A soothing repair efficacy composition, skin care product and method of making same
By combining sodium DNA, snake venom-like peptides, hydrolyzed silk heart protein, active granules, and vine tea extract, this product addresses the limited repair effects of existing cosmetics on sensitive skin, achieving comprehensive anti-aging and soothing effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUAXING SIYUE BIOTECHNOLOGY (SHANGHAI) CO LTD
- Filing Date
- 2026-04-21
- Publication Date
- 2026-06-02
AI Technical Summary
Existing cosmetics have limited repair effects on sensitive skin. Traditional anti-wrinkle ingredients are highly irritating, while gentle ingredients have weak anti-wrinkle effects. Moreover, most cosmetics on the market focus on single moisturizing or basic soothing effects, which are difficult to meet the multiple needs of sensitive skin.
This product uses a combination of sodium DNA, snake venom-like peptides, hydrolyzed silk protein, active granules, and vine tea extract to repair DNA damage by activating DNA repair enzymes, inhibiting neurotransmitter release, forming a breathable protective film, and activating collagen synthesis, providing a comprehensive anti-aging system.
It achieves deep repair and barrier strengthening of sensitive skin, reduces dynamic wrinkles, enhances the skin's resistance to irritation, and provides excellent soothing and anti-wrinkle effects, meeting the needs of sensitive skin.
Smart Images
Figure CN122123940A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of cosmetic technology, specifically to a soothing and repairing composition, a skin care product, and a method for preparing the same. Background Technology
[0002] The increasing pressures of modern life and the growing number of environmental irritants have led to a year-on-year expansion of the sensitive skin population. This group has compromised skin barrier function, resulting in poor tolerance to changes in the external environment and external stimuli. They are highly susceptible to skin discomfort such as dryness, redness, and stinging caused by physical, chemical, and environmental stimuli. Simultaneously, sensitive skin individuals exhibit significantly reduced tolerance to cosmetic ingredients, making them prone to adverse skin reactions to ordinary cosmetics. Therefore, there is an urgent need to develop safer and gentler cosmetics to meet the needs of this population.
[0003] Currently, most cosmetics on the market targeting sensitive skin focus on single moisturizing or basic soothing effects. For example, Chinese invention patent application CN118217182A provides a composition with soothing and repairing effects on sensitive skin. It combines seven active ingredients, including Tremella fuciformis polysaccharide, asiaticoside, and Centella asiatica extract, to form a synergistic composition and construct a soothing and repairing cream system in a specific weight ratio to achieve deep repair and barrier strengthening of sensitive skin. However, its repair effect on damaged skin is relatively limited. In addition, traditional anti-wrinkle ingredients (such as retinol and fruit acids) are highly irritating and unsuitable for sensitive skin; while gentle ingredients (such as peptides) have weak anti-wrinkle effects and lack synergistic repair when used alone. Summary of the Invention
[0004] To address the problems in the prior art, the first aspect of the present invention provides a soothing and repairing composition comprising sodium DNA, snake venom-like peptides, hydrolyzed silk protein, active ingredient and vine tea extract.
[0005] In some embodiments, the active granule includes tea ( CAMELLIA SINENIS ) extract and amla ( PHYLLANTHUS EMBLICA Fruit extract.
[0006] In some embodiments, the snake venom-like peptide is dipeptide diaminobutyryl benzylamide diacetate.
[0007] In some embodiments, the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active grain factor and vine tea extract is (0.001-0.1):(0.001-0.01):(0.001-0.2):(0.001-2):(0.05-1). It can be listed as any value within the range of 0.001:0.001:0.001:0.001:0.05, 0.0015:0.0015:0.0015:0.05, 0.0015:0.0015:0.15:0.0015:0.05, 0.0015:0.0015:0.0015:1:0.05, 0.0015:0.0015:0.0015:0.0015:1, or any value within the range of (0.001-0.1):(0.001-0.01):(0.001-0.2):(0.001-2):(0.05-1).
[0008] The Latin name of the vine tea extract is Ampelopsis thaliana (Variegata var. spp.). AMPELOPSIS GROSSEDENTATA Extract.
[0009] A second aspect of the present invention provides a skin care product, wherein the raw materials for preparing the skin care product include the soothing and repairing composition.
[0010] In some embodiments, the skincare product satisfies at least one of the following characteristics: (1) The sodium DNA comprises 0.001-0.1% of the total mass of the skincare product; (2) The snake venom-like peptides account for 0.001-0.01% of the total mass of the skincare product; (3) The hydrolyzed silk protein accounts for 0.001-0.2% of the total mass of the skin care product; (4) The active ingredients account for 0.001-2% of the total mass of the skincare product; (5) The vine tea extract accounts for 0.05-1% of the total mass of the skin care product.
[0011] In some embodiments, the raw materials for preparing the skincare product include an aqueous phase, an oil phase, an active phase, and purified water, and satisfy at least one of the following characteristics: (1) The raw materials for preparing the aqueous phase include at least one of humectant, emulsifier, thickener and preservative; (2) The raw materials for preparing the oil phase include oils, polydimethylsiloxane, and Myrothamnus flabellifolia (…). MYROTH FLABELLIFOLIA At least one of the following: leaf / stem extract, isododecane, hydrogenated polyisobutylene, and guaiac. (3) The raw materials for preparing the active phase include at least an anti-wrinkle composition.
