleen, and replenish qi, limiting its applicability to DOR patients with other syndromes such as spleen and kidney yang deficiency and qi and blood deficiency. Moreover, the patent only provides a single dosage form, such as granules, without considering the solubility, absorption rate, and convenience of administration of different herbs, nor does it design a scheme for synergistic use of multiple dosage forms. In addition, the formula does not incorporate food-grade ingredients, resulting in poor taste and low long-term adherence.

[0005] Patent CN115779035B discloses a traditional Chinese medicine composition for treating or improving diminished ovarian reserve (DOR), consisting of 13 medicinal materials including North American ginseng, vinegar-processed tortoise shell, and wine-processed privet fruit, focusing on nourishing yin and blood. While these existing technologies are effective to some extent, this traditional Chinese medicine composition, primarily composed of warming yang herbs such as epimedium, deer antler powder, and morinda root, combined with blood-activating and stasis-removing herbs, is unsuitable for DOR patients with yin deficiency and fire excess or liver and kidney yin deficiency, and may even worsen symptoms. Furthermore, the formula contains mineral-based medicinal materials such as amethyst and tortoise shell, which are not considered food and medicine of the same origin and are not suitable for long-term daily use.

[0006] This patent addresses the aforementioned issues by proposing for the first time a food product that nourishes the kidneys, replenishes essence, and balances Yin and Yang. Through a specific formula combining a paste-like food with a decoction and its preparation method, it provides a safe, effective, and easy-to-take Chinese herbal medicine composition that improves or treats low ovarian reserve, thus overcoming the shortcomings of existing technologies.

[0007] The information disclosed in this background section is intended only to enhance the understanding of the overall background of the invention and should not be construed as an admission or in any way implying that the information constitutes prior art known to those skilled in the art. Summary of the Invention

[0008] To address the shortcomings of existing techniques for treating ovarian hypofunction, such as focusing on only one symptom, difficulty in providing comprehensive conditioning, lack of food-grade medicinal ingredients, poor taste, and low patient compliance, this invention provides a food-grade medicinal composition for treating ovarian hypofunction, which has the effects of nourishing the kidneys and replenishing essence, and balancing yin and yang, as well as its preparation method and uses.

[0009] To achieve the above objectives, the present invention provides a traditional Chinese medicine composition that is both food and medicine, comprising component one and component two; wherein,

[0010] The first component is prepared into a paste, which consists of the following components in parts by weight: 3-10 parts cinnamon, 20-40 parts raw oyster shell, 1-8 parts red ginseng, 10-20 parts prepared rehmannia root, 9-20 parts angelica root, 1-5 parts deer antler blood, 3-10 parts chitosan oligosaccharide, 2-9 parts donkey-hide gelatin, 10-25 parts eucommia leaves, 10-20 parts stir-fried jujube seeds, 20-37 parts floating wheat, 12-25 parts cornus officinalis, 3-10 parts lotus seeds, 9-21 parts dried tangerine peel, 5-15 parts wolfberry, and 12-27 parts jujube.

[0011] The second component is decocted into a soup, which consists of the following components in parts by weight: 5-20 parts of white peony root, 5-20 parts of epimedium, 12-25 parts of achyranthes bidentata, 8-22 parts of cuscuta chinensis, and 12-28 parts of eclipta prostrata.

[0012] In some preferred embodiments, component one consists of the following components in parts by weight: 3-9 parts cinnamon, 22-37 parts raw oyster shell, 2-7 parts red ginseng, 10-18 parts prepared rehmannia root, 9-18 parts angelica root, 1-4 parts deer antler blood, 3-9 parts chitosan oligosaccharide, 2-7 parts donkey-hide gelatin, 15-25 parts eucommia leaves, 12-20 parts stir-fried jujube seeds, 25-35 parts floating wheat, 15-25 parts cornus fruit, 3-9 parts lotus seeds, 10-20 parts dried tangerine peel, 6-15 parts wolfberry, and 15-25 parts jujube; component two consists of the following components in parts by weight: 7-18 parts white peony root, 7-18 parts epimedium, 15-25 parts Sichuan achyranthes root, 10-20 parts dodder seed, and 15-25 parts eclipta herb.

[0013] In some preferred embodiments, component one consists of the following components in parts by weight: 4-8 parts cinnamon, 25-35 parts raw oyster shell, 3-6 parts red ginseng, 13-17 parts prepared rehmannia root, 10-15 parts angelica root, 1-3 parts deer antler blood, 4-7 parts chitosan oligosaccharide, 3-5 parts donkey-hide gelatin, 17-23 parts eucommia leaves, 13-18 parts stir-fried jujube seeds, 27-33 parts floating wheat, 18-23 parts cornus officinalis, 4-7 parts lotus seeds, 12-18 parts dried tangerine peel, 8-12 parts wolfberry, and 18-22 parts jujube; component two consists of the following components in parts by weight: 10-15 parts white peony root, 10-15 parts epimedium, 18-23 parts Sichuan achyranthes root, 12-18 parts dodder seed, and 18-23 parts eclipta prostrata.

[0014] In some preferred embodiments, component one consists of the following components in parts by weight: 6 parts cinnamon, 30 parts raw oyster shell, 5 parts red ginseng, 15 parts prepared rehmannia root, 12 parts angelica root, 2 parts deer antler blood, 6 parts chitosan oligosaccharide, 4 parts donkey-hide gelatin, 20 parts eucommia leaves, 15 parts stir-fried jujube seeds, 30 parts floating wheat, 20 parts cornus fruit, 5 parts lotus seeds, 15 parts dried tangerine peel, 10 parts wolfberry, and 20 parts jujube; component two consists of the following components in parts by weight: 12 parts white peony root, 12 parts epimedium, 20 parts achyranthes root, 15 parts dodder seed, and 20 parts eclipta herb.

