Nerve stimulator

Abstract

The invention relates to the field of medical equipment, in particular to a nerve stimulator, and the nerve stimulator comprises a stimulation signal output unit which is used for outputting a stimulation signal; the control unit is connected with the stimulation signal output unit and used for outputting a control signal to control the stimulation signal output unit to output the stimulation signal, and the frequency range of the stimulation signal is 50 KHz and 100 KHz. According to the nerve stimulator, the situation that cells are damaged due to the fact that the tissue temperature of the stimulated part is too high is avoided, use is safer, and a better treatment effect is achieved.

Description

Technical Field

[0001] This application relates to the field of medical devices, and in particular to a neurostimulator. Background Technology

[0002] Neurostimulation, as an innovative treatment method, has been widely used in recent years in the treatment of diseases such as refractory epilepsy, depression, and Parkinson's disease.

[0003] In existing technologies, neurostimulators output stimulation signals with frequencies greater than 100 kHz or less than 50 kHz. When the stimulation signal frequency is greater than 100 kHz, it can cause excessively high tissue temperatures at the stimulation site, damaging cells. Simultaneously, each pulse consumes electrical energy; higher frequencies mean greater power consumption, affecting the neurostimulator's battery life. When the stimulation signal frequency is less than 50 kHz, the activation threshold of neurons cannot be reached, preventing sustained discharge from the target nerve. Furthermore, users will experience noticeable stimulation, causing discomfort. Summary of the Invention

[0004] Therefore, it is necessary to provide a neurostimulator to address the aforementioned technical problems.

[0005] In a first aspect, embodiments of this application provide a neurostimulator, comprising:

[0006] Stimulation signal output unit, used to output stimulation signals;

[0007] The control unit is connected to the stimulation signal output unit and is used to output a control signal to control the stimulation signal output unit to output the stimulation signal, wherein the frequency range of the stimulation signal is [50KHz, 100KHz].

[0008] In some embodiments, the frequency range of the stimulation signal is [50KHz, 60KHz].

[0009] In some embodiments, the frequency range of the stimulation signal is [60KHz, 70KHz].

[0010] In some embodiments, the frequency range of the stimulation signal is [70KHz, 80KHz].

[0011] In some embodiments, the frequency range of the stimulation signal is [80KHz, 90KHz].

[0012] In some embodiments, the frequency range of the stimulation signal is [90KHz, 100KHz].

[0013] In some embodiments, the current range of the stimulation signal is [50mA, 500mA].

[0014] In some embodiments, the voltage range of the stimulation signal is [5V, 25V].

[0015] In some embodiments, the stimulation signal output unit includes:

[0016] A pulse circuit, connected to the control unit, is used to respond to the control signal from the control unit and output a first pulse signal.

[0017] At least one electrode is connected to the pulse circuit for outputting a stimulation signal based on the first pulse signal.

[0018] In some embodiments, the stimulation signal output unit further includes:

[0019] A direct digital frequency synthesizer, connected to the control unit, is used to output a second pulse signal of the desired frequency band in response to the control signal of the control unit;

[0020] The pulse circuit is connected to the direct digital frequency synthesizer and is used to respond to the second pulse signal and output the first pulse signal.

[0021] In some embodiments, the pulse circuit includes:

[0022] An amplifier circuit, connected to the direct digital frequency synthesizer, is used to amplify the second pulse signal and output the first pulse signal.

[0023] A first boost circuit is connected to the amplifier circuit and is used to supply power to the amplifier circuit.

[0024] In some embodiments, it also includes:

[0025] A power supply unit, connected to the control unit and the stimulation signal output unit, is used to supply power.

[0026] In some embodiments, the power supply unit includes:

[0027] Batteries are used for power supply;

[0028] A charging circuit, connected to the battery, is used for charging the battery;

[0029] A DC-DC circuit is connected to the battery, the control unit, and the stimulation signal output unit to convert the output voltage of the battery and output it to the control unit and the stimulation signal output unit.

[0030] In some embodiments, the control unit is further configured to determine the control signal based on user characteristics, the control signal being used to control the stimulation signal output unit to output stimulation signals within a corresponding frequency range.

