Traditional Chinese medicine composition for treating rhinitis and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating rhinitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of radix ophiopogonis, 6-10 parts of radix scrophulariae, 4-8 parts of angelica sinensis, 3-6 parts of flos magnoliae, 2-4 parts of mint, 3-6 parts of dendrobium officinale, 2-4 parts of cicada slough and 2-5 parts of rhizoma bletillae. The treatment principle of moistening dryness and promoting salivation, nourishing blood and promoting tissue regeneration, and clearing and dredging orifices is clung. The traditional Chinese medicine is mainly used for nourishing yin and moistening dryness, and the source of dry noses is solved; the root of atrophy is solved by nourishing blood and activating blood as an assistant; and wind dispelling and orifice opening are assisted, so that the problem of nasal obstruction is solved. All the medicines are combined and tonification and purgation are combined, so that yin liquid is filled, qi and blood are promoted, and nasal orifices are self-dredged.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for the treatment of rhinitis and its preparation method. Background Technology

[0002] Rhinitis is a common and frequently occurring disease in otolaryngology. With the changing modern environment and climate, the widespread use of air conditioning, and the overuse of vasoconstrictors (such as oxymetazoline hydrochloride), the proportion of patients with "dry rhinitis" and "atrophic rhinitis" is on the rise in clinical practice. These patients experience atrophy of the nasal mucosal glands and reduced secretion, manifesting as extreme nasal dryness, crusting, decreased sense of smell, nosebleeds, and discomfort in the nasopharynx.

[0003] Traditional Chinese medicine treatments often focus on "warming the lungs and dispelling cold" (such as Xanthium sibiricum powder) or "clearing heat and detoxifying" (such as Scutellaria baicalensis and Chrysanthemum indicum). However, for patients with yin deficiency and dryness-heat, using pungent, warm, and drying herbs can further deplete lung yin, leading to aggravated symptoms; simply clearing heat can easily damage stomach qi and is difficult to repair atrophied mucosal tissue. Therefore, developing a Chinese medicine composition with the core principles of "moistening dryness and generating fluids, nourishing blood and promoting tissue regeneration, and gently clearing the nasal passages" is of great significance for rebuilding the nasal mucosal barrier function.

[0004] In order to solve the problem of nasal dryness and atrophy, existing technologies mostly use oral decoctions (such as Yangyin Qingfei Decoction) and oils or ointments (such as compound peppermint oil). Although oral decoctions can nourish yin, the effective concentration of the drug reaching the nasal cavity is low after being metabolized in the digestive tract, and the course of treatment is long, resulting in poor patient compliance. Although oils or ointments can temporarily seal and moisturize, the oil matrix can easily block the movement of nasal mucosal cilia, and the extracts of Chinese medicine are often unstable in the oil phase, resulting in low bioavailability.

[0005] In contrast, the direct application or inhalation of ultrafine powders of traditional Chinese medicine offers advantages such as a large specific surface area, strong adhesion, and rapid onset of action. However, currently, there are few similar ultrafine powder products available. The specific reason is that existing equipment cannot process materials that target the symptoms: for example, Ophiopogon japonicus and Scrophularia ningpoensis contain large amounts of mucilage and polysaccharides, exhibiting high viscosity. During room temperature grinding, these components soften upon heating, becoming like "taffy," instantly adhering to the grinding disc and sieve, resulting in a "sticky residue." Angelica sinensis is rich in volatile oils. Under high-speed impact, the oils seep out and mix with the powder to form "oil sludge," which is extremely prone to oxidation and spoilage (rancidity). Magnolia biondii and Mentha haplocalyx contain volatile pore-opening components (such as menthol) with low boiling points; the high temperatures (>50℃) generated by conventional grinding will cause them to evaporate completely. Summary of the Invention

[0006] The purpose of this invention is to provide a traditional Chinese medicine composition for the treatment of rhinitis, which solves the technical problem that existing ultrafine powders are not effective for rhinitis symptoms such as nasal dryness and atrophy; the purpose of this invention is also to provide a method for preparing the traditional Chinese medicine composition.

[0007] The technical solution of the traditional Chinese medicine composition for treating rhinitis of the present invention is as follows:

[0008] The traditional Chinese medicine composition used to treat rhinitis is made from the following raw materials in parts by weight:

[0009] 8-12 parts of Ophiopogon japonicus, 6-10 parts of Scrophularia ningpoensis, 4-8 parts of Angelica sinensis, 3-6 parts of Magnolia biondii, 2-4 parts of Mentha haplocalyx, 3-6 parts of Dendrobium officinale, 2-4 parts of Cicadae periostracum, and 2-5 parts of Bletilla striata.

[0010] Furthermore, the traditional Chinese medicine composition is a powder with a particle size D90 of less than 75 μm.

