Application of Super Brain-Boosting Capsules

SuperBrain Capsules inhibit ferroptosis in Alzheimer's disease cells by activating the Nrf2/HO-1/GPX4 pathway, overcoming the limitations of existing Alzheimer's disease treatments and achieving a protective effect on HT22 cells.

CN122124172APending Publication Date: 2026-06-02SHIJIAZHUANG ZANGNUO BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHIJIAZHUANG ZANGNUO BIOTECH
Filing Date
2026-03-26
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively stop or reverse the progression of Alzheimer's disease, clinical treatments have significant limitations, and research directions for multi-target, low-toxicity natural drugs are inadequate.

Method used

Superbrain capsules regulate iron metabolism in HT22 cells by inhibiting ferroptosis, activating the Nrf2/HO-1/GPX4 pathway, improving Glu-induced cell damage, including inhibiting apoptosis, enhancing mitochondrial membrane potential, reducing ROS levels and lipid peroxidation, and regulating the expression of related genes.

Benefits of technology

Superbrain capsules activate key molecules at the transcriptional and protein levels, significantly improve Glu-induced HT22 cell damage, provide experimental evidence and direction for the prevention and treatment of Alzheimer's disease, and have a protective effect on cells.

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Abstract

This invention discloses the application of a "Super Brain-Boosting Capsule," belonging to the field of pharmaceutical technology. The Super Brain-Boosting Capsule is used in the preparation of drugs for treating Alzheimer's disease. The capsule enhances the mitochondrial membrane potential of Glu-treated HT22 cells by inhibiting ferroptosis. At the transcriptional level, the capsule activates the expression of key Nrf2 / HO-1 / GPX4 signaling molecules NRF2, HO-1, GPX4, SLC7A11, ACSL4, FTH1, and FPN1, while reversing the expression of Bcl-2, Caspase-3, and Caspase-9 to inhibit apoptosis in AD cells. This invention reveals that the Super Brain-Boosting Capsule, based on the Nrf2 / HO-1 / GPX4 pathway, inhibits Glu-induced ferroptosis in HT22 cells, which can treat Alzheimer's disease. This invention provides experimental evidence and direction for the further development of the Super Brain-Boosting Capsule in the prevention and treatment of Alzheimer's disease and other neurodegenerative diseases.
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