An anti-radiation composition, oral preparation and use thereof

Abstract

This invention provides a composition comprising the following components in parts by weight: 20-30 parts of ginseng water extract, 15-25 parts of astragalus water extract, 20-30 parts of angelica water extract, 15-25 parts of donkey-hide gelatin water extract, 10-20 parts of cistanche water extract, 10-20 parts of wolfberry water extract, 10-20 parts of gardenia water extract, 10-20 parts of honeysuckle water extract, 3-10 parts of poria cocos water extract, and 3-10 parts of licorice water extract. This invention also protects the use of the composition in the preparation of health foods or pharmaceuticals that provide auxiliary protection against the hazards of ionizing radiation. The composition provided by this invention can effectively prevent or reduce ionizing radiation damage and has significant application prospects in radiotherapy and meeting the needs of radiation-related special occupations.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine and food technology, specifically relating to an anti-radiation composition, as well as oral preparations and foods containing the composition, and also relating to the application of the composition in the preparation of health foods and medicines. Technical Background With the rapid development of nuclear energy, radiotherapy, and the aerospace industry, human exposure to ionizing radiation is increasing, making radiation damage protection a crucial issue in global public health. Currently, commonly used anti-radiation drugs in clinical practice are mainly chemically synthesized preparations, such as thiol compounds like amifostine, as well as biological agents such as cytokines and antioxidants. However, these drugs generally suffer from significant side effects, high cost, narrow dosing windows, and poor stability, severely limiting their application in preventative healthcare and large-scale emergency protection. Developing highly effective, low-toxicity, and widely available natural anti-radiation drugs has an urgent market demand and broad application prospects.

[0002] Traditional Chinese medicine (TCM), a valuable resource in my country's traditional medicine, exhibits unique advantages in combating radiation damage. Modern research shows that many active ingredients in TCM (such as polysaccharides, flavonoids, saponins, and phenolic acids) possess multiple pharmacological effects, including scavenging free radicals, enhancing immune function, protecting the hematopoietic system, and promoting DNA damage repair. Their mechanisms of action closely align with the pathological processes of radiation damage. Compared to chemical drugs, TCM compositions offer multi-target synergistic effects, overall regulation, fewer toxic side effects, and suitability for long-term use, making them particularly suitable for daily protection for occupationally exposed populations and as adjuvant therapy for cancer patients.

[0003] Therefore, based on the guidance of traditional Chinese medicine theory and combined with modern pharmacological research methods, developing a scientifically formulated, effective, and safe anti-radiation traditional Chinese medicine composition can fill the gap in the field of prevention and health care of existing chemical anti-radiation drugs, thereby meeting the health protection needs of special occupational groups. Summary of the Invention

[0004] To overcome the shortcomings of the prior art, the present invention provides an anti-radiation composition, formulation, and its application in related products.

[0005] In a first aspect, the present invention provides an anti-radiation composition comprising the following components in parts by weight: 20-30 parts of ginseng water extract, 15-25 parts of astragalus water extract, 20-30 parts of angelica water extract, 15-25 parts of donkey-hide gelatin water extract, 10-20 parts of cistanche water extract, 10-20 parts of wolfberry water extract, 10-20 parts of gardenia water extract, 10-20 parts of honeysuckle water extract, 3-10 parts of poria cocos water extract, and 3-10 parts of licorice water extract. The composition is formed by directly mixing the above-mentioned components.

[0006] The composition provided by this invention combines the research findings of traditional Chinese medicine on the properties and meridians of herbs with those of Western pharmacology. Specifically, in the composition provided by this invention, ginseng, astragalus, angelica, and donkey-hide gelatin are the principal ingredients for tonifying qi, nourishing blood, and promoting blood circulation; cistanche and wolfberry are the assistant ingredients for regulating yin and yang; gardenia and honeysuckle are the adjuvant ingredients for clearing heat and detoxifying; and poria and licorice are the guiding ingredients for strengthening the spleen and removing dampness. Based on this, the dosage of each component is further optimized to ensure that the components work together to achieve synergistic effects and a balanced regulatory effect.