[0031] In some embodiments, the neurostimulator is used to treat anxiety disorders.

[0032] In some embodiments, the neurostimulator is used to treat depression.

[0033] In some embodiments, the neurostimulator is used to treat epilepsy.

[0034] In some embodiments, the neurostimulator is used to treat insomnia.

[0035] The aforementioned neurostimulator possesses the following technical advantages: The frequency range of the stimulation signal output by the neurostimulator of this application is [50KHz, 100KHz]. Compared to stimulation signals with frequencies greater than 100KHz, it will not cause excessively high tissue temperatures at the stimulation site, thus preventing cell damage and making it safer to use. Simultaneously, the lower energy consumption increases the battery life of the neurostimulator. Compared to stimulation signals with frequencies less than 50KHz, it can reach the activation threshold of neurons, resulting in better therapeutic effects. Furthermore, the user will not experience noticeable stimulation, improving the user experience. Attached Figure Description

[0036] Figure 1 A schematic diagram of the structure of a neurostimulator in one embodiment provided in this application;

[0037] Figure 2 This is a schematic diagram of the structure of the neurostimulator in another embodiment provided in this application;

[0038] Figure 3 A schematic diagram of the specific structure of the neurostimulator in one embodiment provided in this application;

[0039] Figure 4 A circuit diagram of the charging circuit provided in one embodiment of this application;

[0040] Figure 5 A circuit schematic diagram of the second boost circuit in one embodiment provided in this application;

[0041] Figure 6 A circuit diagram of a voltage regulator circuit provided in one embodiment of this application;

[0042] Figure 7 A circuit schematic diagram of a direct digital frequency synthesizer provided in this application;

[0043] Figure 8 A circuit schematic diagram of the first boost circuit in one embodiment provided in this application;

[0044] Figure 9 A circuit schematic of an amplifier circuit provided in one embodiment of this application;

[0045] Figure 10 A schematic diagram of the specific structure of the neurostimulator in another embodiment provided in this application;

[0046] Figure 11 A waveform diagram of the stimulus signal provided in an example embodiment of this application;

[0047] Figure 12 A waveform diagram of the stimulation signal in another example embodiment provided in this application. Detailed Implementation

[0048] To make the objectives, technical solutions, and advantages of this application clearer, the application is described and illustrated below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the application. All other embodiments obtained by those skilled in the art based on the embodiments provided in this application without inventive effort are within the scope of protection of this application. Furthermore, it is understood that although the efforts made in such a development process may be complex and lengthy, for those skilled in the art related to the content disclosed in this application, modifications to design, manufacturing, or production based on the technical content disclosed in this application are merely conventional technical means and should not be construed as insufficient disclosure of the content of this application.

[0049] In this application, the reference to "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment that is mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described in this application may be combined with other embodiments without conflict.

[0050] Unless otherwise defined, the technical or scientific terms used in this application shall have the ordinary meaning understood by one of ordinary skill in the art to which this application pertains. The terms “a,” “an,” “an,” “the,” and similar words used in this application do not indicate quantity limitation and may indicate singular or plural. The terms “comprising,” “including,” “having,” and any variations thereof used in this application are intended to cover non-exclusive inclusion; for example, a process, method, system, product, or device that includes a series of steps or modules (units) is not limited to the listed steps or units, but may also include steps or units not listed, or may include other steps or units inherent to these processes, methods, products, or devices. The terms “connected,” “linked,” “coupled,” and similar words used in this application are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. “Multiple” used in this application means two or more. “And / or” describes the relationship between related objects, indicating that three relationships may exist; for example, “A and / or B” can represent: A alone, A and B simultaneously, and B alone. The terms “first,” “second,” “third,” etc., used in this application are merely to distinguish similar objects and do not represent a specific ordering of the objects.

[0051] Figure 1 This is a schematic diagram of the structure of a neurostimulator in one embodiment of this application. Figure 1 As shown, the neurostimulator includes a stimulation signal output unit for outputting stimulation signals; and a control unit connected to the stimulation signal output unit for outputting control signals to control the stimulation signal output unit to output the stimulation signals, wherein the frequency range of the stimulation signals is [50KHz, 100KHz].