[0011] A method for preparing a traditional Chinese medicine composition includes the following steps:

[0012] S1. Prepare materials: Weigh each raw medicinal material according to the weight parts, and coarsely crush and mix them;

[0013] S2. Packing: The mixed medicinal materials and solid carbon dioxide particles are loaded into the ball mill jar.

[0014] S3. Grinding and self-cleaning pressure relief: Seal the ball mill tank cover, start the ball mill, and during the grinding process, use solid carbon dioxide sublimation to maintain the low temperature inside the tank, and discharge the sublimation gas through the dual-channel alternating dust removal component on the ball mill tank cover.

[0015] S4. Post-processing: collect the powder and sieve it.

[0016] In S3, the ball mill jar cover includes a cover body and a suspended isolation plate disposed in the cover body, a switching mechanism located above the suspended isolation plate, and a vibration probe connected to the suspended isolation plate and extending into the jar.

[0017] The isolation plate is divided into at least two independent air-permeable zones, including at least a first air-permeable zone and a second air-permeable zone, and each air-permeable zone is sealed with an air-permeable membrane.

[0018] During grinding, the grinding medium impacts the vibration probe, causing the suspended isolation plate to vibrate. The switching mechanism selectively blocks the first air-permeable zone and opens the second air-permeable zone, then switches to opening the first air-permeable zone and blocking the second air-permeable zone. This allows the air-permeable membrane in the blocked air-permeable zone to shake off the attached powder as the suspended isolation plate vibrates without airflow adsorption.

[0019] Furthermore, the suspended isolation plate is suspended and installed in the cover body by an elastic damping element, and an anti-rotation positioning structure is provided between the suspended isolation plate and the cover body to make the isolation plate float along the axial direction.

[0020] Furthermore, the switching mechanism includes a drive shaft passing through the center of the isolation plate, a fan-shaped shielding plate fixed on the shaft, and a self-locking elastic element disposed between the drive shaft and the isolation plate; the self-locking elastic element applies a force to the shielding plate to move towards the isolation plate, so that when the vibration probe is impacted, the fan-shaped shielding plate and the suspended isolation plate remain in close contact and vibrate synchronously.

[0021] Furthermore, a clearance hole is provided at the center of the cover, the drive shaft extends upward through the clearance hole, and a screwing head is provided at the upper end of the drive shaft.

[0022] Furthermore, the elastic damping element consists of two rubber O-rings, located at the upper and lower edges of the suspension isolation plate, respectively, which clamp the suspension isolation plate and suspend it in the countersunk hole inside the cover body.

[0023] Furthermore, in step S2, the mass ratio of solid carbon dioxide to medicinal materials is 1:2 to 1:1; in step S3, the switching frequency of the switching mechanism is once every 10-20 minutes.

[0024] Furthermore, the vibration probe consists of several probes distributed on the lower surface of the suspended isolation plate, and the probes are made of titanium alloy.

[0025] Furthermore, the breathable membrane is an e-PTFE waterproof and breathable membrane with a pore size of 0.1-0.5μm, and is supported by a rigid breathable support mesh for back pressure.

[0026] Analysis of the medicinal properties and efficacy of each component of this invention:

[0027] Ophiopogon japonicus: Sweet and slightly bitter in taste, slightly cold in nature. It enters the heart, lung, and stomach meridians. It has the effects of nourishing yin and promoting body fluid production, moistening the lungs and clearing the heart. In this formula, it is the core principal herb, utilizing its rich polysaccharide components to directly replenish nasal fluid and repair the damaged mucus blanket.

[0028] Scrophularia: Sweet, bitter, and salty in taste, slightly cold in nature. It enters the lung, stomach, and kidney meridians. It has the effects of clearing heat and cooling blood, nourishing yin and detoxifying. Its salty and cold nature can enter the blood and eliminate nasal congestion and chronic inflammation caused by yin deficiency and fire excess.

[0029] Angelica sinensis: sweet and pungent in taste, warm in nature. It enters the liver, heart, and spleen meridians. It has the effects of nourishing blood, promoting blood circulation, regulating menstruation, and relieving pain. The atrophy of the nasal mucosa is essentially due to local malnourishment of qi and blood. Angelica sinensis can improve microcirculation and promote the growth of granulation tissue, reflecting the principle that "blood nourishes flesh."

[0030] Dendrobium officinale: Sweet in taste, slightly cold in nature. It enters the stomach and kidney meridians. It has the effects of nourishing the stomach and promoting the production of body fluids, nourishing yin and clearing heat. Dendrobium polysaccharides have extremely strong film-forming and moisturizing properties, which can assist Ophiopogon japonicus in forming a protective layer on the nasal mucosa surface, preventing moisture evaporation.

[0031] Magnolia flower bud: pungent and warm in nature. It enters the lung and stomach meridians. It has the effects of dispersing wind-cold and clearing nasal passages. Its volatile oil can constrict blood vessels in the nasal mucosa, improve nasal congestion, and guide other medicines upward to the nasal passages.

