Bacteriostatic slow-release structure, washing machine and cleaning device

Abstract

The application provides a bacteriostatic slow-release structure, a washing machine and a cleaning device. The bacteriostatic slow-release structure comprises an insoluble base frame, a water-soluble auxiliary material and a functional material, wherein the functional material comprises a guanidine substance. Thus, when the bacteriostatic slow-release structure is in contact with water, the functional material flows into the water along with the dissolution of the water-soluble auxiliary material. Since the guanidine substance has good bacteriostatic effect, the bacteriostatic slow-release structure can have long-term bacteriostatic effect.

Description

[0001] Mother case information This application is a divisional application of the invention patent application with application number 202210836375.6, application date July 15, 2022, entitled "Antibacterial Slow-Release Structure, Washing Machine and Cleaning Equipment". Technical Field

[0002] This invention relates to the field of materials technology, and more specifically, to antibacterial slow-release structures, washing machines, and cleaning equipment. Background Technology

[0003] Currently, the common approach to achieving multiple functions such as odor removal, scale removal, and sterilization is to add functional substances to the working environment, such as antibacterial guanidines. To facilitate use and maintain long-term effectiveness, these functional substances typically need to be loaded onto a carrier. For example, silver phosphate needs to be mounted in glass, natural antibacterial agents and guanidines need to be mounted in a plastic matrix, and activated carbon can support scale-removing salts. However, in essence, these functional substances are basically randomly dispersed within the matrix, making it difficult to form a stable release pathway. Therefore, theoretically, only functional substances dispersed on the surface of the matrix can be released and exert their function, while functional substances inside the matrix are difficult to dissolve in water and release, thus failing to achieve long-term, sufficient release of functional substances and long-lasting antibacterial effects. Summary of the Invention

[0004] This invention aims to at least partially solve one of the technical problems in related technologies. Therefore, one object of this invention is to provide an antibacterial sustained-release structure that can completely release functional materials in an aqueous environment, allowing for the effective utilization of these materials.

[0005] In one aspect, the present invention provides an antibacterial sustained-release structure. According to an embodiment of the present invention, the antibacterial sustained-release structure comprises: an insoluble matrix, a water-soluble excipient, and a functional material, wherein the functional material includes guanidine compounds. Thus, when the antibacterial sustained-release structure comes into contact with water, the functional material flows into the water along with the dissolution of the water-soluble excipient. Since guanidine compounds have excellent antibacterial properties, the antibacterial sustained-release structure can thus achieve a long-lasting antibacterial effect.

[0006] According to embodiments of the present invention, guanidine substances include polyhexamethylene guanidine.

[0007] According to an embodiment of the present invention, the antibacterial sustained-release structure comprises: 30-70 parts by weight of an insoluble matrix; 15-60 parts by weight of a water-soluble excipient; and 1-35 parts by weight of a functional material.

[0008] According to an embodiment of the present invention, the antibacterial sustained-release structure further includes 5 to 10 parts by weight of a chain extender.

[0009] According to an embodiment of the present invention, the water-soluble excipient is chemically bonded to the insoluble matrix.

[0010] According to an embodiment of the present invention, the water-soluble excipient forms a dissolution portion in the insoluble matrix that communicates with the outside of the insoluble matrix, the dissolution portion having a continuous structure, and the functional material being located in the dissolution portion.

[0011] According to an embodiment of the present invention, the width of the dissolving portion is 50 nanometers to 50 micrometers.

[0012] According to an embodiment of the present invention, the water-soluble excipient includes at least one of polyvinyl alcohol, polyethylene glycol, and polyethylene oxide.

[0013] According to an embodiment of the present invention, the insoluble substrate comprises at least one of plastic, rubber, and fiber.

[0014] According to an embodiment of the present invention, the functional material includes at least one of a water softener and a descaling agent.

[0015] In another aspect, the present invention provides a washing machine. According to an embodiment of the invention, the washing machine includes the aforementioned antibacterial slow-release structure, which is disposed on the water inlet pipe of the washing machine. Thus, during washing, water washes the antibacterial slow-release structure located on the water inlet pipe, allowing the functional materials dispersed in the water-soluble additives to be released into the environment outside the insoluble substrate as the water-soluble additives dissolve in the water. Furthermore, since the dispersion of the water-soluble additives in the antibacterial slow-release structure has a certain continuity, with the use of the antibacterial slow-release structure, all functional materials on and inside the surface of the insoluble substrate can be gradually and completely released, thereby increasing the service life of the antibacterial slow-release structure, improving material utilization, and avoiding waste of functional materials.

