Disposable grinding injection device for parathyroid gland autotransplantation

Abstract

The disposable grinding injection device comprises a cylinder, the rear end of the cylinder is open, and the front end of the cylinder is sequentially provided with a Luer taper and a needle head; according to the double-layer plane grinding net, the mesh diameter of a first grinding net sheet is 1.0-1.5 mm, and the mesh diameter of a second grinding net sheet is 0.5-0.8 mm; the two layers of grinding meshes keep a vertical distance of 2-3mm, and mesh patterns of the two layers of grinding meshes are rotationally staggered at an angle of 30-45 degrees; the cylindrical push rod is hermetically and loosely matched with the inner cavity of the barrel body and is arranged in the barrel body and at the rear end of the double-layer plane grinding net; the push rod pushes the tissue to move towards the mesh when being pushed, negative pressure is generated when the push rod is pulled back, and liquid suction is achieved. Standardized control over the size of tissue particles is achieved; the operation time is shortened to 2-3 minutes; tissue exposure links are reduced, and pollution risks are reduced; a grinding mechanism based on shearing force is adopted, so that the cell survival rate is improved; grinding and injection are integrated, and an intermediate transfer link is eliminated.

Description

Technical Field

[0001] This invention relates to the field of biological tissue processing technology, and more specifically, to a disposable grinding and injection device for autologous parathyroid transplantation. Background Technology

[0002] Autologous parathyroid transplantation is a common procedure in surgeries such as total thyroidectomy and parathyroid adenoma resection, used to maintain normal parathyroid function postoperatively. The fragmentation of parathyroid tissue during autologous parathyroid transplantation is a crucial factor affecting the surgical outcome. Currently, the most commonly used method for fragmenting parathyroid tissue in clinical practice is manual fragmentation, the specific procedure of which is as follows:

[0003] During the procedure, ischemic parathyroid tissue (usually a single gland, weighing approximately 30-50 mg) is placed in a sterile stainless steel dish and kept moist with a small amount of saline. The surgeon uses ophthalmic scissors, tissue scissors, or a scalpel to repeatedly cut the tissue within the culture dish, breaking it down into pieces approximately 3 mm³ in size. The entire cutting process typically takes 5-10 minutes, during which the tissue is exposed to air, requiring the surgeon to continuously adjust the cutting angle and pressure. After cutting, the tissue fragments are held in place using forceps or hemostatic forceps and transferred to the pre-cut transplantation site.

[0004] The existing manual chopping method has the following significant problems:

[0005] First, the tissue particle size is severely uneven: manual cutting relies entirely on the surgeon's experience and technique, lacking standardized size control methods. The size of the fragmented tissue ranges from 0.2mm to 3mm, showing significant variation. Large particles (>2mm) are too large, making it difficult for blood supply to penetrate to the center of the tissue after transplantation, leading to ischemia and necrosis in the central area and loss of endocrine function; while excessively small particles (<0.3mm) suffer from excessive mechanical damage, resulting in a high rate of cell membrane rupture and low survival rate. According to literature reports, uneven particle size is one of the main reasons for the fluctuation in autologous transplantation success rates, with a huge difference between 40% and 85%.

[0006] Secondly, the procedure is time-consuming and highly dependent on the surgeon's experience: manual shredding typically takes 5-10 minutes, and may take even longer for inexperienced young doctors. During the shredding process, the surgeon needs to repeatedly adjust the blade angle and control the cutting force; the entire process lacks objective standards, making quality control difficult. Furthermore, studies have shown that the survival rate of parathyroid cells after manual shredding decreases with prolonged shredding time.

[0007] Secondly, the risk of contamination is high and cell viability is significantly reduced: Repeated cutting of tissue in open containers (culture dishes) for 5-10 minutes increases the risk of bacterial contamination and the introduction of airborne particles. Airflow within the operating room, surgeon respiration, and microorganisms on instrument surfaces can all become sources of contamination. The process of aspirating tissue from the culture dish and transferring it to a syringe increases the chances of repeated contact and exposure, further increasing the risk of infection. Furthermore, the repeated cutting with surgical blades or scissors generates a mixture of compressive and shearing forces on the tissue, but compressive force is dominant. This blunt mechanical damage leads to the rupture of numerous cell membranes and leakage of cellular contents, reducing post-transplant cell survival and functional recovery.