[0032] Peppermint: pungent and cool in flavor. It enters the lung and liver meridians. It has the effects of dispersing wind-heat, clearing the head and eyes, and promoting rash eruption. Menthol has a cooling and analgesic effect and can relieve the burning sensation of the nasal mucosa.

[0033] Cicada molting: Sweet in taste and cold in nature. It enters the lung and liver meridians. It has the effects of dispersing wind-heat, relieving sore throat and hoarseness, promoting rash eruption, improving eyesight and clearing away corneal opacity, and relieving spasms. Its unique anti-allergic effect can effectively relieve symptoms of allergic reactions such as nasal itching and sneezing.

[0034] Bletilla striata: Bitter, sweet, and astringent in taste, slightly cold in nature. It enters the lung, liver, and stomach meridians. It has the effects of astringing and stopping bleeding, reducing swelling and promoting tissue regeneration. For epistaxis and ulcers often accompanied by dry rhinitis, Bletilla striata can promote the healing of fissures.

[0035] The principles of this invention:

[0036] The formulation of this invention strictly follows the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide" in drug formulation. The components complement each other in terms of medicinal properties and achieve deep integration in terms of microscopic physical structure through ultra-fine pulverization.

[0037] The principal herbs (Ophiopogon japonicus and Scrophularia ningpoensis) nourish yin and moisten dryness; the assistant herbs (Angelica sinensis, Dendrobium officinale, and Bletilla striata) nourish blood and promote tissue regeneration; the adjuvant herbs (Magnolia biondii and Cicadae periostracum) open the orifices and relieve allergies; and the guiding herb (Mentha haplocalyx) guides the medicine upwards and clears the orifices. When used together, these herbs work synergistically to nourish yin, moisten dryness, invigorate blood, and open the orifices.

[0038] The herbal composition of this invention closely adheres to the treatment principles of "moistening dryness and generating fluids, nourishing blood and promoting tissue regeneration, and gently clearing the nasal passages." The entire formula is based on nourishing yin and moistening dryness to address the root cause of "nasal dryness"; it is supplemented by nourishing blood and promoting blood circulation to address the root cause of "nasal atrophy"; and it is further supplemented by dispelling wind and clearing the nasal passages to address the symptom of "nasal congestion." The combined effects of these herbs, employing both tonifying and purging methods, replenish yin fluids, promote the flow of qi and blood, and naturally clear the nasal passages.

[0039] The beneficial effects of this technical solution: This composition adopts a combination of yin-nourishing and dryness-moistening with blood-activating and orifice-opening methods, which differs from the traditional approach of formulating prescriptions that primarily focus on warming and drying or clearing heat. It creatively combines yin-nourishing herbs (Ophiopogon japonicus, Scrophularia ningpoensis, Dendrobium nobile) with blood-activating herbs (Angelica sinensis) and orifice-opening herbs (Magnolia biondii, Cicadae periostracum). In particular, by utilizing micro-pulverization technology, the fat-soluble components of Angelica sinensis and the hydrophilic components of Ophiopogon japonicus and Dendrobium nobile undergo physical fusion at the micron scale, forming an oil-sugar microcapsule structure with sustained-release properties. This structure can rapidly absorb water, spread, and provide long-lasting hydration upon contact with the nasal mucosa, significantly improving the bioavailability of the drug. Attached Figure Description

[0040] Figure 1This is a schematic diagram of the structure of a grinding jar specifically used in the preparation method of the traditional Chinese medicine composition of the present invention; Figure 2 for Figure 1 Schematic diagram of the structure during an explosion; Figure 3 for Figure 1 A half-section view; Figure 4 for Figure 1 Another perspective half-section view; Figure 5 for Figure 2 A schematic diagram of the structure of the suspended isolation plate in the middle; Figure 6 for Figure 2 Schematic diagram of the structure of the central sector-shaped shielding plate; Figure 7 for Figure 2 A schematic diagram of the assembly structure of the waterproof and breathable membrane.

[0041] In the diagram: 1 - Tank; 2-Cover body; 21-Counterhead; 22-Allowance hole; 23-Positioning pin; 24-Pressure relief hole; 25-Sealing ring; 3-Suspended isolation plate; 31-First ventilation zone; 32-Second ventilation zone; 33-Anti-rotation notch; 34-Exhaust hole; 35-Probe; 4-Drive shaft; 41-Screwing head; 5-Fan-shaped shielding plate; 51-Sealing gasket layer; 6-Self-locking elastic element; 61-Pressure plate; 62-Rubber sealing ring; 7-Elastic damping element; 8-Waterproof and breathable membrane; 81-Rigid support mesh; 82-Locking ring. Detailed Implementation

[0042] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention; that is, the described embodiments are merely some embodiments of the invention, and not all embodiments. The components of the embodiments of the invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0043] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0044] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0045] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0046] Specific embodiments of the preparation method of the present invention:

[0047] While existing dry ice cryogenic pulverization technology can reduce grinding temperature, during continuous degassing, the airflow will firmly adsorb light and sticky powders onto the filter membrane surface to form a filter cake, causing instantaneous blockage of the pressure relief channel. Simple vibration cannot overcome the continuous aerodynamic adsorption force, making it impossible for the equipment to operate continuously and safely.

