Application containing acne-removing traditional Chinese medicine composition and preparation method thereof

Abstract

The invention discloses an application containing an acne-removing traditional Chinese medicine composition and a preparation method of the application, and belongs to the technical field of traditional Chinese medicine acne-removing patches. The application sequentially comprises a non-woven fabric layer, an ointment layer and a polyethylene layer from top to bottom. The ointment layer comprises a first ointment layer and a second ointment layer; the first ointment layer is prepared from the following components in parts by mass: 6 to 12 parts of fructus forsythiae extract, 2 to 4 parts of cortex phellodendri extract, 3 to 6 parts of honeysuckle flower extract, 2 to 5 parts of herba taraxaci extract, 0.5 to 1.5 parts of radix gentianae extract, 0.5 to 1 part of radix ginseng extract and 1 to 4 parts of herba centellae extract; the second ointment layer is prepared from the following components in parts by mass: 0.5 to 2.5 parts of borneol, 6 to 8 parts of water-soluble chitosan and 3 to 6 parts of modified nano silicon dioxide. According to the application, grease generated by acnes can be adsorbed, redness and swelling can be eliminated, skin barriers can be repaired, relapse can be prevented, and both symptoms and root causes of the acnes can be treated.

Description

Technical Field

[0001] This application relates to a poultice containing a traditional Chinese medicine composition for acne treatment and its preparation method, belonging to the technical field of traditional Chinese medicine acne treatment patches. Background Technology

[0002] Acne is a common chronic skin condition caused by sebaceous glands, also known as pimples, blackheads, or acne vulgaris. It is caused by a variety of factors, including excessive sebum secretion, abnormal keratinization of hair follicles, and inflammatory reactions. It is prone to recurrence and can affect the face, chest, and back. If not treated promptly or properly, it may leave scars.

[0003] Current acne treatments primarily involve antibiotics and anti-inflammatory agents. While these offer rapid relief, they are highly irritating and unsuitable for long-term use. A common daily method is chemical peels, which, while effectively ripening acne, are also highly irritating, causing dryness, flaking, and an unpleasant user experience. Furthermore, most commercially available creams and lotions for acne treatment often suffer from insufficient application, inadequate efficacy, and difficulty in maintaining consistent use, making their effectiveness uncertain.

[0004] To address the aforementioned technical problems, the use of traditional Chinese medicine (TCM) ingredients for acne treatment has become a new research hotspot. Chinese patent CN114617858B discloses a TCM acne-clearing microcrystalline patch and its preparation method. The method involves emulsifying various TCM ingredient extracts with bactericides, preservatives, and pharmaceutical gelatin to obtain a raw liquid, which is then dehydrated and pressed with a film to form the TCM acne-clearing microcrystalline patch. This patented TCM acne-clearing microcrystalline patch exhibits strong inhibitory effects against Propionibacterium acnes and Staphylococcus aureus, preventing recurrence. However, it cannot absorb existing sebum. Due to the presence of sebum, the effective components of the TCM cannot effectively target the acne-causing wounds, resulting in a less than ideal treatment effect.

[0005] Therefore, there is an urgent need for a patch containing a traditional Chinese medicine composition for acne treatment that can absorb the oil produced by acne, eliminate redness and swelling, repair the skin barrier, and achieve both symptomatic and root-cause treatment. Summary of the Invention

[0006] To address the aforementioned issues, a patch containing a traditional Chinese medicine composition for acne treatment is provided. This patch can absorb the oil produced by acne, eliminate redness and swelling, repair the skin barrier, and prevent recurrence, thus achieving both symptomatic and root-cause treatment for acne.

[0007] One aspect of this application provides a patch containing a traditional Chinese medicine composition for acne treatment, the patch comprising, from top to bottom, a non-woven fabric layer, an ointment layer, and a polyethylene layer; The ointment layer includes a first ointment layer and a second ointment layer; The first ointment layer, by mass fraction, comprises: Forsythia extract 6-12 parts, Phellodendron bark extract 2-4 parts, Honeysuckle extract 3-6 parts, Dandelion extract 2-5 parts, Gentian extract 0.5-1.5 parts, Ginseng extract 0.5-1 part, Centella asiatica extract 1-4 parts; The second ointment layer comprises, by mass fraction: 0.5 to 2.5 parts borneol, 6 to 8 parts water-soluble chitosan, and 3 to 6 parts modified nano-silica.

