Antioxidant, lubricating, anti-inflammatory and repairing skin care product and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, and provides an antioxidant, lubricating, anti-inflammatory and repairing skin care product and a preparation method thereof. Ectoine, low-molecular-weight sodium hyaluronate and dipotassium glycyrrhizinate are taken as core active ingredients for compounding, so that the functions of oxidation resistance, lubrication, efficient anti-inflammation and barrier repair are realized, and the problems of single effect and poor synergism of the existing product are solved. Meanwhile, the skin care product provided by the invention is mild and non-irritant in formula, has good use safety, and can be pertinently suitable for people with sensitive skin and skin barrier damaged skin. In addition, the preparation process is simple and convenient, complex equipment and harsh reaction conditions are not needed, industrial large-scale production is easy to realize, and the preparation method has wide market application prospects and popularization value.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an antioxidant, lubricating, anti-inflammatory, and repairing skin care product and its preparation method. Background Technology

[0002] As the largest surface barrier of the human body, the skin is mainly composed of the sebum film, stratum corneum lipids, and intercellular junction structures. It not only defends against external pollutants, ultraviolet rays, and irritants, but also maintains skin homeostasis and participates in regulating water metabolism and immune processes. However, modern lifestyles and environmental factors continuously affect the skin's barrier function and homeostasis. These internal and external aggressors can trigger or exacerbate skin inflammation, disrupt the integrity of the stratum corneum structure, lead to increased transepidermal water loss, and damage key skin moisturizing factors. This can result in a series of skin problems such as dryness, tightness, redness, sensitivity, and itching. In severe cases, it can lead to a persistent inflammatory state, which is closely related to the occurrence and development of chronic skin diseases such as atopic dermatitis and rosacea.

[0003] Inflammation is a major contributing factor to skin barrier damage. Inflammatory factors disrupt lipid synthesis, delay the normal differentiation and shedding of keratinocytes, further weakening the barrier and creating a vicious cycle of "barrier damage - increased inflammation." Currently, commercially available anti-inflammatory and barrier-repairing skincare products typically have limited efficacy. While some formulas offer anti-inflammatory benefits, they lack antioxidant and lubricating properties. Furthermore, some anti-inflammatory products are highly irritating, easily exacerbating the burden on the skin barrier. Moreover, they only treat the symptoms, not the root cause, of "endogenous" dryness resulting from barrier damage, failing to fundamentally repair the skin.

[0004] In conclusion, developing a skincare product with a gentle formula that can simultaneously provide antioxidant, lubricating, highly effective anti-inflammatory, and barrier repair benefits has become a pressing technical challenge in this field. Summary of the Invention

[0005] In view of this, the present invention provides an antioxidant, lubricating, anti-inflammatory, and repairing skincare product and its preparation method. The skincare product formula provided by the present invention is gentle and can achieve antioxidant, lubricating, highly effective anti-inflammatory, and barrier repair functions.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution: An antioxidant, lubricating, anti-inflammatory, and repairing skincare product comprising the following components in weight percentages: The composition includes 0.1%~5.0% ectoine, 0.05%~2.0% low molecular weight sodium hyaluronate, 0.01%~1.0% dipotassium glycyrrhizate, 1%~10% glycerol, 0.1%~5% urea, 1%~5% propylene glycol, 0.1%~5% polysorbate, 0.05%~0.8% preservative, and the balance being purified water; the molecular weight of the low molecular weight sodium hyaluronate is 200~400 kDa.

[0007] Preferably, the components include the following components in the indicated mass percentages: ectoine 0.5%~3.0%, low molecular weight sodium hyaluronate 0.1%~2.0%, dipotassium glycyrrhizate 0.05%~0.5%, glycerol 1%~5%, urea 0.1%~2%, propylene glycol 1%~2%, polysorbate 0.1%~2%, preservative 0.05%~0.2%, with the balance being purified water.

[0008] Preferably, the polysorbate is polysorbate-20.

[0009] Preferably, the preservative is phenoxyethanol.

[0010] Preferably, the purity of the ectoine is ≥98%.