[0048] The key to the formation of the traditional Chinese medicine composition of the present invention lies in the use of a special ball mill jar with self-cleaning function. The core of the design of this device is to solve the technical problem of how to achieve continuous degassing and prevent micron-sized powder from clogging the filter membrane in a fully enclosed dry ice low-temperature grinding environment.

[0049] Specifically, an embodiment of this dedicated grinding jar is as follows:

[0050] like Figures 1 to 7 As shown, the ball mill jar described in this embodiment includes a jar body 1 and a cover body 2. The cover body 2 is equipped with a suspended isolation plate 3 assembly, a vibration probe, and a floating switching assembly.

[0051] The cover 2 serves as a base, with a central clearance hole 22 and an eccentrically arranged pressure relief hole 24. Internally, it forms a stepped countersunk hole 21 structure. A sealing ring 25 seals the bottom of the countersunk hole 21, creating an annular receiving space between the upper end of the sealing ring 25 and the stepped surface of the countersunk hole 21. The suspended isolation plate 3 is floatingly assembled within this receiving space. To achieve vibration of the suspended isolation plate 3, it is not rigidly fixed to the cover 2, but rather suspended within the countersunk hole 21 of the cover 2 by two elastic damping elements 7 (specifically, low-temperature resistant fluorosilicone rubber O-rings). This suspended installation method grants the suspended isolation plate 3 high-frequency vibration freedom along the axial direction (i.e., vertical direction), while simultaneously utilizing the elasticity of the rubber rings to achieve edge airtightness.

[0052] To prevent the suspended isolation plate 3 from rotating circumferentially under the centrifugal force of the ball mill, an anti-rotation positioning structure is provided between the isolation plate and the cover 2. Specifically, a U-shaped anti-rotation notch 33 is machined on the edge of the isolation plate, and a positioning pin 23 is pressed into the corresponding position on the inner wall of the countersunk hole 21 of the cover 2. The positioning pin 23 is inserted into the notch, thereby restricting the rotational freedom of the isolation plate, but not interfering with its axial vibration.

[0053] The vibration probe consists of several titanium alloy probes 35, which are arranged in a cage-like or multi-point distribution and are long enough to penetrate into the core area of ​​the tumbling abrasive media (zirconia beads). The titanium alloy material has high specific strength and excellent elastic modulus, which can effectively receive the random impact energy of the abrasive media and convert this irregular mechanical impact into high-frequency vibration waves that are transmitted upward along the probes 35, ultimately causing the suspended isolation plate 3 to vibrate continuously.

[0054] The suspended isolation plate 3 is divided into at least two independent venting zones, namely the first venting zone 31 and the second venting zone 32. Each venting zone has several vent holes 34, and the holes are sealed by a rigid support mesh 81 with a pore size of 0.1-0.5μm, forming an e-PTFE waterproof and breathable membrane 8. This microporous membrane allows carbon dioxide gas molecules to pass through but effectively intercepts ultrafine powder. Specifically, the vent holes 34, from the inside out, include the rigid support mesh 81, the e-PTFE membrane, and the locking ring 82; the rigid support mesh 81 is used to bear the gas pressure load inside the ball mill jar.

[0055] The switching mechanism located above the suspended isolation plate 3 is the core component for achieving "zero-pressure dust removal". This mechanism includes a drive shaft 4 passing through the central hole of the suspended isolation plate 3, a fan-shaped baffle 5 fixed to the drive shaft 4, and a self-locking elastic element 6 positioned between the drive shaft 4 and the isolation plate. The drive shaft 4 extends upward through the clearance hole 22 of the cover 2 to the outside, and its top end has a screw head 41 for the operator to tighten. The fan-shaped baffle 5 is located on the upper surface of the isolation plate, and its area is sufficient to completely cover any ventilation area. The self-locking elastic element 6 (e.g., a strong compression spring) is sleeved on the end of the drive shaft 4 located below the suspended isolation plate 3. One end of the spring abuts against the bottom surface of the suspended isolation plate 3, and the other end is restricted to the shaft end by a retaining spring, thereby generating a downward pulling force. This pulling force is transmitted to the fan-shaped baffle 5 through the drive shaft 4, keeping the fan-shaped baffle 5 tightly pressed against the upper surface of the suspended isolation plate 3 at all times. The lower surface of the fan-shaped baffle 5 is provided with a wear-resistant PTFE sealing gasket layer 51.

