Application of tangeretin in preparation of hearing loss treatment medicine
By using drugs prepared with hesperidin to protect spiral ganglion neurons, the problem of sensorineural hearing loss caused by chemotherapy drugs has been solved, and effective prevention and treatment of ototoxicity have been achieved.
CN121846079APending Publication Date: 2026-04-14NANJING DRUM TOWER HOSPITAL
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-13
- Publication Date
- 2026-04-14
AI Technical Summary
Technical Problem
Existing chemotherapy drugs such as cisplatin cause ototoxicity leading to sensorineural hearing loss, and there is a lack of effective protective and treatment methods.
Method used
Using hesperidin as the active ingredient, drugs are prepared to prevent or treat sensorineural hearing loss, protect spiral ganglion neurons and hair cells, and prevent cisplatin-induced cell death.
Benefits of technology
Hesperidin significantly protects spiral ganglion neurons and prevents hearing loss induced by ototoxic drugs. Experimental data show that it can effectively prevent hearing loss in adult mice, providing a new approach to the clinical use of ototoxic drugs.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN121846079A_ABST
Abstract
The invention discloses application of tangeretin in preparation of a medicine for treating hearing loss. The invention proposes and verifies that the tangeretin can effectively protect the spiral ganglion neurons for the first time, and avoids the death of the cells caused by cisplatin medication; experimental data show that the preventive tangeretin drug can effectively prevent hearing loss of adult mice and greatly relieve sensorineural deafness caused by cis-platinum, and a new thought is provided for clinical ototoxicity drug administration.
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