[0008] The herbal plaster consists of a first plaster layer and a second plaster layer. The first plaster layer contains extracts of Forsythia suspensa, Phellodendron chinense, Lonicera japonica, Taraxacum mongolicum, Gentiana scabra, Ginseng, and Centella asiatica. Through the synergistic effect of these herbal ingredients, redness and swelling can be eliminated and the skin barrier can be repaired. At the same time, the extracts also contain effective components that have a strong inhibitory effect on Propionibacterium acnes and Staphylococcus aureus, treating acne from the root cause, preventing its recurrence, and further improving the treatment effect of acne.

[0009] The second ointment layer contains borneol, water-soluble chitosan, and modified nano-silica. Borneol, being cooling in nature, has a heat-clearing effect, helping to reduce inflammation by regulating the local skin environment. Its anti-swelling and analgesic effects also enhance the user experience. Water-soluble chitosan offers several advantages: First, it has excellent biocompatibility, gently adhering to the skin and reducing external irritation. It also promotes the repair and regeneration of epidermal cells, aiding in the gradual recovery of the damaged skin barrier. Second, its molecular structure contains numerous hydrophilic groups such as hydroxyl and amino groups, which can form hydrogen bonds with water molecules, providing excellent moisture absorption and retention. This allows it to form a breathable moisturizing film on the surface of acne-prone skin, reducing moisture loss and improving dryness and flaking. Third, water-soluble chitosan acts as an excellent natural carrier, encapsulating the acne-fighting active ingredients in the first ointment layer, preventing premature decomposition and ensuring stable loading of these ingredients. Modified nano-silica has two main advantages: first, it can adsorb some of the oil or impurities on the skin surface, facilitating the penetration of effective acne-removing ingredients in the first ointment layer into the skin; second, it can improve the dispersibility of nano-silica in the second ointment layer, thus improving the uniformity of the application.

[0010] By leveraging the synergistic effects of borneol, water-soluble chitosan, and modified nano-silica, the acne-removing effect is significantly improved, the skin irritation caused by the acne patch is reduced, and skin discomfort caused by product irritation is avoided. This also enhances the user experience. Simultaneously, the effective acne-removing ingredients in the first ointment layer penetrate into the second ointment layer, allowing the active ingredients to penetrate the skin directly. This reduces the probability of allergic reactions, broadens the range of skin types suitable for the acne patch, and improves the safety and comfort of the product.

[0011] Specifically, forsythia, phellodendron bark, honeysuckle, dandelion, gentian, ginseng, and centella asiatica were extracted using a 70% ethanol solution combined with ultrasonic extraction. The extract was then concentrated under reduced pressure to obtain the above-mentioned extract.

[0012] Specifically, the Forsythia suspensa extract, Phellodendron chinense extract, Lonicera japonica extract, Taraxacum mongolicum extract, Gentiana scabra extract, Ginseng extract, and Centella asiatica extract mentioned in this application can also be obtained as qualified extract products through market purchase.

[0013] Optionally, the mass ratio of Phellodendron bark extract, dandelion extract and Centella asiatica extract is 1:(1~2):(0.5~1).

[0014] Phellodendron bark extract can inhibit the growth of bacteria and fungi, and has a certain therapeutic effect on skin infections and acne. It can promote the regeneration of damaged skin tissue and accelerate wound healing. Dandelion extract can improve dermatitis. Centella asiatica extract has two main effects: first, it has anti-inflammatory and swelling-reducing properties, which can prevent the expansion of acne and lighten its appearance; second, it can promote collagen formation and help heal damaged tissue, thus having a good repair function. In this ratio, Phellodendron bark extract, dandelion extract, and Centella asiatica extract work synergistically to reduce inflammation and swelling and repair the skin, improving the therapeutic effect of the patch and achieving a comprehensive treatment.

[0015] Optionally, the mass ratio of water-soluble chitosan to modified nano-silica is 1:(0.5~1).