[0056] In addition, to prevent the air-powder mixture from being discharged upward from the central hole, a pressure plate 61 is pressed on the top of the spring. The pressure plate 61 is sleeved on the drive shaft, and a rubber sealing ring 62 is sandwiched between the pressure plate 61 and the suspension isolation plate. The rubber sealing ring 62 is sleeved on the drive shaft and is always kept in close contact with the central hole of the suspension isolation plate by the spring pressure.

[0057] This "floating self-locking" structure has extremely high engineering value: on the one hand, the preload of the spring forms an internal force closed loop, making the fan-shaped shielding plate 5 and the suspended isolation plate 3 dynamically integrated. When the vibration probe is impacted and causes the isolation plate to vibrate, the shielding plate will vibrate synchronously, and there will be no relative jump or gap between the sealing surfaces due to vibration, thus ensuring airtightness; on the other hand, when it is necessary to switch the flow channel, the operator rotates the screw head 41, and the drive shaft 4 overcomes the frictional torque generated by the spring, causing the fan-shaped shielding plate 5 to slide on the isolation plate surface locked by the positioning pin 23, thereby changing the shielding state of the first ventilated area 31 or the second ventilated area 32.

[0058] The preparation method includes the following steps:

[0059] S1: Material preparation:

[0060] First, accurately weigh the raw medicinal materials including Ophiopogon japonicus, Scrophularia ningpoensis, Angelica sinensis, Dendrobium officinale, Bletilla striata, Magnolia biondii, Cicadae periostracum, and Mentha haplocalyx according to the predetermined formula ratio. To improve grinding efficiency, the medicinal materials need to undergo differentiated pretreatment: Ophiopogon japonicus, Scrophularia ningpoensis, Angelica sinensis, and Dendrobium officinale, which are tough or sticky, are cut into particles with a diameter of about 3-5 mm; while Magnolia biondii, Cicadae periostracum, and Mentha haplocalyx, which are loose or highly volatile, are left as is or only coarsely crushed. Before mixing, all medicinal materials need to be dried at a low temperature of 40℃ until the moisture content is below 8% to reduce the impact of moisture on low-temperature grinding.

[0061] Step S2: Canning

[0062] The mixed medicinal herb granules, solid carbon dioxide granules (dry ice), and zirconia grinding beads are loaded into a ball mill jar. The mass ratio of solid carbon dioxide to medicinal herbs is controlled between 1:2 and 1:1 to ensure sufficient cooling throughout the grinding cycle. The grinding beads are scientifically graded at 3mm, 5mm, and 10mm, with a total weight approximately 3-5 times the weight of the materials. After loading, the dedicated self-cleaning ball mill jar lid is quickly installed and tightened.

[0063] Step S3: Grinding and Self-Cleaning

[0064] Install the assembled grinding jar onto the planetary ball mill. By rotating the screw head 41 on the top of the jar cover, the switching mechanism is placed in its initial state, for example, so that the fan-shaped baffle 5 completely blocks the first venting zone 31 while fully opening the second venting zone 32. Start the ball mill and set the speed to 300-500 rpm.

[0065] During the grinding process, dry ice rapidly sublimates and absorbs heat, maintaining the temperature inside the container at a constant low temperature range of -20℃ to -40℃. Under this environment, viscous components such as Ophiopogon japonicus polysaccharides and Dendrobium nobile gum undergo a glass transition, changing from a viscoelastic state to a cold-brittle state, making them extremely easy to crush by mechanical force; Angelica sinensis volatile oil solidifies into a solid state, preventing seepage and adhesion.

[0066] The carbon dioxide gas flow generated by sublimation carries some ultrafine dust and attempts to exit through the open second ventilated zone 32. The dust is trapped by the filter membrane and forms a filter cake. At this time, the vibration energy generated by the impact of the abrasive media on the probe 35 causes the isolation plate to vibrate continuously. Every 10-20 minutes, a flow channel switching operation is performed: the screw head 41 is rotated 180 degrees, causing the fan-shaped baffle 5 to turn and block the second ventilated zone 32, while opening the first ventilated zone 31.

[0067] The key mechanism of this step lies in the fact that at the instant the second permeable zone 32 is blocked, the airflow through this area is cut off, and the aerodynamic adsorption force (pressure difference) acting on the filter membrane surface instantly returns to zero. At this time, because the isolation plate is still vibrating violently under the drive of the probe 35 and has lost the "pressing" restraint of the airflow pressure, the dust filter cake attached to the membrane surface of the second permeable zone 32 breaks down and falls off under the action of inertia, settling back to the bottom of the tank, thereby realizing the "online regeneration" of the filter membrane in this area. At the same time, the first permeable zone 31 takes over the exhaust task. Through this periodic "work-regeneration" cycle, continuous low-temperature pulverization of highly viscous and lightweight materials is achieved, completely solving the problem of screen clogging.