[0007] The ginseng (artificially cultivated) used in this invention is a new resource food (new food raw material), specifically referring to the dried root and rhizome of Panax ginseng CA Mey., a plant of the Araliaceae family. According to the Chinese Pharmacopoeia (2025), ginseng is sweet, slightly bitter, and slightly warm in nature; it enters the spleen, lung, heart, and kidney meridians; and has the functions of greatly replenishing vital energy, restoring pulse and consolidating the body, tonifying the spleen and lungs, promoting body fluids and nourishing blood, calming the mind and improving intelligence. The ginseng water extract is obtained by using ginseng as raw material, adding water equivalent to 20 times its weight, and extracting it through a decoction method. The resulting extract is then concentrated and dried.

[0008] The raw material used in this invention, Astragalus membranaceus, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to Astragalus mongholicus, a legume. Astragalus membranaceus (Fisch.) Bge. var. Mongolian (Bge.) Hsiao or Astragalus membranaceus Astragalus membranaceus The dried root of *Astragalus membranaceus* (Fisch.) Bge. According to the *Chinese Pharmacopoeia (2025)*, *Astragalus membranaceus* is sweet and slightly warm in nature; it enters the lung and spleen meridians; it has the functions of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting blood circulation and relieving pain, promoting pus drainage and detoxification, and promoting wound healing and tissue regeneration. The aforementioned *Astragalus membranaceus* water extract is obtained by using *Astragalus membranaceus* as raw material, adding water equivalent to 20 times its mass, and extracting by decoction. The resulting extract is then concentrated and dried.

[0009] The raw material used in this invention, Angelica sinensis, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to Angelica sinensis, a plant belonging to the Apiaceae family. Or g Chinese propeller The dried root of (Oliv.) Diels. According to the Chinese Pharmacopoeia (2025), Angelica sinensis is sweet, pungent, and warm in nature; it enters the liver, heart, and spleen meridians; and has the functions of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements. The aforementioned Angelica sinensis water extract is obtained by using Angelica sinensis as raw material, adding water equivalent to 20 times its weight, and extracting it by decoction. The resulting extract is then concentrated and dried.

[0010] The raw material used in this invention, donkey-hide gelatin, is a traditional Chinese tonic food, specifically referring to donkeys (Equus equina). Horse donkeyA solid gelatin made from the dried or fresh bark of *Linnaeus* through decoction and concentration. According to the *Chinese Pharmacopoeia (2025)*, donkey-hide gelatin is sweet and neutral in nature; it enters the lung, liver, and kidney meridians; and has functions such as nourishing blood and yin, moistening dryness, and stopping bleeding. The aforementioned donkey-hide gelatin water extract is obtained by using donkey-hide gelatin as raw material, adding 20 times its weight of water, and extracting it through a decoction method. The resulting extract is then concentrated and dried.

[0011] The raw material used in this invention, Cistanche deserticola, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to Cistanche deserticola, a plant belonging to the Orobanchaceae family. Cistanche deserticola The dried, fleshy stem with scales and leaves of *Cistanche deserticola*. According to the *Chinese Pharmacopoeia (2025)*, *Cistanche deserticola* is sweet, salty, and warm in nature; it enters the kidney and large intestine meridians; and has functions such as tonifying kidney yang, nourishing essence and blood, and moistening the intestines to relieve constipation. The aforementioned water extract of *Cistanche deserticola* is obtained by using the medicinal herb *Cistanche deserticola* as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0012] The raw material used in this invention is wolfberry, a substance that is traditionally both a food and a Chinese medicinal herb, specifically referring to *Lycium barbarum*, a plant belonging to the Solanaceae family. Lycian barbarian The dried, ripe fruit of *Lycium barbarum* (L.) is a substance traditionally used as both food and a Chinese medicinal herb. According to the *Chinese Pharmacopoeia (2025)*, *Lycium barbarum* is sweet and neutral in nature, and enters the liver and kidney meridians; it has the effects of nourishing the liver and kidneys, benefiting essence and improving eyesight. The aforementioned *Lycium barbarum* water extract is obtained by using *Lycium barbarum* as raw material, adding water equivalent to 20 times its weight, and extracting it through a decoction method. The resulting extract is then concentrated and dried.