[0052] It is understandable that the period range corresponding to the stimulus signal after conversion of this frequency range is [10us, 20us].

[0053] In this embodiment, the frequency range of the stimulation signal output by the neurostimulator is [50kHz, 100kHz]. Compared to stimulation signals with frequencies greater than 100kHz, this prevents excessively high tissue temperatures at the stimulation site, thus avoiding cell damage and making it safer to use. Simultaneously, the lower energy consumption increases the battery life of the neurostimulator. Compared to stimulation signals with frequencies less than 50kHz, this signal can reach the activation threshold of neurons, resulting in better therapeutic effects. Furthermore, the user will not experience noticeable stimulation, improving the user experience.

[0054] Furthermore, the frequency range of 50kHz to 100kHz alternating sufficiently rapidly can effectively prevent cell polarization from significantly reducing the therapeutic effect. It also generates enough charge accumulation to generate the necessary stimulus, thus achieving the desired effect. Compared to low-frequency stimulation, this frequency band has stronger pulse penetration, enabling it to act on deeper tissues. It is suitable for treatment scenarios requiring deep stimulation, and it is less irritating to the skin, resulting in better patient tolerance.

[0055] In some embodiments, the nerve stimulator is applied to the vagus nerve, including but not limited to the cervical vagus nerve.

[0056] In some embodiments, the neurostimulator is used to treat anxiety disorders.

[0057] In some embodiments, the neurostimulator is used to treat depression.

[0058] In some embodiments, the neurostimulator is used to treat epilepsy.

[0059] In some embodiments, the neurostimulator is used to treat insomnia.

[0060] In actual treatment, the location of the target nerve can be determined according to the user's symptoms. Then, a nerve stimulator is used to output a stimulation signal with a frequency range of [50KHz, 100KHz] at the location of the target nerve, thereby achieving the therapeutic effect of the above-mentioned symptoms.

[0061] For example, if a user suffers from epilepsy, it is necessary to determine the location of the vagus nerve in the neck, and then use a nerve stimulator to output a stimulation signal with a frequency range of [50KHz, 100KHz] at the location of the vagus nerve in the neck, thereby achieving the therapeutic effect of epilepsy.

[0062] It should be noted that in actual treatment, the frequency range of the stimulation signal output by the neurostimulator can be one of [50KHz, 60KHz], [60KHz, 70KHz], [70KHz, 80KHz], [80KHz, 90KHz], or [90KHz, 100KHz], and the same technical effect can be achieved.

[0063] It should also be noted that in actual treatment, the frequency of the stimulation signal output by the neurostimulator can be any point in the range of 50KHz and 100KHz, such as 75KHz, and the same technical effect can be achieved.

[0064] In some embodiments, the user can also select a corresponding frequency range or frequency point based on their symptoms.

[0065] Different ailments may have different optimal frequency ranges or frequency points. Therefore, by selecting the appropriate frequency range or frequency point based on the user's ailment, the best treatment effect can be achieved.

[0066] In some embodiments, the control unit is further configured to determine the control signal based on user characteristics, the control signal being used to control the stimulation signal output unit to output stimulation signals within a corresponding frequency range.

[0067] The user characteristics include at least one of the following: medical condition, age, etc.

[0068] For example, if a user is younger, they can choose the smaller frequency range [50KHz, 60KHz] between [50KHz, 100KHz].

[0069] For example, if a user's condition is more severe, they can choose a larger frequency range, such as 90kHz or 100kHz, from 50kHz to 100kHz.

[0070] In other examples, factors such as illness and age can be considered, and the corresponding frequency range can be determined by combining the weights of each user characteristic.

[0071] In the above embodiments, stimulation signals of corresponding frequency ranges are matched and output according to user characteristics, resulting in better therapeutic effects and improved user experience.

[0072] In some embodiments, the stimulation signal includes, but is not limited to, an electrical stimulation signal. When the stimulation signal is an electrical stimulation signal, it is important to consider that the current range of the stimulation signal will also affect the user's treatment. For example, when the current is large, the user may not be able to withstand the strong stimulation signal, and it may even cause damage to the stimulation site; when the current is small, the stimulation signal is too weak to achieve a real therapeutic effect.