[0068] Step S4: Post-processing

[0069] After grinding, remove the ball mill jar and place it in a ventilated area to allow any remaining dry ice to completely sublimate and dissipate. Open the jar lid and collect the powder inside. The resulting powder has excellent flowability and dispersibility. Finally, sieve the powder through a 200-mesh sieve; the material passing through the sieve is the finished ultrafine powder of traditional Chinese medicine with a particle size D90 of less than 75 μm.

[0070] To verify the effects of different formulation ratios in different clinical settings, this invention provides the following three typical embodiments:

[0071] Specific Example 1 of the Traditional Chinese Medicine Composition for Treating Rhinitis of the Present Invention:

[0072] This embodiment provides a formula with a relatively balanced ratio of components, suitable for most patients whose main symptoms are nasal dryness and mild nasal congestion.

[0073] Ingredients (by weight): Ophiopogon japonicus 10g, Scrophularia ningpoensis 8g, Angelica sinensis 6g, Magnolia biondii 4g, Mentha haplocalyx 3g, Dendrobium officinale 4g, Cicadae periostracum 3g, Bletilla striata 3g.

[0074] Formula analysis: The proportion of yin-nourishing herbs (Ophiopogon japonicus, Scrophularia ningpoensis, Dendrobium nobile) and nasal-opening herbs (Magnolia biondii, Mentha haplocalyx, Cicadae periostracum) in this formula is just right. It can moisturize the nasal cavity without obstructing the flow of qi due to excessive nourishment.

[0075] Preparation characteristics: The overall viscosity and volatility of the material in this formulation are moderate. During the preparation process, using standard process parameters (dry ice ratio 0.8:1, switching frequency 15 minutes / time), an ultrafine powder with a light gray color, rich aroma, and uniform particle size distribution (D90=42μm) can be successfully obtained.

[0076] Specific Example 2 of the Traditional Chinese Medicine Composition for Treating Rhinitis of the Present Invention:

[0077] This embodiment is designed for patients with a long disease course, severe nasal turbinate atrophy, foul-smelling crusts, and recurrent bleeding, focusing on enhancing the effects of "tissue regeneration" and "hemostasis".

[0078] Ingredients (by weight): Ophiopogon japonicus 12g, Scrophularia ningpoensis 10g, Angelica sinensis 8g, Dendrobium officinale 6g, Bletilla striata 5g, Magnolia biondii 3g, Mentha haplocalyx 2g, Cicadae periostracum 2g.

[0079] Formula Analysis: This formula significantly increases the dosage of Ophiopogon japonicus, Scrophularia ningpoensis, Dendrobium nobile, and Bletilla striata. The heavy use of Ophiopogon japonicus and Dendrobium nobile aims to build a powerful moisturizing layer on the atrophied mucosal surface through high concentrations of polysaccharides; the heavy use of Angelica sinensis and Bletilla striata is to promote granulation tissue growth, heal ulcers, and improve ozena. The reduced dosage of Magnolia biondii and Mentha haplocalyx is to avoid their drying and depleting properties, which could further damage the already severely depleted Yin fluids.

[0080] Preparation Characteristics: Due to the extremely high proportion of highly viscous Ophiopogon japonicus, Dendrobium nobile, and Bletilla striata, this formula contains materials that are extremely difficult to pulverize. During preparation, the dry ice ratio needs to be increased to 1:1, and the switching frequency needs to be increased to once every 10 minutes. Utilizing a dual-channel alternating cleaning process, even with such high-viscosity materials, frequent cycles of "airflow cut-off + strong vibration" can effectively remove polysaccharide deposits on the membrane surface, preventing clogging and ultimately producing ultrafine powder with a particle size D90=45μm.

[0081] Specific Example 3 of the Traditional Chinese Medicine Composition for Treating Rhinitis of the Present Invention:

[0082] This embodiment is for patients who have both dryness symptoms and obvious allergic reactions such as nasal itching and sneezing.

[0083] Ingredients (parts by weight): Ophiopogon japonicus 8g, Scrophularia ningpoensis 6g, Angelica sinensis 4g, Magnolia biondii 6g, Cicadae periostracum 4g, Mentha haplocalyx 4g, Dendrobium officinale 3g, Bletilla striata 2g.

[0084] Formula Analysis: This formula increases the proportions of cicada molting, magnolia flower buds, and peppermint. Cicada molting is rich in chitin, which has significant anti-allergic and immunomodulatory effects; magnolia flower buds and peppermint work synergistically to quickly relieve nasal congestion and itching. The appropriate amount of yin-nourishing herbs is retained to prevent secondary mucosal dryness caused by long-term anti-allergy treatment.