[0012] In some embodiments, the humectant includes at least one of glycerin and butylene glycol.
[0013] In some embodiments, the emulsifier includes hydrogenated lecithin.
[0014] In some embodiments, the thickener includes at least one of carbomer, ammonium acryloyldimethyl taurate / VP copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, xanthan gum, and sodium hyaluronate.
[0015] In some embodiments, the preservative includes at least one selected from capryloyl hydroxamic acid, p-hydroxyacetophenone, and 1,2-hexanediol.
[0016] In some embodiments, the oil includes camellia ( JAPANESE CAMELLIA At least one of the following: seed oil, squalane, caprylic / capric triglyceride, and PEG-40 hydrogenated castor oil.
[0017] The active phase also includes capernaum ( ) SPHINY CAPERS At least one of the following: fruit extract, glyceryl glucoside, and nicotinamide.
[0018] In some embodiments, the skin care product includes at least one of a cream, serum, or gel.
[0019] In some embodiments, the raw materials for preparing the essence cream, by weight percentage, include: Aqueous phase: 4-5% glycerol, 0.2-0.8% hydrogenated lecithin, 1-2% ammonium acryloyldimethyl taurate / VP copolymer, 0.01-0.06% acrylate / C10-30 alkanol acrylate crosspolymer, 0.2-0.8% p-hydroxyacetophenone, and 0.1-0.6% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA Seed oil 1-2%, Myrothamnus flabellifolia ( MYROTH FLABELLIFOLIA Leaf / stem extract 0.1-0.5%, polydimethylsiloxane 1-5%, and caprylic / capric triglyceride 1-5%; Active phase: Sodium DNA 0.001-0.1%, snake venom-like peptides 0.001-0.01%, hydrolyzed silken protein 0.001-0.2%, active granule 0.001-2%, vine tea extract 0.05-1%, glycerol glucoside 0.1-0.5%, and capersana (… SPHINY CAPERS Fruit extract 0.1-0.5%; Add pure water to make up the remaining amount.
[0020] In some embodiments, the raw materials for preparing the serum, by weight percentage, include: Aqueous phase: xanthan gum 0.01-0.05%, butylene glycol 1-3%, capryloyl hydroxamic acid 1-3%, and sodium hyaluronate 0.01-0.05%; Oil phase: 8-13% squalane, 15-25% octanoic acid / capric acid triglycerides, 25-30% isododecane, and 15-25% hydrogenated polyisobutylene; Active phase: sodium DNase 0.001-0.1%, snake venom-like peptides 0.001-0.01%, hydrolyzed silk heart protein 0.001-0.2%, active granule factor 0.001-2%, vine tea extract 0.05-1%, and nicotinamide 0.8-1.5%; Add pure water to make up the remaining amount.
[0021] In some embodiments, the raw materials for preparing the gel, by weight percentage, include: Aqueous phase: 4-5% glycerol, 0.1-0.2% xanthan gum, 0.01-0.05% sodium hyaluronate, 0.1-0.5% carbomer, 0.1-0.5% p-hydroxyacetophenone, and 0.01-0.05% 1,2-hexanediol; Oil phase: 0.01-0.05% guaiac, 0.1-0.5% caprylic / capric triglycerides, and 0.1-0.5% PEG-40 hydrogenated castor oil; Active phase: sodium DNase 0.001-0.1%, snake venom-like peptides 0.001-0.01%, hydrolyzed silk heart protein 0.001-0.2%, vine tea extract 0.05-1%, and active granule factor 0.001-2%; Add pure water to make up the remaining amount.
[0022] A third aspect of the present invention provides a method for preparing the aforementioned skincare product, comprising at least the following steps: (1) Mix the raw materials for the preparation of the aqueous phase until homogeneous; (2) Stir the raw materials for the preparation of the oil phase evenly; (3) Add the material from step (2) to the material from step (1) while stirring; (4) Add the raw materials for preparing the active phase to the material in step (3) while stirring, and stir evenly to obtain the skin care product.
[0023] Beneficial effects 1. The raw materials prepared in this application contain hydrolyzed silk protein, which can form a breathable protective film on the skin surface, reduce external irritants (such as pollutants and ultraviolet rays), and at the same time scavenge free radicals, reduce oxidative damage, and provide basic protection for barrier repair.
[0024] 2. The raw materials prepared in this application contain snake venom-like peptides, which inhibit the release of neurotransmitters (such as acetylcholine), block the signal transmission between facial muscles and nerves, and reduce the production of dynamic wrinkles (such as crow's feet and forehead wrinkles); at the same time, they activate fibroblasts, promote the synthesis of collagen and elastin, improve the skin's supporting structure from deep within, and the ingredients are mild and non-irritating.