[0073] In a further embodiment, the current range of the stimulation signal is [50mA, 500mA]. Within this current range, it avoids situations where the user cannot tolerate a strong stimulation signal, while still achieving a genuine therapeutic effect.

[0074] Similarly, the voltage range of the stimulation signal will also affect the user's treatment. For example, when the voltage is too high, the user cannot withstand the strong stimulation signal, and it may even cause damage to the stimulation site; when the voltage is too low, the stimulation signal is too weak to achieve a real therapeutic effect.

[0075] In a further embodiment, the voltage range of the stimulation signal is [5V, 25V]. Within this voltage range, it avoids situations where the user cannot tolerate a strong stimulation signal, while still achieving a genuine therapeutic effect.

[0076] Figure 2 This is a schematic diagram of the neurostimulator in another embodiment provided in this application. Figure 2 As shown, the neurostimulator also includes a power supply unit, which is connected to the control unit and the stimulation signal output unit for power supply.

[0077] Figure 3 This is a schematic diagram of the specific structure of a neurostimulator in one embodiment of this application. Figure 3 As shown, the stimulation signal output unit includes: a direct digital frequency synthesizer, a pulse circuit, and at least one electrode. The direct digital frequency synthesizer is connected to the control unit and is used to output a second pulse signal of the desired frequency band in response to the control signal of the control unit; the pulse circuit is connected to the direct digital frequency synthesizer and is used to output a first pulse signal in response to the second pulse signal; at least one electrode is connected to the pulse circuit and is used to output a stimulation signal according to the first pulse signal.

[0078] The power supply unit includes a battery, a charging circuit, and a DC-DC circuit. The charging circuit is connected to the battery for charging the battery; the DC-DC circuit is connected to the battery, the control unit, and the stimulation signal output unit for converting the output voltage of the battery and outputting it to the control unit and the stimulation signal output unit.

[0079] The pulse circuit includes: an amplifier circuit connected to the direct digital frequency synthesizer, used to amplify the second pulse signal and output a first pulse signal; and a first boost circuit connected to the amplifier circuit, used to supply power to the amplifier circuit.

[0080] To output a stimulation signal with a frequency range of [50kHz, 100kHz], the built-in ADC converter in the control unit cannot generate an accurate signal waveform. This embodiment employs a Direct Digital Synthesizer (DDS) to adjust the output frequency and phase using frequency and phase control words.

[0081] Direct digital frequency synthesizers have two prominent features. First, they operate in the digital domain, so the output frequency changes accordingly once the frequency control word is updated, resulting in a high frequency hopping rate. Second, they have a wide frequency control word width (48 bits or more) and high frequency resolution.

[0082] During the generation of the stimulation signal, the control unit configures a suitable waveform through software and sends corresponding control signals to a direct digital frequency synthesizer (DDS). The DDS outputs a second pulse signal with a frequency range of [50kHz, 100kHz] based on the control signal. After being amplified by an amplifier circuit, the second pulse signal outputs a first pulse signal with a frequency range of [50kHz, 100kHz]. This first pulse signal, after passing through electrodes or electrode pairs, outputs a stimulation signal with a frequency range of [50kHz, 100kHz]. Compared to directly using the control unit to output the pulse signal, the signal generation method used in this embodiment has higher accuracy.

[0083] The technical solution of the neurostimulator will be explained in detail below with reference to a specific circuit.

[0084] like Figure 4 As shown, the charging circuit includes a charging controller U50, an optocoupler U51, and an optocoupler U46. Pin 1 of the charging controller U50 is connected to a thermistor R158. Pin 2 is connected to ground via resistor R2. Pin 3 is also connected to ground. Pin 4 receives the charging voltage of 4.5V and connects to capacitors C3 and C4. Pin 5 connects to the battery BAT and capacitors C1 and C2 to charge the battery BAT. Pin 6 is connected to one end of resistor R148. Pin 7 is connected to one end of resistor R142. Pin 8 connects to pin 4. Pin 9 is connected to ground. Capacitors C1, C2, C3, and C4 are used for filtering.

