Magnetic nano-drug carrier

Abstract

The invention belongs to the technical field of drug carriers, and particularly relates to a magnetic nano-drug carrier which is prepared by the following steps: selecting traditional Chinese medicine raw materials and auxiliary raw materials, and selecting corresponding equipment for treating the raw materials; traditional Chinese medicine raw materials are pretreated, effective components are extracted through ultrasonic and reflux combination, and finally an extracting solution is purified and concentrated; preparing through a coprecipitation method; the flexible traditional Chinese medicine dressing is prepared by taking anti-inflammatory, analgesic, blood-activating and blood-stasis-removing active ingredients of 19 traditional Chinese medicines as cores and combining with the local magnetic response enrichment characteristic of the magnetic nano-carrier, the flexible traditional Chinese medicine dressing is attached to a pressurized silica gel pad of a PCI postoperative wrist strap for use, local directional enrichment of the active ingredients of the traditional Chinese medicines in a wound is promoted through the magnetic carrier, and the wound healing effect is improved. The pressurizing silica gel pad has the synergistic effects of resisting inflammation, easing pain, improving microcirculation and dredging collaterals and restoring the pulse, solves clinical pain points such as inflammation edema, obvious pain and unsmooth local blood supply of a wrist puncture wound after the PCI operation, and meets the requirements of flexibility, ventilation and fitting of the pressurizing silica gel pad at the same time.

Description

Technical Field

[0001] This invention relates to the field of drug carrier technology, specifically to a magnetic nanoparticle drug carrier. Background Technology

[0002] Magnetic nanomedicine carriers are intelligent drug delivery systems that combine nanotechnology with magnetic responsive properties. Their core principle involves loading therapeutic molecules such as chemotherapy drugs, gene therapies, or immunomodulators onto magnetically responsive nanoparticles. Guided by an external magnetic field and the response of the lesion's microenvironment, targeted delivery, controlled release, and synergistic therapy of the drug are achieved. This technology holds promise for overcoming the limitations of traditional drugs, such as systemic distribution, poor targeting, significant side effects, and insufficient efficacy.

[0003] However, existing magnetic nanomedicine carriers still have significant limitations. Current research mainly focuses on loading single drug components (such as flavonoids like quercetin or curcumin), which limits their therapeutic focus and function. Especially when dealing with the complex clinical problems of wrist puncture wounds after PCI, these single drug carriers cannot fully meet the comprehensive treatment needs of wound repair, reduction of inflammation and edema, pain relief, and improvement of local microcirculation.

[0004] Therefore, developing a multifunctional composite magnetic nanomedicine carrier that can synergistically reduce inflammation, promote repair, and improve blood circulation is of great clinical significance and research value, given the multi-stage pathophysiological characteristics of wound healing after PCI. Summary of the Invention

[0005] The purpose of this invention is to provide a magnetic nanomedicine carrier to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a magnetic nanomedicine carrier, the preparation steps of which are as follows:

[0007] Step 1: Select Chinese medicinal materials and auxiliary materials, and choose the appropriate equipment for processing the materials;

[0008] Step 2: Pre-treat the Chinese herbal raw materials by extracting the effective components through a combination of ultrasound and reflux, and finally purify and concentrate the extract.

[0009] Step 3: Preparation by co-precipitation method ;

[0010] Step 4: Surface modification of the loading and carrier of effective components of traditional Chinese medicine;

[0011] Step 5: Prepare the traditional Chinese medicine magnetic nano-dressing into a flexible, breathable, and well-fitting dressing;

[0012] Step 6: Perform quality control and performance verification on the dressing.

[0013] Preferably, in step one, the Chinese medicinal materials include 30g of natural copper, 30g of *Imperata cylindrica*, 15g of *Gnaphalium affine*, 30g of *Lycopodium clavatum*, 15g of *Dipsacus asper*, 10g of frankincense, 10g of myrrh, 15g of *Ligusticum chuanxiong*, 15g of *Angelica sinensis*, 9g of earthworm, 15g of *Periploca sepium*, 12g of *Caesalpinia sappan*, 6g of *Corydalis yanhusuo*, 9g of *Panax notoginseng*, 9g of *Asarum heterotropoides*, 20g of *Salvia miltiorrhiza*, 20g of mulberry twigs, 20g of pine twigs, and 6g of *Eupolyphaga sinensis*.