[0016] At this ratio, water-soluble chitosan and modified nano-silica can work synergistically to adsorb impurities or excess oil on the skin surface, promoting the penetration of the active ingredients in the first ointment layer into the skin, and promoting the removal of acne and the repair of the skin.

[0017] Optionally, the powder particle size of the forsythia extract, phellodendron extract, honeysuckle extract, dandelion extract, gentian extract, ginseng extract, and centella asiatica extract is 20-50 μm.

[0018] The particle size of Forsythia suspensa extract, Phellodendron chinense extract, Lonicera japonica extract, Taraxacum mongolicum extract, Gentiana scabra extract, Ginseng extract, and Centella asiatica extract is within this range, which can improve the release of the active ingredients in the above extracts and enhance the efficacy of the application.

[0019] Another aspect of this application provides a method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment, characterized in that the method for preparing the ointment layer includes the following steps: S1: Forsythia extract, Phellodendron bark extract, honeysuckle extract, dandelion extract, gentian extract, ginseng extract, and centella asiatica extract are dissolved in 5 to 10 times the amount of deionized water, heated to 40 to 50°C and stirred until homogeneous. After concentration under reduced pressure, the first extract is obtained. S2: Apply the first extract to the middle position of the polyethylene layer to form the first ointment layer; S3: Add borneol and water-soluble chitosan to 3-5 times the amount of deionized water, heat to 60-70℃, stir evenly, cool, add modified nano-silica, stir evenly, concentrate under reduced pressure to obtain the second extract. S4: Apply the second extract onto the nonwoven fabric layer to form the second ointment layer. The polyethylene layer from step S2 is used as the backing layer, and the nonwoven fabric layer is used as the covering layer. After compression molding, cutting, and curing, the product is obtained.

[0020] Optionally, the thickness ratio of the first ointment layer to the second ointment layer is (3~4):1.

[0021] At this ratio, the first ointment layer contains sufficient active ingredients to remove acne and repair the skin. These active ingredients can quickly penetrate the second ointment layer and reach the skin's surface. If the first ointment layer is too thick, the effect on the skin won't be significantly improved, but it will increase the production cost of the patch. If the first ointment layer is too thin, the content of active ingredients will be reduced, failing to effectively remove acne and diminishing the patch's effectiveness. If the second ointment layer is too thick, the active ingredients from the first ointment layer cannot penetrate to reach the skin's surface; if the second ointment layer is too thin, it cannot effectively reduce sensitivity or absorb oil and impurities from the skin's surface, affecting the user's experience.

[0022] Optionally, the modified nano-silica is prepared as follows: A1: Dissolve fatty alcohol in 2-4 times the amount of anhydrous ethanol, then add nano-silica, and treat with ultrasound for 20-30 minutes to obtain treated nano-silica. A2: After removing the solvent from the treated nano-silica, modified nano-silica is obtained.

[0023] Optionally, the fatty alcohol is a fatty alcohol having 16 to 24 carbon atoms.

[0024] The addition of fatty alcohols has several advantages: first, it improves the dispersibility of modified nano-silica, thereby enhancing the uniformity of the application; second, it improves the skin feel during application, reducing the greasiness of the product and providing a more refreshing and smooth user experience; and third, it dissolves the oily components in acne, which helps the modified nano-silica to absorb the oil in acne.

[0025] Optionally, the mass ratio of the nano-silica to the fatty alcohol is 1:(1~2).

[0026] At this ratio, fatty alcohols can be effectively introduced onto the surface of nano-silica, allowing the nano-silica to disperse better, improving its adsorption of skin oils, and enhancing the therapeutic effect of the patch on acne.

[0027] Optionally, the particle size of the modified nano-silica is 16~20nm.

[0028] At this particle size, modified nano-silica has a very large specific surface area and significantly improved adsorption performance. It can adsorb oil, dirt and acne inflammation secretions on the skin surface, help clean pores and reduce pore blockage.

[0029] The beneficial effects of this application include, but are not limited to: 1. The patch containing the acne-removing traditional Chinese medicine composition according to this application has a reasonable combination of traditional Chinese medicine composition, with the principal, assistant, adjuvant and guide herbs having a good synergistic effect. It can effectively remove acne, eliminate redness and swelling, repair the skin barrier, treat both the symptoms and the root cause, and effectively prevent recurrence.