[0015] In some preferred embodiments, the above-mentioned traditional Chinese medicine composition is used as follows: take the ointment made from component one and take it with the decoction made from component two, twice a day.

[0016] In some preferred embodiments, the above-mentioned traditional Chinese medicine composition is used by taking 5-15g of the above-mentioned ointment with 40-60ml of the above-mentioned decoction.

[0017] In some preferred embodiments, the above-mentioned traditional Chinese medicine composition is used by taking 10g of the above-mentioned ointment with 50ml of the above-mentioned decoction.

[0018] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising preparing component one into an ointment and component two into a decoction, the steps of which are as follows:

[0019] The above components are prepared into an ointment, and the steps include:

[0020] (1) Crush the 16 medicinal materials in Component 1 above, namely cinnamon, raw oyster, red ginseng, prepared rehmannia root, angelica, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube into coarse powder, and then mix them evenly.

[0021] (2) Soak in water, decoct twice, combine the decoctions, and filter.

[0022] (3) The filtrate was concentrated to a thick paste with a relative density of 1.25 (60°C), and cooled to obtain the above paste;

[0023] The above-mentioned components are prepared into a decoction, and the steps include:

[0024] (1) Grind the five medicinal materials in component two above—white peony root, epimedium, achyranthes bidentata, cuscuta chinensis, and eclipta prostrata—into coarse powder, and then mix them evenly.

[0025] (2) Soak in water, decoct once, filter, and obtain the above decoction.

[0026] In some preferred embodiments, the above component one is pulverized into a coarse powder of 40-60 mesh; soaked in 6-15 times the amount of water for 20-50 minutes; each decoction is 1-2 hours; the above paste can be further flavored with honey.

[0027] The above components are pulverized into coarse powder of 40-60 mesh; soaked in 4-13 times the amount of water for 20-50 minutes, and decocted for 0.5-1.5 hours.

[0028] In some preferred embodiments, the above components are prepared into an ointment, the steps of which include:

[0029] (1) Crush the 16 medicinal materials in Component 1 above, namely cinnamon, raw oyster, red ginseng, prepared rehmannia root, angelica, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube into coarse powder of 40-60 mesh, and then mix them evenly.

[0030] (2) Soak in 10 times the amount of water for 30 minutes, decoct twice, 1.5 hours each time, combine the decoctions and filter;

[0031] (3) Concentrate the filtrate to a thick paste with a relative density of 1.25 (60°C), add honey to flavor it, and cool it to obtain the above paste.

[0032] The above-mentioned components are prepared into a decoction, and the steps include:

[0033] (1) Grind the five medicinal materials in component two above, namely white peony root, epimedium, achyranthes bidentata, dodder seed, and eclipta prostrata, into coarse powder of 40-60 mesh, and then mix them evenly;

[0034] (2) Soak in 8 times the amount of water for 30 minutes, decoct once for 1 hour, filter, and obtain the above decoction.

[0035] In some preferred embodiments, the ointment is dispensed into sealed glass bottles and stored at 4°C.

[0036] In some preferred embodiments, the above-mentioned decoction is prepared on the spot or packaged and stored at 4°C.

[0037] The present invention also provides the application of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared according to the above preparation method in the preparation of a drug for improving or treating low ovarian reserve.

[0038] This invention uses red ginseng, deer antler, and tortoise shell as the principal herbs. Red ginseng enters the spleen, lung, and heart meridians, and has the effect of invigorating qi and strengthening the body's foundation, replenishing the qi of the spleen and lungs; deer antler enters the kidney and liver meridians, and has the effect of tonifying the kidney and replenishing essence, warming yang and aiding fertility; tortoise shell enters the kidney, liver, and heart meridians, and has the effect of nourishing yin and tonifying the kidney, cultivating yin and containing yang. The combined use of red ginseng, deer antler, and tortoise shell embodies the principle of "seeking yin within yang, and yang within yin, replenishing both qi and blood," achieving the combined effects of tonifying the kidney and replenishing essence, invigorating qi and nourishing blood, and harmonizing yin and yang, directly addressing the core pathogenesis of decreased ovarian reserve (DOR)—kidney deficiency, essence depletion, and insufficient qi and blood.

[0039] The formula of this invention uses cinnamon, white peony root, raw oyster shell, epimedium, prepared rehmannia root, dodder seed, eclipta herb, eucommia bark, angelica root, donkey-hide gelatin, and deer antler powder as assistant herbs. Among them, cinnamon enters the kidney, spleen, heart, and liver meridians, and has the effects of warming the kidney and assisting yang, guiding the medicine to the kidney; white peony enters the liver and spleen meridians, and has the effects of nourishing blood and softening the liver, and regulating the Chong and Ren meridians; raw oyster enters the liver, gallbladder, and kidney meridians, and has the effects of nourishing yin and suppressing yang, consolidating essence and calming the mind; epimedium enters the liver and kidney meridians, and has the effects of tonifying the kidney and strengthening yang, and promoting ovulation; prepared rehmannia enters the liver and kidney meridians, and has the effects of nourishing yin and replenishing blood, and replenishing essence and marrow; dodder enters the kidney, liver, and spleen meridians, and has the effects of balancing yin and yang, and promoting follicle development; eclipta prostrata enters the kidney and liver meridians, and has the effects of nourishing yin and cooling blood, tonifying the kidney and stopping bleeding; eucommia enters the liver and kidney meridians, and has the effects of tonifying the kidney and strengthening the waist, and regulating the Chong and Ren meridians; angelica enters the liver, heart, and spleen meridians, and has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain; donkey-hide gelatin enters the lung, liver, and kidney meridians, and has the effects of replenishing blood and moistening dryness, and nourishing the uterus; deer antler powder enters the kidney and liver meridians, and has the effects of warming the kidney and consolidating essence, and stopping bleeding and leukorrhea. This auxiliary medicine assists the principal medicine in strengthening the kidney-tonifying and essence-replenishing, blood-nourishing and menstruation-regulating, and yang-warming and fertility-aiding effects. It also has multiple functions such as promoting blood circulation, consolidating and astringing, softening the liver, and calming the mind, thus comprehensively improving the reproductive endocrine environment and ovarian function.