[0011] This invention also provides a method for preparing the antioxidant, lubricating, anti-inflammatory, and repairing skincare product described above, comprising the following steps: Purified water, glycerol, propylene glycol, and polysorbate were first mixed to obtain an aqueous phase; Ectoin, low molecular weight sodium hyaluronate, dipotassium glycyrrhizate, urea and the aqueous phase are mixed a second time to obtain a mixed system; The mixture system and preservatives are then mixed a third time to obtain the antioxidant, lubricating, anti-inflammatory, and repairing skin care product.

[0012] Preferably, the temperature of the first mixing is 40~45℃, the time is 10~15min, and the stirring speed is 300~500r / min.

[0013] Preferably, the temperature of the second mixing is 40~45℃, the time is 20~30min, and the stirring speed is 200~300r / min.

[0014] Preferably, the temperature of the third mixing is 20~30℃.

[0015] Preferably, after the third mixing, the resulting mixture is further filtered through a microporous membrane; the microporous membrane has a pore size of 0.22 μm.

[0016] This invention provides an antioxidant, lubricating, anti-inflammatory, and repairing skincare product, comprising the following components by weight percentage: 0.1%~5.0% ectoin, 0.05%~2.0% low molecular weight sodium hyaluronate, 0.01%~1.0% dipotassium glycyrrhizate, 1%~10% glycerin, 0.1%~5% urea, 1%~5% propylene glycol, 0.1%~5% polysorbate, 0.05%~0.8% preservative, and the balance being purified water; the low molecular weight sodium hyaluronate has a molecular weight of 200~400 kDa. This invention uses ectoin, low molecular weight sodium hyaluronate, and dipotassium glycyrrhizate as core active ingredients in a compound formulation. Through the synergistic effect of these three components, it can achieve antioxidant, lubricating, highly effective anti-inflammatory, and barrier repair functions. This skincare product effectively builds a hydration protective layer on the skin, enhances cell resilience, deeply replenishes moisture to the skin's base, repairs damaged barriers, and effectively inhibits the release of pro-inflammatory factors such as IL-6, TNF-α, iNOS, and IL-1β, thus effectively alleviating inflammatory responses. It solves the problems of existing products having single efficacy and poor synergy. At the same time, the active ingredients in this skincare product are not easily deactivated and can exert long-lasting and stable antioxidant, lubricating, anti-inflammatory, and barrier repair effects, continuously improving skin dryness, sensitivity, and other problems.

[0017] The skincare formula provided by this invention is gentle and non-irritating, suitable for various skin types. In vitro cell experiments (cell live / dead staining experiments) have proven that the skincare products of this invention have good biocompatibility and a wide range of applications, and can be effectively used in scenarios such as post-medical aesthetic repair and daily sensitive skin care. At the same time, this invention strictly controls the content of each ingredient in the skincare products to ensure the optimal ratio of each ingredient and improve the utilization rate of active ingredients.

[0018] The present invention also provides a method for preparing the antioxidant, lubricating, anti-inflammatory and repairing skin care product described in the above-mentioned scheme. The preparation method provided by the present invention is simple to operate, requires no special equipment, and the process parameters are easy to control, making it suitable for large-scale production. Furthermore, the present invention controls a suitable temperature during the preparation process, which can effectively avoid the deactivation of active ingredients, and the filtration step can remove impurities and improve the purity of the product. Attached Figure Description

[0019] Figure 1 The results of the live / dead dye test for the skincare product in Test Example 1 are shown in the figure. Figure 2 The image shows the tube formation morphology of MUVEC cells in the skincare product tested in Example 2. Figure 3 This is a comparison of the expression levels of pro-inflammatory factors in the skincare products tested in Example 3 using RT-PCR. Figure 4 To test the in vitro PTIO free radical scavenging ability of the skin care product in Example 4; Figure 5 The results of the friction performance test for the skin care product in Test Example 5 are shown. Detailed Implementation

[0020] This invention provides an antioxidant, lubricating, anti-inflammatory, and repairing skincare product, comprising the following components in weight percentages: The composition includes 0.1%~5.0% ectoine, 0.05%~2.0% low molecular weight sodium hyaluronate, 0.01%~1.0% dipotassium glycyrrhizate, 1%~10% glycerol, 0.1%~5% urea, 1%~5% propylene glycol, 0.1%~5% polysorbate, 0.05%~0.8% preservative, and the balance being purified water; the molecular weight of the low molecular weight sodium hyaluronate is 200~400 kDa.