[0025] 3. The raw materials prepared in this application contain active granulocyte colony-stimulating factor (AVCS) and vine tea extract. AVCS contains tea extract and amla fruit extract, which reduces the release of inflammatory factors. The flavonoids such as dihydromyricetin in the vine tea extract directly scavenge superoxide free radicals and activate antioxidant pathways. The two form a synergistic effect of targeting inflammation and oxidation: the vine tea extract first scavenge free radicals to reduce oxidative damage, while AVCS further blocks the inflammatory cascade reaction triggered by oxidative stress, jointly stabilizing the skin barrier, making it particularly suitable for soothing and repairing sensitive skin.
[0026] 4. The raw materials prepared in this application contain sodium DNA. After being absorbed by keratinocytes, sodium DNA activates DNA repair enzymes to repair DNA damage caused by ultraviolet radiation or oxidative stress, reducing cell apoptosis. At the same time, sodium DNA promotes filaggrin expression and enhances the density of the stratum corneum. It forms a molecular-structural linkage with the physical protective film of hydrolyzed filaggrin: DNA repair restores barrier function at the cellular level, while hydrolyzed filaggrin strengthens barrier integrity at the physical level, jointly enhancing the skin's resistance to irritation.
[0027] 5. This application utilizes the combined effects of sodium DNA, snake venom-like peptides, hydrolyzed silk protein, active granule factor, and vine tea extract: sodium DNA repairs DNA damage and promotes cell regeneration; snake venom-like peptides inhibit neurotransmitter release, reduce dynamic wrinkles, and activate collagen synthesis; hydrolyzed silk protein forms a physical protective film to scavenge free radicals; active granule factor inhibits inflammatory factors; and vine tea extract provides potent antioxidant effects. These five components work together to protect the skin's surface, repair deep layers, regulate the nervous system, and strengthen the antioxidant defense system, forming a comprehensive anti-aging system.
[0028] 6. This application provides an anti-wrinkle composition. By controlling the amount of each raw material in the skin care product, the prepared essence cream, serum and gel have excellent soothing, repairing and anti-wrinkle effects, meeting the needs of people with sensitive skin. Attached Figure Description
[0029] Figure 1 The image shows the anti-wrinkle effect test results of the essence cream prepared in Example 1. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0030] Figure 2 The image shows the soothing effect test results of the essence cream prepared in Example 1. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0031] Figure 3 The image shows the anti-wrinkle effect test results of the serum prepared in Example 6. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0032] Figure 4 The image shows the soothing effect test of the serum prepared in Example 6. The left side of the image is the initial effect, and the right side is the effect after 30 days of application to the sample.
[0033] Figure 5 The image shows the anti-wrinkle effect test results of the gel prepared in Example 8. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0034] Figure 6 The image shows the soothing effect test results of the gel prepared in Example 8. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application to the test sample. Detailed Implementation
[0035] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments and accompanying drawings. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. Experimental methods not specifying specific conditions in the embodiments were performed under conventional conditions or conditions recommended by the manufacturer. Reagents not specifying manufacturers are all commercially available conventional products.
[0036] Example 1 The first aspect of this example provides a soothing and repairing composition comprising sodium DNA, snake venom-like peptides, hydrolyzed silk protein, active ingredient and vine tea extract.
[0037] The mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active grain factor, and vine tea extract is 0.0015:0.0015:0.0015:0.0015:0.05.
[0038] The sodium DNA was sourced from Shanghai Huiwen Biotechnology Co., Ltd.
[0039] The snake venom-like peptide is dipeptide diaminobutyryl benzylamide diacetate, which is derived from Huaxing Siyue Biotechnology (Shanghai) Co., Ltd.
[0040] The hydrolyzed silk heart protein is from Parasun Biotechnology (Shanghai) Co., Ltd.
[0041] The active ingredient includes tea ( CAMELLIA SINENIS ) extract and amla ( PHYLLANTHUS WRISTWEARThe fruit extract is derived from the mitochondrial activating factor of Phyllanthus emblica from Huaxing Silky Biotechnology (Shanghai) Co., Ltd.
[0042] The vine tea extract was obtained from Cuiyuan Biotechnology (Shanghai) Co., Ltd.
[0043] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: Sodium DNA 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silken protein 0.0015%, active granule factor 0.0015%, glyceryl glucoside 0.5%, vine tea extract 0.05%, and capersana (… SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0044] The acrylamide dimethyl taurate ammonium / VP copolymer is from Aristoflex AVC of Clariant Chemical Technology (Shanghai) Co., Ltd.
[0045] The acrylate / C10-30 alkanol acrylate crosslinking polymer is from Lubrizol Advanced Materials, Carbopol. ® μLtrez 20 Polymer.
[0046] The camellia ( JAPANESE CAMELLIA The seed oil is model YH-52041 and comes from Shanghai Lihong Chemical Technology Co., Ltd.
[0047] The Myrothamnus ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract from MYRAMAZE, RAHN AG ® -ESSENCE.
[0048] The polydimethylsiloxane is derived from XIAMETER™ PMX-200Silicone Fluid 100 cSt from Dow Siloxanes (Zhangjiagang) Co., Ltd.
[0049] The citrus ( SPHINY CAPERSThe fruit extract comes from Gmoist CS, a product of Shanghai Jiakai Biotechnology Co., Ltd.