[0085] The first pin 1 of the optocoupler U51 receives a charging voltage of 4.5V, the second pin 2 is connected to the other end of resistor R148, the third pin 3 is connected to the common ground, and the fourth pin 4 is connected to one end of resistor R147 and outputs the charging completion signal CHARGE_STDBY to the control unit. The other end of resistor R147 outputs the supply voltage VCC_3V3.

[0086] The first pin 1 of the optocoupler U46 receives a charging voltage of 4.5V, the second pin 2 is connected to the other end of resistor R142, the third pin 3 is connected to the common ground, the fourth pin 4 is connected to one end of resistor R1 and outputs a charging signal CHARGE-FLAG to the control unit, and the other end of resistor R1 outputs the supply voltage VCC_3V3.

[0087] When the battery is charging, the charging controller U50 controls the optocoupler U51 to light up and conduct, and controls the optocoupler U46 to turn off and disconnect; when the battery is fully charged, the charging controller U50 controls the optocoupler U51 to turn off and disconnect, and controls the optocoupler U46 to light up and conduct; when the charging voltage is low, or the battery temperature is too high or too low, the charging controller U50 controls the optocoupler U51 to turn off and disconnect, and controls the optocoupler U46 to turn off and disconnect; when there is no battery, the charging controller U50 controls the optocoupler U51 to flash and controls the optocoupler U46 to light up and conduct.

[0088] In some embodiments, the charging controller U50 is model TP4056.

[0089] The DC-DC circuit includes a second boost circuit and a voltage regulator circuit connected in sequence. The second boost circuit is connected to the battery, and the voltage regulator circuit is connected to the control unit and the direct digital frequency synthesizer. Figure 5 As shown, the second boost circuit includes a DC-DC chip U42, capacitors C140, C141, and C139, and inductor L5. Pin 1 of the DC-DC chip U42 is connected to the battery BAT, receiving the battery voltage as input. Pin 3 is connected to capacitor C140, and pin 4 is connected to capacitors C141 and C139, outputting the boosted supply voltage BAT1, which is 5V. Pin 5 is connected to one end of inductor L5, and the other end of inductor L5 is connected to the battery BAT. Capacitors C140, C141, and C139 are all used for filtering.

[0090] In some embodiments, the DC-DC chip U42 is model ME2107A50M5G.

[0091] like Figure 6 As shown, the voltage regulator circuit includes a voltage regulator U25, capacitors C99, C100, C101, and C102. The first pin 1 of the voltage regulator U25 receives the supply voltage BAT1. Capacitors C99 and C100 are connected in parallel between the first pin 1 and the second pin 2 of the voltage regulator U25. Capacitors C101 and C102 are connected in parallel between the fifth pin 5 and the second pin 2 of the voltage regulator U25. The voltage regulator U25 regulates the 5V supply voltage BAT1 to output the supply voltage VCC_3V3. Capacitors C99, C100, C101, and C102 are all used for filtering.

[0092] In some embodiments, the voltage regulator U25 is model ADP151AUJZ-3.3-R7.

[0093] like Figure 7As shown, the direct digital frequency synthesizer includes a waveform generator chip U17. Pin 1 of the waveform generator chip U17 is connected to capacitor C75; pin 2 receives the supply voltage VCC_3V3; pin 3 receives capacitor C79; pin 4 is connected to common ground; pin 5 receives the control signal MCLK; pin 6 receives the control signal SDATA and is connected to resistor R71; pin 7 receives the control signal SCLK and is connected to resistor R73; pin 8 receives the control signal FSYNC and is connected to resistor R68; pin 9 is connected to common ground; and pin 10, connected to capacitor C76, outputs the second pulse signal 100kHz_IN. The control signals MCLK, SDATA, SCLK, and FSYNC are all output by the control unit.

[0094] The waveform generation chip U17 accurately generates the second pulse signal 100KHz_IN based on the control signals SDATA, SCLK, FSYNC, and MCLK sent by the control unit.

[0095] In some embodiments, the waveform generator chip U17 is model AD9833BRMZ.