[0030] 2. The patch containing the acne-removing traditional Chinese medicine composition according to this application reduces the probability of allergies in users, reduces skin irritation, broadens the range of skin types suitable for the patch, and improves the safety and comfort of product use by including a first ointment layer and a second ointment layer in the ointment layer.

[0031] 3. The patch containing the acne-removing traditional Chinese medicine composition according to this application, by adding water-soluble chitosan to encapsulate the acne-removing active ingredients that permeate from the first ointment layer, prevents the effective ingredients from decomposing and becoming ineffective in a premature manner, achieves a stable load of active ingredients, and improves the effect of the patch.

[0032] 4. The patch containing the acne-removing traditional Chinese medicine composition according to this application can absorb the oil produced by acne and the oil or impurities on the skin surface, eliminate redness and swelling, repair the skin barrier, and prevent recurrence. It can also inhibit bacterial growth, relieve inflammation from the root cause, and prevent further redness and swelling of acne, thus achieving both symptomatic and radical treatment. Detailed Implementation

[0033] The present application is described in detail below with reference to the embodiments, but the present application is not limited to these embodiments.

[0034] Unless otherwise specified, the raw materials used in the embodiments and comparative examples of this application were all purchased commercially.

[0035] Unless otherwise specified, the methods used in the embodiments and comparative examples of this application are conventional methods in the prior art. The molecular weight of the water-soluble chitosan in these embodiments and comparative examples is 40,000-80,000.

[0036] Example 1 This embodiment relates to a patch containing a traditional Chinese medicine composition for acne treatment. The patch includes, from top to bottom, a non-woven fabric layer, a medicated ointment layer, and a polyethylene layer. The ointment layer includes a first ointment layer and a second ointment layer; The first ointment layer, by mass fraction, includes: 6 parts forsythia extract, 2 parts phellodendron extract, 3 parts honeysuckle extract, 2 parts dandelion extract, 0.5 parts gentian extract, 0.5 parts ginseng extract, and 1 part centella asiatica extract. The second ointment layer, by mass fraction, includes: 0.5 parts borneol, 6 parts water-soluble chitosan, and 3 parts modified nano-silica.

[0037] A method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment includes the following steps: S1: Dissolve 6 parts of Forsythia suspensa extract, 2 parts of Phellodendron chinense extract, 3 parts of Lonicera japonica extract, 2 parts of Taraxacum mongolicum extract, 0.5 parts of Gentiana scabra extract, 0.5 parts of Ginseng extract, and 1 part of Centella asiatica extract (with a particle size of 20 μm) in 5 times the amount of deionized water. After heating to 40°C and stirring until homogeneous, concentrate under reduced pressure to obtain the first extract. S2: Apply the first extract to the middle position of the polyethylene layer to form the first ointment layer; S3: Add 0.5 parts of borneol and 6 parts of water-soluble chitosan (molecular weight 40,000) to 3 times the volume of deionized water. Heat to 60℃, stir evenly, cool, add 3 parts of modified nano-silica, stir evenly, and concentrate under reduced pressure to obtain the second extract. The preparation method of modified nano-silica is as follows: A1: Dissolve 1 part cetyl alcohol in 2 times the amount of anhydrous ethanol, then add 1 part of silica with a particle size of 16nm, and treat with ultrasound for 20min to obtain the treated nano silica. A2: After drying the treated nano-silica and removing the solvent, modified nano-silica is obtained; S4: Apply the second extract onto the nonwoven fabric layer to form the second ointment layer. The thickness ratio of the first ointment layer to the second ointment layer is 3:1. Using the polyethylene layer in step S2 as the backing layer and the nonwoven fabric layer as the covering layer, the ointment is obtained after compression molding, cutting, and curing.

[0038] Example 2 This embodiment relates to a patch containing a traditional Chinese medicine composition for acne treatment. The patch includes, from top to bottom, a non-woven fabric layer, a medicated ointment layer, and a polyethylene layer. The ointment layer includes a first ointment layer and a second ointment layer; The first ointment layer, by mass fraction, includes: 12 parts forsythia extract, 4 parts phellodendron extract, 6 parts honeysuckle extract, 5 parts dandelion extract, 1.5 parts gentian extract, 1 part ginseng extract, and 4 parts centella asiatica extract. The second ointment layer, by mass fraction, includes: 2.5 parts borneol, 8 parts water-soluble chitosan, and 6 parts modified nano-silica.