[0050] The third aspect of this example provides a method for preparing the aforementioned skincare product, comprising the following steps: (1) Mix the raw materials for the preparation of the aqueous phase until homogeneous; (2) Stir the raw materials for the preparation of the oil phase evenly; (3) Add the material from step (2) to the material from step (1) while stirring; (4) Add the raw materials for preparing the active phase to the material in step (3) while stirring, and stir evenly to obtain the skin care product.
[0051] Figure 1 The image shows the anti-wrinkle effect test results of the essence cream prepared in Example 1. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0052] Figure 2 The image shows the soothing effect test results of the essence cream prepared in Example 1. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0053] Example 2 The specific implementation method of this example is the same as that of Example 1, except that the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active grain factor and vine tea extract is 0.0015:0.005:0.0015:0.0015:0.05.
[0054] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: Sodium DNA 0.0015%, snake venom-like peptides 0.005%, hydrolyzed silken protein 0.0015%, active granule 0.0015%, vine tea extract 0.05%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0055] Example 3 The specific implementation method of this example is the same as that of Example 1, except that the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active grain factor and vine tea extract is 0.0015:0.0015:0.15:0.0015:0.05.
[0056] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: Sodium DNA 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silken protein 0.15%, active granule 0.0015%, vine tea extract 0.05%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0057] Example 4 The specific implementation method in this example is the same as in Example 1, except that the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk protein, active granulin and vine tea extract is 0.0015:0.0015:0.0015:1:0.05.
[0058] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: Sodium DNA 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silken protein 0.0015%, active granule 1%, vine tea extract 0.05%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0059] Example 5 The specific implementation method in this example is the same as in Example 1, except that the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active granulin and vine tea extract is 0.0015:0.0015:0.0015:0.0015:1.
[0060] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: Sodium DNA 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silken protein 0.0015%, active granule 0.0015%, vine tea extract 1%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0061] Example 6 The specific implementation method of this example is the same as that of Example 1, except that the second aspect of this example provides a skin care product, which is a serum. The raw materials for preparing the serum, by weight percentage, include: Aqueous phase: xanthan gum 0.02%, butylene glycol 2%, capryloyl hydroxamic acid 1%, and sodium hyaluronate 0.02%; Oil phase: 10% squalane, 20% caprylic / capric triglyceride, 30% isododecane, and 20% hydrogenated polyisobutylene; Active phase: sodium DNase 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silk heart protein 0.0015%, active granule factor 0.0015%, vine tea extract 0.05%, and nicotinamide 1%; Add pure water to make up the remaining amount.
[0062] Figure 3 The image shows the anti-wrinkle effect test results of the serum prepared in Example 6. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0063] Figure 4The image shows the soothing effect test of the serum prepared in Example 6. The left side of the image is the initial effect, and the right side is the effect after 30 days of application to the sample.
[0064] Example 7 The specific implementation method of this example is the same as that of Example 6, except that the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active grain factor and vine tea extract is 0.0015:0.0015:0.0015:0.0015:1.
[0065] The second aspect of this example provides a skincare product, which is a serum. The raw materials for preparing the serum, by weight percentage, include: Aqueous phase: xanthan gum 0.02%, butylene glycol 2%, capryloyl hydroxamic acid 1%, and sodium hyaluronate 0.02%; Oil phase: 10% squalane, 20% caprylic / capric triglyceride, 30% isododecane, and 20% hydrogenated polyisobutylene; Active phase: sodium DNase 0.0015%, snake venom-like peptide 0.015%, hydrolyzed silk heart protein 0.0015%, active granule factor 0.0015%, vine tea extract 1%, and nicotinamide 1%; Add pure water to make up the remaining amount.
[0066] Example 8 The specific implementation method of this example is the same as that of Example 1, except that the second aspect of this example provides a skin care product, which is a gel. The raw materials for preparing the gel, by weight percentage, include: Aqueous phase: 5% glycerol, 0.1% xanthan gum, 0.05% sodium hyaluronate, 0.5% carbomer, 0.5% p-hydroxyacetophenone, and 0.05% 1,2-hexanediol; Oil phase: 0.01% guaiac, 0.5% caprylic / capric triglycerides, and 0.5% PEG-40 hydrogenated castor oil; Active phase: sodium DNase 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silk heart protein 0.0015%, active granule factor 0.0015%, and vine tea extract 0.05%; Add pure water to make up the remaining amount.
[0067] The guaiac extract is from Gandalf, a biopharmaceutical company of Shuobang (Huzhou) Biomedical Technology Co., Ltd. ® - Guaiac
[0068] The PEG-40 hydrogenated castor oil is from SOLUBILISANTLRI of Senxin Flavor & Pigment Technology (China) Co., Ltd.
[0069] Figure 5The image shows the anti-wrinkle effect test results of the gel prepared in Example 8. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application of the sample.
[0070] Figure 6 The image shows the soothing effect test results of the gel prepared in Example 8. The left side of the image shows the initial effect, and the right side shows the effect after 30 days of application to the test sample.
[0071] Example 9 The specific implementation method of this example is the same as that of Example 8, except that the mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active grain factor and vine tea extract is 0.0015:0.0015:0.0015:0.0015:1.