[0085] Preparation characteristics: This formula contains a large amount of lightweight components (cicada molting, magnolia flower), which are easily suspended under airflow. When switching to the blocking state, not only is the airflow cut off, but a time window for gravity settling of the suspended lightweight powder is also provided. Combined with the vibration of probe 35, it effectively prevents the lightweight powder from "bridging" and clogging at the exhaust port 34, ensuring that components such as cicada molting are fully pulverized and uniformly dispersed in the matrix.

[0086] To further verify the clinical efficacy of the traditional Chinese medicine composition of the present invention, three typical cases treated with different formulations are described in detail below:

[0087] Case 1: Reversal treatment of atrophic rhinitis-associated ozena:

[0088] Patient information: Ms. Zhang, 52 years old, retired textile factory worker.

[0089] Medical History and Symptoms: The patient has an 8-year history of atrophic rhinitis. The chief complaint is an abnormally wide nasal cavity, with hyperventilation yet a feeling of suffocation (decreased sensation). The nasal cavity is filled with a large amount of dry, hard, yellowish-green crusts; when forcefully blown out, the crusts appear tubular, and pinpoint bleeding occurs after removing the crusts. The most troubling symptom is a distinctly foul, putrid odor from the breath (ozena), causing social anxiety. Long-term use of streptomycin nasal drops and menthol oil nasal drops has gradually reduced their effectiveness.

[0090] Treatment plan: Discontinue the original medication. Use the ultrafine powder prepared in Example 2 (severe repair type). Instruct the patient to take 1g of the powder, mix it with 3g of honey to form a paste, and apply it to the deep part of the nasal cavity and the surface of the nasal turbinates with a sterile cotton swab in the morning and evening.

[0091] Treatment process and effects:

[0092] One week after treatment: The patient reported that the stinging sensation in the nasal cavity had disappeared, the crusts had softened and were easier to blow out, and there was no longer any bleeding when blowing the nose. This indicates that the astringent and hemostatic effects of Bletilla striata and the blood-activating effects of Angelica sinensis have begun to take effect.

[0093] Four weeks after treatment: The family reported a significant reduction in the patient's nasal odor. Examination revealed that the nasal mucosa had changed from grayish-white to pale red, and the secretions had increased and thinned, no longer forming hard crusts. This indicates that the high concentration of polysaccharides from Ophiopogon japonicus and Dendrobium nobile successfully repaired the damaged glandular function.

[0094] Three months after treatment: the patient's sense of smell partially recovered, and he was able to smell strong, pungent odors. The atrophy of the nasal turbinates showed visible improvement, and the nasal microenvironment was significantly reconstructed.

[0095] Case 2: Combined treatment of atrophic rhinitis and seasonal allergy:

[0096] Patient information: Li, male, 14 years old, middle school student.

[0097] Medical history and symptoms: The patient suffers from seasonal allergic rhinitis, which flares up every spring and autumn. Due to unbearable nasal itching, the patient frequently rubs their nose, leading to erosion, dryness, peeling, and yellow crusting of the nasal vestibule skin. The patient experiences frequent sneezing and a persistent runny nose upon waking, accompanied by nasal bleeding.

[0098] Treatment plan: Use the ultrafine powder prepared in Example 3 (anti-allergic and antipruritic type). Pack the powder into a portable spray bottle and instruct the patient to spray it into the nasal cavity three times daily, forming a thin mist.

[0099] Treatment process and effects:

[0100] Immediate effect: After the first spray, the patient immediately felt a cool and refreshing sensation in the nasal cavity, and the nasal itching symptoms were significantly relieved within 5 minutes, and the rubbing of the nose stopped. This is because the peppermint and cicada molting exerted an immediate anti-itch and anti-allergic effect.

[0101] After 3 days of treatment: the number of sneezes in the morning decreased from dozens to single digits, and the amount of clear nasal discharge decreased.

[0102] Ten days after treatment: the nasal vestibule eczema completely healed, the eroded areas scabbed off, revealing new skin, and the nasal mucosa returned to a moist state, with no more peeling or bleeding. During a six-month follow-up, the frequency of allergy symptoms decreased significantly, and the common side effect of nasal dryness seen with steroid nasal sprays was not observed.

[0103] Case 3: Chronic simple rhinitis caused by occupational environment

[0104] Patient Information: Wang, male, 35 years old, IT data center engineer.

[0105] Medical history and symptoms: Long-term work in a computer room with constant temperature and humidity (low humidity). Patient experiences persistent nasal dryness, scanty but thick nasal discharge, significant nasal congestion upon waking, occasional expulsion of dry crusts with blood streaks, accompanied by frontal headache and difficulty concentrating.

[0106] Treatment plan: Use the ultrafine powder prepared in Example 1 (balanced type). Instruct the patient to mix the powder with compound peppermint oil or pure sesame oil at a ratio of 1:10 to make a suspension nasal drop, and instill it with the head tilted back before going to bed every day.

