Acetabular bone defect repair system

Abstract

The invention relates to the field of medical repair, in particular to an acetabular bone defect repair system which comprises a moldable complex module made of a flowable composite material formed by mixing porous metal particles and bone cement according to a predetermined volume mixing ratio, and the moldable complex module is configured to be positioned in an acetabular bone defect area after being implanted, the bionic support frame module is used for providing mechanical support for the moldable complex module and the acetabular cup prosthesis; the inclusive cushion film can also be included; the bionic supporting frame module provides initial mechanical stability and has a space structure allowing the flowable composite material to permeate and be solidified, so that the bionic supporting frame module and the flowable composite material form a mechanically-interlocked integrated bearing structure. The inclusive cushion film is laid in the acetabular bone defect area, and a filling space is defined by the inclusive cushion film and the host bone. According to the acetabular cup prosthesis, the technical effects of anatomical matching and long-term biological integration of the irregular bone defect surface and the acetabular cup prosthesis are achieved.

Description

Technical Field

[0001] This application relates to the field of medical repair, and in particular to a system for repairing acetabular bone defects. Background Technology

[0002] With the increasing number of patients undergoing hip replacement surgery each year, revision replacement is gradually entering its peak period. In the entire field of orthopedics, hip-related treatment techniques have always been a focus of research and development. The widespread implementation of hip replacement surgery has brought new hope to many patients with hip joint diseases, significantly improving their quality of life and mobility. However, with the increase in the number of surgeries, the demand for revision replacement is becoming increasingly prominent. Revision replacement is crucial for addressing various problems that arise after the initial replacement, as it relates to whether patients can continue to use their hip joint normally, profoundly impacting their lives. In revision replacement, bone loss in the acetabulum often occurs due to factors such as prosthesis wear, loosening, or infection leading to osteolysis, osteoporotic bone defects, excessive bone removal during previous surgeries, and bone damage caused when removing the previous prosthesis or bone cement.

[0003] Currently, there are several commonly used methods to address acetabular defects in clinical practice. One approach involves using an enlarged acetabular cup prosthesis. Its larger diameter hemispherical design covers more of the bone defect area, promoting bone ingrowth, better conforming to anatomical position, reducing the risk of dislocation, and improving biomechanical performance. Multiple screws can also be used for reinforced fixation, enhancing initial stability. Another approach utilizes a metal reinforcement block on the acetabular side. This implant effectively fills the acetabular bone defect, providing stable support for the acetabular prosthesis, especially suitable for patients with severe bone defects. It reduces the risk of prosthesis loosening. The metal reinforcement block is fixed to the acetabular cup prosthesis with screws or bone cement, providing reliable initial stability, promoting bone ingrowth, and long-term fixation. Allogeneic bone is a commonly used bone graft material. It avoids the trauma of autologous bone harvesting, eliminates the need for bone harvesting from the patient, has a relatively abundant bone source, and offers a variety of shapes to choose from. The appropriate shape and size of allogeneic bone can be selected based on the patient's specific situation, better adapting to different bone defect locations and needs.

[0004] Currently available prostheses for acetabular defect repair and revision reconstruction have limitations in handling complex and severe defects. Enlarged acetabular cups are not suitable for all bone defects; severe non-contained bone defects and damage to the posterior column of the acetabulum must be excluded. Long-term friction between the metal reinforcement and the acetabular prosthesis or surrounding bone tissue can lead to wear particles, causing aseptic inflammation and affecting implant lifespan. Furthermore, its effectiveness is limited for complex defects such as pelvic discontinuities, potentially requiring combination with other techniques. There are also potential complications such as screw loosening or breakage, or metal reinforcement displacement or subsidence. Allogeneic bone carries the risk of immune rejection; the body may react to allogeneic bone, leading to local inflammation, pain, and even affecting fusion. Even after treatment, certain risks remain, including the risk of disease transmission, potentially prolonged fusion time, higher costs, and the possibility of secondary surgery. These risks are particularly evident in the time-consuming and labor-intensive process of defect fixation, the difficulty in achieving anatomical reduction, long-term stability, and production cycle. Summary of the Invention

[0005] To overcome the shortcomings of the prior art, this application provides a acetabular bone defect repair system that can achieve anatomical matching and long-term biological integration with the irregular bone defect surface and the acetabular cup prosthesis.