[0008] Finally, the transfer process is cumbersome: the chopped tissue needs to be aspirated from the culture dish using a syringe. Because the tissue pieces vary in size, the needle is easily clogged or residue remains on the container wall during aspiration, resulting in tissue waste. After aspiration, the contents need to be transferred to another syringe; multiple transfers are not only cumbersome but also increase the risk of contamination and tissue loss.

[0009] Therefore, developing a disposable grinding and injection device that can overcome the above problems is an urgent industry challenge. Summary of the Invention

[0010] To address the aforementioned problems in existing technologies, the present invention aims to provide a disposable grinding and injection device for autologous parathyroid gland transplantation. This device achieves standardized control of tissue particle size, ensuring a uniform final particle size within the range of 0.4-0.6 mm; shortens the operation time to 2-3 minutes, reducing reliance on the surgeon's experience; minimizes tissue exposure, reducing the risk of contamination; and employs a shear-force-based grinding mechanism to improve cell viability. The method of tissue transfer using this disposable grinding and injection device integrates grinding and injection, eliminating intermediate transfer steps.

[0011] To achieve the above objectives, the present invention provides a disposable grinding and injection device for autologous parathyroid gland transplantation, comprising:

[0012] A cylindrical body with an opening at the rear end and a Luer connector and a needle arranged sequentially at the front end, providing space for tissue grinding;

[0013] A double-layer planar grinding mesh is set at the front end of the cylinder, 5-8mm away from the Luer joint, and consists of two parallel grinding mesh sheets; the mesh diameter of the first grinding mesh sheet is 1.0-1.5mm, and the mesh diameter of the second grinding mesh sheet is 0.5-0.8mm; the two grinding mesh sheets maintain a vertical spacing of 2-3mm, and the mesh patterns of the two grinding mesh sheets are rotated and misaligned at an angle of 30-45°;

[0014] A cylindrical push rod, loosely fitted with the inner cavity of the cylinder, is located inside the cylinder at the rear end of the double-layer planar grinding mesh. When the push rod is advanced, it pushes the tissue towards the mesh, and when it is pulled back, it generates negative pressure to achieve liquid suction.

[0015] Furthermore, the two layers of abrasive mesh are reliably connected to the cylinder using a snap-fit ​​mechanism. The snap-fit ​​and other detachable and replaceable meshes allow for quick replacement with meshes of different apertures to accommodate target particle sizes (such as those used for tissue transplantation in other organs).

[0016] In the above technical solution, the cylindrical body provides a sealed space for tissue grinding, preventing contamination. It also serves as a container for liquid aspiration and injection, and supports the double-layer grinding mesh, providing mechanical support. The tissue is ground layer by layer through the double-layer planar grinding mesh. The first layer initially breaks large tissue pieces into medium-sized fragments; the second layer further refines the grinding, forming uniform 0.5mm particles. The rotating, staggered design of the mesh pattern ensures that the tissue does not pass through the holes in a straight line, but is subjected to lateral shear force, maximizing the protection of cell membrane integrity. The fixed pore size ensures the consistency of particle size. The push rod propels the tissue towards the mesh, and during rotation, it generates frictional shearing action on the tissue, achieving efficient grinding in conjunction with the mesh. The pullback generates negative pressure, enabling liquid aspiration.

[0017] Furthermore, the front end of the push rod is tapered; the first grinding mesh is fixedly connected to the tapered top of the push rod; the first grinding mesh and the push rod move synchronously. Thus, the tissue to be chopped is located between the first and second grinding meshes, with the first grinding mesh serving to increase friction and assist in cutting.