[0072] The second aspect of this example provides a skincare product, which is a gel, and the raw materials for preparing the gel, by weight percentage, include: Aqueous phase: 5% glycerol, 0.1% xanthan gum, 0.05% sodium hyaluronate, 0.5% carbomer, 0.5% p-hydroxyacetophenone, and 0.05% 1,2-hexanediol; Oil phase: 0.01% guaiac, 0.5% caprylic / capric triglycerides, and 0.5% PEG-40 hydrogenated castor oil; Active phase: sodium DNase 0.0015%, snake venom-like peptides 0.0015%, hydrolyzed silk heart protein 0.0015%, active granule factor 0.0015%, and vine tea extract 1%; Add pure water to make up the remaining amount.
[0073] Comparative Example 1 The specific implementation method of this example is the same as that of Example 1, except that the composition is sodium DNA, hydrolyzed silk protein and active granule; the mass ratio of sodium DNA, hydrolyzed silk protein and active granule is 0.0015:0.0015:0.0015.
[0074] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: sodium DNase 0.0015%, hydrolyzed filocule protein 0.0015%, active granule 0.0015%, glycerol glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0075] Comparative Example 2 The specific implementation method of this example is the same as that of Example 1, except that the composition is a snake venom peptide, hydrolyzed silk protein and active granule; the mass ratio of the snake venom peptide, hydrolyzed silk protein and active granule is 0.0015:0.0015:0.0015.
[0076] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: snake venom-like peptide 0.0015%, hydrolyzed silken protein 0.0015%, active granule 0.0015%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0077] Comparative Example 3 The specific implementation method of this example is the same as that of Example 1, except that the composition is a snake venom peptide, sodium DNA and active granulocytes; the mass ratio of the snake venom peptide, sodium DNA and active granulocytes is 0.0015:0.0015:0.0015.
[0078] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: snake venom-like peptide 0.0015%, sodium DNase 0.0015%, active granule 0.0015%, glycerol glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0079] Comparative Example 4 The specific implementation method of this example is the same as that of Example 1, except that the composition is a snake venom-like peptide, sodium DNA and hydrolyzed silk protein; the mass ratio of the snake venom-like peptide, sodium DNA and hydrolyzed silk protein is 0.0015:0.0015:0.0015.
[0080] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: 0.0015% snake venom-like peptide, 0.0015% sodium DNase, 0.0015% hydrolyzed filocule protein, 0.5% glycerol glucoside, and capersana (… SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0081] Comparative Example 5 The specific implementation method of this example is the same as that of Example 1, except that the composition is a snake venom peptide, vine tea extract and hydrolyzed silk protein; the mass ratio of the active granule, vine tea extract and hydrolyzed silk protein is 0.0015:0.05:0.0015.
[0082] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIALeaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: hydrolyzed silken protein 0.0015%, snake venom-like peptide 0.0015%, vine tea extract 0.05%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0083] Comparative Example 6 The specific implementation method of this example is the same as that of Example 1, except that the composition is sodium DNA and active granulocytes; the mass ratio of active granulocytes to sodium DNA is 0.0015:0.0015.
[0084] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: 0.0015% active granule, 0.0015% sodium DNase, 0.5% glycerol glucoside, and capersana (… CAPERS SPORN Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0085] Comparative Example 7 The specific implementation method of this example is the same as that of Example 1, except that the composition is active granulocyte colony-derived protein and vine tea extract; the mass ratio of active granulocyte colony-derived protein and vine tea extract is 0.0015:0.05.
[0086] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIALeaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: 0.0015% active ingredient, 0.05% vine tea extract, 0.5% glyceryl glucoside, and capersana (… CAPERS SPORN Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0087] Comparative Example 8 The specific implementation method of this example is the same as that of Example 1, except that the composition is hydrolyzed silk protein and active granule; the mass ratio of hydrolyzed silk protein to active granule is 0.0015:0.0015.
[0088] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: hydrolyzed fibroin 0.0015%, active granule 0.0015%, glyceryl glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0089] Comparative Example 9 The specific implementation method of this example is the same as that of Example 1, except that the composition is hydrolyzed silk protein and sodium DNA; the mass ratio of hydrolyzed silk protein to sodium DNA is 0.0015:0.0015.
[0090] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIALeaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: hydrolyzed filocule protein 0.0015%, sodium DNase 0.0015%, glyceryl glucoside 0.5%, and capersana (… SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0091] Comparative Example 10 The specific implementation method of this example is the same as that of Example 1, except that the composition is a snake venom-like peptide and sodium DNA; the mass ratio of the snake venom-like peptide and sodium DNA is 0.0015:0.0015.
[0092] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: 0.0015% snake venom-like peptide, 0.0015% sodium DNA, 0.5% glycerol glucoside, and capersana (… CAPERS SPORN Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0093] Comparative Example 11 The specific implementation method in this example is the same as in Example 1, except that the composition is sodium DNA.
[0094] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: sodium DNA 0.0015%, glycerol glucoside 0.5%, and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0095] Comparative Example 12 The specific implementation method in this example is the same as in Example 1, except that the composition is a vine tea extract.