[0013] The raw material used in this invention, gardenia, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to the plant *Gardenia jasminoides*, belonging to the Rubiaceae family. Gardenia jasminoides The dried, ripe fruit of Ellis. According to the Chinese Pharmacopoeia (2025), Gardenia is bitter and cold in nature; it enters the heart, lung, and triple burner meridians; it has the effects of purging fire and relieving irritability, clearing heat and promoting diuresis, cooling blood and detoxifying. The Gardenia water extract is obtained by using Gardenia as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0014] The raw material used in this invention, honeysuckle, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to the honeysuckle plant (Lonicera japonica) of the Caprifoliaceae family. Japanese honeysuckle The dried flower buds or newly opened flowers of *Thunb.*. According to the *Chinese Pharmacopoeia (2025)*, honeysuckle is sweet and cold in nature; it enters the lung, heart, and stomach meridians; and has functions such as clearing heat and detoxifying, and dispersing wind-heat. The honeysuckle water extract is obtained by using honeysuckle as raw material, adding 20 times its weight of water, and extracting by decoction. The resulting extract is then concentrated and dried.

[0015] The raw material used in this invention, Poria cocos, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to the fungus Poria cocos of the Polyporaceae family. Poria cocca The dried sclerotium of (Schw.) Wolf. According to the Chinese Pharmacopoeia (2025), Poria cocos is sweet, bland, and neutral in nature; it enters the heart, lung, spleen, and kidney meridians; and has the functions of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind. The Poria cocos water extract is obtained by using Poria cocos as raw material, adding water equivalent to 20 times its weight, and extracting it by decoction. The resulting extract is then concentrated and dried.

[0016] The licorice used in this invention is a substance that is traditionally both a food and a Chinese medicinal herb, specifically referring to the legume plant licorice. Glycyrrhiza uralensis Fisch., Licorice inflata Inflated licorice Bat. or Licorice root Glycyrrhiza glabra The dried roots and rhizomes of L. According to the Chinese Pharmacopoeia (2025), licorice is sweet and neutral in nature; it enters the heart, lung, spleen, and stomach meridians; it has the functions of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasms and pain, and harmonizing other medicines. The licorice water extract is obtained by using licorice as raw material, adding water equivalent to 20 times its mass, and extracting by decoction. The resulting extract is then concentrated and dried.

[0017] As a preferred embodiment of the present invention, the composition may further include American ginseng and hawthorn components. These components, together with ginseng, astragalus, angelica, and donkey-hide gelatin in the composition, synergistically exert the functions of replenishing qi and nourishing blood, thereby improving the overall efficacy of the composition. As a preferred embodiment of the present invention, the composition may further include the following components in parts by weight: 10-15 parts of American ginseng water extract and 5-10 parts of hawthorn water extract.

[0018] The raw material used in this invention, American ginseng, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to the American ginseng plant (Panax quinquefolius), a member of the Araliaceae family. Panax quinquefolium The dried root of L. According to the Chinese Pharmacopoeia (2025), American ginseng is sweet and slightly bitter in taste, and cool in nature; it enters the heart, lung, and kidney meridians; it has the functions of replenishing qi and nourishing yin, clearing heat and promoting body fluids. The American ginseng water extract is obtained by using American ginseng as raw material, adding water equivalent to 20 times its weight, and extracting it by decoction. The resulting extract is then concentrated and dried.