[0006] This application is achieved through the following technical solution: A system for repairing acetabular bone defects includes: The malleable composite module is composed of a flowable composite material made by mixing porous metal particles and bone cement in a predetermined volume mixing ratio. The acetabular cup prosthesis has a groove that mimics the lunate surface of the acetabulum and is configured to be positioned in the acetabular region after implantation. The biomimetic support frame module is configured to be positioned within the acetabular bone defect area after implantation, and is used to provide mechanical support for the malleable composite module and the acetabular cup prosthesis. The biomimetic support frame module provides initial mechanical stability and has a spatial structure for the infiltration and curing of the flowable composite material. After the flowable composite material is cured in the acetabular bone defect area, it forms a mechanically interlocked integrated support structure with the biomimetic support frame module. The integrated support structure provides support for the acetabular cup prosthesis to achieve anatomical matching and long-term biological integration between the acetabular cup prosthesis and the irregular bone defect surface.

[0007] By employing the above-mentioned technical solution, the malleable composite module is made by mixing porous metal particles and bone cement at a predetermined volume mixing ratio to form a flowable composite material. This material has good fluidity, making it easy to fill every corner of the acetabular bone defect area and effectively cover irregular bone defect surfaces. The biomimetic support frame module is positioned within the acetabular bone defect area, providing mechanical support for the malleable composite module and the acetabular cup prosthesis. Its initial mechanical stability ensures the stability of the structure in the early stages of surgery. This module has a spatial structure for the flowable composite material to infiltrate and solidify. After the flowable composite material solidifies within the acetabular bone defect area, it can form a mechanically interlocked integrated load-bearing structure with the biomimetic support frame module. This integrated load-bearing structure not only firmly fixes the acetabular cup prosthesis but also achieves anatomical matching with the irregular bone defect surface and the acetabular cup prosthesis, making the repaired structure more in line with human physiological structure. At the same time, it is conducive to long-term biological integration, promoting bone tissue growth and fusion, improving the effect and stability of acetabular bone defect repair, reducing the occurrence of postoperative complications, and bringing patients a better treatment experience and rehabilitation effect.

[0008] Optionally, the biomimetic support frame module includes at least one load-bearing beam unit, which is configured to have extensions corresponding to and capable of extending along the iliac, ischium and pubis of the human body to form a three-point anchored support.

[0009] By adopting the above technical solution, the biomimetic support frame module includes load-bearing beam units with extensions corresponding to the iliac, ischium, and pubis bones, forming a three-point anchoring support. This unique structural design conforms to the biomechanical characteristics of the pelvis and can simulate the supporting function of the acetabulum. After implantation into the acetabular bone defect area, this structure can provide reliable mechanical support for the malleable composite module and the acetabular cup prosthesis, enhancing initial mechanical stability. Compared with single-point or two-point support, the three-point anchoring support can more evenly distribute stress, reduce local stress concentration, and lower the risk of prosthesis loosening and displacement; at the same time, it provides a stable spatial structure for the infiltration and solidification of flowable composite materials, which helps to form a mechanically interlocked integrated load-bearing structure, thereby achieving anatomical matching and long-term biological integration with irregular bone defect surfaces and the acetabular cup prosthesis.

[0010] Optionally, the load-bearing beam unit includes a metal frame and fixation pins for securing the frame to the host bone; the metal frame has a grid frame for the infiltration of the flowable composite material, including a plurality of staggered transverse and longitudinal metal ribs.

[0011] By adopting the above technical solutions, the mesh frame of the metal skeleton allows for the infiltration of flowable composite materials, and the staggered horizontal and vertical metal ribs can enhance the strength and stability of the skeleton; the fixation pins can fix the metal skeleton to the host bone. The combination of the three enables the bionic support frame module to better provide mechanical support for the malleable composite module and the acetabular cup prosthesis, forming a more stable integrated load-bearing structure, achieving anatomical matching and long-term biological integration with the irregular bone defect surface and the acetabular cup prosthesis, and the three-point anchoring support is more stable due to the improvement of the load-bearing beam unit structure.