[0039] A method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment includes the following steps: S1: Dissolve 12 parts of Forsythia suspensa extract, 4 parts of Phellodendron chinense extract, 6 parts of Lonicera japonica extract, 5 parts of Taraxacum mongolicum extract, 1.5 parts of Gentiana scabra extract, 1 part of Ginseng extract, and 4 parts of Centella asiatica extract with a particle size of 50 μm in 10 times the amount of deionized water, heat to 50℃ and stir to mix evenly, then concentrate under reduced pressure to obtain the first extract. S2: Apply the first extract to the middle position of the polyethylene layer to form the first ointment layer; S3: Add 2.5 parts of borneol and 8 parts of water-soluble chitosan (molecular weight 80,000) to 5 times the volume of deionized water. Heat to 70℃, stir evenly, cool, add 6 parts of modified nano-silica, stir evenly, and concentrate under reduced pressure to obtain the second extract. The preparation method of modified nano-silica is as follows: A1: Dissolve 1 part stearyl alcohol in 2 times the amount of anhydrous ethanol, then add 2 parts of 20nm nano-silica, and treat with ultrasound for 30 minutes to obtain the treated nano-silica. A2: After drying the treated nano-silica and removing the solvent, modified nano-silica is obtained; S4: Apply the second extract onto the nonwoven fabric layer to form the second ointment layer. The thickness ratio of the first ointment layer to the second ointment layer is 4:1. Using the polyethylene layer in step S2 as the backing layer and the nonwoven fabric layer as the covering layer, the ointment is obtained after compression molding, cutting, and curing.

[0040] Example 3 This embodiment relates to a patch containing a traditional Chinese medicine composition for acne treatment. The patch includes, from top to bottom, a non-woven fabric layer, a medicated ointment layer, and a polyethylene layer. The ointment layer includes a first ointment layer and a second ointment layer; The first ointment layer, by mass fraction, includes: 9 parts forsythia extract, 3 parts phellodendron extract, 5 parts honeysuckle extract, 4 parts dandelion extract, 1 part gentian extract, 0.8 parts ginseng extract, and 2 parts centella asiatica extract. The second ointment layer, by mass fraction, includes: 1.5 parts borneol, 7 parts water-soluble chitosan, and 5 parts modified nano-silica.

[0041] A method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment includes the following steps: S1: Dissolve 9 parts of Forsythia suspensa extract, 3 parts of Phellodendron chinense extract, 5 parts of Lonicera japonica extract, 4 parts of Taraxacum mongolicum extract, 1 part of Gentiana scabra extract, 0.8 parts of Ginseng extract, and 2 parts of Centella asiatica extract with a particle size of 30 μm in 8 times the amount of deionized water, heat to 45℃ and stir to mix evenly, then concentrate under reduced pressure to obtain the first extract. S2: Apply the first extract to the middle position of the polyethylene layer to form the first ointment layer; S3: Add 1.5 parts of borneol and 7 parts of water-soluble chitosan (molecular weight 60,000) to 4 times the volume of deionized water. Heat to 65°C, stir until homogeneous, cool, add 5 parts of modified nano-silica, stir until homogeneous, and concentrate under reduced pressure to obtain the second extract. The preparation method of modified nano-silica is as follows: A1: Dissolve 1 part cetyl alcohol in 3 times the amount of anhydrous ethanol, then add 1.5 parts of nano-silica with a particle size of 18nm, and treat with ultrasound for 25 minutes to obtain the treated nano-silica. A2: After drying the treated nano-silica and removing the solvent, modified nano-silica is obtained; S4: Apply the second extract onto the nonwoven fabric layer to form the second ointment layer. The thickness ratio of the first ointment layer to the second ointment layer is 3.5:1. Use the polyethylene layer in step S2 as the backing layer and the nonwoven fabric layer as the covering layer. After compression molding, cutting, and curing, the product is obtained.

[0042] Example 4 The difference between this embodiment and Embodiment 3 is that the amount of Centella asiatica extract added is 4 parts.