[0019] The raw material used in this invention, hawthorn, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to the plant *Haworthia cooperi*, belonging to the Rosaceae family. Hawthorn pinnatifida Bge. var. older NE Br. or hawthorn Hawthorn pinnateThe dried, ripe fruit of *B. ge.*. According to the *Chinese Pharmacopoeia (2025)*, hawthorn is sour, sweet, and slightly warm in nature; it enters the spleen, stomach, and liver meridians; and has functions such as promoting digestion, strengthening the stomach, regulating qi and dispersing blood stasis, and reducing turbidity and lipids. The hawthorn water extract is obtained by using hawthorn as raw material, adding water equivalent to 20 times its weight, and extracting it by decoction. The resulting extract is then concentrated and dried.

[0020] As a preferred embodiment of the present invention, the composition may further include Ganoderma lucidum components, which, together with Cistanche deserticola and Lycium barbarum in the composition, exert a synergistic effect in regulating Yin and Yang, thus enhancing the overall efficacy of the composition. Specifically, the composition also includes 15-20 parts of Ganoderma lucidum water extract.

[0021] The raw material used in this invention, Ganoderma lucidum, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to the fungus Ganoderma lucidum of the Polyporaceae family. Ganoderma lucidum (Leyss. ex Fr.) Karst. or Ganoderma lucidum Ganoderma sinensis The dried fruiting bodies of Zhao, Xu et Zhang. The Ganoderma lucidum water extract is obtained by using Ganoderma lucidum as raw material, adding water equivalent to 20 times its mass, and extracting by water decoction. The resulting extract is then concentrated and dried.

[0022] As a preferred embodiment of the present invention, the composition may further include green tea and Haematococcus pluvialis components. These components, together with gardenia and honeysuckle in the composition, exert a synergistic effect in clearing heat and detoxifying, thus enhancing the overall efficacy of the composition. Specifically, the composition also includes the following components in parts by weight: 5-10 parts green tea powder and 10-15 parts Haematococcus pluvialis powder.

[0023] The green tea used in this invention is a non-fermented tea, typically made from fresh leaves through processes such as fixation, rolling, and drying. The green tea used in this invention is preferably a renowned high-quality green tea from the East my country region, such as Longjing, Biluochun, Huangshan Maofeng, Taiping Houkui, Liuan Guapian, Enshi Yulu, and Xinyang Maojian. The green tea powder is obtained by drying and pulverizing fresh green tea.

[0024] The raw material used in this invention is Haematococcus pluvialis, a new resource food (new food raw material). The Haematococcus pluvialis powder used in this invention specifically refers to the spore powder obtained by artificially cultivating Haematococcus pluvialis, a species of algae in the order Volvariales of the phylum Chlorophyta, harvesting spores, breaking the cell wall, and drying the spores.

[0025] In a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 28-30 parts of ginseng water extract, 20-22 parts of astragalus water extract, 23-25 ​​parts of angelica water extract, 13-15 parts of donkey-hide gelatin water extract, 10-12 parts of American ginseng water extract, 8-10 parts of hawthorn water extract, 15-17 parts of cistanche water extract, 13-15 parts of wolfberry water extract, 15-17 parts of ganoderma lucidum water extract, 15-17 parts of gardenia water extract, 15-17 parts of honeysuckle water extract, 5-8 parts of green tea powder, 12-14 parts of Haematococcus pluvialis powder, 3-5 parts of poria cocos water extract, and 3-5 parts of licorice water extract.

[0026] As a specific embodiment of the present invention, the composition may further include 3-8 parts of saffron water extract. The raw material involved in this invention, saffron, is the upper part of the style and stigma of the saffron flower (Iridaceae family). It has a sweet and slightly sour taste, and is neutral and warm in nature; it enters the heart and liver meridians; and has the effects of promoting blood circulation, removing blood stasis, and relieving stagnation.

[0027] In a second aspect, the present invention provides an oral formulation comprising the composition described in the first aspect, and an appropriate amount of excipients acceptable in the food, health food, or pharmaceutical fields.

[0028] In one specific embodiment of the present invention, the oral preparation is a tablet, preferably selected from ordinary tablets, lozenges, chewable tablets, dispersible tablets, and effervescent tablets.

