A process for the preparation of monohydrate n-methyl guanidino acetic acid
By controlling reaction conditions and purification processes, the problem of impurity generation in the production of N-methylguanidinoacetic acid monohydrate was solved, achieving high-purity products and low-cost production.
CN122102961APending Publication Date: 2026-05-29SHANDONG TAIHE WATER TREATMENT TECH CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANDONG TAIHE WATER TREATMENT TECH CO LTD
- Filing Date
- 2024-11-29
- Publication Date
- 2026-05-29
AI Technical Summary
Technical Problem
Existing technologies for producing N-methylguanidinoacetic acid monohydrate are prone to generating impurities such as dicyandiamide and dihydrotriazine, leading to high purification difficulty and increased production costs.
Method used
By controlling reaction conditions, including temperature, pH, and reaction time, dicyandiamide is avoided in the initial reaction stage of sodium N-methylglycinate and aminocyanide. The material separation process is simplified by using negative pressure distillation and crystallization purification processes.
Benefits of technology
It effectively avoids the formation of impurities such as dicyandiamide and dihydrotriazine, improves product purity and raw material utilization, and reduces production costs and purification difficulty.
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Figure CN122102961A_ABST
Abstract
The application discloses a preparation method of monohydrate N-methyl guanidino acetic acid and belongs to the technical field of organic synthesis. A sodium N-methyl glycine aqueous solution is heated to 65-80 DEG C, adjusted to a pH value of >8.0, and then an amino cyanide aqueous solution is added dropwise, and the dropwise addition is completed in 1-2 hours. After the dropwise addition is completed, the reaction is preserved for 0-0.5 h. The reaction solution is cooled to <10 DEG C, acid is added to adjust the pH value of the system to 7-8, and then aging, filtration, filter cake purification and drying are carried out to obtain the monohydrate N-methyl guanidino acetic acid. It is found that by controlling the reaction conditions and the reaction time, the generation of dicyandiamide can be avoided, the product is easier to purify, and the unreacted materials can be recycled after simple treatment under the influence of no impurities, so that the purification difficulty of the raw material recycling is reduced, and the raw material utilization is improved.
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