[0014] Auxiliary raw materials include , 25% ammonia water, medical silicone gel, sodium carboxymethyl cellulose, glycerin, polyethylene glycol, medical breathable non-woven fabric, 75% anhydrous ethanol, ultrapure water, 0.45µm filter membrane;

[0015] The corresponding equipment includes a Chinese herbal medicine pulverizer, an ultrasonic extractor, a rotary evaporator, a high-pressure reactor, a centrifuge, a transmission electron microscope (TEM), a vibrating sample magnetometer (VSM), a high-performance liquid chromatograph (HPLC), a dressing forming machine, and a UV-Vis spectrophotometer.

[0016] Preferably, the detailed steps of step two are as follows: after crushing the natural copper, soak it in 5% dilute hydrochloric acid for 30 minutes to remove surface impurities, rinse it with distilled water until neutral, and dry it. After drying the frankincense and myrrh at a low temperature of 60°C, remove the oil. Crush Panax notoginseng, earthworm, and ground beetle through a 100-mesh sieve, and crush the remaining Chinese medicines through an 80-mesh sieve to obtain a mixed Chinese medicine powder.

[0017] Take the mixed powder of traditional Chinese medicine, add 10 times the volume of 75% anhydrous ethanol, and soak for 2 hours; extract ultrasonically at 60℃ and 200W for 30 minutes, then transfer to a reflux evaporator and reflux at 80℃ for 2 hours, filter and collect the first extract; add 8 times the volume of 75% anhydrous ethanol to the residue, repeat the reflux extraction once, and combine the two extracts; filter the extract under reduced pressure through a 0.45µm filter membrane to remove solid impurities, and concentrate the filtrate in a rotary evaporator until there is no ethanol odor to obtain the traditional Chinese medicine extract. Add 5 times the volume of ultrapure water to the extract, stir to dissolve, and then perform column chromatography on an AB-8 macroporous adsorption resin column at a flow rate of 2 BV / h. Elute impurities with distilled water and elute the active ingredients with 70% ethanol. Collect the eluent and concentrate it to a concentration of 80 mg / mL of the active ingredients of traditional Chinese medicine, and refrigerate at 4℃ for later use.

[0018] Preferably, the detailed steps of step three are as follows: (According to...) A molar ratio of 1:2 is used to weigh... 2.78g 7.02g was added to 200mL of ultrapure water, and stirred in a 60℃ water bath under nitrogen protection until completely dissolved, forming a brownish-yellow homogeneous solution. 25% ammonia was slowly added dropwise to adjust the pH to 9-10, and the solution rapidly turned into a black suspension. The reaction was continued with stirring for 1 hour. A black precipitate was adsorbed using an external magnet. The supernatant was discarded, and the solution was washed three times with ultrapure water and twice with anhydrous ethanol to remove chloride ions and residual ammonia. The solution was then vacuum dried at 60℃ for 12 hours and ground to obtain… Magnetic nanopowder.

[0019] Preferably, the detailed steps of step four are as follows: Weigh 0.5g Nanoparticles were added to 100 mL of ultrapure water and ultrasonically dispersed for 30 min to form a uniform suspension. Then, according to... Nanoparticles: Traditional Chinese medicine active ingredients in a mass ratio of 1:0.4 were slowly added to 40 mL of concentrated traditional Chinese medicine active ingredient solution. The mixture was magnetically stirred at 25 °C for 4 h, followed by magnetic separation. The unloaded upper layer of traditional Chinese medicine solution was discarded, and the loaded magnetic nanoparticles were collected. The nanoparticles were washed twice with ultrapure water, and 50 mL of ultrapure water was added to the particles. The mixture was ultrasonically dispersed for 20 min, and 0.1 g of PEG-2000 was added. The mixture was stirred at 50 °C for 2 h. PEG molecules react with the active ingredients through hydroxyl groups. Surface hydroxyl groups are bound to enhance biocompatibility and dispersibility. After magnetic separation, the mixture is washed three times with ultrapure water and vacuum dried at 60°C for 8 hours to obtain a magnetic nanocarrier for traditional Chinese medicine.