[0029] In one specific embodiment of the present invention, the oral preparation is a capsule, preferably a hard capsule or a soft capsule.

[0030] In one specific embodiment of the present invention, the oral preparation is a granule, preferably a soluble granule, a suspension granule, or an effervescent granule.

[0031] In one specific embodiment of the present invention, the oral preparation is a powder.

[0032] In one specific embodiment of the present invention, the oral preparation is a paste.

[0033] In one specific embodiment of the present invention, the oral preparation is a candy, preferably hard candy, hard filled candy, cream candy, gel candy, gum-based candy, aerated candy, or compressed candy.

[0034] In one specific embodiment of the present invention, the oral preparation is a syrup.

[0035] In one specific embodiment of the present invention, the oral preparation is an alcoholic beverage.

[0036] In one specific embodiment of the present invention, the oral preparation is an oral liquid.

[0037] In one specific embodiment of the present invention, the oral preparation is a beverage.

[0038] Thirdly, the present invention provides a food comprising the composition described in the first aspect or the oral formulation described in the second aspect.

[0039] The composition provided by this invention uses all raw materials that are substances that are both food and traditional Chinese medicine or new food raw materials (new resource foods) published by health administration departments. It can be used in food, has high safety and low toxicity and side effects.

[0040] Fourthly, the present invention provides the use of the composition described in the first aspect or the oral preparation described in the second aspect in the preparation of health foods that have an auxiliary protective effect against the hazards of ionizing radiation.

[0041] Fifthly, the present invention provides the use of the composition described in the first aspect and the oral formulation described in the second aspect in the preparation of a pharmaceutical product that provides auxiliary protection against the hazards of ionizing radiation.

[0042] The ionizing radiation described in this invention includes particle radiation and electromagnetic radiation; wherein particle radiation includes alpha particles, beta particles and neutrons, and electromagnetic radiation includes X-rays and gamma rays.

[0043] As a preferred embodiment of the present invention, the composition, oral preparation, health food or medicine achieves an auxiliary protective effect against the hazards of ionizing radiation by protecting the body's blood system or promoting the recovery of the body's blood system function.

[0044] As a preferred embodiment of the present invention, the composition, oral preparation, health food or medicine achieves an auxiliary protective effect against the hazards of ionizing radiation by protecting the body's redox reaction system or promoting the recovery of the body's redox reaction system.

[0045] As a preferred embodiment of the present invention, the composition, oral preparation, health food or medicine serves as a supplement to radiotherapy for diseases, preferably radiotherapy for tumors, to reduce the side effects of radiotherapy or enhance the efficacy of radiotherapy.

[0046] Compared with existing technologies, the composition provided by this invention combines traditional Chinese medicine compatibility theory with modern pharmacological research results, enabling the components to complement and enhance each other in terms of their mechanism of action. This results in an overall efficacy of the composition that is far greater than the simple sum of the individual effects of the components. The raw materials selected for this invention are all nationally approved medicinal and edible substances or new food ingredients, exhibiting high safety, low toxicity and side effects, and a wide range of sources, thus possessing significant market value and development prospects. Detailed Implementation

[0047] The present invention provides the following embodiments to further illustrate various aspects of the invention. These embodiments are non-limiting and should not be construed as limiting any aspect of the invention. The scope of protection of the present invention is limited only by the claims. Various modifications and improvements can be made to various aspects of the present invention by those skilled in the art without departing from the scope of the claims, and these modifications and improvements also fall within the scope of protection of the present invention.

[0048] Additionally, it should be noted that, unless otherwise specified, all materials and reagents used in the following embodiments are commonly used in the art and can be obtained through conventional commercial means; all methods used are conventional methods known to those skilled in the art.

[0049] The following are ingredients used in the composition of the experimental examples: The ginseng water extract is prepared by the following method: Take ginseng purchased from Tongrentang, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the extract.

[0050] Astragalus water extract is prepared by the following method: Astragalus purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the extract.