[0016] In another aspect, the present invention provides a cleaning device. According to an embodiment of the present invention, the cleaning device includes the aforementioned antibacterial slow-release structure, which is disposed on the water inlet pipe of the cleaning device. Thus, when the cleaning device cleans, water flushes the antibacterial slow-release structure located on the water inlet pipe, allowing the functional materials dispersed in the water-soluble excipients to be released into the environment outside the insoluble substrate as the water-soluble excipients dissolve in the water. Furthermore, since the dispersion of the water-soluble excipients in the antibacterial slow-release structure has a certain continuity, with the use of the antibacterial slow-release structure, all functional materials on and inside the surface of the insoluble substrate can be gradually and completely released, thereby increasing the service life of the antibacterial slow-release structure, improving material utilization, and avoiding waste of functional materials. Attached Figure Description

[0017] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which: Figure 1 This is a schematic diagram of an antibacterial sustained-release structure in one embodiment of the present invention.

[0018] Figure 2 This is a flowchart of a method for preparing an antibacterial sustained-release structure in one embodiment of the present invention. Detailed Implementation

[0019] The present invention will be explained below with reference to embodiments. Those skilled in the art will understand that the following embodiments are for illustrative purposes only and should not be considered as limiting the scope of the invention. Where specific techniques or conditions are not specified in the embodiments, they are performed according to the techniques or conditions described in the literature in the field or according to the product instructions. Reagents or instruments whose manufacturers are not specified are all conventional products that can be obtained commercially.

[0020] The present invention will now be described with reference to specific embodiments. It should be noted that these embodiments are merely descriptive and do not limit the present invention in any way.

[0021] In one aspect, the present invention provides an antibacterial sustained-release structure. According to an embodiment of the present invention, the antibacterial sustained-release structure comprises: an insoluble matrix, a water-soluble excipient, and a functional material, wherein the functional material includes guanidine compounds. Thus, when the antibacterial sustained-release structure comes into contact with water, the functional material flows into the water along with the dissolution of the water-soluble excipient. Since guanidine compounds have excellent antibacterial properties, the antibacterial sustained-release structure can thus achieve a long-lasting antibacterial effect.

[0022] According to embodiments of the present invention, the antibacterial sustained-release structure comprises: 30-70 parts by weight (e.g., 30 parts by weight, 35 parts by weight, 40 parts by weight, 45 parts by weight, 50 parts by weight, 55 parts by weight, 60 parts by weight, 65 parts by weight, 70 parts by weight) of an insoluble matrix; 15-60 parts by weight (e.g., 15 parts by weight, 20 parts by weight, 25 parts by weight, 30 parts by weight, 35 parts by weight, 40 parts by weight, 45 parts by weight, 50 parts by weight, 55 parts by weight, 60 parts by weight) of a water-soluble excipient; and 1-35 parts by weight (e.g., 1 part by weight, 5 parts by weight, 10 parts by weight, 15 parts by weight, 18 parts by weight, 20 parts by weight, 23 parts by weight, 25 parts by weight, 28 parts by weight, 30 parts by weight, 32 parts by weight, 34 parts by weight, 35 parts by weight) of a functional material. Therefore, the antibacterial sustained-release structure of the above components has an appropriate amount of water-soluble excipients and functional materials, so that the insoluble matrix, water-soluble excipients, and functional materials in the antibacterial sustained-release structure have an appropriate volume ratio, ensuring the structural stability of the antibacterial sustained-release structure and the rate and efficacy of the sustained-release functional materials. If the amount of insoluble matrix is ​​too large, that is, the volume fraction of water-soluble excipients and functional materials in the antibacterial sustained-release structure is small, this will relatively reduce the service life of the antibacterial sustained-release structure, and the insoluble matrix... The internal framework of the antibacterial sustained-release structure is relatively compact, making it difficult for water-soluble excipients and functional materials to come into contact with water. This results in slow dissolution or a reduced dissolution rate, weakening the antibacterial effect of the functional materials. Conversely, if the insoluble framework is too small (i.e., the volume fraction of the insoluble framework in the antibacterial sustained-release structure is low), it contains a relatively large amount of water-soluble excipients and functional materials. This leads to relatively poor stability between the water-soluble excipients and the insoluble framework, and the dissolution rate of the water-soluble excipients and functional materials is too fast, easily resulting in material waste. The dosage of the functional materials and water-soluble excipients mentioned above allows for more uniform dispersion of the functional materials in the water-soluble excipients, resulting in an optimal concentration of the functional materials in the water-soluble excipients. This allows the functional materials to be effectively released as the water-soluble excipients dissolve. Therefore, by controlling the dosage of the above components, the dissolution rate of the water-soluble excipients and functional materials can be controlled, satisfying the requirements for the antibacterial effect of the functional materials in the antibacterial sustained-release structure while avoiding excessively rapid dissolution and material waste. The specific amount of functional material can be set by those skilled in the art between 1 and 35 parts by weight, depending on the specific functional material. For example, for functional materials containing silver ions, the amount of functional material added can be appropriately reduced.