[0020] Preferably, the detailed steps of step five are as follows: Take 10g of medical silicone gel, add 2g of glycerin, 1g of CMC-Na, and 50mL of ultrapure water, stir evenly to form a flexible gel matrix, weigh 0.3g of traditional Chinese medicine magnetic nanocarrier, add it to the gel matrix, and ultrasonically disperse for 20min to ensure that the carrier is evenly dispersed and does not agglomerate. Spread the mixed gel evenly on medical breathable non-woven fabric; place it in a dressing forming machine and dry it at 37℃ and 50% humidity for 12h to form a flexible traditional Chinese medicine magnetic nano dressing. Cut the dressing according to the size of the PCI wristband silicone pad, aseptically package it, and set it aside for later use.

[0021] Preferably, the detailed steps of step six are as follows: TEM is used to observe whether the magnetic carrier morphology is spherical and uniformly dispersed; DLS is used to determine whether the particle size is between 30 and 100 nm and the zeta potential is between -15 and -8 mV; VSM is used to determine whether the saturation magnetization is ≥40 emu / g; HPLC is used to determine the content of tanshinone IIA, notoginsenoside R1, and corydaline in the dressing, and the loading rate and encapsulation rate are calculated; the dialysis bag method is used to determine the cumulative release rate at 24 h and 48 h, showing sustained-release characteristics.

[0022] Compared with the prior art, the beneficial effects of the present invention are:

[0023] This application utilizes the anti-inflammatory, analgesic, and blood-activating active ingredients of 19 kinds of traditional Chinese medicine as its core, combined with the local magnetic response enrichment characteristics of magnetic nanocarriers, to prepare a flexible traditional Chinese medicine dressing. This dressing is designed to be used as a pressure silicone pad on the wrist after PCI surgery. The magnetic carrier promotes the targeted enrichment of the active ingredients of traditional Chinese medicine in the local wound, exerting a synergistic effect of anti-inflammatory and analgesic properties, improving microcirculation, and unblocking meridians and restoring blood vessels. This addresses the clinical pain points of inflammation, edema, significant pain, and poor local blood circulation in the wrist puncture wound after PCI surgery, while also meeting the flexibility, breathability, and fit requirements of pressure silicone pads. Attached Figure Description

[0024] Figure 1 This is a flowchart of the preparation steps for the magnetic nanomedicine carrier;

[0025] Figure 2 This is a schematic diagram of local symptoms at the puncture site after percutaneous coronary intervention of the radial artery. Detailed Implementation

[0026] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] Example:

[0028] Please see Figure 1-2 The present invention provides a technical solution:

[0029] A magnetic nanomedicine carrier, the preparation steps of which are as follows:

[0030] Step 1: Select Chinese medicinal materials and auxiliary materials, and choose the appropriate equipment for processing the materials;

[0031] Step 2: Pre-treat the Chinese herbal raw materials by extracting the effective components through a combination of ultrasound and reflux, and finally purify and concentrate the extract.

[0032] Step 3: Preparation by co-precipitation method ;

[0033] Step 4: Surface modification of the loading and carrier of effective components of traditional Chinese medicine;

[0034] Step 5: Prepare the traditional Chinese medicine magnetic nano-dressing into a flexible, breathable, and well-fitting dressing;

[0035] Step 6: Perform quality control and performance verification on the dressing.