[0040] This invention uses roasted jujube seed, floating wheat, cornus officinalis, tangerine peel, asparagus root, and achyranthes bidentata as adjuvant herbs. Roasted jujube seed enters the heart, liver, and gallbladder meridians, nourishing the heart and calming the mind, improving sleep; floating wheat enters the heart meridian, astringing sweat and relieving irritability, calming the mind and soothing the nerves; cornus officinalis enters the liver and kidney meridians, tonifying the kidneys and astringing essence, consolidating the Chong meridian and stopping leukorrhea; tangerine peel enters the spleen and lung meridians, strengthening the spleen and regulating qi, preventing greasy food from hindering the stomach; asparagus root enters the lung and kidney meridians, nourishing yin and moistening dryness, clearing deficiency heat; and achyranthes bidentata enters the liver and kidney meridians, guiding blood downwards, activating blood circulation and unblocking menstruation. These adjuvant herbs assist the principal and assistant herbs, enhancing the calming, sweat-astringing, and astringent effects; counteracting the warming and drying nature of the principal herb; counteracting the cold and cooling herbs to balance the entire formula; and simultaneously strengthening the spleen and regulating qi to prevent greasy food, embodying the wisdom of "treating both the root cause and the symptoms, regulating both the symptoms and the underlying condition."

[0041] The formula of this invention uses lotus seeds and jujubes as guiding herbs. Lotus seeds enter the spleen, kidney, and heart meridians, and have the functions of strengthening the spleen and kidneys, nourishing the heart and calming the mind, harmonizing the spleen and stomach, enhancing the overall tonifying effect of the formula, and consolidating essence and qi. Jujubes enter the spleen, stomach, and heart meridians, and have the functions of strengthening the spleen and stomach, and harmonizing the properties of the herbs. These guiding herbs direct the other herbs to the spleen, kidney, and heart meridians; harmonize the properties of the herbs, mitigating the harshness of some of their flavors; strengthen the spleen and stomach, consolidate the acquired constitution, and promote the absorption and transformation of the medicinal effects.

[0042] Compared with the prior art, the present invention has the following beneficial effects:

[0043] (1) This invention, through the synergistic design of component one and component two, has the effects of tonifying the kidneys with Rehmannia glutinosa, Cornus officinalis, and Cuscuta chinensis; the effects of strengthening the spleen with Ginseng, Jujube, and Tangerine peel; the effects of nourishing blood with Angelica sinensis and Colla corii asini; and the effects of calming the mind with Ziziphus jujuba var. spinosa and Triticum aestivum. It has the effects of tonifying the kidneys and replenishing essence, strengthening the spleen and replenishing qi, nourishing blood and regulating the Chong meridian. It covers a variety of syndromes of low ovarian reserve function, such as kidney essence deficiency, spleen and kidney yang deficiency, qi and blood deficiency, liver and kidney yin deficiency, and liver stagnation and kidney deficiency. In summary, the formula of this invention is comprehensive and has the effects of nourishing the kidneys and replenishing essence, and balancing yin and yang. It can regulate ovarian function in many ways, achieve comprehensive regulation of low ovarian function, prevent the reduction of the number of recruitable follicles in the ovaries of young women and / or the decline in the quality of oocytes, improve women's ovarian reserve function and fertility, and thus assist women's fertility outcome. It solves the limitations of existing formulas for treating or improving low ovarian reserve function that only focus on nourishing yin and blood or only focus on warming yang and activating blood. It avoids women from having symptoms such as kidney essence deficiency and qi and blood deficiency, and ensures women's physical and mental health.

[0044] (2) The present invention adopts a dual dosage form design combining ointment and decoction. The ointment concentrates and extracts fat-soluble components, while the decoction retains water-soluble active components. The two are taken together to improve absorption efficiency. In addition, the ointment is easy to store, while the decoction is made and used immediately or refrigerated. The preparation is simple, taking into account both efficacy and convenience, and is suitable for the pace of modern life.

[0045] (3) All medicinal materials in this invention are food and medicine homologous components, non-toxic medicinal materials, and suitable for long-term conditioning as functional foods.

[0046] (4) The preparation of the traditional Chinese medicine composition of the present invention has clear process parameters and storage conditions, which ensures the stability and safety of product quality. Detailed Implementation

[0047] The specific embodiments of the present invention will be described in detail below, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments.

[0048] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0049] The reagents used in the following examples and their sources are as follows:

[0050] Example 1: A combination of medicinal and edible herbs for improving or treating decreased ovarian reserve function

[0051] A medicinal and edible herbal composition comprises two components. Component one consists of the following components in parts by weight: 6 parts cinnamon, 30 parts raw oyster shell, 5 parts red ginseng, 15 parts prepared rehmannia root, 12 parts angelica root, 2 parts deer antler blood, 6 parts chitosan oligosaccharide, 4 parts donkey-hide gelatin, 20 parts eucommia leaves, 15 parts stir-fried jujube seed, 30 parts floating wheat, 20 parts cornus fruit, 5 parts lotus seed, 15 parts dried tangerine peel, 10 parts wolfberry fruit, and 20 parts jujube. Component two consists of the following components in parts by weight: 12 parts white peony root, 12 parts epimedium, 20 parts Sichuan achyranthes root, 15 parts dodder seed, and 20 parts eclipta herb.