[0051] Angelica sinensis water extract is prepared by the following method: Angelica sinensis purchased from Tongrentang is boiled in water and extracted 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected and spray-dried to obtain the extract.

[0052] The aqueous extract of donkey-hide gelatin was prepared by the following method: donkey-hide gelatin purchased from Tongrentang was boiled in water for 3 times, each time for 3 hours. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0053] American ginseng water extract is prepared by the following method: American ginseng purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the extract.

[0054] Hawthorn water extract is prepared by the following method: Hawthorn purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the final product.

[0055] The water extract of Cistanche deserticola was prepared by the following method: Cistanche deserticola purchased from Tongrentang was boiled in water and extracted three times, each time for 3 hours. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0056] The water extract of wolfberry was prepared by the following method: wolfberry purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected and spray-dried to obtain the final product.

[0057] The Ganoderma lucidum water extract is prepared by the following method: Ganoderma lucidum purchased from Tongrentang is boiled in water and extracted 3 times, each time for 3 hours. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the extract.

[0058] Gardenia water extract is prepared by the following method: Gardenia purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the final product.

[0059] Honeysuckle water extract is prepared by the following method: honeysuckle purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the final product.

[0060] The aqueous extract of Poria cocos was prepared by the following method: Poria cocos purchased from Tongrentang was boiled in water for 3 times, each time for 3 hours. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0061] The licorice water extract was prepared by the following method: licorice purchased from Tongrentang was boiled in water and extracted three times, each time for 3 hours. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0062] Green tea powder, CAS 94650-60-2, purchased from Jiangsu Caiwei Biotechnology Co., Ltd.

[0063] Haematococcus pluvialis powder, CAS 472-61-7, purchased from Jiangsu Caiwei Biotechnology Co., Ltd.

[0064] The saffron water extract was prepared by the following method: saffron purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, and the filtrate was collected and spray-dried to obtain the final product.

[0065] Example 1 This embodiment provides an anti-radiation composition, which is composed of the following components: 20 g of ginseng water extract, 25 g of astragalus water extract, 20 g of angelica water extract, 25 g of donkey-hide gelatin water extract, 10 g of cistanche water extract, 20 g of wolfberry water extract, 10 g of gardenia water extract, 20 g of honeysuckle water extract, 3 g of poria water extract, and 10 g of licorice water extract.

[0066] Example 2 This embodiment provides an anti-radiation composition, which is composed of the following components: 30 g of ginseng water extract, 15 g of astragalus water extract, 30 g of angelica water extract, 15 g of donkey-hide gelatin water extract, 20 g of cistanche water extract, 10 g of wolfberry water extract, 20 g of gardenia water extract, 10 g of honeysuckle water extract, 10 g of poria water extract, and 3 g of licorice water extract.

[0067] Example 3 This embodiment provides an anti-radiation composition, which is composed of the following components: 29 g of ginseng water extract, 21 g of astragalus water extract, 24 g of angelica water extract, 14 g of donkey-hide gelatin water extract, 16 g of cistanche water extract, 14 g of wolfberry water extract, 16 g of gardenia water extract, 16 g of honeysuckle water extract, 4 g of poria water extract, and 4 g of licorice water extract.

[0068] Example 4 This embodiment provides an anti-radiation composition, which is composed of the following components: 29 g of ginseng water extract, 21 g of astragalus water extract, 24 g of angelica water extract, 14 g of donkey-hide gelatin water extract, 11 g of American ginseng water extract, 9 g of hawthorn water extract, 16 g of cistanche water extract, 14 g of wolfberry water extract, 16 g of gardenia water extract, 16 g of honeysuckle water extract, 4 g of poria water extract, and 4 g of licorice water extract.

[0069] Example 5 This embodiment provides an anti-radiation composition, which is composed of the following components: 29 g of ginseng water extract, 21 g of astragalus water extract, 24 g of angelica water extract, 14 g of donkey-hide gelatin water extract, 17 g of ganoderma lucidum water extract, 16 g of cistanche water extract, 14 g of wolfberry water extract, 16 g of gardenia water extract, 16 g of honeysuckle water extract, 4 g of poria cocos water extract, and 4 g of licorice water extract.