[0012] Optionally, the shank of the fixation nail is provided with a bone cement anchoring structure for enhancing the bonding force with the bone cement. The surface area of ​​the bone cement anchoring structure is larger than the surface area of ​​the bone thread of the fixation nail shank for screwing into the host bone, and the surface of the bone cement anchoring structure has a conical structure.

[0013] By adopting the above technical solution, the bone cement anchoring structure in the fixation pin shaft enhances the bonding force with the bone cement. Its conical surface increases the contact area with the bone cement compared to ordinary flat or simple shapes, resulting in a tighter and more secure bond. In practical applications, when the bone cement is bonded to the fixation pin, the conical structure allows the bone cement to better encapsulate and adhere to the pin, effectively preventing separation and further improving the stability of the fixation pin in the acetabular bone defect repair system. This provides more reliable support for the acetabular cup prosthesis, facilitating anatomical matching and long-term biological integration with irregular bone defect surfaces and the acetabular cup prosthesis.

[0014] Optionally, the bone cement anchoring structure is a threaded groove provided along the rod portion; the threaded groove is provided with a bioactive coating or a trabecular interface.

[0015] By adopting the above technical solution, the threaded groove along the fixation pin shaft serves as a bone cement anchoring structure, significantly enhancing the bonding force with bone cement. Compared to a conventional shaft structure, the threaded groove increases the contact area with bone cement, making the bond more stable. Simultaneously, the bioactive coating or trabecular interface on the threaded groove exhibits excellent biocompatibility, promoting bone tissue growth and attachment. This allows for better fusion of bone tissue with the fixation pin, further improving the stability and long-term fixation effect of the fixation pin within the bone. This contributes to improving the overall performance of the acetabular bone defect repair system, better securing the acetabular cup prosthesis, and providing more reliable support for patient rehabilitation.

[0016] Optionally, an inclusive pad membrane, made of a flexible biocompatible material, is also included, which is laid within the acetabular bone defect area and placed between the bone tissue and the malleable composite module to define, together with the host bone, the filling space for restraining the malleable composite module.

[0017] By employing the above-mentioned technical solution, the inclusive membrane, made of a flexible biocompatible material, is laid within the acetabular bone defect area and positioned between the bone tissue and the malleable composite module. Together with the host bone, it defines the filling space for confining the malleable composite module. This design offers several advantages. The flexible material allows it to conform to irregular bone defect surfaces, effectively preventing the malleable composite module from overflowing and ensuring the precision of the filling area. The biocompatible material reduces rejection reactions with human tissues, improving post-implantation safety and stability. Defining the filling space helps to accurately fill the required area with the malleable composite module, better achieving anatomical matching with irregular bone defect surfaces and the acetabular cup prosthesis, thereby promoting long-term biological integration, providing stable support for the acetabular cup prosthesis, and improving the overall performance and repair effect of the acetabular bone defect repair system.

[0018] Optionally, the inclusive pad membrane is a flexible mesh that forms a three-dimensional biomimetic folded structure with the mating surface of the bone structure, so that the inclusive pad membrane can conform to the irregular bone surface and form a three-dimensional interlocking interface after solidification with the malleable composite.

[0019] By adopting the above technical solution, the three-dimensional biomimetic wrinkled structure refers to a non-uniform, random, or multi-scale undulating morphology on the surface of the pad membrane that mimics the arrangement of bone trabeculae. The depth, spacing, and direction of the wrinkles are configured to conform to the geometry of the host bone defect surface and deform accordingly. After the composite material is cured, it interlocks with the pad membrane, designing the inclusive pad membrane as a three-dimensional biomimetic wrinkled mesh structure, which has significant advantages. First, it can fit well with irregular bone surfaces and closely adapt to the complex surface of the bone defect area, avoiding gaps in the fit and improving the compatibility between the repair system and bone tissue. Second, after the mesh body and the malleable composite are cured, they form a three-dimensional interlocking interface. This interlocking structure greatly enhances the bonding force and stability between the inclusive pad membrane and the malleable composite, making them a solid whole. During long-term use, it can effectively prevent the malleable composite from shifting or loosening, ensuring the reliability and durability of the acetabular bone defect repair system, thereby better realizing the repair and reconstruction of acetabular bone defects.