[0021] Unless otherwise specified, all raw materials / components used in this invention are commercially available.

[0022] The antioxidant, lubricating, anti-inflammatory, and repairing skin care product provided by this invention, by weight percentage, includes 0.1% to 5.0% ectoine, preferably 0.5% to 3%, specifically 0.1%, 0.2%, 0.5%, 0.6%, 0.8%, 1%, 1.5%, 2%, or 3%; the purity of the ectoine is preferably ≥98%; the ectoine has antioxidant properties, which can slow down the oxidative damage process of the skin, help maintain skin health, and also has anti-inflammatory and soothing effects, strengthens the skin barrier, reduces transepidermal water loss, and can enhance the skin's ability to resist external environmental pressures and maintain skin homeostasis.

[0023] The antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention, by weight percentage, comprises 0.05% to 2.0% low molecular weight sodium hyaluronate, preferably 0.1% to 2%, specifically 0.1%, 0.5%, 1.0%, 1.5%, or 2%; the molecular weight of the low molecular weight sodium hyaluronate is 200 to 400 kDa. The sodium hyaluronate used in this invention has a small molecular weight, strong penetration ability, and good skin compatibility, enabling deep penetration and moisturizing, improving endogenous dryness, repairing the skin barrier, enhancing barrier integrity, and also possessing certain anti-inflammatory, soothing, and anti-irritant effects.

[0024] The antioxidant, lubricating, anti-inflammatory, and repairing skin care product provided by this invention, by weight percentage, includes 0.01% to 1.0% dipotassium glycyrrhizate, preferably 0.05% to 0.5%, specifically 0.05%, 0.08%, 0.1%, 0.3%, or 0.5%. The dipotassium glycyrrhizate has significant anti-inflammatory, soothing, and anti-allergic effects. It can inhibit the release of inflammatory factors, reduce discomfort symptoms such as skin redness, stinging, and itching, and regulate the skin's immune response, improve the inflammatory state caused by barrier damage, and assist in skin barrier repair.

[0025] This invention uses ectoine, low molecular weight sodium hyaluronate, and dipotassium glycyrrhizate as core active ingredients in a compound formulation. These three ingredients work synergistically and complement each other, achieving a synergistic effect of anti-oxidation, lubrication, highly effective anti-inflammation, and barrier repair. Ectoine stabilizes skin cell structure and enhances cellular stress resistance and antioxidant capacity, reducing damage caused by external stimuli at its source. Low molecular weight sodium hyaluronate penetrates deep into the skin, improving stratum corneum hydration, promoting normal differentiation of keratinocytes, and strengthening the skin's own water retention and barrier structure integrity. Dipotassium glycyrrhizate effectively inhibits the release of inflammatory factors, soothes skin redness and sensitivity, and breaks the vicious cycle of barrier damage and increased inflammation. Compared to single-ingredient formulations, the compound active ingredients used in this invention can more comprehensively and persistently improve skin dryness, sensitivity, and barrier fragility, significantly enhancing skincare efficacy.

[0026] The antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention, by weight percentage, comprises 1% to 10% glycerin, preferably 1% to 5%, specifically 1%, 2%, 3%, 4%, or 5%. In this invention, the glycerin acts as a humectant and moisture absorber, reducing transepidermal water loss and increasing skin hydration and softness; it also enhances the dispersibility and skin compatibility of active ingredients.

[0027] The antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention, by weight percentage, comprises 0.1% to 5% urea, preferably 0.1% to 2%, specifically 0.1%, 0.5%, 1%, 1.5%, or 2%. In this invention, the urea has moisturizing, keratin softening, and penetration-promoting effects, which can enhance the hydration capacity of the stratum corneum, promote stratum corneum metabolism, help damaged keratinocytes renew normally, improve the skin's own water-locking ability, and synergistically strengthen the barrier structure and moisturizing effect.