[0096] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: 0.05% vine tea extract, 0.5% glyceryl glucoside, and capersana (… SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0097] Comparative Example 13 The specific implementation method in this example is the same as in Example 1, except that the composition is active granule.
[0098] The second aspect of this example provides a skincare product, which is an essence cream. The ingredients for preparing the essence cream, by weight percentage, include: Aqueous phase: 5% glycerol, 0.6% hydrogenated lecithin, 1% ammonium acryloyldimethyl taurate / VP copolymer, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 0.5% p-hydroxyacetophenone, and 0.5% 1,2-hexanediol; Oil phase: Camellia ( JAPANESE CAMELLIA ) Seed oil 1%, Myrothamnus flabellifolia ( MYROTHAMNUS FLABELLIFOLIA Leaf / stem extract 0.15%, polydimethylsiloxane 3%, and caprylic / capric triglyceride 2%; Active phase: 0.0015% active granule, 0.5% glyceryl glucoside and capersana ( SPHINY CAPERS Fruit extract 0.5%; Add pure water to make up the remaining amount.
[0099] Comparative Example 14 The specific implementation method of this example is the same as that of Example 6, except that the composition is sodium DNA, hydrolyzed silk protein, active granulin and snake venom peptide; the mass ratio of sodium DNA, hydrolyzed silk protein, active granulin and snake venom peptide is 0.0015:0.0015:0.0015:0.0015.
[0100] The second aspect of this example provides a skincare product, which is a serum. The raw materials for preparing the serum, by weight percentage, include: Aqueous phase: xanthan gum 0.02%, butylene glycol 2%, capryloyl hydroxamic acid 1%, and sodium hyaluronate 0.02%; Oil phase: 10% squalane, 20% caprylic / capric triglyceride, 30% isododecane, and 20% hydrogenated polyisobutylene; Active phase: sodium DNase 0.0015%, hydrolyzed filamentin 0.0015%, active granule 0.0015%, snake venom-like peptide 0.0015%, and nicotinamide 1%; Add pure water to make up the remaining amount.
[0101] Comparative Example 15 The specific implementation method of this example is the same as that of Example 6, except that the composition is a snake venom peptide, hydrolyzed silk protein, active granulin and vine tea extract; the mass ratio of the snake venom peptide, hydrolyzed silk protein, active granulin and vine tea extract is 0.0015:0.0015:0.0015:0.05.
[0102] The second aspect of this example provides a skincare product, which is a serum. The raw materials for preparing the serum, by weight percentage, include: Aqueous phase: xanthan gum 0.02%, butylene glycol 2%, capryloyl hydroxamic acid 1%, and sodium hyaluronate 0.02%; Oil phase: 10% squalane, 20% caprylic / capric triglyceride, 30% isododecane, and 20% hydrogenated polyisobutylene; Active phase: 0.0015% snake venom-like peptide, 0.0015% hydrolyzed silk heart protein, 0.0015% active granule factor, 0.05% vine tea extract, and 1% nicotinamide; Add pure water to make up the remaining amount.
[0103] Comparative Example 16 The specific implementation method of this example is the same as that of Example 6, except that the composition is a snake venom peptide, active granulin and vine tea extract; the mass ratio of the snake venom peptide, active granulin and vine tea extract is 0.0015:0.0015:0.05.
[0104] The second aspect of this example provides a skincare product, which is a serum. The raw materials for preparing the serum, by weight percentage, include: Aqueous phase: xanthan gum 0.02%, butylene glycol 2%, capryloyl hydroxamic acid 1%, and sodium hyaluronate 0.02%; Oil phase: 10% squalane, 20% caprylic / capric triglyceride, 30% isododecane, and 20% hydrogenated polyisobutylene; Active phase: 0.0015% snake venom peptide, 0.0015% active granule, 0.05% vine tea extract, and 1% nicotinamide; Add pure water to make up the remaining amount.
[0105] Comparative Example 17 The specific implementation method of this example is the same as that of Example 8, except that the composition is sodium DNA, snake venom-like peptide, hydrolyzed silk heart protein and active granulin; the mass ratio of sodium DNA, snake venom-like peptide, hydrolyzed silk heart protein and active granulin is 0.0015:0.0015:0.0015:0.0015.
[0106] The second aspect of this example provides a skincare product, which is a gel, and the raw materials for preparing the gel, by weight percentage, include: Aqueous phase: 5% glycerol, 0.1% xanthan gum, 0.05% sodium hyaluronate, 0.5% carbomer, 0.5% p-hydroxyacetophenone, and 0.05% 1,2-hexanediol; Oil phase: 0.01% guaiac, 0.5% caprylic / capric triglycerides, and 0.5% PEG-40 hydrogenated castor oil; Active phase: sodium DNase 0.0015%, snake venom-like peptide 0.0015%, hydrolyzed silk heart protein 0.0015%, and active granule 0.0015%; Add pure water to make up the remaining amount.
[0107] Comparative Example 18 The specific implementation method of this example is the same as that of Example 8, except that the composition is a snake venom peptide, hydrolyzed silk protein, active granulin and vine tea extract; the mass ratio of the snake venom peptide, hydrolyzed silk protein, active granulin and vine tea extract is 0.0015:0.0015:0.0015:0.05.
