Combination therapy with cell therapy expressing car targeting GPRC5d and related methods and uses
By combining CAR-T cell therapy with bispecific antibodies, specifically GPRC5D and BCMA, the problem of poor efficacy of GPRC5D combined with CAR therapy in treating RRMM has been solved in existing technologies, thus achieving effective treatment for RRMM.
CN122122187APending Publication Date: 2026-05-29JUNO THERAPEUTICS INC
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Patent Information
- Application Number
- CN202480070122.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-09-13
- Filing Date
- 2024-09-12
- Publication Date
- 2026-05-29
AI Technical Summary
Technical Problem
In the existing technology, cell therapy combining GPRC5D and CAR has limited efficacy in treating relapsed and refractory multiple myeloma (RRMM), and there is a need for improved targeted cell and combination therapies.
Method used
CAR-T cell therapy involves administering a chimeric antigen receptor (CAR) to the subject. This CAR specifically binds to G protein-coupled receptor class C5 member D (GPRC5D) and a bispecific antibody that binds to B cell maturation antigen (BCMA) and CD3. The therapeutic effect is enhanced through a specific dosing regimen.
Benefits of technology
It significantly improved the treatment outcomes for relapsed and refractory multiple myeloma, prolonging patient survival and improving quality of life.
✦ Generated by Eureka AI based on patent content.
Abstract
Provided herein are methods and uses of combination therapies involving GPRC5D targeted cell therapies comprising chimeric antigen receptors (CARs) and combined agents, e.g., bispecific antibodies, for treating subjects suffering from cancer, such as multiple myeloma, as well as related methods, uses, and articles of manufacture, the chimeric antigen receptor contains an extracellular antigen binding domain that binds to G protein coupled receptor class C family 5 member D (GPRC5D).
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