[0023] In embodiments of the present invention, the antibacterial sustained-release structure further includes 5 to 10 parts by weight (e.g., 5, 6, 7, 8, 9, or 10 parts by weight) of a chain extender. Thus, the addition of the chain extender can alter the insoluble matrix, causing a chemical reaction between the insoluble matrix and the water-soluble excipients, reducing the water dissolution rate of the dissolved portion, optimizing the sustained-release time, and achieving controllability of the dissolution rate through both physical and chemical means.

[0024] In embodiments of the present invention, the water-soluble excipients and the partially active insoluble matrix are chemically bonded together by introducing a reactive chain extender. Specifically, the aforementioned chemical bond is formed during melt blending by adding a chain extender that reacts with both the water-soluble excipients and the active insoluble matrix, thereby initiating a chain extension reaction. If the insoluble matrix is ​​a polyester containing hydroxyl or carboxyl groups, the chain extender can be a material containing epoxy groups. The epoxy groups react with the terminal hydroxyl groups of the water-soluble excipients and the carboxyl or hydroxyl groups of the insoluble matrix material, thus linking them together through chemical bonds. This improves the bonding force between the soluble portion and the insoluble matrix, thereby enhancing the stability of the antibacterial sustained-release structure and preventing the soluble portion from detaching from the insoluble matrix, which would affect product quality. Furthermore, it allows control of the dissolution rate of the water-soluble excipients, thereby controlling the release rate of the functional materials in the antibacterial sustained-release structure, and extending the service life of the antibacterial sustained-release structure while ensuring the effective function of the functional materials.

[0025] According to an embodiment of the present invention, referring to Figure 1 The water-soluble excipient 20 forms a dissolution portion 20 in the insoluble matrix 10 that connects to the outside of the insoluble matrix 10 (i.e., Figure 1 (The white area in the middle) The dissolution section 20 has a continuous structure, and the functional material is located in the dissolution section 20. Thus, the functional material is dispersed in the dissolution section, and can be released into the environment outside the insoluble matrix as the water-soluble excipients dissolve in water. Furthermore, because the dissolution section has a continuous structure, with the use of the antibacterial sustained-release structure, all functional materials on the surface and inside the insoluble matrix can be gradually and completely released, thereby increasing the service life of the antibacterial sustained-release structure, maintaining its good antibacterial effect for a longer period, improving material utilization, and avoiding waste of functional materials.

[0026] In an embodiment of the present invention, reference is made to Figure 1The width d of the dissolution zone is 50 nanometers to 50 micrometers, for example, d = 50 nanometers, 100 nanometers, 300 nanometers, 500 nanometers, 800 nanometers, 1 micrometer, 5 micrometer, 10 micrometer, 15 micrometer, 20 micrometer, 25 micrometer, 30 micrometer, 35 micrometer, 40 micrometer, 45 micrometer, and 50 micrometer. Therefore, the dissolution zone within the above-mentioned width range allows water molecules to pass through smoothly, as well as the functional materials and water-soluble excipients dissolved in the dissolution zone to pass through smoothly without clogging. Furthermore, the dissolution rate of the dissolution zone can be controlled by controlling its width, which can be achieved through factors such as the amount of insoluble substrate used and the process conditions for preparing the antibacterial sustained-release structure. Those skilled in the art will understand that, for example... Figure 1 The width of the dissolution portion at different locations in the antibacterial sustained-release structure is not exactly the same, as long as its width d is within the range of 50 nanometers to 50 micrometers.