[0028] Based on mass percentage, the antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention includes 1% to 5% propylene glycol, preferably 1% to 2%, and can be arbitrarily 1%, 1.5%, 1.8%, 2%, or 5%. In this invention, the propylene glycol acts as a moisturizer, solvent, and penetration enhancer, which can help improve the moisturizing ability of the system, promote the uniform dispersion and stable existence of active ingredients, and at the same time help the active ingredients to gently penetrate to the skin surface, thereby improving the utilization rate of active ingredients.

[0029] The antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention, by weight percentage, comprises 0.1% to 5% polysorbate, preferably 0.1% to 2%, specifically 0.1%, 0.5%, 1%, 1.5%, 2%, 3%, or 5%; the polysorbate is preferably polysorbate-20; in this invention, the polysorbate is a hydrophilic polysorbate, which can play a role in emulsification, solubilization, dispersion, and stabilization, effectively improving the stability of the formula and avoiding phenomena such as layering, oil separation, and precipitation; at the same time, it can promote the uniform dispersion and gentle penetration of active ingredients, and improve the utilization rate of active ingredients.

[0030] The antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention, by weight percentage, comprises 0.05% to 0.8% preservative, preferably 0.05% to 0.2%, specifically 0.05%, 0.1%, 0.15%, 0.2%, 0.5%, or 0.8%. In this invention, the preservative is preferably phenoxyethanol. In this invention, the preservative can inhibit the growth and reproduction of bacteria, fungi, and other microorganisms, effectively reducing the risk of microbial contamination during production, storage, and use, and ensuring the hygiene, safety, and stability of the skincare product.

[0031] The antioxidant, lubricating, anti-inflammatory, and repairing skincare product provided by this invention, by weight percentage, includes the remainder purified water.

[0032] This invention also provides a method for preparing the antioxidant, lubricating, anti-inflammatory, and repairing skincare product described above, comprising the following steps: Purified water, glycerol, propylene glycol, and polysorbate were first mixed to obtain an aqueous phase; Ectoin, low molecular weight sodium hyaluronate, urea, dipotassium glycyrrhizate and the aqueous phase are mixed a second time to obtain a mixed system; The mixture system and preservatives are then mixed a third time to obtain the antioxidant, lubricating, anti-inflammatory, and repairing skin care product.

[0033] In this invention, purified water, glycerol, propylene glycol, and polysorbate are first mixed to obtain an aqueous phase. In this invention, the preferred temperature for the first mixing is 40-45°C, the preferred time is 10-15 min, and the preferred stirring speed is 300-500 r / min.

[0034] After obtaining the aqueous phase, the present invention performs a second mixing of ectoine, low molecular weight sodium hyaluronate, dipotassium glycyrrhizate, urea, and the aqueous phase to obtain a mixed system. In the present invention, the preferred temperature for the second mixing is 40-45°C, the preferred time is 20-30 minutes, and the preferred stirring speed is 200-300 r / min. In a specific embodiment of the present invention, it is preferable to add ectoine, low molecular weight sodium hyaluronate, dipotassium glycyrrhizate, and urea sequentially to the aqueous phase. After the addition is complete, the stirring speed is adjusted to 200-300 r / min, and stirring is performed under heat preservation conditions until all components are completely dissolved. By controlling the mixing temperature, the present invention can effectively avoid the deactivation of active ingredients.

[0035] After obtaining the mixed system, the present invention performs a third mixing with the preservative to obtain the antioxidant, lubricating, anti-inflammatory, and repairing skin care product. In the present invention, the temperature of the third mixing is preferably 20-30°C, specifically at room temperature; preferably, after the second mixing is completed, the mixed system is allowed to cool naturally to room temperature before adding the preservative. The present invention does not have special requirements for the rotation speed and time of the third mixing, as long as uniform stirring is achieved.

[0036] In this invention, after the third mixing, it is preferable to further filter the resulting mixture through a microporous membrane; the pore size of the microporous membrane is preferably 0.22 μm; this invention can remove impurities and improve product purity through microporous membrane filtration.

[0037] The technical solutions of this invention will be clearly and completely described below with reference to the embodiments thereof. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0038] The purity of ectoine used in the following examples is ≥98%, and the molecular weight of low molecular weight sodium hyaluronate is 200~400 kDa.