[0096] like Figure 8 As shown, the first boost circuit includes a boost controller U13. Its first pin 1 receives the control signal HV-EN output by the control unit and is connected to resistor R75. Its second pin 2 receives the supply voltage BAT1 and is connected to capacitors C19 and C26. Its third pin 3 is connected to the midpoint of resistors R25 and R11. Its fifth pin 5 and sixth pin 6 are connected to the positive terminal of Zener diode D11 and capacitor C21. The negative terminal of Zener diode D11 is connected to resistor R25, capacitor C17, and capacitor C18. An inductor L1 is connected between the fifth pin 5 and the second pin 2. Both capacitors C17 and C18 are connected in parallel with resistors R25 and R11 to output the supply voltage POS-HV to the amplifier circuit. Capacitor C21 is connected to the positive terminal of Zener diode D13 and the negative terminal of Zener diode D12. The negative terminal of Zener diode D13 is grounded, and the positive terminal of Zener diode D12 is grounded through capacitors C22 and C23 connected in parallel. After capacitors C22 and C23 are connected in parallel with Zener diodes D13 and D12, the output supply voltage NEG-HV is supplied to the amplifier circuit.

[0097] If the voltage at pin 3 of boost controller U13 is V3, then the supply voltage NEG-HV = V3 / R11 × (R25 + R11) = V3 × (1 + R25 / R11). When the voltage V3 at pin 3 of boost controller U13 is 1.25V, the resistance of resistor R25 is 180k ohms, and the resistance of resistor R11 is 10k ohms, then the supply voltage POS-HV is 23.7V, and the supply voltage NEG-HV is -23.7V, which is used by the amplifier circuit.

[0098] In some embodiments, the boost controller U13 is model XL6007E1.

[0099] like Figure 9 As shown, the amplifier circuit includes a signal amplifier U18. Its first pin 1 is connected to capacitor C105 and inductor L6. Inductor L6 is supplied with the power supply voltage NEG-HV. The second pin 2 is connected to the midpoint of resistors R86 and R87. The third pin 3 is connected to the second pulse signal 100KHz_IN and resistor R98. The fourth pin 4 is connected to the fifth pin 5. The sixth pin 6 is connected to the midpoint of resistor R87 and capacitor C121. Capacitor C121 is also connected to electrode pair H3. The seventh pin 7 is connected to the midpoint of capacitor C104 and inductor L5. Inductor L5 is supplied with the power supply voltage POS-HV.

[0100] Signal amplifier U18, powered by the first boost circuit, amplifies the second pulse signal 100kHz_IN by 3.4 times and outputs the first pulse signal AC-ENG to electrode pair H3. If the amplification factor needs to be changed, the value of resistor R87 can be modified. Electrode pair H3 outputs a stimulation signal with a frequency range of [50kHz, 100kHz] based on the first pulse signal AC-ENG.

[0101] In some embodiments, the signal amplifier U18 is model OPA551UA / 2K5.

[0102] In one example embodiment, the control unit includes a control chip, such as an STM32F103RCT6, which has a main frequency of 72MHz and a built-in 12-bit ADC conversion function. This control chip can implement the technical solutions described in the above embodiments.

[0103] Figure 10 This is a schematic diagram of the neurostimulator in another embodiment provided in this application. Figure 10 As shown, compared with the above embodiments, the neurostimulator in this embodiment omits the direct digital frequency synthesizer and directly uses the ADC converter built into the control unit to generate the first pulse signal. The electrode pair outputs a stimulation signal with a frequency range of [50KHz, 100KHz] according to the first pulse signal.

[0104] In this embodiment, the control unit uses, for example, an STM32F103RCT6 as the control chip, which has a built-in 12-bit ADC conversion function. It uses the ADC converter to read the external analog voltage and generates a pulse signal of the corresponding frequency according to the digital value read by the ADC converter. The electrode pair outputs a stimulation signal with a frequency range of [50KHz, 100KHz] according to the first pulse signal.

[0105] Although the built-in ADC converter of the control unit cannot generate high-precision pulse signals, the electrode pair can still output stimulation signals with a frequency range of [50KHz, 100KHz], thus achieving the technical effect that this solution can achieve.

[0106] To obtain more accurate pulse signals, in some improved embodiments, a filtering circuit can be built around the control unit to optimize the pulse signal output by the control unit.