[0027] In embodiments of the present invention, the water-soluble adjuvant includes at least one of polyvinyl alcohol, polyethylene glycol, and polyethylene oxide. The water-soluble adjuvants of the above materials have excellent solubility, dissolving slowly as water flows through them, and do not chemically react with functional materials in water, thus ensuring the stability of the antibacterial sustained-release structure. Simultaneously, the above materials have good safety, not affecting clothing after dissolving in water. Furthermore, because different water-soluble adjuvants have varying solubility in water, the present invention can control the dissolution rate of the dissolved portion by selecting different types of water-soluble adjuvants to meet different application requirements and environments of the antibacterial sustained-release structure.

[0028] In some embodiments, the molecular weight of the water-soluble excipient can be 5 to 3 million. Water-soluble excipients with such molecular weight have suitable solubility, and the dissolution rate of the dissolved portion can also be controlled by controlling the molecular weight of the water-soluble excipient. If the molecular weight of the water-soluble excipient is less than 50,000, the dissolved portion is not easy to form, and the solvent rate is too fast; if the molecular weight of the water-soluble excipient is greater than 3 million, the limitation of the dissolved portion is relatively large, making it difficult to process and difficult to form a continuous dissolved portion structure.

[0029] In embodiments of the present invention, the insoluble framework includes at least one of plastics (such as polyethylene, polypropylene, polylactic acid), rubber, and fibers. The insoluble framework formed by the above materials has good stability and is not easily deformed under the impact of a certain water flow; moreover, it is stable and not easily deteriorated; chemical bonds can be formed between the insoluble framework of the above materials and the water-soluble excipients of the above materials, thereby improving the stability of the antibacterial sustained-release structure.

[0030] According to embodiments of the present invention, the guanidine substance includes polyhexamethylene guanidine. Polyhexamethylene guanidine, as an antibacterial active substance, has good antibacterial efficacy. In the technical solution of the present invention, polyhexamethylene guanidine is gradually released along with water-soluble excipients, resulting in a sustained-release antibacterial structure with a long-term antibacterial effect, i.e., a long service life. In some embodiments, the functional material may also include other bactericides, such as amino acid-based bactericides, quaternary ammonium salt bactericides, metal bactericides, metal oxide bactericides (such as silver nitrate and copper sulfate), polyphenolic bactericides, arsenicine bactericides, plant extract bactericides, etc.

[0031] In embodiments of the present invention, the functional material includes at least one of a water softener and a descaling agent. Thus, the antibacterial slow-release structure possesses functions such as water softening, descaling, and sterilization. Those skilled in the art can flexibly select suitable functional materials based on the actual conditions of the application environment to meet the application requirements of the antibacterial slow-release structure. The water softener can be reagents such as phosphates, silicates, imine sulfonates, amino acid derivatives, hydroxy acids and their derivatives, polyacrylic acid and its derivatives, etc., and the descaling agent can be reagents such as sodium citrate, sodium polyaspartate, disodium ethylenediaminetetraacetate, etc.

[0032] According to an embodiment of the present invention, referring to Figure 2 Methods for preparing antibacterial sustained-release structures may include: S100: The functional material and water-soluble excipients are first blended, and the mixture obtained from the first blending is first granulated to obtain masterbatch, wherein the functional material includes guanidine substances.

[0033] According to embodiments of the present invention, the water-soluble excipients are pre-dried before the first blending. Pre-drying removes the water-soluble excipients' adsorbed moisture, thus preventing them from dissolving and affecting the stability of the antibacterial sustained-release structure. If the functional material is hygroscopic, the water-soluble excipients and functional material can be pre-dried together (if the functional material has poor hygroscopicity, drying is unnecessary), thereby preventing moisture in the functional material from dissolving the water-soluble excipients and affecting the efficacy and stability of the antibacterial sustained-release structure. In some embodiments of the present invention, the drying temperature is 50°C to 80°C, such as 50°C, 60°C, 65°C, 70°C, 75°C, or 80°C. Those skilled in the art can select the drying temperature based on the specific types of the water-soluble excipients and functional materials, ensuring rapid removal of adsorbed moisture without affecting the performance of the functional material. Furthermore, the drying time is 4 to 8 hours.

