Centella asiatica exosome vesicle and preparation method and application thereof

By preparing Centella asiatica exosome vesicles with an average particle size of 100-200 nm, the stability and cost issues of existing technologies for treating diabetic wounds have been resolved, achieving a highly efficient repair effect on diabetic wounds.

CN122128209APending Publication Date: 2026-06-02UNIV OF MACAU
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF MACAU
Filing Date
2026-03-27
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies for treating diabetic wounds suffer from poor stability, high costs, and potential safety risks, and the application of plant-derived exosomes in diabetic ulcers has not been reported.

Method used

Centella asiatica exosomes with an average particle size of 100-200 nm were prepared by crushing Centella asiatica, followed by solid-liquid separation, differential centrifugation, and purification centrifugation with a sucrose pad. These exosomes are used as a drug for skin wound repair.

Benefits of technology

Centella asiatica exosomes can regulate macrophage polarization, reduce the level of inflammatory factors, enhance vascular endothelial cell function, promote angiogenesis, significantly accelerate wound healing, improve local blood supply, and achieve effective repair of diabetic wounds.

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Abstract

This invention discloses a Centella asiatica exosome vesicle, its preparation method, and its applications, relating to the field of biomedical technology. The Centella asiatica exosome vesicles of this invention possess natural anti-inflammatory activity, and the raw material, Centella asiatica, is widely available and naturally safe. This invention utilizes Centella asiatica exosome vesicles to achieve a dual synergistic effect of anti-inflammation and angiogenesis promotion in diabetic chronic wounds, significantly accelerating the wound repair process. This invention confirms that Centella asiatica exosome vesicles have a clear therapeutic effect in treating diabetic wounds. The extraction process is simple, low-cost, and highly efficient, stably yielding high-purity, highly bioactive plant exosome vesicle products, combining excellent therapeutic effects with significant cost advantages.
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