[0039] Example 1 A method for preparing an antioxidant, lubricating, and anti-inflammatory skincare product, wherein the components, calculated by mass percentage, are as follows: The ingredients are: 1% ectoine, 0.1% low molecular weight sodium hyaluronate, 0.1% dipotassium glycyrrhizate, 2% glycerol, 2% propylene glycol, 0.5% urea, 0.5% polysorbate-20, 0.8% phenoxyethanol, and the remainder is purified water.

[0040] The preparation method is as follows: Purified water, glycerin, propylene glycol, and polysorbate-20 are added to a reaction vessel and heated to 40°C. The mixture is stirred at 400 r / min for 15 min until the glycerin is completely dissolved, resulting in an aqueous phase. Ectoin, low molecular weight sodium hyaluronate, dipotassium glycyrrhizate, and urea are added to the aqueous phase sequentially. The stirring speed is adjusted to 200 r / min, and the temperature is maintained at 40°C. The mixture is stirred for 20 min until all components are completely dissolved. After the system has cooled naturally to room temperature, phenoxyethanol is added. The mixture is then filtered through a 0.22 μm microporous membrane to remove impurities, yielding an antioxidant, lubricating, anti-inflammatory, and repairing skincare product.

[0041] Examples 2-4 The mass percentages of other components are the same as in Example 1, except that the content of ectoine is changed to 0.1%, 0.2%, and 0.5%, and the amount of purified water is adjusted to keep the total mass of raw materials at 100%. The preparation method is the same as in Example 1.

[0042] Test Example 1: Biocompatibility Test of Antioxidant, Lubricating, Anti-inflammatory, and Repairing Skincare Products Mouse fibroblasts (L929) were seeded at a density of 4000 cells / 100 µL in 24-well plates. The experiment included a control group (DMEM containing only 10% FBS) and an experimental group. The core component (ectoin) in the experimental group samples was 0.1%, 0.2%, 0.5%, and 1% by mass (i.e., the skin care products prepared in Examples 1-4). The sample was added at a volume fraction of 1%. After group treatment and co-culture with cells for 48 h, the culture medium was discarded, live / dead staining solution was added, and the cells were incubated in the dark for 15-20 min. After washing three times with PBS, the 24-well plates were observed and photographed under an inverted fluorescence microscope. The number of live / dead cells was counted to visually analyze the effect of the sample on cell viability.

[0043] Cell live / dead staining results as follows Figure 1 As shown. Figure 1 The results indicate that the skincare product of this invention has good biocompatibility, demonstrating good safety during cell culture and further confirming its potential value and reliability in the field of skincare products. Through cell viability / dead staining experiments (showing good biocompatibility), the optimal experimental concentration of 1% (high mass fraction) of the core ingredient was determined to be the optimal concentration for subsequent efficacy verification experiments.

[0044] Test Example 2: Tube Formation Experiment of Antioxidant, Lubricating, Anti-inflammatory and Repairing Skin Care Products Mouse umbilical vein endothelial cells (MUVECs) were starved 24 hours prior to treatment with serum-free culture medium. Low-growth factor matrix gels were plated into 24-well plates and incubated at 37°C in a 5% CO2 incubator until the gel completely solidified. A suspension of MUVEC cells treated with the sample (added at a volume fraction of 1%) was then seeded onto the gel surface. Experimental and control groups were included, and cells were cultured using standard methods. Cell morphology was observed and photographed under an inverted fluorescence microscope at specified times of 3, 6, and 9 hours.

[0045] Experimental results are as follows Figure 2 As shown, the left side represents the control group, and the right side represents the experimental group. Figure 2 The results showed that the in vitro tube formation ability of MUVEC cells in the experimental group was significantly enhanced, indicating that the sample has a good effect on promoting angiogenesis and accelerating tissue repair.