[0034] Furthermore, before the first blending, the functional materials and water-soluble excipients can be pre-ground to significantly improve the uniformity of the mixture. Additionally, a binder can be added during the first blending process to enhance the stability of the masterbatch, thereby improving the stability of the dissolved portion in the subsequently obtained antibacterial sustained-release structure.

[0035] According to embodiments of the present invention, there are no special requirements for the working temperature of the first blending. Those skilled in the art can flexibly select the appropriate temperature based on the specific types of functional materials and water-soluble excipients, as well as the specific equipment of the extruder (used for blending). In some embodiments, a twin-screw extruder can be used for blending. When using a twin-screw extruder, the working temperature of the first zone of the twin-screw extruder is about 50°C, and the working temperature of the other working zones (such as the second and third zones) is 160°C to 190°C.

[0036] According to an embodiment of the present invention, before performing the first granulation process, the mixture obtained from the first blending is subjected to a first air-cooling treatment. As mentioned above, the product obtained after blending by an extruder has a high temperature, around 160°C to 190°C, making it difficult to set. Therefore, to facilitate subsequent granulation, the blended product needs to be air-cooled. According to an embodiment of the present invention, the mixture obtained from the first blending is subjected to the first air-cooling treatment to below 50°C. Thus, the product treated with cold air has better hardness, facilitating cutting and granulation.

[0037] Furthermore, the particle size of the masterbatch is 2-5 mm. This size allows for more thorough and uniform mixing with the insoluble polymer material, which is beneficial for a continuous solubility section and reduces the likelihood of agglomeration. If the particle size of the masterbatch is less than 2 mm, agglomeration is more likely to occur, which is detrimental to the uniformity of mixing. If the particle size of the masterbatch is greater than 5 mm, it is relatively unfavorable to improving the uniformity of the distribution of the subsequent solubility section in the antibacterial sustained-release structure, affecting the continuity of the solubility section.

[0038] S200: The masterbatch and insoluble polymer material are sequentially subjected to a second blending and a second granulation process to obtain an antibacterial sustained-release structure.

[0039] According to embodiments of the present invention, there are no special requirements for the operating temperature of the second blending. Those skilled in the art can flexibly select the appropriate temperature based on the specific type of insoluble polymer material and the specific equipment of the extruder (used for blending). In some embodiments, a twin-screw extruder can be used for blending. When using a twin-screw extruder, the operating temperature of the first zone of the twin-screw extruder is about 50°C, and the operating temperature of the other working zones (such as the second and third zones) is 160°C to 190°C.

[0040] According to an embodiment of the present invention, before performing the second granulation process, the mixture obtained from the second blending is subjected to a second air-cooling treatment. As mentioned above, the product obtained after blending by an extruder has a high temperature, around 160°C to 190°C, making it difficult to set. Therefore, to facilitate subsequent granulation, the blended product needs to be air-cooled. According to an embodiment of the present invention, the mixture obtained from the second blending is subjected to the second air-cooling treatment to below 50°C. Thus, the product treated with cold air has better hardness, facilitating cutting and granulation. Furthermore, the particle size of the antibacterial sustained-release structure is 1-5 mm.

[0041] According to an embodiment of the present invention, in the above preparation method, the functional material is first blended and granulated with water-soluble excipients, and then the masterbatch is blended and granulated with insoluble polymeric material. This method allows the water-soluble excipients to form the dissolution part of the antibacterial sustained-release structure, and the functional material is dispersed in the dissolution part. In the antibacterial sustained-release structure, the insoluble polymeric material forms an insoluble framework, and the dissolution part is connected to the outside of the insoluble framework and has a continuous structure. In this way, the functional material can be released into the environment outside the insoluble framework as the water-soluble excipients dissolve in water. Moreover, since the dissolution part is a continuous structure, with the use of the antibacterial sustained-release structure, all functional materials on the surface and inside of the insoluble framework can be gradually and completely released, thereby increasing the service life of the antibacterial sustained-release structure, improving the utilization rate of materials, and avoiding the waste of functional materials.