[0020] Optionally, the material used to make the containable pad membrane is selected from one or more of polyethylene woven fabric, carbon fiber woven fabric, metal soft armor, or malleable titanium alloy foil.

[0021] By adopting the above technical solution, the malleable composite module of the acetabular bone defect repair system is made of porous metal particles mixed with bone cement, which can flow and fill the space in the acetabular bone defect area; the biomimetic support frame module forms a three-point anchoring support through load-bearing beam units, providing mechanical support for the malleable composite module and the acetabular cup prosthesis and forming an integrated load-bearing structure; if the containment membrane is made of one or more of polyethylene woven fabric, carbon fiber woven fabric or malleable titanium alloy foil, because polyethylene woven fabric has good compatibility with human tissue, carbon fiber woven fabric has specific properties, and malleable titanium alloy foil has certain shaping properties and support, they help the containment membrane to fit the irregular bone surface, define the filling space with the host bone, and form a three-dimensional interlocking interface after curing, thereby better binding the malleable composite module and achieving anatomical matching and long-term biological integration with the irregular bone defect surface and the acetabular cup prosthesis.

[0022] Optionally, the porous metal particles are titanium or titanium alloy trabecular bone structure particles with three-dimensional interconnected pores and a particle size of 2mm to 8mm; the volume ratio of the porous metal particles to bone cement is selected from: first-grade blending ratio of 5% to 15%, second-grade density blending ratio of 15% to 40%, and third-grade density blending ratio of 40% to 80%.

[0023] By employing the above-mentioned technical solution, titanium or titanium alloy trabecular bone structure particles with three-dimensional interconnected pores and a particle size of 2mm to 8mm are selected. This allows the porous metal particles to form a porous structure conducive to bone ingrowth after mixing with bone cement, promoting the biological integration of bone tissue and repair materials. Simultaneously, three different volumetric mixing ratios are provided: low-density mixing ratio 5%–15%, medium-density mixing ratio 15%–40%, and high-density mixing ratio 40%–80%. The appropriate mixing ratio can be flexibly selected based on the specific circumstances of the patient's acetabular bone defect, such as defect size, location, and bone quality. For mild defects, a low-density mixing ratio can be used to reduce material usage, while for severe defects, a high-density mixing ratio can be used to enhance the strength and stability of the repair structure. This achieves personalized acetabular bone defect repair, improving repair outcomes and the patient's rehabilitation quality.

[0024] Optionally, the malleable composite module is provided as a separate unit kit, which includes porous metal particle units encapsulated to a predetermined mass and corresponding bone cement units.

[0025] By adopting the above technical solution, the malleable composite module is provided as an independent unit kit, containing porous metal particle units and corresponding bone cement units packaged to a predetermined weight. This design greatly facilitates surgical procedures. During surgery, surgeons can quickly select the appropriate unit kit based on the patient's specific acetabular bone defect, eliminating the need for on-site weighing and mixing of porous metal particles and bone cement, thus saving surgical time. Simultaneously, the predetermined weight packaging ensures the accuracy and stability of the material ratio, making the malleable composite module more reliable. This contributes to the formation of a stable, integrated load-bearing structure, better achieving anatomical matching and long-term biological integration with irregular bone defect surfaces and the acetabular cup prosthesis, thereby improving the effectiveness and quality of acetabular bone defect repair.