[0043] Example 5 The difference between this embodiment and Embodiment 3 is that the amount of modified nano-silica added is 1 part.

[0044] Example 6 The difference between this embodiment and Embodiment 3 is that the powder particle size of Forsythia suspensa extract, Phellodendron chinense extract, Lonicera japonica extract, Taraxacum mongolicum extract, Gentiana scabra extract, Ginseng extract, and Centella asiatica extract is 500 μm.

[0045] Example 7 The difference between this embodiment and Embodiment 3 is that the thickness ratio of the first ointment layer to the second ointment layer is 6:1.

[0046] Example 8 The difference between this embodiment and Embodiment 3 is that the mass ratio of nano-silica to fatty alcohol is 1:0.1.

[0047] Example 9 The difference between this embodiment and Embodiment 3 is that the particle size of the nano-silica is 50nm.

[0048] Comparative Example 1 The difference between this comparative example and Example 3 is that the extracts of Forsythia suspensa, Phellodendron chinense, Lonicera japonica, Taraxacum mongolicum, Gentiana scabra, Ginseng, Centella asiatica, Borneol, water-soluble chitosan, and modified nano-silica are directly mixed to obtain an ointment layer. A polyethylene layer is used as the backing layer, and a non-woven fabric layer is used as the covering layer. After compression molding, cutting, and curing, the ointment is obtained.

[0049] Comparative Example 2 The difference between this comparative example and Example 3 is that the amount of Phellodendron bark extract added is 1 part.

[0050] Comparative Example 3 The difference between this comparative example and Example 3 is that the amount of dandelion extract added is 9 parts.

[0051] Comparative Example 4 The difference between this comparative example and Example 3 is that water-soluble chitosan is not added.

[0052] Comparative Example 5 The difference between this comparative example and Example 3 is that the modified nano-silica is replaced with silicon dioxide.

[0053] Test Example 1 Propionibacterium acnes strain (ATCC11827) and Staphylococcus aureus strain (CICCB0142) were diluted with sterile physiological saline to a concentration of 1.0 × 10⁻⁶. 8 CFU / mL. On a clean bench, *Propionibacterium acnes* and *Staphylococcus aureus* strains were inoculated onto petri dishes using a 6×6 streak pattern. The portions of the patches containing the first and second ointment layers obtained in Examples 1-9 and Comparative Examples 1-5 were cut into 1×1 cm samples. A 1×1 cm patch formed by bonding a polyethylene layer to a non-woven fabric layer served as a blank control. Each sample and each strain used one culture medium. A cross was drawn on the bottom of the culture dish containing the culture medium, dividing it into four parts, with one blank control on each medium. The remaining three parts were three replicates of each example or comparative example. *Propionibacterium acnes* culture dishes were placed in an anaerobic incubator at 35°C for 48 hours, and *Staphylococcus aureus* culture dishes were placed in an aerobic incubator at 37°C for 48 hours. The diameter of the inhibition zone for each sample and the blank control was measured using calipers, and the average value was taken. The results are shown in Table 1.

[0054] Table 1

[0055] As shown in Table 1, the patches prepared in Examples 1-3 have a better antibacterial effect against Propionibacterium acnes and Staphylococcus aureus than the patches prepared in other examples and comparative examples. Meanwhile, Examples 1-9 have a significantly higher effect against Propionibacterium acnes and Staphylococcus aureus than Comparative Examples 1-5, which can effectively inhibit the bacteria that easily cause acne, improve the acne treatment effect, and prevent recurrence.

[0056] Test Example 2 The patches prepared using Examples 1-9 and Comparative Examples 1-5 were used. Subjects with facial acne were selected and randomly divided into 14 groups of 40 subjects each. The patches were applied to the acne-affected areas of the subjects once daily for 10 consecutive days. Treatment effects were recorded. During the test, subjects did not use any cosmetics on the patch-applied areas. The number of pimples was counted at the same time before and after 3, 7, and 10 days of continuous patch use. The acne removal rate was calculated using the following formula: Acne Removal Rate = (Number of pimples before treatment - Number of pimples after treatment) / Number of pimples before treatment × 100%. Acne mainly included inflammatory papules, open comedones, and closed comedones. The number of facial pimples in each group of 40 subjects was counted on the 3rd, 7th, and 10th days after continuous patch use. The results are shown in Table 2.