[0036] In step one, the Chinese medicinal materials include 30g of natural copper, 30g of *Imperata cylindrica*, 15g of *Hemiberlesia asiatica*, 30g of *Lycopodium clavatum*, 15g of *Dipsacus asper*, 10g of frankincense, 10g of myrrh, 15g of *Ligusticum chuanxiong*, 15g of *Angelica sinensis*, 9g of earthworm, 15g of *Periploca sepium*, 12g of *Caesalpinia sappan*, 6g of *Corydalis yanhusuo*, 9g of *Panax notoginseng*, 9g of *Asarum heterotropoides*, 20g of *Salvia miltiorrhiza*, 20g of mulberry twigs, 20g of pine twigs, and 6g of *Eupolyphaga sinensis*.

[0037] Auxiliary raw materials include , 25% ammonia water, medical silicone gel, sodium carboxymethyl cellulose, glycerin, polyethylene glycol, medical breathable non-woven fabric, 75% anhydrous ethanol, ultrapure water, 0.45µm filter membrane;

[0038] The corresponding equipment includes a Chinese herbal medicine pulverizer, an ultrasonic extractor, a rotary evaporator, a high-pressure reactor, a centrifuge, a transmission electron microscope (TEM), a vibrating sample magnetometer (VSM), a high-performance liquid chromatograph (HPLC), a dressing forming machine, and a UV-Vis spectrophotometer.

[0039] The detailed steps of step two are as follows: After crushing the natural copper, soak it in 5% dilute hydrochloric acid for 30 minutes to remove surface impurities, rinse it with distilled water until neutral, and dry it. Dry the frankincense and myrrh at a low temperature of 60°C to remove oil, so as to avoid the oil affecting the drug load. Crush Panax notoginseng, earthworm, and ground beetle through a 100-mesh sieve, and crush the remaining Chinese medicines through an 80-mesh sieve to obtain a mixed Chinese medicine powder.

[0040] Take the mixed powder of Chinese herbal medicine, add 10 times its volume of 75% anhydrous ethanol (solid-liquid ratio 1:10, w / v), and soak for 2 hours; then perform ultrasonic extraction at 60℃ and 200W for 30 minutes to break the cell walls and improve extraction efficiency. The mixture is then transferred to a reflux filtration device and refluxed at 80℃ for 2 hours. The first extract is collected by filtration. The residue is then added to 8 times its volume of 75% anhydrous ethanol and refluxed again for 2 hours. The two extracts are combined. The extract is then filtered through a 0.45µm filter membrane under reduced pressure to remove solid impurities. The filtrate was placed in a rotary evaporator, which was set to 60°C and -0.08 MPa. The evaporator was concentrated until there was no ethanol odor, and a traditional Chinese medicine extract was obtained. Five times the volume of ultrapure water was added to the extract and stirred to dissolve it. The extract was then subjected to chromatography on an AB-8 macroporous adsorption resin column at a flow rate of 2 BV / h. Impurities were eluted with distilled water (3 BV) and active ingredients were eluted with 70% ethanol (5 BV). The eluent was collected and concentrated to a concentration of 80 mg / mL of active ingredients. The extract was then refrigerated at 4°C for later use.

[0041] The detailed steps of step three are as follows: (Please refer to the steps outlined in the original text.) A molar ratio of 1:2 is used to weigh... 2.78g 7.02g was added to 200mL of ultrapure water, and stirred in a 60℃ water bath under nitrogen protection until completely dissolved, forming a brownish-yellow homogeneous solution. 25% ammonia was slowly added dropwise to adjust the pH to 9-10, and the solution rapidly turned into a black suspension. The reaction was continued with stirring for 1 hour. A black precipitate was adsorbed using an external magnet. The supernatant was discarded, and the solution was washed three times with ultrapure water and twice with anhydrous ethanol to remove chloride ions and residual ammonia. The solution was then vacuum dried at 60℃ for 12 hours and ground to obtain… Magnetic nanopowder with a particle size controlled between 30-80 nm, exhibiting superparamagnetic properties.