[0108] The second aspect of this example provides a skincare product, which is a gel, and the raw materials for preparing the gel, by weight percentage, include: Aqueous phase: 5% glycerol, 0.1% xanthan gum, 0.05% sodium hyaluronate, 0.5% carbomer, 0.5% p-hydroxyacetophenone, and 0.05% 1,2-hexanediol; Oil phase: 0.01% guaiac, 0.5% caprylic / capric triglycerides, and 0.5% PEG-40 hydrogenated castor oil; Active phase: 0.0015% snake venom peptide, 0.0015% hydrolyzed silk heart protein, 0.05% vine tea extract, and 0.0015% active granule factor; Add pure water to make up the remaining amount.
[0109] Performance testing 1. Anti-wrinkle effect test of the essence cream: Samples to be tested: Essence creams prepared in Examples 1 and 5 and Comparative Examples 1, 5, 7, and 12.
[0110] Testing Method: Healthy women aged 30-50 years were selected as subjects. Six groups of tests were conducted, involving 180 subjects. To ensure data accuracy, the average of three test data sets was taken for each sample. In the data in the table below, T0 represents the initial wrinkle depression index, T... 30T The wrinkle depression index and ΔT represent the wrinkle depression index 30 days after the sample was applied. 30T The value representing the difference between the initial wrinkle depression index T0 and the value 30 days after the sample was applied is: ΔT 30T =(T 30T -T0).
[0111] Testing instrument: Antera 3D skin analyzer, Miravex Corporation. Test results are shown in Table 1.
[0112] Table 1
[0113] As can be seen from Table 1, the wrinkle depression index of the essence cream prepared in this application decreased more significantly after 30 days of use compared with comparative examples 1, 5, 7, and 12. This indicates that the anti-wrinkle effect of the essence cream containing sodium DNA, snake venom peptide, hydrolyzed silk protein, active ingredient and vine tea extract in this application is significantly better than that of the essence creams in the comparative examples.
[0114] 2. Anti-wrinkle effect test of the serum: Samples to be tested: the serums prepared in Examples 6 and 7 and Comparative Examples 14-16.
[0115] Testing Method: Healthy women aged 30-50 years were selected as subjects. Six groups of tests were conducted, involving 180 subjects. To ensure data accuracy, the average of three test data sets was taken for each sample. In the data in the table below, T0 represents the initial wrinkle depression index, T... 30T The wrinkle depression index and ΔT represent the wrinkle depression index 30 days after the sample was applied. 30T The value representing the difference between the initial wrinkle depression index T0 and the value 30 days after the sample was applied is: ΔT 30T =(T 30T -T0).
[0116] Testing instrument: Antera 3D skin analyzer, Miravex Corporation. Test results are shown in Table 2.
[0117] Table 2
[0118] As can be seen from Table 2, the essence prepared in this application containing sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active granule and vine tea extract showed a more significant decrease in wrinkle depression index after 30 days of use compared with the comparative example. This indicates that the anti-wrinkle effect of the essence in this application is significantly better than that of the comparative example.
[0119] 3. Gel anti-wrinkle effect test: Test samples: gels prepared in Examples 8 and 9 and Comparative Examples 17 and 18.
[0120] Testing Method: Healthy women aged 30-50 years were selected as subjects. Four groups were tested, with a total of 120 subjects. To ensure data accuracy, the average of three test data sets was taken for each sample. In the data in the table below, T0 represents the initial wrinkle depression index, T... 30T The wrinkle depression index and ΔT represent the wrinkle depression index 30 days after the sample was applied. 30T The value representing the difference between the initial wrinkle depression index T0 and the value 30 days after the sample was applied is: ΔT 30T =(T 30T -T0).
[0121] Testing instrument: Antera 3D skin analyzer, Miravex Corporation. Test results are shown in Table 3.
[0122] Table 3
[0123] As can be seen from Table 3, the gel prepared in this application containing sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active granule and vine tea extract showed a more significant decrease in wrinkle depression index after 30 days of use compared with the comparative example. This indicates that the anti-wrinkle effect of the gel in this application is significantly better than that of the comparative example.
[0124] 4. Soothing effect test: Samples to be tested: serum creams prepared in Examples 1-5 and Comparative Examples 1-13; serums prepared in Examples 6-7 and Comparative Examples 14-16; gels prepared in Examples 8-9 and Comparative Examples 17-18.
[0125] Test Method: Thirty healthy women aged 30-40 years were selected as subjects. A 2.0cm × 2.0cm area was selected on the subject's forearm. Hypoallergenic adhesive tape was applied to the test area, pressed for 2 seconds, and then slowly peeled off, continuing to peel until visible erythema appeared. The test sample was administered at a concentration of 1.5 μL / cm². 2 The sample was evenly applied to the area, and the skin hemoglobin in that area was tested, as well as the skin hemoglobin in the arm area 30T after application. To ensure data accuracy, the average of three sets of test data was taken for each sample. In the data in the table below, T0 represents the initial skin hemoglobin, T... 30T This represents skin hemoglobin 30 days after application of the test sample. ΔT 30T The difference between the skin hemoglobin level 30 days after application of the test sample and the initial skin hemoglobin level (T0) is represented by: ΔT 30T =(T 30T -T0).