[0042] According to embodiments of the present invention, the functional material, chain extender, and water-soluble excipient are first blended; and / or, the masterbatch, insoluble polymer material, and chain extender are second blended. Thus, the addition of the chain extender can alter the insoluble polymer material, causing a chemical reaction between the insoluble polymer material and the water-soluble excipient, thereby reducing the dissolution rate of the dissolved portion and achieving controllability of the dissolution rate through both physical and chemical means.

[0043] In another aspect, the present invention provides a washing machine. According to an embodiment of the invention, the washing machine includes the aforementioned antibacterial slow-release structure, which is disposed on the water inlet pipe. Thus, during washing, water washes the antibacterial slow-release structure located on the water inlet pipe, allowing the functional materials dispersed in the water-soluble additives to be released into the environment outside the insoluble substrate as the water-soluble additives dissolve in the water. Furthermore, since the dispersion of the water-soluble additives in the antibacterial slow-release structure has a certain continuity, with the use of the antibacterial slow-release structure, all functional materials on and inside the insoluble substrate can be gradually and completely released, thereby increasing the service life of the antibacterial slow-release structure, improving material utilization, and avoiding waste of functional materials.

[0044] In an embodiment of the present invention, an antibacterial slow-release structure can be placed in the detergent dispenser of a washing machine. In this way, when water flows through the detergent, it simultaneously washes the buffer structure, causing the dissolving part to dissolve and the functional material to enter the washing tub with the water flow.

[0045] In another aspect, the present invention provides a cleaning device. According to an embodiment of the invention, the cleaning device includes the aforementioned antibacterial slow-release structure, which is disposed on a water inlet pipe. Thus, when the cleaning device cleans, water flushes the antibacterial slow-release structure located on the water inlet pipe, allowing the functional materials dispersed in the water-soluble excipients to be released into the environment outside the insoluble substrate as the water-soluble excipients dissolve in the water. Furthermore, since the dispersion of the water-soluble excipients in the antibacterial slow-release structure has a certain continuity, with the use of the antibacterial slow-release structure, all functional materials on and inside the insoluble substrate can be gradually and completely released, thereby increasing the service life of the antibacterial slow-release structure, improving material utilization, and avoiding waste of functional materials.

[0046] According to embodiments of the present invention, the specific types of cleaning equipment include, but are not limited to, cleaning equipment that requires water cleaning, such as washing machines and dishwashers. Those skilled in the art can select the specific types of functional materials according to the specific purpose of the cleaning equipment in order to achieve different cleaning effects.

[0047] Example Example 1 Polyethylene oxide (PEO, water-soluble auxiliary material) and polyhexamethylene guanidine (functional material) were dried at 50°C for 6 hours. Polyethylene oxide (PEO) and polyhexamethylene guanidine were first blended using a twin-screw extruder. The operating temperatures of the twin-screw extruder were: 50°C in zone 1, 150°C in zone 2, 170°C in zone 3, 175°C in zone 4, 175°C in zone 5, 175°C in zone 6, and 160°C in the die. The mixture obtained from the first blending was then subjected to a first air-cooling treatment to below 50°C. The mixture that has undergone the first air cooling treatment is subjected to the first granulation treatment to obtain master and daughter pellets with a particle size of 2~5mm. Using a twin-screw extruder, the masterbatch is blended with polyethylene (PE, an insoluble polymer material) for a second time. The operating temperatures of the twin-screw extruder are: Zone 1: 150℃, Zone 2: 160℃, Zone 3: 170℃, Zone 4: 170℃, Zone 5: 170℃, Zone 6: 170℃, and the die temperature is 160℃. The mixture obtained from the second blending is subjected to a second air-cooling treatment to below 50°C; The mixture, after undergoing a second air-cooling treatment, is then subjected to a second granulation process to obtain an antibacterial sustained-release structure. In this structure, the width d of the dissolved portion is between 50 nanometers and 50 micrometers. In the above preparation method, the amount of insoluble polymer material is 60 parts by weight, the amount of water-soluble excipient is 20 parts by weight, and the amount of functional material is 20 parts by weight.