[0057] Table 2

[0058] As shown in Table 2, the patches prepared in Examples 1-3 have a significant acne-removing effect compared with other examples and comparative examples. The acne removal rate after ten days of continuous use is above 81%, which can effectively remove acne. At the same time, the acne removal effect of Examples 1-9 is significantly higher than that of Comparative Examples 1-5, which can improve the acne removal effect, have a better skin repair effect, and reduce the probability of recurrence.

[0059] The above description is merely an embodiment of this application, and the scope of protection of this application is not limited to these specific embodiments, but is determined by the claims of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the technical concept and principles of this application should be included within the scope of protection of this application.

Claims

1. A poultice containing a traditional Chinese medicine composition for acne treatment, characterized in that, The dressing, from top to bottom, includes a non-woven fabric layer, an ointment layer, and a polyethylene layer; The ointment layer includes a first ointment layer and a second ointment layer; The first ointment layer, by mass fraction, includes: 6-12 parts of Forsythia suspensa extract, 2-4 parts of Phellodendron chinense extract, 3-6 parts of Lonicera japonica extract, 2-5 parts of Taraxacum mongolicum extract, 0.5-1.5 parts of Gentiana scabra extract, 0.5-1 part of Ginseng extract, and 1-4 parts of Centella asiatica extract. The second ointment layer comprises, by mass fraction: 0.5 to 2.5 parts borneol, 6 to 8 parts water-soluble chitosan, and 3 to 6 parts modified nano-silica.

2. The poultice containing the acne-removing traditional Chinese medicine composition according to claim 1, characterized in that, The mass ratio of Phellodendron bark extract, dandelion extract and Centella asiatica extract is 1:(1~2):(0.5~1).

3. The poultice containing the acne-removing traditional Chinese medicine composition according to claim 1, characterized in that, The mass ratio of water-soluble chitosan to modified nano-silica is 1:(0.5~1).

4. The poultice containing the acne-removing traditional Chinese medicine composition according to claim 1, characterized in that, The powder particle size of the forsythia extract, phellodendron extract, honeysuckle extract, dandelion extract, gentian extract, ginseng extract, and centella asiatica extract is 20-50 μm.

5. A method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment according to any one of claims 1 to 4, characterized in that, The preparation method of the patch containing the acne-removing traditional Chinese medicine composition includes the following steps: S1: Forsythia extract, Phellodendron bark extract, honeysuckle extract, dandelion extract, gentian extract, ginseng extract, and centella asiatica extract are dissolved in 5 to 10 times the amount of deionized water, heated to 40 to 50°C and stirred until homogeneous. After concentration under reduced pressure, the first extract is obtained. S2: Apply the first extract to the middle position of the polyethylene layer to form the first ointment layer; S3: Add borneol and water-soluble chitosan to 3-5 times the amount of deionized water, heat to 60-70℃, stir evenly, cool, add modified nano-silica, stir evenly, and concentrate under reduced pressure to obtain the second extract. S4: Apply the second extract onto the nonwoven fabric layer to form the second ointment layer. Use the polyethylene layer from step S2 as the backing layer and the nonwoven fabric layer as the covering layer. After compression molding, cutting, and curing, the product is obtained.

6. The method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment according to claim 5, characterized in that, The thickness ratio of the first ointment layer to the second ointment layer is (3~4):

1.

7. The method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment according to claim 5, characterized in that, The modified nano-silica is prepared as follows: A1: Dissolve fatty alcohol in 2-4 times the amount of anhydrous ethanol, then add nano-silica, and treat with ultrasound for 20-30 minutes to obtain treated nano-silica. A2: After removing the solvent from the treated nano-silica, modified nano-silica is obtained.

8. The method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment according to claim 7, characterized in that, The fatty alcohol is a fatty alcohol having 16 to 24 carbon atoms.

9. The method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment according to claim 7, characterized in that, The mass ratio of the nano-silica to the fatty alcohol is 1:(1~2).

10. A method for preparing a poultice containing a traditional Chinese medicine composition for acne treatment according to claim 7, characterized in that, The particle size of the nano-silica is 16~20nm.

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