[0107] In one example embodiment, the stimulation signal output by the neurostimulator is as follows: Figure 11 As shown, the period of the stimulation signal is T=40ms, and each period T includes a stimulation period Nτ and a silent period T-Nτ. The stimulation period Nτ includes 5 waveforms with a period of τ=12us, corresponding to a frequency of 83.33 kHz. The output voltage is 0V during the silent period T-Nτ.

[0108] In another example embodiment, the stimulation signal output by the neurostimulator is as follows: Figure 12 As shown, the period of the stimulation signal is T=40ms, and each period T includes a stimulation period Nτ and a silent period T-Nτ. The stimulation period Nτ includes 5 waveforms with a period of τ=18us, corresponding to a frequency of 55.56kHz. The output voltage is 0V during the silent period T-Nτ.

[0109] In the two example embodiments above, the frequencies of the stimulation signals are both within the range of [50KHz, 100KHz], thus achieving the technical effects that this technical solution can achieve.

[0110] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0111] The above embodiments merely illustrate several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A neurostimulator, characterized in that, include: Stimulation signal output unit, used to output stimulation signals; The control unit is connected to the stimulation signal output unit and is used to output a control signal to control the stimulation signal output unit to output the stimulation signal, wherein the frequency range of the stimulation signal is [50KHz, 100KHz].

2. The neurostimulator according to claim 1, characterized in that, The frequency range of the stimulation signal is [50KHz, 60KHz].

3. The neurostimulator according to claim 1, characterized in that, The frequency range of the stimulation signal is [60KHz, 70KHz].

4. The neurostimulator according to claim 1, characterized in that, The frequency range of the stimulation signal is [70KHz, 80KHz].

5. The neurostimulator according to claim 1, characterized in that, The frequency range of the stimulation signal is [80KHz, 90KHz].

6. The neurostimulator according to claim 1, characterized in that, The frequency range of the stimulation signal is [90KHz, 100KHz].

7. The neurostimulator according to claim 1, characterized in that, The current range of the stimulation signal is [50mA, 500mA].

8. The neurostimulator according to claim 1, characterized in that, The voltage range of the stimulation signal is [5V, 25V].

9. The neurostimulator according to claim 1, characterized in that, The stimulation signal output unit includes: A pulse circuit, connected to the control unit, is used to respond to the control signal from the control unit and output a first pulse signal. At least one electrode is connected to the pulse circuit for outputting a stimulation signal based on the first pulse signal.

10. The neurostimulator according to claim 9, characterized in that, Also includes: A direct digital frequency synthesizer, connected to the control unit, is used to output a second pulse signal of the desired frequency band in response to the control signal of the control unit; The pulse circuit is connected to the direct digital frequency synthesizer and is used to respond to the second pulse signal and output the first pulse signal.

11. The neurostimulator according to claim 10, characterized in that, The pulse circuit includes: An amplifier circuit, connected to the direct digital frequency synthesizer, is used to amplify the second pulse signal and output the first pulse signal. A first boost circuit is connected to the amplifier circuit and is used to supply power to the amplifier circuit.

12. The neurostimulator according to claim 1, characterized in that, Also includes: A power supply unit, connected to the control unit and the stimulation signal output unit, is used to supply power.

13. The neurostimulator according to claim 12, characterized in that, The power supply unit includes: Batteries are used for power supply; A charging circuit, connected to the battery, is used for charging the battery; A DC-DC circuit is connected to the battery, the control unit, and the stimulation signal output unit to convert the output voltage of the battery and output it to the control unit and the stimulation signal output unit.

14. The neurostimulator according to claim 1, characterized in that, The control unit is also configured to determine the control signal based on user characteristics, and the control signal is configured to control the stimulation signal output unit to output stimulation signals within a corresponding frequency range.

15. The neurostimulator according to claim 1, characterized in that, Used to treat anxiety disorders.

16. The neurostimulator according to claim 1, characterized in that, Used to treat depression.

17. The neurostimulator according to claim 1, characterized in that, Used to treat epilepsy.

18. The neurostimulator according to claim 1, characterized in that, Used to treat insomnia.

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