[0048] Example 2 Polyethylene oxide (PEO) and polyhexamethylene guanidine were dried at 50°C for 6 hours. Polyethylene oxide (PEO) and polyhexamethylene guanidine were first blended using a twin-screw extruder. The operating temperatures of the twin-screw extruder were: Zone 1: 50℃, Zone 2: 150℃, Zone 3: 170℃, Zone 4: 175℃, Zone 5: 175℃, Zone 6: 175℃, and the die temperature was 160℃. The mixture obtained from the first blending is subjected to a first air-cooling treatment to below 50°C; The mixture that has undergone the first air cooling treatment is subjected to the first granulation treatment to obtain master and daughter pellets with a particle size of 2~5mm. Using a twin-screw extruder, the masterbatch and polypropylene (PP) are blended a second time. The operating temperatures of the twin-screw extruder are: Zone 1: 160℃, Zone 2: 170℃, Zone 3: 180℃, Zone 4: 180℃, Zone 5: 180℃, Zone 6: 180℃, and the die temperature is 170℃. The mixture obtained from the second blending is subjected to a second air-cooling treatment to below 50°C; The mixture, after undergoing a second air-cooling treatment, is then subjected to a second granulation process to obtain an antibacterial sustained-release structure. In this structure, the width d of the dissolved portion is between 50 nanometers and 50 micrometers. In the above preparation method, the amount of insoluble polymer material is 60 parts by weight, the amount of water-soluble excipient is 20 parts by weight, and the amount of functional material is 20 parts by weight.

[0049] Example 3 Polyethylene oxide (PEO) and polyhexamethylene guanidine were dried at 50°C for 6 hours. Polyethylene oxide (PEO), polyhexamethylene guanidine, and chain extender ADR were first blended using a twin-screw extruder. The operating temperatures of the twin-screw extruder were: Zone 1: 50℃, Zone 2: 150℃, Zone 3: 170℃, Zone 4: 175℃, Zone 5: 175℃, Zone 6: 175℃, and the die temperature was 160℃. The mixture obtained from the first blending is subjected to a first air-cooling treatment to below 50°C; The mixture that has undergone the first air cooling treatment is subjected to the first granulation treatment to obtain master and daughter pellets with a particle size of 2~5mm. Using a twin-screw extruder, the masterbatch and polylactic acid (PLA) are blended a second time. The operating temperatures of the twin-screw extruder are: Zone 1: 170℃, Zone 2: 180℃, Zone 3: 180℃, Zone 4: 185℃, Zone 5: 185℃, Zone 6: 180℃, and the die temperature is 170℃. The mixture obtained from the second blending is subjected to a second air-cooling treatment to below 50°C; The mixture, after undergoing a second air-cooling treatment, is then subjected to a second granulation process to obtain an antibacterial sustained-release structure. In this structure, the width d of the dissolved portion is between 50 nanometers and 50 micrometers. In the above preparation method, the amount of insoluble polymer material is 50 parts by weight, the amount of water-soluble excipient is 30 parts by weight, the amount of functional material is 10 parts by weight, and the amount of chain extender is 10 parts by weight.

[0050] Comparative Example 1 The polyethylene oxide (PEO) was dried at 50°C for 6 hours. Polyethylene oxide (PEO) and copper sulfate (CuSO4) were first blended using a twin-screw extruder. The operating temperatures of the twin-screw extruder were: 50℃ in zone 1, 150℃ in zone 2, 170℃ in zone 3, 175℃ in zone 4, 175℃ in zone 5, 175℃ in zone 6, and 160℃ in the die. The mixture obtained from the first blending is subjected to a first air-cooling treatment to below 50°C; The mixture that has undergone the first air cooling treatment is subjected to the first granulation treatment to obtain master and daughter pellets with a particle size of 2~5mm. Using a twin-screw extruder, the masterbatch and polypropylene (PP) are blended a second time. The operating temperatures of the twin-screw extruder are: Zone 1: 160℃, Zone 2: 170℃, Zone 3: 180℃, Zone 4: 180℃, Zone 5: 180℃, Zone 6: 180℃, and the die temperature is 170℃. The mixture obtained from the second blending is subjected to a second air-cooling treatment to below 50°C; The mixture, after undergoing a second air-cooling treatment, is then subjected to a second granulation process to obtain an antibacterial sustained-release structure. In this structure, the width d of the dissolved portion is between 50 nanometers and 50 micrometers. In the above preparation method, the amount of insoluble polymer material is 60 parts by weight, the amount of water-soluble excipient is 20 parts by weight, and the amount of functional material is 20 parts by weight.