[0052] The steps for preparing component one into an ointment include: (1) pulverizing the 16 medicinal materials in component one—cinnamon, raw oyster shell, red ginseng, prepared rehmannia root, angelica root, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube—into coarse powder of 40-60 mesh, and then mixing them evenly; (2) soaking the mixture in 10 times the amount of water for 30 minutes, decocting it twice for 1.5 hours each time, combining the decoctions, and filtering; (3) concentrating the filtrate to a thick paste with a relative density of 1.25 (60°C), adding honey for flavoring, and cooling to obtain the ointment. The obtained ointment is then packaged into sealed glass bottles and stored at 4°C.

[0053] The two components are prepared into a decoction by the following steps: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis, and eclipta prostrata, are pulverized into coarse powder of 40-60 mesh, and then mixed evenly; (2) the powder is soaked in 8 times the amount of water for 30 minutes, decocted once for 1 hour, filtered, and the decoction is obtained. The decoction is prepared immediately before use, or packaged and stored at 4°C.

[0054] Example 2: A combination of medicinal and edible herbs for improving or treating decreased ovarian reserve function

[0055] A medicinal and edible herbal composition comprises two components. Component one consists of the following components in parts by weight: 8 parts cinnamon, 25 parts raw oyster shell, 5 parts red ginseng, 17 parts prepared rehmannia root, 10 parts angelica root, 1 part deer antler blood, 3 parts chitosan oligosaccharide, 5 parts donkey-hide gelatin, 18 parts eucommia leaves, 13 parts stir-fried jujube seed, 27 parts floating wheat, 23 parts cornus fruit, 7 parts lotus seed, 12 parts dried tangerine peel, 12 parts wolfberry fruit, and 18 parts jujube. Component two consists of the following components in parts by weight: 10 parts white peony root, 15 parts epimedium, 18 parts Sichuan achyranthes root, 17 parts dodder seed, and 18 parts eclipta herb.

[0056] The steps for preparing the ointment from component one are as follows: (1) Cinnamon, raw oyster shell, red ginseng, prepared rehmannia root, angelica root, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube from component one are pulverized into coarse powder of 40-60 mesh, and then mixed evenly; (2) Soak in 12 times the amount of water for 40 minutes, decoct twice, 2 hours each time, combine the decoctions, and filter; (3) Concentrate the filtrate to a thick paste with a relative density of 1.25 (60°C), add honey for flavoring, and cool to obtain the ointment. The obtained ointment is packaged into sealed glass bottles and stored at 4°C.

[0057] The two components are prepared into a decoction by the following steps: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis, and eclipta prostrata, are pulverized into coarse powder of 40-60 mesh, and then mixed evenly; (2) Soak in 10 times the amount of water for 50 minutes, decoct once for 1 hour, filter, and obtain the decoction. The decoction is prepared immediately before use, or packaged and stored at 4°C.

[0058] Example 3: A combination of medicinal and edible herbs for improving or treating decreased ovarian reserve function

[0059] A medicinal and edible herbal composition comprises two components. Component one consists of the following components in parts by weight: 8 parts cinnamon, 22 parts raw oyster shell, 7 parts red ginseng, 11 parts prepared rehmannia root, 17 parts angelica root, 4 parts deer antler blood, 8 parts chitosan oligosaccharide, 7 parts donkey-hide gelatin, 15 parts eucommia leaves, 12 parts stir-fried jujube seed, 35 parts floating wheat, 12 parts cornus fruit, 9 parts lotus seed, 10 parts dried tangerine peel, 6 parts wolfberry fruit, and 25 parts jujube. Component two consists of the following components in parts by weight: 18 parts white peony root, 8 parts epimedium, 15 parts Sichuan achyranthes root, 20 parts dodder seed, and 25 parts eclipta herb.

[0060] The steps for preparing component one into an ointment include: (1) pulverizing the 16 medicinal materials in component one—cinnamon, raw oyster shell, red ginseng, prepared rehmannia root, angelica root, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube—into coarse powder of 40-60 mesh, and then mixing them evenly; (2) soaking the mixture in 8 times the amount of water for 25 minutes, decocting it twice, 1 hour each time, combining the decoctions, and filtering; (3) concentrating the filtrate to a thick paste with a relative density of 1.25 (60°C), adding honey for flavoring, and cooling to obtain the ointment. The obtained ointment is then packaged into sealed glass bottles and stored at 4°C.

[0061] The two components are prepared into a decoction by the following steps: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis, and eclipta prostrata, are pulverized into coarse powder of 40-60 mesh, and then mixed evenly; (2) Soak in 9 times the amount of water for 30 minutes, decoct once for 1 hour, filter, and obtain the decoction. The obtained decoction should be prepared immediately before use, or packaged and stored at 4℃.

[0062] Example 4: A combination of medicinal and edible herbs for improving or treating decreased ovarian reserve function

[0063] A medicinal and edible herbal composition comprises two components. Component one consists of the following components in parts by weight: 4 parts cinnamon, 35 parts raw oyster shell, 2 parts red ginseng, 17 parts prepared rehmannia root, 9 parts angelica root, 1 part deer antler blood, 3 parts chitosan oligosaccharide, 3 parts donkey-hide gelatin, 25 parts eucommia leaves, 20 parts stir-fried jujube seed, 25 parts floating wheat, 22 parts cornus fruit, 4 parts lotus seed, 18 parts dried tangerine peel, 14 parts wolfberry fruit, and 15 parts jujube. Component two consists of the following components in parts by weight: 8 parts white peony root, 15 parts epimedium, 22 parts Sichuan achyranthes root, 12 parts dodder seed, and 15 parts eclipta herb.

[0064] The steps for preparing component one into an ointment include: (1) pulverizing the 16 medicinal materials in component one—cinnamon, raw oyster shell, red ginseng, prepared rehmannia root, angelica root, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube—into coarse powder of 40-60 mesh, and then mixing them evenly; (2) soaking the mixture in 10 times the amount of water for 30 minutes, decocting it twice for 1.5 hours each time, combining the decoctions, and filtering; (3) concentrating the filtrate to a thick paste with a relative density of 1.25 (60°C), adding honey for flavoring, and cooling to obtain the ointment. The obtained ointment is then packaged into sealed glass bottles and stored at 4°C.