[0042] The detailed steps of step four are as follows: Weigh 0.5g Nanoparticles were added to 100 mL of ultrapure water and ultrasonically dispersed for 30 min to form a uniform suspension. Then, according to... Nanoparticles: Traditional Chinese medicine active ingredients = 1:0.4 mass ratio. 40 mL of concentrated traditional Chinese medicine active ingredient solution (80 mg / mL) was slowly added. The mixture was magnetically stirred at 25℃ (300 r / min) for 4 h. Magnetic separation was performed, and the unloaded upper layer of traditional Chinese medicine solution was discarded. The loaded magnetic nanoparticles were collected, washed twice with ultrapure water, and 50 mL of ultrapure water was added to the particles. The mixture was ultrasonically dispersed for 20 min, and 0.1 g of PEG-2000 (1 / 5 of the carrier mass) was added. The mixture was stirred at 50℃ for 2 h. PEG molecules react with the active ingredients through hydroxyl groups. Surface hydroxyl groups are bound to enhance biocompatibility and dispersibility. After magnetic separation, the mixture is washed three times with ultrapure water and vacuum dried at 60°C for 8 hours to obtain a magnetic nanocarrier for traditional Chinese medicine.

[0043] The detailed steps of step five are as follows: Take 10g of medical silicone gel, add 2g of glycerin, 1g of CMC-Na, and 50mL of ultrapure water, stir evenly to form a flexible gel matrix, suitable for the softness of the silicone pad, to avoid pressure on the wound. Weigh 0.3g of traditional Chinese medicine magnetic nanocarrier, add it to the gel matrix, and ultrasonically disperse for 20min to ensure uniform dispersion of the carrier without agglomeration. Spread the mixed gel evenly on medical breathable nonwoven fabric with a thickness of 0.5-0.8mm and an area suitable for the wristband silicone pad, approximately 5cm×3cm. Place it in a dressing forming machine and dry it at 37℃ and 50% humidity for 12h to form a flexible traditional Chinese medicine magnetic nano dressing. Cut the dressing according to the size of the PCI wristband silicone pad, aseptically package it, and set it aside for later use.

[0044] The detailed steps of step six are as follows: TEM is used to observe whether the magnetic carrier is spherical and uniformly dispersed; DLS is used to determine whether the particle size is between 30 and 100 nm and the zeta potential is between -15 and -8 mV; VSM is used to determine whether the saturation magnetization is ≥40 emu / g; HPLC is used to determine the content of tanshinone IIA, notoginsenoside R1, and corydaline in the dressing, and the loading rate (≥25%) and encapsulation rate (≥55%) are calculated; the dialysis bag method is used to determine the cumulative release rate (≥50%) at 24 h and (≥70%) at 48 h, showing sustained-release characteristics.

[0045] Application example:

[0046] The local puncture symptom scores of 15 patients who underwent percutaneous coronary intervention of the radial artery were statistically analyzed on days 0, 3, 5, and 7 after the application of traditional Chinese medicine magnetic nano dressing.

[0047] Instructions for use: After PCI, apply the sterile Chinese herbal magnetic nano dressing to the inside of the pressure silicone pad of the wristband, fitting it to the puncture wound area. Wear the wristband and apply pressure as usual, at a pressure of 15-20 mmHg, 3-4 times a day, for a course of 7 days.

[0048] Symptoms: pain and tenderness at the puncture site, subcutaneous bruising, local swelling at the puncture site, numbness and abnormal sensation in the hand, local induration at the puncture site, and active bleeding.

[0049] The ratings are as follows:

[0050] score Severity Detailed description and definition 0 points none There was no discomfort, and it was no different from the opposite arm. 1 point slight Mild discomfort, only noticeable when you pay attention, does not affect any activities. 2 points Mild There are noticeable symptoms, but they are easily tolerated. They have slight or no impact on daily activities. 3 points moderate The symptoms are obvious and affect some activities, which may cause the patient to avoid using the arm to lift heavy objects. 4 points Severe The symptoms are severe, leading to limited mobility. The patient actively protects the arm, and daily activities (such as writing and using chopsticks) are significantly restricted. 5 points Very serious If the symptoms are unbearable and there is a complete loss of motor function, you need to contact a doctor for a medical evaluation.