[0026] In summary, this application includes at least one of the following beneficial technical effects: The malleable composite module and the biomimetic support frame module of this application form a mechanically interlocked integrated load-bearing structure, which can achieve anatomical matching and long-term biological integration with irregular bone defect surfaces and acetabular cup prostheses, solving the problem that existing methods are difficult to achieve anatomical reduction. The load-bearing beam unit of the biomimetic support frame module of this application forms a three-point anchoring support, which conforms to the biomechanical characteristics of the pelvis and can simulate the supporting function of the human acetabulum, providing a robust and durable support structure for the acetabular cup prosthesis and improving postoperative stability. The malleable composite module of this application is provided as an independent unit kit, which is convenient to select during surgery, simplifies the surgical procedure, shortens the operation time, and solves the problems of traditional block prosthesis surgery being time-consuming, labor-intensive, and demanding on physicians. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the arrangement structure of the acetabulum and acetabular cup prosthesis described in Embodiment 1; Figure 2 This is a schematic diagram of the arrangement structure of the encapsulated pad membrane described in Embodiment 1; Figure 3 This is a schematic diagram of the layout structure of the acetabular bone defect repair system described in Embodiment 1; Figure 4 This is a schematic diagram of the porous metal particle unit described in Embodiment 1; Figure 5 This is a schematic diagram of the arrangement structure of the biomimetic support frame module described in Embodiment 1; Figure 6 This is a schematic diagram of the cone-shaped surface structure of the fixed nail-bone cement anchoring structure described in Embodiment 1; Figure 7 This is a schematic diagram of the cylindrical surface structure of the fixed nail-bone cement anchoring structure described in Embodiment 1; Figure 8This is a schematic diagram of the porous metal particles described in Example 1; Figure 9 This is a schematic diagram of the bone cement unit described in Embodiment 1.

[0028] In the diagram: 1. Acetabular cup prosthesis; 2. Bionic support frame module; 21. Fixation screw; 211. Bone thread; 212. Threaded groove; 22. Metal skeleton; 213. Internal hexagonal head; 221. Transverse metal rib; 222. Longitudinal metal rib; 23. Containing pad; 3. Molded composite module; 31. Porous metal particles; 32. Bone cement; 4. Acetabular bone; 41. Iliac bone; 42. Ischium; 43. Pubis; 5. Porous metal particle unit; 6. Bone cement unit. Detailed Implementation

[0029] The technical solutions of various embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application. Example

[0030] Reference Figures 1 to 3 This application discloses a system for repairing acetabular bone defects, comprising: The malleable composite module is composed of a flowable composite material made by mixing porous metal particles and bone cement in a predetermined volume mixing ratio. The acetabular cup prosthesis has a groove that mimics the lunate surface of the acetabulum and is configured to be positioned in the acetabular region after implantation. The biomimetic support frame module is configured to be positioned within the acetabular bone defect area after implantation to provide mechanical support for the malleable composite module and the acetabular cup prosthesis. The biomimetic support frame module provides initial mechanical stability and has a spatial structure for the infiltration and curing of flowable composite materials. After the flowable composite materials are cured in the acetabular bone defect area, they form a mechanically interlocked integrated support structure with the biomimetic support frame module. The integrated support structure provides support for the acetabular cup prosthesis to achieve anatomical matching and long-term biological integration between the acetabular cup prosthesis and the irregular bone defect surface.

[0031] Specifically, refer to Figures 3 to 4The porous metal particles are titanium or titanium alloy trabecular bone structure particles with three-dimensional interconnected pores. This structure can increase the contact area with bone cement and improve the stability after mixing. The particle size is 2mm to 8mm. The similar particles that can be replaced can be other metal particles with similar pore structure and particle size range, such as tantalum metal particles. There are various options for the volume ratio of porous metal particles to bone cement, including low-density blending ratios of 5%–15%, medium-density blending ratios of 15%–40%, and high-density blending ratios of 40%–80%, which can be selected according to the patient's different bone conditions. Among them, the lower the density blending ratio, the stronger the toughness of the material, and the higher the density blending ratio, the greater the stiffness of the material. Experimental verification shows that when the particle size is less than 1 mm, the mixture absorbs liquid and thickens rapidly due to its excessive specific surface area, and the operable time is less than 3 minutes, which cannot meet the needs of surgery. When the particle size is greater than 8 mm, the fluidity of the mixture decreases significantly, making it difficult to inject into complex defect areas. The mixture is usable in the range of 1 mm to 10 mm, with the 2 mm to 8 mm range showing good overall performance, while the 3 mm to 5 mm range achieves the best balance in terms of fluidity, operable time, final strength, and osteogenic capacity.