[0018] Furthermore, the first grinding mesh has a mesh size of 1.2 mm and a thickness of 0.3-0.5 mm; the second grinding mesh has a mesh size of 0.6 mm and a thickness of 0.3-0.5 mm; the meshes of either grinding mesh are arranged in a regular circular or hexagonal pattern, and the edges of the meshes are polished. This technical solution is applicable to the chopping and grinding of general parathyroid tissue; the polishing process maintains moderate sharpness to facilitate tissue cutting, but avoids excessive sharpness that could cause large-area rupture of the cell membrane.

[0019] Furthermore, the first abrasive mesh has a mesh size of 1.5 mm and a thickness of 0.3-0.5 mm; the second abrasive mesh has a mesh size of 0.8 mm and a thickness of 0.3-0.5 mm; the mesh shape of either abrasive mesh is a regular circular or hexagonal arrangement, and the edges of the mesh are polished. This technical solution is applicable to pathological parathyroid glands with harder tissue texture or more fibrous components, such as patients with secondary hyperparathyroidism.

[0020] Furthermore, the end face of the push rod is uniformly provided with an organized pushing structure.

[0021] Furthermore, the tissue-propelling structure comprises an array of 10-20 hemispherical or conical protrusions, each 2-3 mm in diameter and 1-2 mm in height. These protrusions effectively grasp and propel the tissue toward the mesh.

[0022] Furthermore, the tissue-pushing structure is a conical structure with a spiral pattern. The spiral pattern generates a downward thrust when rotating, allowing the operator to complete the grinding without applying force, making it suitable for single-handed operation scenarios or situations where the operator has weak grip strength.

[0023] Furthermore, the cylinder has a transparency of ≥90%, and the grinding mesh is made of medical-grade 316L stainless steel or high-strength polyetheretherketone (PEEK); the Luer connector at the front end of the cylinder is tapered. The cylinder's transparency allows for visual monitoring. The tapered space at the front end facilitates the drainage of pulverized tissue.

[0024] Furthermore, the rear end of the push rod is provided with a rotating handle, and the surface of the handle is provided with anti-slip texture.

[0025] Compared with the prior art, the present invention has the following technical effects:

[0026] (1) The tissue particles are highly uniform.

[0027] Using a precisely controlled double-layer grinding mesh (first layer 1.0-1.5mm, second layer 0.5-0.8mm, maintaining a pore size ratio of approximately 2:1), the final ground tissue particles are concentrated in the range of 0.4-0.6mm, with a standard deviation of <0.1mm. This size ensures sufficient blood supply penetration (blood vessels can ingrow within 2-3 days) while preserving the functional integrity of endocrine cell clusters. Compared to the broad distribution of 0.2-3mm after manual chopping, uniformity is improved by more than 90%.

[0028] (2) Operation time is significantly reduced

[0029] The entire grinding process (from tissue loading to grinding completion) takes only 2-3 minutes, a significant improvement in efficiency compared to the 5-10 minutes required for traditional manual chopping. This is of great importance for rapid surgical procedures and reducing tissue ischemia time.

[0030] (3) Cell survival rate was significantly improved.

[0031] (4) Reduced pollution risk

[0032] The device uses disposable aseptic packaging, and the grinding process is completed within a sealed cylinder, reducing tissue exposure time from 5-10 minutes to near zero. This eliminates open container operations and multiple transfer steps, theoretically reducing the risk of bacterial contamination by more than 80%.

[0033] (5) Standardize operations to reduce reliance on experience.

[0034] The device is simple and easy to use (loading → aspiration → rotation and compression → injection), and novice doctors can master it after 3-5 practice sessions. The quality of operation no longer heavily depends on the operator's experience. Standardized operation greatly improves the predictability of clinical outcomes and facilitates the promotion of the technology.

[0035] (6) Integrated design improves economic efficiency

[0036] After grinding, it can be directly connected to a needle for injection without the need for additional containers, syringes, or transfer steps, thus reducing the use of medical consumables.