[0046] Test Example 3: RT-PCR Experiment of Antioxidant, Lubricating, Anti-inflammatory, and Repairing Skincare Products RAW 264.7 mouse mononuclear macrophages (RAW 264.7) were pretreated. An in vitro inflammation model was constructed by stimulating RAW 264.7 cells with lipopolysaccharide (LPS) to simulate cellular inflammatory stress. The experiment included a blank control group, a positive control group (stimulated with LPS only, without sample treatment), and an experimental group (stimulated with LPS plus 1% sample treatment, 1% being the optimal concentration selected previously). After treatment, RNA was extracted from each group of cells, reverse transcribed into cDNA, and amplified using real-time quantitative PCR (RT-PCR) as a template. The RT-PCR results are shown below. Figure 3 As shown, Figure 3 The results showed that the relative expression levels of four pro-inflammatory factors—IL-6, TNF-α, IL-1β, and iNOS—were significantly reduced in the sample of this invention. Using GAPDH as an internal reference gene, the relative gene expression level was calculated using the 2^ΔΔCt method to analyze the sample's regulatory effect on the transcription of pro-inflammatory factor genes, confirming that the sample has significant anti-inflammatory regulatory activity, synergistically supporting the previously mentioned repair efficacy. Combined with the results of cell scratch assays and synthesis tube experiments, this demonstrates that the skincare product of this invention can inhibit the expression of pro-inflammatory factors while promoting vascular repair, achieving a synergistic effect of "anti-inflammatory + repair promotion," reducing the inhibition of angiogenesis by inflammation, and creating a more favorable microenvironment for the repair and healing of damaged tissues, further supporting the comprehensive moisturizing, anti-inflammatory, and repair efficacy of the sample.

[0047] Test Example 4: Antioxidant Properties Experiment of Antioxidant, Lubricating, Anti-inflammatory, and Repairing Skincare Products The in vitro antioxidant activity of ectoine, the core ingredient of this skincare product, was determined using the PTIO method. The experiment included a blank group, a control group, and an experimental group. The control group was tested using a PTIO aqueous solution with a concentration of 0.05 mg / mL. The experimental groups had ectoine concentrations of 2 mg / mL, 5 mg / mL, and 10 mg / mL. During the experiment, the absorbance at 557 nm was measured using a microplate reader. The OD values ​​of the blank group, control group, and experimental group were expressed as Ao, Ac, and As, respectively. The PTIO free radical scavenging rate was calculated using the following formula: PTIO free radical scavenging rate (%) = [1 - (As - Ao) / Ac] × 100%.

[0048] Experimental results are as follows Figure 4 As shown, the left figure shows the appearance of the test solution when the PTIO concentration is 0.05 mg / mL, and the right figure shows the PTIO free radical scavenging rate when the PTIO concentration is 0.05 mg / mL. Figure 4 The results showed that ectoine, the core ingredient of the skincare product of this invention, has a good scavenging ability against PTIO free radicals: the scavenging rate of 0.05 mg / mL PTIO free radicals reached 68-79%, indicating that it has excellent in vitro antioxidant activity. This active ingredient can effectively scavenge free radicals in the body, reduce oxidative stress damage to cells, and alleviate the synergistic effect of oxidation and inflammation, thus helping to reduce inflammatory responses and protect cell structure and function. The excellent antioxidant properties and anti-inflammatory and repairing effects of the experimental results corroborate each other, jointly confirming the comprehensive efficacy advantages of the antioxidant, lubricating, anti-inflammatory, and repairing skincare product of this invention.

[0049] Test Example 5: Tribological Properties Test of Antioxidant, Lubricating, Anti-inflammatory, and Repairing Skincare Products This experiment used a traditional reciprocating friction tester to determine the tribological properties of the samples. The test conditions were set as follows: load 1N, frequency 1Hz. A 6 mm diameter elastic polydimethylsiloxane (PDMS) hemisphere served as the upper friction pair in this test. A glass slide was used as the test substrate. During the test, the sample was dropped onto the glass slide, and the PDMS hemisphere was used for friction testing. The preparation process of the elastic polydimethylsiloxane hemisphere used in the experiment was as follows: A 96-well polystyrene cell culture plate with circular holes (diameter d=6 mm) was used as a mold. The base oil (polydimethylsiloxane) and curing agent (siloxane crosslinking agent) were mixed at a mass ratio of 10:1. After degassing to remove air bubbles, the mixture was poured into the mold and incubated in an 80℃ oven for 3 h to complete the preparation of the silicone elastomer.

