Application of hippophae rhamnoides extract in melanin resistance
By extracting the aqueous phase of sea buckthorn, the research deficiencies in the effects of sea buckthorn extract on inhibiting melanin production and anti-oxidation were addressed, achieving significant tyrosinase inhibition and anti-oxidation effects, and providing safe and effective whitening and skin care products.
Patent Information
- Application Number
- CN202610054983.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-15
- Publication Date
- 2026-05-01
AI Technical Summary
In the existing technology, research on the effects of sea buckthorn extract on inhibiting melanin production and anti-oxidation is relatively limited. In particular, the specific inhibitory effect of its different polar sites on tyrosinase activity and its in vivo anti-melanin efficacy are still unclear, and there is a lack of safe and effective whitening and skin care products.
Different polar fractions of sea buckthorn were obtained by systematic solvent extraction. It was found that the aqueous extract had the strongest tyrosinase inhibitory activity and antioxidant capacity. The preparation method included ethanol extraction followed by extraction with petroleum ether, ethyl acetate, and n-butanol. The aqueous fraction was retained and concentrated and dried. The composition contained vitamin C, vitamin E, total flavonoids, and total saponins.
Sea buckthorn aqueous extract significantly inhibits tyrosinase activity and has excellent antioxidant capacity. In vitro and in vivo experiments have verified its clear whitening efficacy and good biosafety. It regulates melanin synthesis-related genes and signaling pathways, providing a highly efficient and safe raw material for whitening and antioxidant cosmetics or pharmaceuticals.