[0070] Example 6 This embodiment provides an anti-radiation composition, which is composed of the following components: 29 g of ginseng water extract, 21 g of astragalus water extract, 24 g of angelica water extract, 14 g of donkey-hide gelatin water extract, 16 g of cistanche water extract, 14 g of wolfberry water extract, 16 g of gardenia water extract, 16 g of honeysuckle water extract, 7 g of green tea powder, 13 g of Haematococcus pluvialis powder, 4 g of poria cocos water extract, and 4 g of licorice water extract.

[0071] Example 7 This embodiment provides an anti-radiation composition, which is composed of the following components: 29 g of ginseng water extract, 21 g of astragalus water extract, 24 g of angelica water extract, 14 g of donkey-hide gelatin water extract, 11 g of American ginseng water extract, 9 g of hawthorn water extract, 17 g of ganoderma lucidum water extract, 16 g of cistanche water extract, 14 g of wolfberry water extract, 16 g of gardenia water extract, 16 g of honeysuckle water extract, 7 g of green tea powder, 13 g of Haematococcus pluvialis powder, 4 g of poria cocos water extract, and 4 g of licorice water extract.

[0072] Example 8 This embodiment provides an anti-radiation composition, which differs from Example 3 only in that it also contains 5 g of saffron water extract.

[0073] Example 9 This embodiment provides an anti-radiation composition, which differs from Example 7 only in that it also contains 5 g of saffron water extract.

[0074] Example 10 This embodiment provides a granule preparation, which is prepared by the following method: 28 g of the composition provided in Example 1, 10 g of xylitol and 18 g of maltodextrin are mixed and granulated by dry granulation to obtain the granule.

[0075] In the granules provided in this embodiment, the composition provided in Example 1 is replaced with the composition provided in Examples 2 to 9, and the amount of excipients is appropriately adjusted to obtain the corresponding granules of each embodiment composition, which can be further processed into solid beverages or liquid beverages.

[0076] Experimental Example Seventy SPF-grade male KM mice were randomly divided into seven groups (control group, model group, Example 3, Example 4, Example 5, Example 6, and Example 7), with ten mice in each group. The test samples (Examples 3-7, all at a concentration of 20 mg / mL) were administered orally via gavage at a dose of 12 mL / kg BW for 24 consecutive days. The experimental groups (Examples 3-7) received the above-mentioned concentration of the combined sample via gavage, while the control and model groups received an equal volume of physiological saline. On day 25, all groups except the control group underwent a single whole-body irradiation with X-rays from an electron linear accelerator at a dose of 5.0 Gy and a dose rate of 5.0 Gy / min, with a source-to-skin distance of 100 cm, to establish an acute radiation injury model. Two hours after modeling, each group was gavaged once more as described above. The gavage regimen was continued for another 5 days. Blood was collected from the eyes of the mice, and liver tissue was collected for biochemical analysis.

[0077] A decrease in peripheral blood leukocyte (WBC) count is one of the manifestations of radiation damage caused by ionizing radiation, and the number of WBCs in peripheral blood can represent the state of damage to the blood system. WBC counts were performed in peripheral blood of each group. The results are shown in Table 1.

[0078] Table 1: Peripheral blood leukocyte levels (n=10)

[0079] The results show that the composition provided by the present invention can effectively increase the number of peripheral blood leukocytes in radiation model mice, thereby avoiding and alleviating damage to the body's blood system.

[0080] Decreased superoxide dismutase (SOD) activity in liver tissue is one manifestation of radiation damage caused by ionizing radiation, representing a state of impairment in the body's redox reaction system. The SOD level in homogenate samples (1% concentration) of liver tissue from each group was detected using an SOD detection kit (Nanjing Jiancheng Bioengineering Institute). The results are shown in Table 2.

