Osteogenic differentiation induction medium based on pilose antler polypeptide and osteogenic differentiation induction method

By using deer antler polypeptide osteogenic induction medium, combined with dexamethasone, L-ascorbic acid and β-glycerophosphate sodium, the instability and cross-species applicability of existing osteogenic induction mediums were solved, achieving efficient and cross-species osteogenic differentiation.

CN121674333APending Publication Date: 2026-03-17JILIN UNIVERSITY
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Patent Information

Application Number
CN202610173806.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-06
Publication Date
2026-03-17

AI Technical Summary

Technical Problem

Existing osteogenic induction media are characterized by unstable osteogenic induction effects, lengthy cycles, low differentiation efficiency, and poor cross-species applicability, making it difficult to meet the needs of efficient osteogenic induction.

Method used

Using deer antler polypeptide as the main component of osteogenic induction medium, combined with dexamethasone, L-ascorbic acid and β-glycerophosphate sodium, an osteogenic differentiation induction medium was prepared. Through multi-step extraction and purification of deer antler polypeptide, an osteogenic differentiation induction medium suitable for humans and mice was prepared.

Benefits of technology

It significantly improved the osteogenic differentiation of mesenchymal stem cells, shortened the osteogenic induction cycle, and achieved cross-species universality and high efficiency, outperforming the induction effect of commercially available osteogenic induction culture media.

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Abstract

The invention discloses an osteogenic differentiation induction medium based on pilose antler polypeptide and an osteogenic differentiation induction method, and belongs to the technical field of biology. The osteogenic differentiation induction culture medium based on the cornu cervi pantotrichum polypeptide contains a cornu cervi pantotrichum polypeptide solution, dexamethasone, L-ascorbic acid, beta-sodium glycerophosphate and a complete culture medium, the cornu cervi pantotrichum polypeptide provided by the invention can greatly improve the osteogenic differentiation effect of mesenchymal stem cells as an additive component of an osteogenic induction culture medium, and is superior to a commercial osteogenic induction culture medium in a certain scene; according to the osteogenic induction differentiation method disclosed by the invention, the defects in the prior art are improved, and the osteogenic differentiation effect of the mesenchymal stem cells can be improved by adopting the pilose antler polypeptide osteogenic differentiation induction culture medium.
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