[0037] This invention can effectively improve the success rate of autologous parathyroid transplantation, reduce the incidence and duration of postoperative hypocalcemia, reduce patients' dependence on long-term calcium supplementation and active vitamin D therapy, and improve their quality of life. Attached Figure Description

[0038] The invention, its features, shape, and advantages will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings. The same reference numerals denote the same parts throughout the drawings. The drawings are not drawn to scale; the focus is on illustrating the main points of the invention. To make the illustrations clearer, the thickness of some parts has been appropriately exaggerated in the drawings.

[0039] Figure 1 This is a three-dimensional structural schematic diagram of a disposable grinding and injection device according to an embodiment of the present invention;

[0040] Figure 2 This is a three-dimensional structural diagram of the double-layer grinding mesh in an embodiment of the present invention;

[0041] Figure 3 yes Figure 2 Corresponding top view structural diagram;

[0042] Figure 4 This is a schematic diagram of the axial cross-sectional structure of the double-layer grinding mesh inside the cylinder in an embodiment of the present invention.

[0043] Explanation of reference numerals in the attached drawings: 1. Cylinder body; 2. Luer joint; 31. First grinding screen; 32. Second grinding screen; 4. Push rod; 41. Rotating handle. Detailed Implementation

[0044] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but these are not intended to limit the scope of the invention.

[0045] In the following detailed description, numerous specific details are set forth to provide a more thorough understanding of the invention. Unless otherwise expressly specified and limited, the terms “set,” “install,” and “connect” should be interpreted broadly, for example, as a fixed connection, a detachable connection, or an integral connection; as a welding, threaded, or snap-fit ​​connection; and as a direct connection or an indirect connection via an intermediate medium. Those skilled in the art will understand the specific meaning of these terms in this application based on the specific circumstances.

[0046] It should also be noted that the machinery and parts all adopt conventional models in the existing technology. The standard parts used can all be purchased from the market, and the structure and principle of the components known to those skilled in the art can be learned by those skilled in the art through technical manuals or conventional experimental methods. Furthermore, the technologies involved in the following effect examples that are not detailed are existing technologies that can be retrieved.

[0047] Example 1

[0048] See Figures 1 to 3 This embodiment provides a disposable grinding and injection device for autologous parathyroid gland transplantation. The device adopts a syringe-type integrated design and mainly consists of the following components:

[0049] Cylinder 1 Structure: Preferably made of medical-grade transparent polypropylene (PP) material, integrally molded using an injection molding process, with a capacity of 10ml. Cylinder 1 has an outer diameter of 16-20mm, a wall thickness of 1.5-2.0mm, and a transparency of ≥90%, facilitating real-time observation of tissue grinding progress during surgery. The front end of cylinder 1 is equipped with a standard puncture needle via a Luer connector 2, allowing for seamless locking with commercially available 18G, 20G, and 21G needles. The Luer connector 2 serves as both the liquid aspiration channel and the final interface for connecting the needle for tissue injection, achieving an integrated operation of grinding, mixing, and injection.

[0050] The transparent cylinder 1 serves the following purposes in this invention: (1) to provide a closed space for tissue grinding to prevent contamination; (2) to enable visual monitoring through transparency; (3) to serve as a container for liquid aspiration and injection; and (4) to support the double-layer grinding mesh and provide mechanical support.

[0051] Double-layer planar grinding mesh: Located 25-8mm from the Luer connector at the front end of the cylinder 1, this is the core innovative component of the invention. The grinding mesh consists of two parallel metal mesh sheets, which are integrally fixed to the cylinder 1 through injection molding or reliably connected by a snap-fit ​​method, ensuring that the mesh sheets will not shift or fall off during the grinding process. It is understood that the double-layer grinding mesh is designed with a detachable and replaceable snap-fit ​​connection, allowing for quick replacement of mesh sheets with different apertures to accommodate different target particle sizes (such as for tissue transplantation in other organs).