[0050] Tribological test results as follows Figure 5 As shown, the left side is the friction coefficient curve, and the right side is the average friction coefficient. Figure 5The results show that under a load of 1N and a frequency of 1Hz, the friction coefficient of the skincare product of this invention is consistently 0.005, and the coating surface maintains a stable friction coefficient over 1000 friction cycles. These experimental results demonstrate that under low-load conditions, the skincare product of this invention exhibits excellent lubrication and wear resistance, effectively improving application smoothness, reducing barrier friction damage, and facilitating the penetration of active ingredients. This complements its anti-inflammatory, repairing, and antioxidant effects, further enhancing the overall skincare value of the sample.

[0051] In addition, the skin care product samples used in the test examples of this invention were samples that had been stored for 7 to 30 days, proving that they can exert long-term and stable antioxidant, lubricating, anti-inflammatory and barrier repair effects.

[0052] In summary, the skincare product provided by this invention not only exhibits outstanding lubrication performance, but also demonstrates excellent anti-inflammatory activity and good biocompatibility in in vitro experiments. Furthermore, it possesses superior antioxidant capacity and highly efficient skin repair function, and its formula is gentle and non-irritating, making it suitable for sensitive skin and skin with damaged skin barriers. Moreover, the preparation process of this invention is simple and convenient, requiring no complex equipment or harsh reaction conditions, making it easy to achieve industrial-scale production. Combined with its multiple skincare benefits and good safety profile, it has broad market application prospects and promotional value.

[0053] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. An antioxidant, lubricating, anti-inflammatory, and repairing skincare product, characterized in that, The components include the following components by mass percentage: The composition includes 0.1%~5.0% ectoine, 0.05%~2.0% low molecular weight sodium hyaluronate, 0.01%~1.0% dipotassium glycyrrhizate, 1%~10% glycerol, 0.1%~5% urea, 1%~5% propylene glycol, 0.1%~5% polysorbate, 0.05%~0.8% preservative, and the balance being purified water; the molecular weight of the low molecular weight sodium hyaluronate is 200~400 kDa.

2. The antioxidant, lubricating, anti-inflammatory, and repairing skincare product according to claim 1, characterized in that, It includes the following components by weight percentage: ectoine 0.5%~3.0%, low molecular weight sodium hyaluronate 0.1%~2.0%, dipotassium glycyrrhizate 0.05%~0.5%, glycerin 1%~5%, urea 0.1~2%, propylene glycol 1%~2%, polysorbate 0.1%~2%, preservative 0.05%~0.2%, and the balance being purified water.

3. The antioxidant, lubricating, anti-inflammatory, and repairing skincare product according to claim 1, characterized in that, The polysorbate is polysorbate-20.

4. The antioxidant, lubricating, anti-inflammatory, and repairing skincare product according to claim 1, characterized in that, The preservative is phenoxyethanol.

5. The antioxidant, lubricating, anti-inflammatory, and repairing skincare product according to claim 1, characterized in that, The purity of the ectoine is ≥98%.

6. The method for preparing the antioxidant, lubricating, anti-inflammatory, and repairing skincare product according to any one of claims 1 to 5, characterized in that, Includes the following steps: Purified water, glycerol, propylene glycol, and polysorbate were first mixed to obtain an aqueous phase; Ectoin, low molecular weight sodium hyaluronate, dipotassium glycyrrhizate, urea and the aqueous phase are mixed a second time to obtain a mixed system; The mixture system and preservatives are then mixed a third time to obtain the antioxidant, lubricating, anti-inflammatory, and repairing skin care product.

7. The preparation method according to claim 6, characterized in that, The temperature of the first mixing is 40~45℃, the time is 10~15min, and the stirring speed is 300~500r / min.

8. The preparation method according to claim 6, characterized in that, The second mixing temperature is 40~45℃, the time is 20~30min, and the stirring speed is 200~300r / min.

9. The preparation method according to claim 6, characterized in that, The temperature of the third mixture is 20~30℃.

10. The preparation method according to claim 6, characterized in that, The third mixing process further includes filtering the resulting mixture through a microporous membrane; the microporous membrane has a pore size of 0.22 μm.

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