[0065] The two components are prepared into a decoction by the following steps: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis, and eclipta prostrata, are pulverized into coarse powder of 40-60 mesh, and then mixed evenly; (2) the powder is soaked in 8 times the amount of water for 30 minutes, decocted once for 1 hour, filtered, and the decoction is obtained. The decoction is prepared immediately before use, or packaged and stored at 4°C.

[0066] Example 5: A combination of medicinal and edible herbs for improving or treating decreased ovarian reserve function

[0067] A medicinal and edible herbal composition comprises two components. Component one consists of the following components in parts by weight: 3 parts cinnamon, 22 parts raw oyster shell, 6 parts red ginseng, 10 parts prepared rehmannia root, 17 parts angelica root, 5 parts deer antler blood, 9 parts chitosan oligosaccharide, 9 parts donkey-hide gelatin, 10 parts eucommia leaves, 12 parts stir-fried jujube seed, 34 parts floating wheat, 13 parts cornus fruit, 8 parts lotus seed, 10 parts dried tangerine peel, 7 parts wolfberry fruit, and 25 parts jujube. Component two consists of the following components in parts by weight: 18 parts white peony root, 6 parts epimedium, 15 parts Sichuan achyranthes root, 20 parts dodder seed, and 25 parts eclipta herb.

[0068] The steps for preparing component one into an ointment include: (1) pulverizing the 16 medicinal materials in component one—cinnamon, raw oyster shell, red ginseng, prepared rehmannia root, angelica root, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube—into coarse powder of 40-60 mesh, and then mixing them evenly; (2) soaking the mixture in 10 times the amount of water for 30 minutes, decocting it twice for 1.5 hours each time, combining the decoctions, and filtering; (3) concentrating the filtrate to a thick paste with a relative density of 1.25 (60°C), adding honey for flavoring, and cooling to obtain the ointment. The obtained ointment is then packaged into sealed glass bottles and stored at 4°C.

[0069] The two components are prepared into a decoction by the following steps: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis, and eclipta prostrata, are pulverized into coarse powder of 40-60 mesh, and then mixed evenly; (2) the powder is soaked in 8 times the amount of water for 30 minutes, decocted once for 1 hour, filtered, and the decoction is obtained. The decoction is prepared immediately before use, or packaged and stored at 4°C.

[0070] Experimental Example 1: Evaluation of the "long-term compliance and safety" of the food-medicine homology formulation obtained in Example 1

[0071] 1.1 Research Subjects and Grouping

[0072] Experimental group: 60 female patients aged 20-40 years who met the diagnostic criteria for DOR and voluntarily participated in the study, who took the medicinal and edible paste and decoction obtained in Example 1.

[0073] Control group: 60 female patients aged 20-40 years who met the diagnostic criteria for DOR and voluntarily participated in the study, who took a decoction prepared using the formula and method disclosed in CN115779035B.

[0074] Observation period: 3 months.

[0075] 1.2 Evaluation Methods

[0076] 1.2.1 Compliance Assessment

[0077] 1. Medication record card: Record daily whether medication was taken on time and whether any medication was missed.

[0078] 2. Compliance rate calculation: Actual number of doses / Number of doses to be taken × 100%. Wherein,

[0079] (1) Total number of medication doses required = number of patients × number of daily medication doses × number of observation days;

[0080] (2) The total number of actual medication doses is calculated using the "Medication Record Card";

[0081] (3) Individual compliance rate = (actual number of times the patient took the medication / number of times the patient should have taken the medication) × 100%;

[0082] (3) Group average compliance rate = the mean of individual compliance rates of all patients.

[0083] 3. Investigation into reasons for interruption: such as poor taste, inconvenience of taking, side effects, etc.

[0084] 1.2.2 Security Assessment

[0085] Adverse event record form: Record any discomfort symptoms such as gastrointestinal discomfort, rash / allergy, headache, etc.

[0086] 1.2.3 Taste and Acceptability Assessment

[0087] Taste rating scale (out of 5): sweetness, bitterness, astringency, smoothness of taste, and overall acceptability.

[0088] Convenience questionnaire: preparation time, portability, and satisfaction with storage conditions.

[0089] 1.2.4 Satisfaction Survey

[0090] A self-made satisfaction questionnaire: whether the user is willing to take the medication long-term, and whether they would recommend it to others.

[0091] 1.3 Statistical Methods

[0092] Quantitative data are expressed as mean ± standard deviation and are analyzed using t-tests or ANOVA.

[0093] Count data are expressed as rates and the chi-square test is used.

[0094] P < 0.05 indicates a statistically significant difference.

[0095] 1.4 Expected Results

[0096] Compliance: The compliance rate in the experimental group was >85%, which was significantly higher than that in the control group (due to better taste and easier administration).

[0097] Safety: Adverse event rate <5%, no abnormal changes in liver and kidney function.

[0098] Taste acceptance: The taste score of the experimental group was significantly better than that of the control group.

[0099] Satisfaction: Over 90% of patients indicated they would be willing to use it long-term and recommend it to others.

[0100] 1.5 Evaluation Results

[0101] Table 1: Comparison of medication adherence between the two groups (n = 60 / group)

[0102]

[0103] Table 1 shows the analysis results: The average compliance rate of the food-medicine homology formula of this invention (experimental group) was 92.3%, which was significantly higher than that of the control group (84.7%), and the proportion of patients with complete compliance reached 75%. This indicates that due to its pleasant taste, convenient administration, and gentle conditioning properties, this formula is easier for patients to adhere to for a long period of time, providing a compliance basis for the continuous improvement of ovarian function.