[0052] The first abrasive layer (coarse abrasive mesh) has a pore size of 1.0-1.5 mm, preferably 1.2 mm, and a thickness of 0.3-0.5 mm. It is made of medical-grade 316L stainless steel or high-strength polyether ether ketone (PEEK). The pores are arranged in a regular circular or hexagonal pattern, and the edges of the pores are precisely polished to maintain a moderate sharpness to facilitate tissue cutting, but avoid excessive sharpness that could cause large-area rupture of the cell membrane.

[0053] The second grinding layer (fine grinding mesh) has a pore size of 0.5-0.8mm, preferably 0.6mm, and the material and thickness are the same as the first layer.

[0054] See Figure 2 and Figure 3 The two mesh layers are parallel to each other and maintain a vertical spacing of 2-3 mm. The mesh pattern of the second layer is rotated and offset at an angle of 30-45° relative to the mesh pattern of the first layer (this offset refers to the rotational shift of the mesh pattern in the plane, not the tilting of the mesh). This planar rotational offset design ensures that tissue does not pass through the perforations in a straight line, but is subjected to lateral shear force, simulating the mechanical effect of scissors cutting.

[0055] The functions of the double-layer grinding mesh are: (1) the first layer initially breaks large tissues into medium-sized fragments; (2) the second layer further refines the grinding to form uniform 0.5mm particles; (3) the misaligned design generates shear force to protect the integrity of the cell membrane to the maximum extent; (4) the fixed pore size ensures the consistency of particle size.

[0056] As an example, the first abrasive layer can have a pore size of 1.5 mm (suitable for pathological parathyroid glands with harder tissue or more fibrous components, such as patients with secondary hyperparathyroidism), and the second abrasive layer can have a pore size of 0.8 mm, maintaining a pore size ratio of approximately 2:1. Larger pore sizes can reduce pushing resistance and shorten operation time.

[0057] Push rod 4: The push rod is cylindrical in shape, with an outer diameter slightly smaller than the inner diameter of the cylinder cavity (gap 0.5-1.0mm), ensuring smooth sliding while maintaining good sealing. The end of push rod 4 features a special tissue-pushing structure, including 10-20 hemispherical or conical protrusions, 2-3mm in diameter and 1-2mm in height, evenly distributed on the end face of push rod 4. A rotating handle is located at the top of push rod 4, with anti-slip textured surfaces. Push rod 4 is inserted from the rear end of cylinder 1, with the protrusion array facing the abrasive mesh. During pushing and rotation, continuous frictional shear forces are generated between the protrusion array and the tissue, and between the tissue and the mesh.

[0058] The functions of push rod 4 are: (1) to effectively grasp and push tissue to move towards the mesh through the array of protrusions; (2) to generate frictional shearing action on tissue during rotation, and to achieve efficient grinding in conjunction with the mesh; (3) to control grinding speed and force through the combined action of pushing and rotating; (4) to generate negative pressure when pulling back, and to achieve liquid suction function.

[0059] Understandably, the end of push rod 4 can also use a spiral pattern design (3-5mm pitch) instead of the raised array. The spiral pattern can generate a downward thrust when rotating, so the operator can complete the grinding without having to press down hard, which is suitable for one-handed operation scenarios or situations where the operator has weak grip strength.

[0060] The device employs a negative pressure suction method by pulling back the push rod 4, replacing the traditional side injection port design. The specific operation is as follows: immerse the Luer connector 2 at the front end of the device into a container filled with ice-cold saline (4°C), pull back the push rod 4 to generate negative pressure, and draw 1-2 ml of liquid into the cylinder 1 through the Luer connector 2.

[0061] The purpose of this operation is: (1) to provide a moist environment for the tissue before and after grinding, and to prevent dryness that leads to cell death; (2) to use the liquid as a carrier to facilitate the smooth injection of the fragmented cell suspension into the muscle; (3) to cool the ice liquid and reduce the amount of heat generated by mechanical friction; (4) to dilute the tissue fluid, reduce the osmotic pressure, and alleviate cell edema; (5) to simplify the structure of the device and reduce manufacturing costs and pollution risks.

