Collagen composition with anti-aging effect and application thereof

By combining the single-domain antibody VHH-IL6-B01, which targets IL-6, with collagen hydrolysate in skin care, inflammatory signals are blocked and collagen synthesis is promoted. This addresses the systemic lack of integration and synergistic effect in existing anti-aging strategies for skin care, achieving significant anti-aging effects.

CN122127461APending Publication Date: 2026-06-02GUANGDONG HUIJIANG BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG HUIJIANG BIOTECHNOLOGY CO LTD
Filing Date
2026-03-19
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing anti-skin aging strategies lack a systematic integration of "source anti-aging" and "matrix repair." In particular, existing technologies struggle to achieve highly efficient and synergistic anti-aging effects in skin care, failing to effectively block key signaling pathways such as IL-6 and promote collagen synthesis.

Method used

The combined use of the single-domain antibody VHH-IL6-B01, which targets human interleukin IL-6, and collagen hydrolysate peptides with a molecular weight of 2-5 kDa, blocks IL-6 signaling and promotes collagen synthesis, thereby producing a synergistic effect by blocking inflammatory damage and promoting matrix repair.

Benefits of technology

It significantly improves cell function, reverses extracellular matrix metabolic imbalance, enhances the transdermal rate and dermal distribution of macromolecular single-domain antibodies, and provides a skin anti-aging solution with a clear mechanism and synergistic efficacy.

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Abstract

This invention relates to a composition for anti-skin aging and its application, belonging to the field of biomedical technology. The composition contains two core active ingredients: one is a single-domain antibody that targets and neutralizes human interleukin IL-6, the specific amino acid sequence of which is shown in SEQ ID NO:1; the other is a collagen hydrolysate peptide with a molecular weight of 2-5 kDa. This composition precisely inhibits the core inflammatory signal IL-6 driving aging through the single-domain antibody, while simultaneously replenishing the synthetic matrix and promoting repair using the collagen peptide, resulting in a synergistic effect. Experiments have demonstrated that this composition can significantly improve wrinkles and elasticity in photo-aged skin, promote collagen regeneration, and its collagen peptide component can effectively enhance the skin penetration efficiency of the single-domain antibody. This composition is suitable for preparing safe and effective topical anti-skin aging formulations.
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