[0107] Treatment process and effects:

[0108] In the initial stage of treatment: On the day of use, patients felt their nasal cavity was moist and comfortable, their dizziness was reduced, and their sleep at night was improved.

[0109] Two weeks after treatment: morning nasal congestion completely disappeared, nasal secretions returned to normal, and even working all day in a low-humidity machine room, the nasal cavity no longer felt unbearably dry. This indicates that Ophiopogon japonicus and Scrophularia ningpoensis effectively replenished deep body fluids and improved the resistance of the nasal mucosa to dry environments, achieving the expected therapeutic effect of "moistening dryness and generating fluids".

[0110] The traditional Chinese medicine composition of this invention, through scientific formulation and innovative low-temperature ultra-micro pulverization process, successfully solves the clinical problems of "dryness, atrophy, and congestion" in yin deficiency and dryness-heat type rhinitis. Moreover, the preparation process overcomes the physical processing bottleneck of traditional Chinese medicine materials and has the feasibility of industrial production.

[0111] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. The scope of patent protection of the present invention shall be determined by the claims. Similarly, any equivalent structural changes made based on the description and drawings of the present invention shall also be included within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating rhinitis, characterized in that, Made from the following parts by weight of raw materials: 8-12 parts of Ophiopogon japonicus, 6-10 parts of Scrophularia ningpoensis, 4-8 parts of Angelica sinensis, 3-6 parts of Magnolia biondii, 2-4 parts of Mentha haplocalyx, 3-6 parts of Dendrobium officinale, 2-4 parts of Cicadae periostracum, and 2-5 parts of Bletilla striata.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is a powder with a particle size D90 of less than 75 μm.

3. A method for preparing the traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Includes the following steps: S1. Prepare materials: Weigh each raw medicinal material according to the weight parts, and coarsely crush and mix them; S2. Packing: The mixed medicinal materials and solid carbon dioxide particles are loaded into the ball mill jar. S3. Grinding and self-cleaning pressure relief: Seal the ball mill tank cover, start the ball mill, and during the grinding process, use solid carbon dioxide sublimation to maintain the low temperature inside the tank, and discharge the sublimation gas through the dual-channel alternating dust removal component on the ball mill tank cover. S4. Post-processing: collect the powder and sieve it. In S3, the ball mill jar cover includes a cover body and a suspended isolation plate disposed in the cover body, a switching mechanism located above the suspended isolation plate, and a vibration probe connected to the suspended isolation plate and extending into the jar. The isolation plate is divided into at least two independent air-permeable zones, including at least a first air-permeable zone and a second air-permeable zone, and each air-permeable zone is sealed with an air-permeable membrane. During grinding, the grinding medium impacts the vibration probe, causing the suspended isolation plate to vibrate. The switching mechanism selectively blocks the first air-permeable zone and opens the second air-permeable zone, then switches to opening the first air-permeable zone and blocking the second air-permeable zone. This allows the air-permeable membrane in the blocked air-permeable zone to shake off the attached powder as the suspended isolation plate vibrates without airflow adsorption.

4. The preparation method according to claim 3, characterized in that, The suspended isolation plate is suspended and installed in the cover body by an elastic damping element, and an anti-rotation positioning structure is provided between the suspended isolation plate and the cover body to make the isolation plate float along the axial direction.

5. The preparation method according to claim 4, characterized in that, The switching mechanism includes a drive shaft passing through the center of the isolation plate, a fan-shaped shielding plate fixed on the shaft, and a self-locking elastic element disposed between the drive shaft and the isolation plate; the self-locking elastic element applies a force to the shielding plate to move towards the isolation plate, so that when the vibration probe is impacted, the fan-shaped shielding plate and the suspended isolation plate remain in close contact and vibrate synchronously.

6. The preparation method according to claim 5, characterized in that, An clearance hole is provided at the center of the cover, and the drive shaft extends upward through the clearance hole. A screwing head is provided at the upper end of the drive shaft.

7. The preparation method according to claim 4, characterized in that, The elastic damping element consists of two rubber O-rings, located at the upper and lower edges of the suspension plate, respectively, which clamp the suspension plate and suspend it in the sinkhole inside the cover body.

8. The preparation method according to claim 3, characterized in that, In step S2, the mass ratio of solid carbon dioxide to medicinal materials is 1:2 to 1:1; in step S3, the switching frequency of the switching mechanism is once every 10-20 minutes.

9. The preparation method according to claim 3, characterized in that, The vibration probe consists of several probes distributed on the lower surface of the suspended isolation plate, and the probes are made of titanium alloy.

10. The preparation method according to claim 3, characterized in that, The breathable membrane is an e-PTFE waterproof and breathable membrane with a pore size of 0.1-0.5μm, and is supported by a rigid breathable support mesh for back pressure.

Images