[0062] See Figure 4 More specifically, the process of dissecting and transferring parathyroid tissue using the aforementioned device includes the following steps:

[0063] Step 1: Organize loading

[0064] During the procedure, the excised parathyroid tissue (usually one gland, total weight 30mg) is inserted through the opening at the rear end of the tube 1, and the tissue should be placed as close as possible to the double-layer abrasive mesh 3. At this time, the push rod 4 has not yet been inserted, and there is ample operating space.

[0065] Step 2: Mix the liquid by suction

[0066] Immerse the Luer connector 2 at the front end of the device into a sterile container filled with ice-cold saline (4°C, approximately 5 ml). Insert the plunger 4 and slowly pull back the plunger to create negative pressure, drawing 1-2 ml of saline into the cylinder 1 through the Luer connector 2. After aspiration, gently shake the device or repeatedly push and pull the plunger in small amplitudes to ensure the liquid is thoroughly mixed with the tissue and that the tissue is moistened.

[0067] Step 3: Rotary pressing and grinding

[0068] The operator holds the cylinder 1 with their left hand and grips the rotating handle 41 with their right hand, employing a combined rotating and pushing motion. The rotation speed of the push rod 4 is controlled at 20-30 revolutions per minute, and the pushing force is controlled at 5-10 N (equivalent to the force of light finger pressure). During the pushing process, the tissue first contacts the first abrasive layer 31 and is initially broken into fragments of about 1 mm; the fragments continue to move forward, passing through the second abrasive layer 32, where they are further finely ground into uniform particles of 0.4-0.6 mm. Due to the 30-45° rotational misalignment of the two mesh layers, the tissue is subjected to lateral shear force as it passes through, minimizing cell membrane damage. The entire grinding process takes about 2-3 minutes, and the operator can observe it in real time through the transparent cylinder 1. The process can be stopped when the tissue has been completely ground into a uniform suspension (dispersed as uniformly dispersed pink fine particles).

[0069] Step 4: Connect the needle for injection

[0070] After grinding, connect an 18G or 20G needle (40-50mm in length) to Luer connector 2. Position the needle in the sternocleidomastoid muscle for injection, and slowly push the plunger 4 to evenly inject the ground tissue suspension into the muscle. After injection, remove the needle, apply pressure to stop bleeding, and the procedure is complete.

[0071] Example 2

[0072] This embodiment provides a disposable grinding and injection device for autologous parathyroid gland transplantation. Its structure is similar to that of Embodiment 1, except that the front end of the push rod 4 is conical; the first grinding mesh 31 is fixedly connected to the conical top of the push rod 4; and the first grinding mesh 31 and the push rod 4 move synchronously. In use, the tissue is placed between the first grinding mesh 31 and the second grinding mesh 32, and the push rod 4 is repeatedly pushed and pulled to achieve the purpose of tissue fragmentation.

[0073] In summary, this invention provides a disposable grinding and injection device and a tissue transfer method for autologous parathyroid transplantation, comprising a cylindrical body with an opening at the rear end and a Luer connector and a needle sequentially arranged at the front end to provide space for tissue grinding; a double-layer planar grinding mesh, located at the front end of the cylindrical body 5-8 mm away from the Luer connector, consisting of two parallel grinding mesh sheets; the mesh aperture of the first grinding mesh sheet is 1.0-1.5 mm, and the mesh aperture of the second grinding mesh sheet is 0.5-0.8 mm; the two grinding mesh sheets maintain a vertical spacing of 2-3 mm, and the mesh patterns of the two grinding mesh sheets are rotated and misaligned at an angle of 30-45°; a cylindrical push rod, loosely fitted with a sealed inner cavity of the cylindrical body, is located inside the cylindrical body at the rear end of the second grinding mesh sheet; when the push rod is advanced, it pushes the tissue towards the mesh sheet, and when it is pulled back, it generates negative pressure to achieve liquid aspiration. This invention achieves standardized control of tissue particle size, ensuring that the final particle size is uniform within the range of 0.4-0.6 mm; shortens the operation time to 2-3 minutes, reducing reliance on the operator's experience; reduces tissue exposure steps, lowering the risk of contamination; adopts a shear force-based grinding mechanism to improve cell survival rate; and integrates grinding and injection, eliminating intermediate transfer steps.