[0126] Testing instrument: Antera 3D skin analyzer, Miravex Corporation. Test results are shown in Table 4.
[0127] Table 4
[0128] As can be seen from Table 4, the serum, cream, and gel prepared in this application, containing sodium DNA, snake venom peptide, hydrolyzed silk protein, active ingredient and vine tea extract, showed a more significant decrease in skin hemoglobin index after 30 days of use compared to the comparative sample. This indicates that the soothing effects of the serum, cream, and gel prepared in this application are significantly better than those of the comparative sample.
[0129] 5. Repair effect test: Samples to be tested: serum creams prepared in Examples 1-5 and Comparative Examples 1-13; serums prepared in Examples 6-7 and Comparative Examples 14-16; gels prepared in Examples 8-9 and Comparative Examples 17-18.
[0130] Test Method: Thirty healthy women aged 30-40 years were selected as subjects. A 2.0cm × 2.0cm area was selected on the subject's forearm. Hypoallergenic adhesive tape was applied to the test area, pressed for 2 seconds, and then slowly peeled off, continuing to peel until visible erythema appeared. The test sample was administered at a concentration of 1.5 μL / cm². 2 The sample was evenly applied to the area, and the transepidermal water loss value of that area was measured, as well as the transepidermal water loss value of the arm area 30T after application. To ensure data accuracy, the average of three sets of test data was taken for each sample. In the data in the table below, T0 represents the initial transepidermal water loss value, T... 30TΔT represents the transepidermal water loss value 30 days after the sample is applied. 30T ΔT represents the difference between the transepidermal water loss value 30 days after the sample was applied and the initial transepidermal water loss value T0. 30T =(T 30T -T0).
[0131] Test instrument: Tewameter™ Hex transdermal moisture loss probe, COURAGE+KHAZAKA (CK) GmbH, Germany. Test results are shown in Table 5.
[0132] Table 5
[0133] As can be seen from Table 5, the serum, cream, and gel prepared in this application, containing sodium DNA, snake venom peptides, hydrolyzed silk protein, active ingredient, and vine tea extract, showed a more significant decrease in transepidermal water loss after 30 days of use compared to the comparative sample. This indicates that the repair effects of the serum, cream, and gel prepared in this application are significantly better than those of the comparative sample.
Claims
1. A composition with soothing and repairing effects, characterized in that, The composition includes sodium DNA, snake venom-like peptides, hydrolyzed silk heart protein, active grain factor, and vine tea extract.
2. The soothing and repairing composition according to claim 1, characterized in that, The active ingredient includes tea extract and amla fruit extract.
3. The soothing and repairing composition according to claim 2, characterized in that, The mass ratio of sodium DNA, snake venom peptide, hydrolyzed silk heart protein, active granulin and vine tea extract is (0.001-0.1):(0.001-0.01):(0.001-0.2):(0.001-2):(0.05-1).
4. A skincare product, characterized in that, The raw materials for preparing the skin care product include the soothing and repairing composition as described in any one of claims 1-3.
5. The skincare product according to claim 4, characterized in that, The skincare product meets at least one of the following characteristics: (1) The sodium DNA comprises 0.001-0.1% of the total mass of the skincare product; (2) The snake venom-like peptides account for 0.001-0.01% of the total mass of the skincare product; (3) The hydrolyzed silk protein accounts for 0.001-0.2% of the total mass of the skin care product; (4) The active ingredients account for 0.001-2% of the total mass of the skincare product; (5) The vine tea extract accounts for 0.05-1% of the total mass of the skin care product.
6. The skincare product according to claim 4, characterized in that, The raw materials for preparing the skincare product include an aqueous phase, an oil phase, an active phase, and purified water, and meet at least one of the following characteristics: (1) The raw materials for preparing the aqueous phase include at least one of humectant, emulsifier, thickener and preservative; (2) The raw materials for preparing the oil phase include at least one of the following: oil, polydimethylsiloxane, Myrothamnus flabellifolia leaf / stem extract, isododecane, hydrogenated polyisobutylene, and guaiac. (3) The raw materials for preparing the active phase include at least the soothing and repairing composition.
7. The skincare product according to claim 6, characterized in that, The moisturizer includes at least one of glycerin and butylene glycol.
8. The skincare product according to claim 6, characterized in that, The active phase also includes at least one of capernaum fruit extract, glyceryl glucoside, and nicotinamide.
9. The skincare product according to claim 6, characterized in that, The skincare products include at least one of the following: essence cream, serum, and gel.
10. A method for preparing a skincare product according to any one of claims 6-9, characterized in that, At least the following steps are included: (1) Mix the raw materials for the preparation of the aqueous phase until homogeneous; (2) Stir the raw materials for the preparation of the oil phase evenly; (3) Add the material from step (2) to the material from step (1) while stirring; (4) Add the raw materials for preparing the active phase to the material in step (3) while stirring, and stir evenly to obtain the skin care product.