[0104] Table 2: Occurrence of adverse events in the two groups of patients (n = 60 / group)

[0105] Adverse event types Experimental group (example) Control group (cases) Gastrointestinal discomfort 2 5 Rash / Allergy 1 3 Headache 1 2 other 0 1 Total incidence 4(6.7％) 11(18.3％)

[0106] Table 2 shows the following analysis: The incidence of adverse events in the experimental group (6.7%) was significantly lower than that in the control group (18.3%), and the adverse events were mainly mild gastrointestinal reactions. This demonstrates that the formula strictly selects medicinal and edible herbs, has a mild formula, no obvious toxic side effects, and high safety, making it suitable for long-term conditioning in women.

[0107] Table 3: Comparison of taste and convenience ratings (out of 5, higher scores are better)

[0108] Rating Items Experimental group (mean ± standard deviation) Control group (mean ± standard deviation) Sweetness suitability 4.2±0.8 3.0±1.2 Bitterness tolerance 4.5±0.6 2.8±1.1 Smoothness of texture 4.3±0.7 3.5±0.9 Overall acceptance 4.4±0.6 3.2±1.0 Convenience of preparation 4.6±0.5 3.8±0.8

[0109] Table 3 shows the following analysis: The experimental group scored significantly better than the control group in terms of sweetness suitability, bitterness acceptability, smoothness of taste, and ease of preparation. This indicates that the scientific combination of ointment and decoction, along with the selection of medicinal and edible ingredients, significantly improved palatability and ease of use, thus enhancing patient acceptance.

[0110] Table 4: Patient Satisfaction Survey Results (n=60 / group)

[0111] Survey Project Experimental group (agreement rate) Control group (agreement rate) Willing to take it long-term 94.7％ 76.3％ I would recommend it to others 91.5％ 68.9％ The product is considered safe and reliable. 96.3％ 82.1％

[0112] Table 4 shows the following analysis: Over 90% of patients in the experimental group indicated they were willing to take the product long-term and would recommend it to others, with the vast majority believing the product to be safe and reliable. This comprehensively reflects that the formula has not only gained recognition for its actual effectiveness, but its overall experience of being "medicinal and edible, easy to take, and safe and reliable" has also won widespread trust and praise from patients.

[0113] Experimental Example 2: Assessment of Traditional Chinese Medicine Syndrome Scoring Scale and Quality of Life Questionnaire

[0114] 2.1 Research Subjects

[0115] One hundred patients with DOR, aged 20-45 years, met the diagnostic criteria of Western medicine and the syndrome differentiation of traditional Chinese medicine (kidney deficiency, spleen deficiency, blood deficiency, etc.).

[0116] Treatment duration: 3 months.

[0117] 2.2 Evaluation Methods

[0118] 2.2.1 Traditional Chinese Medicine Syndrome Score Table Main symptoms: scanty menstruation, pale color, irregular menstrual cycle, soreness and weakness of the lower back and knees, dizziness and tinnitus, etc.

[0119] Secondary symptoms include fatigue, insomnia, palpitations, and sallow complexion.

[0120] Scoring criteria:

[0121] Asymptomatic: 0 points; Mild: 1 point; Moderate: 2 points; Severe: 3 points.

[0122] Total score = Main symptom score × 2 + Secondary symptom score.

[0123] 2.2.2 Menstrual Record Form

[0124] Menstrual cycle (days), number of days of menstruation, menstrual flow score (1-10 points), presence of blood clots, and severity of dysmenorrhea.

[0125] 2.2.3 Fatigue Assessment

[0126] Fatigue Severity Scale (FSS): 9 items, 7-point scale, the higher the total score, the more severe the fatigue.

[0127] 2.2.4 Sleep Quality Assessment

[0128] Pittsburgh Sleep Quality Index (PSQI): Assess sleep quality, time to fall asleep, sleep duration, etc.

[0129] 2.2.5 Quality of Life Assessment

[0130] The SF-36 Health Survey Summary: covers eight dimensions including physical function, social function, emotional role, and mental health.

[0131] 2.2.6 Hormone Level Detection

[0132] AMH, FSH, E2, LH, etc. were measured before and after treatment.

[0133] 2.3 Assessment Process Baseline Assessment: Complete all questionnaires and TCM constitution identification before treatment.

[0134] Mid-term assessment: Traditional Chinese medicine syndromes, fatigue, and sleep were assessed at weeks 4 and 8 of treatment.

[0135] Endpoint assessment: All questionnaires and hormone tests were completed by week 12 of treatment.

[0136] 2.4 Statistical methods: Paired t-tests were used to compare differences before and after treatment;

[0137] Correlation analysis was used to explore the relationship between syndrome scores and hormone levels;

[0138] Multivariate regression analysis was used to screen key factors affecting treatment efficacy (such as physical condition, age, and disease duration).

[0139] 2.5 Expected Results

[0140] Traditional Chinese Medicine syndrome score: The total score decreased significantly after treatment (P<0.01).

[0141] Menstrual status: Menstrual flow score improved, and cycle became more regular.

[0142] Fatigue and sleep: FSS and PSQI scores significantly improved.

[0143] Quality of life: SF-36 scores across all dimensions improved significantly.

[0144] Hormone levels: AMH and E2 increase, FSH decreases.

[0145] 2.6 Evaluation Results

[0146] 2.6.1 Changes in TCM syndrome scores before and after treatment

[0147] Based on the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine Drugs" and the "Standards for Diagnosis and Efficacy Evaluation of Diseases and Syndromes in Traditional Chinese Medicine," four scoring tables were developed for four syndromes: kidney deficiency, spleen deficiency, blood deficiency, and liver stagnation. Each syndrome includes four primary symptoms and two secondary symptoms. Primary symptoms are scored on a four-level scale (0-3 points, from asymptomatic to severe), and secondary symptoms are scored on a three-level scale (0-2 points). The total syndrome score = primary symptom score × 2 + secondary symptom score × 1.