[0051] The following are the local puncture symptom scores of 15 patients who underwent percutaneous coronary intervention (PCI) of the radial artery on days 0, 3, 5, and 7 after using a traditional Chinese medicine magnetic nano-dress. The specific results are as follows:

[0052]

[0053]

[0054] The symptoms of the 15 patients who underwent percutaneous coronary intervention on the radial artery were all alleviated after using the traditional Chinese medicine magnetic nano-dress for 7 days.

[0055] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or basic characteristics. Therefore, the embodiments should be considered exemplary and non-limiting in all respects. The scope of the invention is defined by the appended claims rather than the foregoing description. Therefore, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention, and no reference numerals in the claims should be construed as limiting the scope of the claims.

[0056] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A magnetic nanomedicine carrier, characterized in that, The preparation steps of this magnetic nanomedicine carrier are as follows: Step 1: Select Chinese medicinal materials and auxiliary materials, and choose the appropriate equipment for processing the materials; Step 2: Pre-treat the Chinese herbal raw materials by extracting the effective components through a combination of ultrasound and reflux, and finally purify and concentrate the extract. Step 3: Preparation by co-precipitation method ; Step 4: Surface modification of the loading and carrier of effective components of traditional Chinese medicine; Step 5: Prepare the traditional Chinese medicine magnetic nano-dressing into a flexible, breathable, and well-fitting dressing; Step 6: Perform quality control and performance verification on the dressing.

2. The magnetic nanomedicine carrier according to claim 1, characterized in that: In step one, the Chinese medicinal materials include 30g of natural copper, 30g of *Imperata cylindrica*, 15g of *Hemiberlesia asiatica*, 30g of *Lycopodium clavatum*, 15g of *Dipsacus asper*, 10g of frankincense, 10g of myrrh, 15g of *Ligusticum chuanxiong*, 15g of *Angelica sinensis*, 9g of earthworm, 15g of *Periploca sepium*, 12g of *Caesalpinia sappan*, 6g of *Corydalis yanhusuo*, 9g of *Panax notoginseng*, 9g of *Asarum heterotropoides*, 20g of *Salvia miltiorrhiza*, 20g of mulberry twigs, 20g of pine twigs, and 6g of *Eupolyphaga sinensis*. Auxiliary raw materials include , 25% ammonia water, medical silicone gel, sodium carboxymethyl cellulose, glycerin, polyethylene glycol, medical breathable non-woven fabric, 75% anhydrous ethanol, ultrapure water, 0.45µm filter membrane; The corresponding equipment includes a Chinese herbal medicine pulverizer, an ultrasonic extractor, a rotary evaporator, a high-pressure reactor, a centrifuge, a transmission electron microscope (TEM), a vibrating sample magnetometer (VSM), a high-performance liquid chromatograph (HPLC), a dressing forming machine, and a UV-Vis spectrophotometer.

3. The magnetic nanomedicine carrier according to claim 1, characterized in that: The detailed steps of step two are as follows: After crushing the natural copper, soak it in 5% dilute hydrochloric acid for 30 minutes to remove surface impurities, rinse it with distilled water until neutral, and dry it. Dry the frankincense and myrrh at a low temperature of 60°C to remove oil. Crush Panax notoginseng, earthworm, and ground beetle through a 100-mesh sieve, and crush the remaining Chinese medicines through an 80-mesh sieve to obtain a mixed Chinese medicine powder. Take the mixed powder of traditional Chinese medicine, add 10 times the volume of 75% anhydrous ethanol, and soak for 2 hours; extract ultrasonically at 60℃ and 200W for 30 minutes, then transfer to a reflux evaporator and reflux at 80℃ for 2 hours, filter and collect the first extract; add 8 times the volume of 75% anhydrous ethanol to the residue, repeat the reflux extraction once, and combine the two extracts; filter the extract under reduced pressure through a 0.45µm filter membrane to remove solid impurities, and concentrate the filtrate in a rotary evaporator until there is no ethanol odor to obtain the traditional Chinese medicine extract. Add 5 times the volume of ultrapure water to the extract, stir to dissolve, and then perform column chromatography on an AB-8 macroporous adsorption resin column at a flow rate of 2 BV / h. Elute impurities with distilled water and elute the active ingredients with 70% ethanol. Collect the eluent and concentrate it to a concentration of 80 mg / mL of the active ingredients of traditional Chinese medicine, and refrigerate at 4℃ for later use.