[0032] Reference Figures 3 to 4 Bone cement is usually polymethyl methacrylate (PMMA) bone cement, which is commonly used in clinical practice. It has good flowability and curing properties and can form a flowable composite material when mixed with porous metal particles.

[0033] Reference Figures 3 to 4 This paper specifically describes the combination logic and effect of porous metal particles and bone cement that make up the malleable composite module. When the two are mixed at a predetermined volume mixing ratio, the bone cement fills the pores of the porous metal particles to form a monolithic flowable composite material. Before curing, the composite material can be easily filled into the acetabular bone defect area, and the presence of porous metal particles increases the strength and stability of the composite material. After curing, the composite material can better integrate with the surrounding bone tissue and biomimetic support frame module, playing a role in fixing the acetabular cup prosthesis. This is because the three-dimensional interconnected pores of the porous metal particles provide space for bone tissue ingrowth, which is conducive to long-term biological integration, while the bone cement ensures the fluidity and stability of the composite material during filling and curing.

[0034] Reference Figures 3 to 4 The dorsal side of the acetabular cup prosthesis is a hemispherical curved surface, and the dorsal surface can be provided with a multi-layered porous coating. The pore size of the porous coating can be between 100 and 800 μm, which facilitates the infiltration of uncured flowable composite material to form a tenon-and-mortise micro-mechanical interlock, and is also conducive to the secondary biological fixation of bone tissue ingrowth in the later stage. According to finite element analysis simulation, under this design, the micro-movement distance between the interface between the acetabular cup prosthesis and the integrated support structure is less than 50 μm, which meets the initial stability requirements for bone ingrowth.

[0035] Reference Figures 3 to 4 The load-bearing beam unit is constructed with extensions that correspond to and can extend along the iliac, ischium and pubis of the human body to form a three-point anchoring support. This design based on human anatomy conforms to the biomechanical characteristics of the pelvis and can better simulate the supporting role of the human acetabulum, providing more stable mechanical support for the acetabular cup prosthesis. Of course, single-point anchoring support can also be used when the acetabular bone defect is not severe.

[0036] Reference Figures 3 to 4 The description specifically details the combination logic and effects of the load-bearing beam units that make up the biomimetic support frame module. The metal skeleton is fixed to the host bone by fixation pins, forming a stable frame structure. The flowable composite material is infiltrated into the grid frame of the metal skeleton and, after curing, forms an integral part with the metal skeleton, further enhancing the strength and stability of the load-bearing beam units. The three-point anchoring support design allows the load-bearing beam units to evenly distribute the pressure borne by the acetabular cup prosthesis, reducing local stress concentration and thus improving the stability and service life of the entire repair system. At the same time, the bone cement anchoring structure and bioactive coating or trabecular interface on the fixation pins are conducive to bone tissue ingrowth and fixation, promoting biological integration.

[0037] Reference Figures 3 to 4 The inclusive pad membrane is a flexible mesh with a surface that can be woven into a three-dimensional biomimetic wrinkled structure. This structure can conform to irregular bone surfaces and form a three-dimensional interlocking interface after solidification with the malleable composite. The material used to make it is selected from one or more of polyethylene woven fabric, carbon fiber woven fabric, or malleable titanium alloy foil. Polyethylene woven fabric has good flexibility and biocompatibility, and can better conform to bone surfaces; carbon fiber woven fabric has high strength and modulus, which can enhance the overall performance of the inclusive pad membrane; malleable titanium alloy foil has good plasticity and biocompatibility. Of course, metal soft armor made using relatively mature 3D printing technology can also be used.