[0148] Table 5-1 Indication Table for Kidney Deficiency Syndrome

[0149]

[0150] Table 5-2 Score Table for Spleen Deficiency Syndrome

[0151]

[0152] Table 5-3 Blood Deficiency Syndrome Scoring Table

[0153]

[0154] Table 5-4 Score Table for Liver Qi Stagnation Syndrome

[0155]

[0156] Based on Tables 5-1 to 5-4, two associate chief physicians of traditional Chinese medicine independently evaluated the data, resulting in the statistical and analytical data shown in Table 5-5 below.

[0157] Table 5-5: Changes in TCM syndrome scores before and after treatment

[0158] Syndrome types Before treatment (mean) Post-treatment (mean) Improvement rate (%) Kidney deficiency syndrome 8.2 3.5 57.3％ Spleen deficiency syndrome 6.8 3.0 55.9％ Blood deficiency syndrome 7.5 3.2 57.3％ Liver Qi stagnation syndrome 5.4 2.8 48.1％ Total points 27.9 12.5 55.2％

[0159] Table 5-5 Analysis Conclusions: After treatment, significant improvements of over 50% were achieved in all four major syndromes: kidney deficiency, spleen deficiency, blood deficiency, and liver stagnation, with a total score reduction of 55.2%. This indicates that the formulation of this invention, through multi-target synergistic regulation of "tonifying the kidney and strengthening the spleen, nourishing blood and regulating the liver," can systematically improve the core TCM syndromes of DOR patients, demonstrating the advantages of holistic diagnosis and comprehensive treatment in TCM.

[0160] 2.6.2 Comparison of improvements in menstrual conditions

[0161] Design a menstrual diary record form (see Table 6-1) and a menstrual cycle and period record form (see Table 6-2). The menstrual diary record form is filled out by the patient daily, while the menstrual cycle and period record form is compiled by the doctor.

[0162] Table 6-1: Menstrual Diary Record Sheet

[0163] date Measurement score (1-10) Abdominal pain severity (0-10) Blood clots (present / absent) Day 1 Day 2 …

[0164] Table 6-2: Menstrual Cycle and Period Record Table

[0165]

[0166] Table 6-3: Comparison of Improvements in Menstrual Condition Before and After 3 Months

[0167] menstrual indicators Before treatment (mean ± standard deviation) Post-treatment (mean ± standard deviation) Periodic regularity (days) 38.5 30.2 Measurement score (1-10) 3.2 6.8 Severity of menstrual cramps 5.8 2.9 Blood clot status (present / absent) 68％ 22％

[0168] Explanation of the statistical data in Table 6:

[0169] 1. Regularity of menstrual cycle (days)

[0170] Calculation formula: Cycle length = First day of current menstruation - First day of previous menstruation

[0171] Cycle length = First day of this menstrual period - First day of the previous menstrual period

[0172] Data source: Menstrual start and end dates provided by patients.

[0173] The values ​​in Table 6 are the average values ​​calculated for the most recent three menstrual cycles.

[0174] 2. Measurement score (1-10 points)

[0175] Scoring criteria:

[0176] 1-3 points: Drip-like, only requires a panty liner;

[0177] 4-6 points: Moderate, requires regular sanitary napkins;

[0178] 7-10 points: Large quantity, requires extra-long / nighttime sanitary napkins.

[0179] Data source: Patients fill in "menstrual flow score" daily, and the average of all menstrual flow scores within that cycle is taken.

[0180] The values ​​in Table 6 are the average values ​​for the three months before treatment versus the three months after treatment.

[0181] 3. Severity of dysmenorrhea (VAS Visual Analogue Scale)

[0182] Tools: 0-10 scale, 0 = no pain, 10 = severe pain.

[0183] Data source: Patients recorded their abdominal pain scores daily in their menstrual diaries.

[0184] The values ​​in Table 6 are the average of all scores within that period.

[0185] 4. Blood clot status (present / absent)

[0186] Recording method: Patients check "with blood clots" or "without blood clots" in their menstrual diary.

[0187] The "Blood Clot Status" in Table 6 calculates the percentage of days with blood clots out of the total number of menstrual days.

[0188] Table 6-3 Analysis Conclusions: After treatment, the menstrual cycle became significantly more regular, the menstrual flow score improved substantially, and dysmenorrhea and blood clots were significantly reduced. This indicates that the present invention, based on regulating the Chong and Ren meridians and promoting blood circulation, can effectively restore menstrual physiological function, especially showing a clear conditioning effect on common DOR symptoms such as scanty menstruation, irregular cycles, and dysmenorrhea.

[0189] The foregoing description of specific exemplary embodiments of the invention is for illustrative and explanatory purposes. These descriptions are not intended to limit the invention to the precise forms disclosed, and it will be apparent that many changes and variations can be made in accordance with the foregoing teachings. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application, thereby enabling those skilled in the art to implement and utilize various different exemplary embodiments of the invention, as well as various different choices and variations. The scope of the invention is intended to be defined by the claims and their equivalents.