[0081] Table 2: SOD levels in liver tissue (n=10)

[0082] The results show that the composition provided by the present invention can effectively increase the activity of SOD in radiation model mice, thereby reducing the damage to the body's redox reaction system.

[0083] Elevated malondialdehyde (MDA) levels in liver tissue are one manifestation of radiation damage caused by ionizing radiation, indicating impairment of the body's redox system. The MDA levels in homogenate samples (10% concentration) of liver tissue from each group were detected using an MDA detection kit (Nanjing Jiancheng Bioengineering Institute). The results are shown in Table 3.

[0084] Table 3: MDA levels in liver tissue (n=10)

[0085] The results show that the composition provided by the present invention can effectively reduce the content of MDA in radiation model mice, thereby reducing the damage to the body's redox reaction system.

[0086] Unless otherwise stated, the technical terms used herein have the same meanings as commonly understood by one of ordinary skill in the art. This invention may also be practiced using any methods and materials similar to or equivalent to those described herein. While specific embodiments and preferred methods and materials are described herein, they do not impose any limitation on the invention.

Claims

1. A radiation-resistant composition, characterized in that, It contains the following ingredients in parts by weight: 20-30 parts ginseng water extract, 15-25 parts astragalus water extract, 20-30 parts angelica water extract, 15-25 parts donkey-hide gelatin water extract, 10-20 parts cistanche water extract, 10-20 parts wolfberry water extract, 10-20 parts gardenia water extract, 10-20 parts honeysuckle water extract, 3-10 parts poria cocos water extract, and 3-10 parts licorice water extract.

2. The composition according to claim 1, characterized in that, The composition also includes: 10-15 parts of American ginseng water extract and 5-10 parts of hawthorn water extract.

3. The composition according to claim 1 or 2, characterized in that, The composition also includes 15-20 parts of Ganoderma lucidum water extract.

4. The composition according to any one of claims 1 to 3, characterized in that, The composition also includes: 5-10 parts of green tea powder and 10-15 parts of Haematococcus pluvialis powder.

5. The composition according to claim 1, characterized in that, It contains the following ingredients in parts by weight: 28-30 parts ginseng water extract, 20-22 parts astragalus water extract, 23-25 ​​parts angelica water extract, 13-15 parts donkey-hide gelatin water extract, 10-12 parts American ginseng water extract, 8-10 parts hawthorn water extract, 15-17 parts cistanche water extract, 13-15 parts wolfberry water extract, 15-17 parts ganoderma lucidum water extract, 15-17 parts gardenia water extract, 15-17 parts honeysuckle water extract, 5-8 parts green tea powder, 12-14 parts Haematococcus pluvialis powder, 3-5 parts poria cocos water extract, and 3-5 parts licorice water extract.

6. The composition according to claim 1 or 5, characterized in that, The composition also includes 3-8 parts of saffron water extract.

7. An oral preparation, characterized in that, The composition comprises the composition according to any one of claims 1 to 6, and excipients; preferably, The preparation is a tablet, preferably a regular tablet, lozenge, chewable tablet, dispersible tablet or effervescent tablet; Alternatively, the formulation is a capsule, preferably a hard capsule or a soft capsule; Alternatively, the formulation is a granule, preferably a soluble granule, a suspension granule or an effervescent granule; Alternatively, the preparation may be a powder; Alternatively, the formulation may be a paste; Alternatively, the preparation may be candy; Alternatively, the formulation may be a syrup. Alternatively, the preparation may be an oral liquid; Alternatively, the preparation may be an alcoholic beverage; Alternatively, the preparation may be a beverage.

8. A food product, characterized in that, It comprises the composition according to any one of claims 1 to 6 or the oral formulation according to claim 7.

9. The use of the composition according to any one of claims 1 to 6 or the oral preparation according to claim 7 in the preparation of health food with auxiliary protective effect against ionizing radiation hazards.

10. The use of the composition according to any one of claims 1 to 6 or the oral formulation according to claim 7 in the preparation of a pharmaceutical product that provides auxiliary protection against the hazards of ionizing radiation.

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