[0038] Reference Figures 5 to 7 The load-bearing beam unit includes a metal skeleton and fixation pins for securing the skeleton to the host bone. The metal skeleton has a grid framework for the infiltration of flowable composite materials, including several staggered transverse and longitudinal metal ribs. The transverse and longitudinal metal ribs are typically made of titanium alloy, which has good biocompatibility and mechanical properties. The staggered arrangement of the transverse and longitudinal metal ribs forms a grid structure, which not only provides space for the infiltration of flowable composite materials but also enhances the overall strength of the metal skeleton. An alternative metal skeleton structure can be a honeycomb structure, which can also achieve the functions of allowing flowable composite materials to infiltrate and providing mechanical support.

[0039] Reference Figures 5 to 7The fixation screw has a bone cement anchoring structure on its shaft to enhance bonding with bone cement. The surface area of ​​the bone cement anchoring structure is larger than the surface area of ​​the bone threads on the shaft for screwing into the host bone, and the surface of the bone cement anchoring structure is conical. Of course, in general, the surface of the bone cement anchoring structure can also be cylindrical. To facilitate screwing in, an internal hexagonal head is provided at the tail of the fixation screw. The bone cement anchoring structure is a threaded groove along the shaft, and the threaded groove is coated with a bioactive coating or a trabecular interface. The bioactive coating can be Ti sprayed, HA sprayed, or a mixture of Ti and HA sprayed, etc. The trabecular interface can be realized by 3D printing technology. This design allows the fixation screw to better bond with bone cement, enhancing the fixation effect. The tip of the fixation screw has a traditional titanium screw thread, which can be implanted into good bone as a bone screw to play a fixation role.

[0040] Reference Figures 8 to 9 The malleable composite module is provided as a separate unit kit, which contains porous metal particle units packaged to a predetermined weight and corresponding bone cement units, allowing for easier mixing during surgery.

[0041] The implementation principle of this embodiment is as follows: This acetabular bone defect repair system, through the synergistic effect of the malleable composite module, the biomimetic support frame module, and the inclusive pad membrane, solves the shortcomings of existing acetabular defect repair technologies when dealing with complex and severe defects. The malleable composite module, formed by mixing porous metal particles with bone cement to create a flowable composite material, can be easily filled into irregular acetabular bone defect areas before curing, and forms a good bond with surrounding bone tissue, the biomimetic support frame module, and the inclusive pad membrane after curing. The three-point anchoring support design and unique fixation nail structure of the biomimetic support frame module provide stable mechanical support and good fixation for the acetabular cup prosthesis. The addition of the inclusive pad membrane further optimizes the repair system, improving its bonding strength with bone tissue and its matching degree with the bone defect surface. This design achieves anatomical matching and long-term biological integration with the irregular bone defect surface and the acetabular cup prosthesis, greatly improving the stability and service life of the repair system, reducing the complexity and difficulty of surgery, and reducing patient pain and economic burden. Example

[0042] Reference Figures 1 to 3 This application also discloses a method for repairing acetabular bone defects, utilizing the acetabular bone defect repair system described in the above embodiments, specifically including the following steps: S1. In vitro, porous metal particles are mixed with bone cement at a predetermined volume mixing ratio to form a flowable composite material. S2. Locate the acetabulum, reshape and ream it, and implant a suitable acetabular cup. S3. Perform "foundation repair" on the defect area by laying an inclusive membrane. The inclusive membrane, made of flexible biocompatible material, is laid in the acetabular bone defect area, placing it between the bone tissue and the subsequent malleable composite module to be filled. The inclusive membrane and the host bone jointly define the filling space for binding the malleable composite module. The inclusive membrane has fixing holes and is initially fixed with nails. S4. Implant the bionic support frame module, and implant the tip of the fixing nail of the load-bearing beam unit into the appropriate position of the host bone through the traditional titanium nail thread, so that the metal skeleton is fixed to the host bone by the fixing nail to form a stable frame structure; note that the extension of the load-bearing beam unit should correspond to and be able to extend along the direction of the iliac bone, ischium and pubis to form a three-point anchoring support. S5. Fill the defect area of ​​the cover-enclosing pad membrane with the flowable composite material and flexibly shape it until it abuts the acetabular cup. S6. Wait for the flowable composite material to compact and solidify. After solidification, it will bond to the acetabular cup prosthesis as a whole. Grind the sharp edges and repair any excess material.