4. The magnetic nanomedicine carrier according to claim 1, characterized in that: The detailed steps of step three are as follows: (Please refer to the steps outlined in the original text.) A molar ratio of 1:2 is used to weigh... 2.78g 7.02g was added to 200mL of ultrapure water, and stirred in a 60℃ water bath under nitrogen protection until completely dissolved, forming a brownish-yellow homogeneous solution. 25% ammonia was slowly added dropwise to adjust the pH to 9-10, and the solution rapidly turned into a black suspension. The reaction was continued with stirring for 1 hour. A black precipitate was adsorbed using an external magnet. The supernatant was discarded, and the solution was washed three times with ultrapure water and twice with anhydrous ethanol to remove chloride ions and residual ammonia. The solution was then vacuum dried at 60℃ for 12 hours and ground to obtain… Magnetic nanopowder.

5. A magnetic nanomedicine carrier according to claim 1, characterized in that: The detailed steps of step four are as follows: Weigh 0.5g Nanoparticles were added to 100 mL of ultrapure water and ultrasonically dispersed for 30 min to form a uniform suspension. Then, according to... Nanoparticles: Traditional Chinese medicine active ingredients in a mass ratio of 1:0.4 were slowly added to 40 mL of concentrated traditional Chinese medicine active ingredient solution. The mixture was magnetically stirred at 25 °C for 4 h, followed by magnetic separation. The unloaded upper layer of traditional Chinese medicine solution was discarded, and the loaded magnetic nanoparticles were collected. The nanoparticles were washed twice with ultrapure water, and 50 mL of ultrapure water was added to the particles. The mixture was ultrasonically dispersed for 20 min, and 0.1 g of PEG-2000 was added. The mixture was stirred at 50 °C for 2 h. PEG molecules react with the active ingredients through hydroxyl groups. Surface hydroxyl groups are bound to enhance biocompatibility and dispersibility. After magnetic separation, the mixture is washed three times with ultrapure water and vacuum dried at 60°C for 8 hours to obtain a magnetic nanocarrier for traditional Chinese medicine.

6. The magnetic nanomedicine carrier according to claim 1, characterized in that: The detailed steps of step five are as follows: Take 10g of medical silicone gel, add 2g of glycerin, 1g of CMC-Na, and 50mL of ultrapure water, stir evenly to form a flexible gel matrix, weigh 0.3g of traditional Chinese medicine magnetic nanocarrier, add it to the gel matrix, and ultrasonically disperse for 20min to ensure that the carrier is evenly dispersed and does not agglomerate. Spread the mixed gel evenly on medical breathable non-woven fabric; place it in a dressing forming machine and dry it at 37℃ and 50% humidity for 12h to form a flexible traditional Chinese medicine magnetic nano dressing. Cut the dressing according to the size of the PCI wristband silicone pad, aseptically package it, and set it aside for later use.

7. A magnetic nanomedicine carrier according to claim 1, characterized in that: The detailed steps of step six are as follows: TEM is used to observe whether the magnetic carrier is spherical and uniformly dispersed; DLS is used to determine whether the particle size is between 30 and 100 nm and the zeta potential is between -15 and -8 mV; VSM is used to determine whether the saturation magnetization is ≥40 emu / g; HPLC is used to determine the content of tanshinone IIA, notoginsenoside R1, and corydaline in the dressing, and the loading rate and encapsulation rate are calculated; the dialysis bag method is used to determine the cumulative release rate at 24 h and 48 h, showing sustained-release characteristics.

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