[0074] Those skilled in the art should understand that variations can be implemented by combining existing technology with the above embodiments, which will not be elaborated here. Such variations do not affect the essence of the present invention, and will not be elaborated here either.

[0075] The preferred embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above. Systems and structures not described in detail should be understood as being implemented in a conventional manner in the art. Any person skilled in the art can make many possible variations and modifications to the technical solutions of the present invention using the methods and techniques disclosed above, or modify them into equivalent embodiments with equivalent changes, without departing from the scope of the present invention. This does not affect the essential content of the present invention. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the present invention are still within the scope of protection of the present invention.

Claims

1. A disposable grinding and injection device for autologous parathyroid gland transplantation, characterized in that: include: A cylindrical body with an opening at the rear end and a Luer connector and a needle arranged sequentially at the front end, providing space for tissue grinding; A double-layer planar grinding mesh is set at the front end of the cylinder, 5-8mm away from the Luer joint, and consists of two parallel grinding mesh sheets; the mesh diameter of the first grinding mesh sheet is 1.0-1.5mm, and the mesh diameter of the second grinding mesh sheet is 0.5-0.8mm; the two grinding mesh sheets maintain a vertical spacing of 2-3mm, and the mesh patterns of the two grinding mesh sheets are rotated and misaligned at an angle of 30-45°; A cylindrical push rod, loosely fitted with the inner cavity of the cylinder, is located inside the cylinder at the rear end of the second grinding screen. When the push rod is advanced, it pushes the tissue towards the screen, and when it is pulled back, it generates negative pressure to achieve liquid suction.

2. The disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 1, characterized in that, The two layers of grinding mesh are reliably connected to the cylinder by means of snap fasteners.

3. The disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 1, characterized in that, The front end of the push rod is tapered; the first grinding mesh is fixedly connected to the tapered top of the push rod; the first grinding mesh and the push rod move synchronously.

4. A disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 2 or 3, characterized in that, The first grinding screen has a mesh size of 1.2 mm and a thickness of 0.3-0.5 mm; the second grinding screen has a mesh size of 0.6 mm and a thickness of 0.3-0.5 mm; the holes of either grinding screen are arranged in regular circles or hexagons, and the edges of the holes are polished.

5. A disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 2 or 3, characterized in that, The first grinding screen has a mesh size of 1.5 mm and a thickness of 0.3-0.5 mm; the second grinding screen has a mesh size of 0.8 mm and a thickness of 0.3-0.5 mm; the holes of either grinding screen are arranged in regular circles or hexagons, and the edges of the holes are polished.

6. The disposable grinding and injection device for autologous parathyroid transplantation according to claim 1, characterized in that, The end face of the push rod is uniformly provided with a push mechanism.

7. The disposable grinding and injection device for autologous parathyroid transplantation according to claim 6, characterized in that, The tissue-propelling structure comprises an array of 10-20 hemispherical or conical protrusions with a diameter of 2-3 mm and a height of 1-2 mm.

8. A disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 6, characterized in that, The tissue-promoting structure is a conical structure with a spiral pattern.

9. A disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 1, characterized in that, The cylinder has a transparency of ≥90%, and the grinding mesh is made of medical-grade 316L stainless steel or high-strength polyetheretherketone; the front end of the cylinder is connected to a Luer connector in a conical shape.

10. A disposable grinding and injection device for autologous parathyroid gland transplantation according to claim 1, characterized in that, The push rod has a rotating handle at its rear end, and the surface of the handle has anti-slip texture.

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