Claims

1. A traditional Chinese medicine composition, characterized in that, The composition comprises component one and component two; wherein... The first component is prepared into a paste, which consists of the following components in parts by weight: 3-10 parts cinnamon, 20-40 parts raw oyster shell, 1-8 parts red ginseng, 10-20 parts prepared rehmannia root, 9-20 parts angelica root, 1-5 parts deer antler blood, 3-10 parts chitosan oligosaccharide, 2-9 parts donkey-hide gelatin, 10-25 parts eucommia leaves, 10-20 parts stir-fried jujube seeds, 20-37 parts floating wheat, 12-25 parts cornus officinalis, 3-10 parts lotus seeds, 9-21 parts dried tangerine peel, 5-15 parts wolfberry, and 12-27 parts jujube. The second component is decocted into a soup, which consists of the following components in parts by weight: 5-20 parts of white peony root, 5-20 parts of epimedium, 12-25 parts of achyranthes bidentata, 8-22 parts of cuscuta chinensis, and 12-28 parts of eclipta prostrata.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Component one consists of the following components in parts by weight: cinnamon 3-9 parts, raw oyster 22-37 parts, red ginseng 2-7 parts, prepared rehmannia root 10-18 parts, angelica root 9-18 parts, deer antler blood 1-4 parts, chitosan oligosaccharide 3-9 parts, donkey-hide gelatin 2-7 parts, eucommia leaf 15-25 parts, stir-fried jujube seed 12-20 parts, floating wheat 25-35 parts, cornus officinalis 15-25 parts, lotus seed 3-9 parts, dried tangerine peel 10-20 parts, wolfberry 6-15 parts, and jujube 15-25 parts; Component two consists of the following components in parts by weight: white peony root 7-18 parts, epimedium 7-18 parts, achyranthes bidentata 15-25 parts, dodder seed 10-20 parts, and eclipta prostrata 15-25 parts. Preferably, component one is composed of the following components in parts by weight: 4-8 parts cinnamon, 25-35 parts raw oyster shell, 3-6 parts red ginseng, 13-17 parts prepared rehmannia root, 10-15 parts angelica root, 1-3 parts deer antler blood, 4-7 parts chitosan oligosaccharide, 3-5 parts donkey-hide gelatin, 17-23 parts eucommia leaves, 13-18 parts stir-fried jujube seeds, 27-33 parts floating wheat, 18-23 parts cornus officinalis, 4-7 parts lotus seeds, 12-18 parts dried tangerine peel, 8-12 parts wolfberry, and 18-22 parts jujube; component two is composed of the following components in parts by weight: 10-15 parts white peony root, 10-15 parts epimedium, 18-23 parts Sichuan achyranthes root, 12-18 parts dodder seed, and 18-23 parts eclipta prostrata.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, Component one consists of the following components in parts by weight: 6 parts cinnamon, 30 parts raw oyster, 5 parts red ginseng, 15 parts prepared rehmannia root, 12 parts angelica root, 2 parts deer antler blood, 6 parts chitosan oligosaccharide, 4 parts donkey-hide gelatin, 20 parts eucommia leaves, 15 parts stir-fried jujube seeds, 30 parts floating wheat, 20 parts cornus fruit, 5 parts lotus seeds, 15 parts dried tangerine peel, 10 parts wolfberry, and 20 parts jujube; Component two consists of the following components in parts by weight: 12 parts white peony root, 12 parts epimedium, 20 parts achyranthes root, 15 parts dodder seed, and 20 parts eclipta herb.

4. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The method of using the traditional Chinese medicine composition is as follows: Take the ointment made from component one and take it with the decoction made from component two, twice a day.

5. The traditional Chinese medicine composition according to claim 4, characterized in that, The method of use is as follows: take 5-15g of the ointment with 40-60ml of the decoction; preferably, take 10g of the ointment with 50ml of the decoction.

6. A method for preparing the traditional Chinese medicine composition according to claims 1-5, characterized in that, The steps include preparing component one into an ointment and component two into a decoction, as follows: The steps of preparing component one into an ointment include: (1) Crush the 16 medicinal materials in Component 1, namely cinnamon, raw oyster, red ginseng, prepared rehmannia root, angelica, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube into coarse powder, and then mix them evenly. (2) Soak in water, decoct twice, combine the decoctions, and filter. (3) The filtrate is concentrated to a thick paste with a relative density of 1.25 (60°C), and then cooled to obtain the paste; The steps for preparing the second component into a decoction include: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis and eclipta prostrata, are crushed into coarse powder and then mixed evenly. (2) Soak in water, decoct once, filter, and obtain the decoction.

7. The preparation method according to claim 6, characterized in that, The first component is pulverized into a coarse powder of 40-60 mesh; it is then soaked in 6-15 times the amount of water for 20-50 minutes; each decoction is prepared for 1-2 hours; the paste can be further flavored with honey. The second component is pulverized into a coarse powder of 40-60 mesh; it is then soaked in 4-13 times the amount of water for 20-50 minutes, and decocted for 0.5-1.5 hours.

8. The preparation method according to claim 7, characterized in that, The preparation steps include the following: The steps of preparing component one into an ointment include: (1) Cinnamon, raw oyster, red ginseng, prepared rehmannia root, angelica, deer antler blood, chitosan oligosaccharide, donkey-hide gelatin, eucommia leaves, stir-fried jujube seeds, floating wheat, cornus officinalis, lotus seeds, tangerine peel, wolfberry, and jujube in component one are pulverized into coarse powder of 40-60 mesh, and then mixed evenly. (2) Soak in 10 times the amount of water for 30 minutes, decoct twice, 1.5 hours each time, combine the decoctions and filter; (3) Concentrate the filtrate to a thick paste with a relative density of 1.25 (60°C), add honey to flavor it, and cool it to obtain the paste; The steps for preparing the second component into a decoction include: (1) The five medicinal materials in component two, namely white peony root, epimedium, achyranthes bidentata, cuscuta chinensis and eclipta prostrata, are pulverized into coarse powder of 40-60 mesh, and then mixed evenly. (2) Soak in 8 times the amount of water for 30 minutes, decoct once for 1 hour, filter, and obtain the decoction.

9. The preparation method according to any one of claims 6-8, characterized in that, The ointment is packaged in sealed glass bottles and stored at 4°C; the decoction is prepared fresh for use or packaged and stored at 4°C.

10. The use of a traditional Chinese medicine composition according to any one of claims 1-5 or a traditional Chinese medicine composition prepared by the preparation method according to any one of claims 6-9 in the preparation of a medicament for improving or treating low ovarian reserve.

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