[0043] The implementation principle of this application embodiment is as follows: the method follows a reasonable sequence of steps, first implanting the acetabular cup, then constructing a support structure, then filling and shaping a flowable composite material, and finally waiting for the material to cure and bond with the acetabular cup as one piece; in this way, acetabular bone defects can be effectively repaired, achieving anatomical matching and long-term biological integration with the irregular bone defect surface and the acetabular cup prosthesis, improving the stability and service life of the repair system, and reducing the complexity and difficulty of the surgery.

[0044] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the technical solutions of the embodiments of this application.

Claims

1. A system for repairing acetabular bone defects, characterized in that, include: The malleable composite module is composed of a flowable composite material made by mixing porous metal particles and bone cement in a predetermined volume mixing ratio. The acetabular cup prosthesis has a groove that mimics the lunate surface of the acetabulum and is configured to be positioned in the acetabular region after implantation. The biomimetic support frame module is configured to be positioned within the acetabular bone defect area after implantation, and is used to provide mechanical support for the malleable composite module and the acetabular cup prosthesis. The biomimetic support frame module provides initial mechanical stability and has a spatial structure for the infiltration and curing of the flowable composite material. After the flowable composite material is cured in the acetabular bone defect area, it forms a mechanically interlocked integrated support structure with the biomimetic support frame module. The integrated support structure provides support for the acetabular cup prosthesis to achieve anatomical matching and long-term biological integration between the acetabular cup prosthesis and the irregular bone defect surface.

2. The acetabular bone defect repair system according to claim 1, characterized in that, The biomimetic support frame module includes at least one load-bearing beam unit, which is configured to have extensions that correspond to and can extend along the iliac, ischium and pubis of the human body to form a three-point anchoring support.

3. The acetabular bone defect repair system according to claim 2, characterized in that, The load-bearing beam unit includes a metal frame and fixation pins for fixing the frame to the host bone; the metal frame has a grid frame for the infiltration of the flowable composite material, including a plurality of staggered transverse and longitudinal metal ribs.

4. The acetabular bone defect repair system according to claim 3, characterized in that, The shank of the fixation nail is provided with a bone cement anchoring structure to enhance the bonding force with the bone cement. The surface area of ​​the bone cement anchoring structure is larger than the surface area of ​​the bone thread of the fixation nail shank for screwing into the host bone, and the surface of the bone cement anchoring structure has a conical structure.

5. The acetabular bone defect repair system according to claim 4, characterized in that, The bone cement anchoring structure is a threaded groove provided along the rod; the threaded groove is provided with a bioactive coating or a trabecular interface.

6. The acetabular bone defect repair system according to claim 1, characterized in that, It also includes an inclusive pad membrane made of a flexible biocompatible material, which is laid in the acetabular bone defect area and placed between the bone tissue and the malleable composite module to define, together with the host bone, the filling space for binding the malleable composite module.

7. The acetabular bone defect repair system according to claim 6, characterized in that, The containable pad is a flexible mesh that forms a three-dimensional biomimetic folded structure with the mating surface of the bone structure, so that the containable pad can conform to the irregular bone surface and form a three-dimensional interlocking interface after solidification with the malleable composite.

8. The acetabular bone defect repair system according to claim 6, characterized in that, The material used to make the containable membrane is selected from one or more of polyethylene woven fabric, carbon fiber woven fabric, or shaped titanium alloy foil.

9. The acetabular bone defect repair system according to claim 1, characterized in that, The porous metal particles are titanium or titanium alloy trabecular bone structure particles with three-dimensional interconnected pores and a particle size of 2mm to 8mm; the volume ratio of the porous metal particles to bone cement is selected from: low density blending ratio 5% to 15%, medium density blending ratio 15% to 40%, and high density blending ratio 40% to 80%.

10. The acetabular bone defect repair system according to claim 9, characterized in that, The malleable composite module is provided as a separate unit kit, which includes porous metal particle units packaged to a predetermined mass and corresponding bone cement units.

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