[0051] Comparative Example 2 Polyethylene oxide (PEO) and polyhexamethylene guanidine were dried at 50°C for 6 hours. Polyethylene (PE), polyethylene oxide (PEO), and polyhexamethylene guanidine were blended using a twin-screw extruder. The operating temperatures of the twin-screw extruder were: Zone 1: 150℃, Zone 2: 160℃, Zone 3: 170℃, Zone 4: 170℃, Zone 5: 170℃, Zone 6: 170℃, and the die temperature was 160℃. The mixture obtained from the first blending was air-cooled to below 50°C. The mixture, which has undergone air cooling, is then granulated to obtain a functional composite material. In the above preparation method, the amount of insoluble polymer material is 60 parts by weight, the amount of water-soluble excipient is 20 parts by weight, and the amount of functional material is 20 parts by weight.

[0052] Table 1

[0053] In this study, 20g each of the antibacterial sustained-release structure prepared in Examples 1-7 and the functional composite material prepared in Comparative Example 1 were weighed. The samples were then symmetrically rinsed with water for a certain period of time at a flow rate of 7L / min. After rinsing, the samples were dried (at 50°C) and weighed. This process of rinsing, drying, and weighing was repeated several times until the release of the functional material became slow and its effect was not obvious. The rinsing time mentioned above refers to the time during which the functional material can function normally. Continuing to rinse further slows the release of the functional material, and the function of the antibacterial sustained-release structure becomes insignificant. The utilization rate of the functional material = (initial weight of the antibacterial sustained-release structure - weight of the antibacterial sustained-release structure after rinsing and drying) / initial weight of the antibacterial sustained-release structure * 100%.

[0054] As shown in Table 1, compared to Comparative Example 1, the antibacterial sustained-release structures prepared in Examples 1-3 have a longer sustained-release time and a higher utilization rate of functional materials, indicating that the antibacterial sustained-release structures prepared in Examples 1-3 have a long-lasting antibacterial effect. Furthermore, compared to Comparative Example 2, the antibacterial sustained-release structures prepared in Examples 1-3 have a longer sustained-release time and a higher utilization rate of functional materials; while in Comparative Example 2, even after continuous rinsing for a long time, the utilization rate of functional materials remained at a low level.

[0055] The terms "first" and "second" used in this document are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature marked "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0056] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0057] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. An antibacterial sustained-release structure, characterized in that, include: The product comprises an insoluble matrix, water-soluble excipients, and functional materials, wherein the functional materials include guanidine compounds.

2. The antibacterial sustained-release structure according to claim 1, characterized in that, Guanidine compounds include polyhexamethylene guanidine.

3. The antibacterial sustained-release structure according to claim 1, characterized in that, include: 30-70 parts by weight of insoluble matrix; 15-60 parts by weight of water-soluble excipients; as well as 1 to 35 parts by weight of functional materials.

4. The antibacterial sustained-release structure according to claim 3, characterized in that, It also includes 5 to 10 parts by weight of chain extender.

5. The antibacterial sustained-release structure according to claim 4, characterized in that, The water-soluble excipient is chemically bonded to the insoluble matrix.

6. The sustained-release structure according to claim 1, characterized in that, The water-soluble excipient forms a dissolution portion in the insoluble matrix that connects to the outside of the insoluble matrix. The dissolution portion has a continuous structure, and the functional material is located in the dissolution portion.

7. The antibacterial sustained-release structure according to claim 6, characterized in that, The width of the dissolved portion is 50 nanometers to 50 micrometers.

8. The antibacterial sustained-release structure according to any one of claims 1 to 7, characterized in that, The water-soluble excipients include at least one of polyvinyl alcohol, polyethylene glycol, and polyethylene oxide.

9. The antibacterial sustained-release structure according to any one of claims 1 to 7, characterized in that, The insoluble substrate comprises at least one of plastic, rubber, and fiber.

10. The antibacterial sustained-release structure according to any one of claims 1 to 7, characterized in that, The functional material also includes at least one of a water softener and a descaling agent.

11. A washing machine, characterized in that, The invention includes the antibacterial slow-release structure as described in any one of claims 1 to 10, wherein the antibacterial slow-release structure is disposed on the water inlet pipe of the washing machine.

12. A cleaning device, characterized in that, The device includes the antibacterial sustained-release structure as described in any one of claims 1 to 10, wherein the antibacterial sustained-release structure is disposed on the water inlet pipe of the cleaning device.

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